Photo of Peter van Galen,  PhD

Peter van Galen, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 525-4919


pvangalen@bwh.harvard.edu

Peter van Galen, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Medicine, Harvard Medical School
  • Associate Molecular Biologist, Hematology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

The van Galen laboratory investigates normal and malignant hematopoiesis, with a focus on acute myeloid leukemia (AML). We use innovative experimental and computational technologies to study human cells at the transcriptional, genetic and epigenetic levels. The ultimate goal is to design new therapies that can prevent the initiation or progression of leukemia.

Publications

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  • van Galen P, Hovestadt V, Wadsworth Ii MH, Hughes TK, Griffin GK, Battaglia S, Verga JA, Stephansky J, Pastika TJ, Lombardi Story J, Pinkus GS, Pozdnyakova O, Galinsky I, Stone RM, Graubert TA, Shalek AK, Aster JC, Lane AA, Bernstein BE. Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity. Cell 2019; 176:1265-1281.e24. PubMed
  • van Galen P, Mbong N, Kreso A, Schoof EM, Wagenblast E, Ng SWK, Krivdova G, Jin L, Nakauchi H, Dick JE. Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia. Cell Rep 2019; 25:1109-1117.e5. PubMed
  • van Galen P, Viny AD, Ram O, Ryan RJ, Cotton MJ, Donohue L, Sievers C, Drier Y, Liau BB, Gillespie SM, Carroll KM, Cross MB, Levine RL, Bernstein BE. A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes. Mol Cell 2016; 61:170-80. PubMed
  • van Galen P, Kreso A, Mbong N, Kent DG, Fitzmaurice T, Chambers JE, Xie S, Laurenti E, Hermans K, Eppert K, Marciniak SJ, Goodall JC, Green AR, Wouters BG, Wienholds E, Dick JE. The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress. Nature 2019; 510:268-72. PubMed
  • van Galen P, Kreso A, Wienholds E, Laurenti E, Eppert K, Lechman ER, Mbong N, Hermans K, Dobson S, April C, Fan JB, Dick JE. Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion. Cell Stem Cell 2016; 14:94-106. PubMed