B and T cells are important in vaccines, infections, autoimmunity, aging, and cancer. There are millions of these cells in a typical blood sample. High-throughput sequencing and big-data computational biology make it possible to investigate how this unique set of cells carries out its functionsâ€”and raise the possibility of using them as early diagnostics and biological therapeutics for a range of conditions. In our lab, we are sequencing and analyzing antibodies and T cell receptors across species and medical conditions to understand this complex system. Specific projects include sequencing and analysis of B- and T-cell repertoires in melanoma and cancer and other vaccines.