Photo of Robert C. Green,  MD, MPH

Robert C. Green, MD, MPH

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 264-5834
Fax: (617) 264-8795

Robert C. Green, MD, MPH

Brigham And Women's Hospital


  • Professor, Medicine, Harvard Medical School
  • Geneticist, Medicine, Brigham And Women's Hospital


Research Abstract

I am a medical geneticist and physician-scientist with a research focus in translational genomics and health outcomes. I have over 20 years of experience directing large multi-disciplinary and multi-institutional projects that have generated empirical data around the medical, behavioral and economic impact of utilizing genomics in the practice of medicine and have led the field in designing and implementing randomized trials in genomic medicine. For example, as PI of the REVEAL Study, continuously funded since 1999, I have led 5 randomized trials that will have enrolled a total of over 1,100 individuals to explore emerging themes in translational genomics of susceptibility genes. As PI of the MedSeq Project within the Clinical Sequencing Exploratory Research Consortium, I directed one of the first randomized trials to examine the impact of whole genome sequencing in the adult practice of medicine. As mPI of the BabySeq Project, within the Newborn Sequencing in Genomic Medicine and Public Health Consortium, I am co-directing a randomized trial to examine the risks and benefits of newborn genome sequencing, which the current proposal will expand upon. As PI of the MilSeq Project, I am leading a pilot project of genome sequencing in active duty members of the US military. I am also co-PI of the Harvard Partners (BWH) site for the Electronic Medical Records and Genomics Network, and a co-investigator within the Partners recruitment site for Precision Medicine Initiative (AllofUs).

I have participated in a number of working groups around policy issues in genomic medicine. In particular, I was co-chair and lead author of the process and publication of the 2013 ACMG recommendations on return of incidental variants in clinical sequencing. I see patients in an adult genetics clinic and participate in gene discovery research as a member of the Brigham Genomic Medicine Gene Discovery Program.

BWH Preventive Genomics Clinic:

Publications from Harvard Catalyst Profiles

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  • Blout Zawatsky CL, Shah N, Machini K, Perez E, Christensen KD, Zouk H, Steeves M, Koch C, Uveges M, Shea J, Gold N, Krier J, Boutin N, Mahanta L, Rehm HL, Weiss ST, Karlson EW, Smoller JW, Lebo MS, Green RC. Returning actionable genomic results in a research biobank: Analytic validity, clinical implementation, and resource utilization. Am J Hum Genet 2021. PubMed
  • Wynn J, Milo Rasouly H, Vasquez-Loarte T, Saami AM, Weiss R, Ziniel SI, Appelbaum PS, Wright Clayton E, Christensen KD, Fasel D, Green RC, Hain HS, Harr M, Hoell C, Kullo IJ, Leppig KA, Myers MF, Pacyna JE, Perez EF, Prows CA, Kulchak Rahm A, Campbell-Salome G, Sharp RR, Smith ME, Wiesner GL, Williams JL, Blout Zawatsky CL, Gharavi AG, Chung WK, Holm IA. Do research participants share genomic screening results with family members? J Genet Couns 2021. PubMed
  • Lewis ACF, Knoppers BM, Green RC. An international policy on returning genomic research results. Genome Med 2021; 13:115. PubMed
  • Raoof S, Kennedy CJ, Wallach DA, Bitton A, Green RC. Molecular cancer screening: in search of evidence. Nat Med 2021; 27:1139-1142. PubMed
  • Galbraith LN, Preys CL, Rehm HL, Scheuner MT, Hajek C, Green RC, Christensen KD. Primary care providers' responses to unsolicited Lynch syndrome secondary findings of varying clinical significance. Genet Med 2021. PubMed
  • Linderman MD, Suckiel SA, Thompson N, Weiss DJ, Roberts JS, Green RC. Development and Validation of a Comprehensive Genomics Knowledge Scale. Public Health Genomics 2021. PubMed
  • Yeh JM, Stout NK, Chaudhry A, Christensen KD, Gooch M, McMahon PM, O'Brien G, Rehman N, Blout Zawatsky CL, Green RC, Lu CY, Rehm HL, Williams MS, Diller L, Wu AC. Universal newborn genetic screening for pediatric cancer predisposition syndromes: model-based insights. Genet Med 2021. PubMed
  • Lewis ACF, Green RC. Polygenic risk scores in the clinic: new perspectives needed on familiar ethical issues. Genome Med 2021; 13:14. PubMed
  • Christensen KD, Bell M, Zawatsky CLB, Galbraith LN, Green RC, Hutchinson AM, Jamal L, LeBlanc JL, Leonhard JR, Moore M, Mullineaux L, Petry N, Platt DM, Shaaban S, Schultz A, Tucker BD, Van Heukelom J, Wheeler E, Zoltick ES, Hajek C, . Precision Population Medicine in Primary Care: The Sanford Chip Experience. Front Genet 2021; 12:626845. PubMed
  • Haverfield EV, Esplin ED, Aguilar SJ, Hatchell KE, Ormond KE, Hanson-Kahn A, Atwal PS, Macklin-Mantia S, Hines S, Sak CW, Tucker S, Bleyl SB, Hulick PJ, Gordon OK, Velsher L, Gu JYJ, Weissman SM, Kruisselbrink T, Abel C, Kettles M, Slavotinek A, Mendelsohn BA, Green RC, Aradhya S, Nussbaum RL. Physician-directed genetic screening to evaluate personal risk for medically actionable disorders: a large multi-center cohort study. BMC Med 2021; 19:199. PubMed
  • Hayeems RZ, Dimmock D, Bick D, Belmont JW, Green RC, Lanpher B, Jobanputra V, Mendoza R, Kulkarni S, Grove ME, Taylor SL, Ashley E, . Clinical utility of genomic sequencing: a measurement toolkit. NPJ Genom Med 2020; 5:56. PubMed
  • Marzulla T, Roberts JS, DeVries R, Koeller DR, Green RC, Uhlmann WR. Genetic counseling following direct-to consumer genetic testing: Consumer perspectives. J Genet Couns 2020. PubMed
  • Wiesner GL, Kulchak Rahm A, Appelbaum P, Aufox S, Bland ST, Blout CL, Christensen KD, Chung WK, Clayton EW, Green RC, Harr MH, Henrikson N, Hoell C, Holm IA, Jarvik GP, Kullo IJ, Lammers PE, Larson EB, Lindor NM, Marasa M, F Myers M, Peterson JF, Prows CA, Ralston JD, Milo Rasouly H, Sharp RR, Smith ME, Van Driest SL, Williams JL, Williams MS, Wynn J, Leppig KA. Returning Results in the Genomic Era: Initial Experiences of the eMERGE Network. J Pers Med 2020. PubMed
  • Arges K, Assimes T, Bajaj V, Balu S, Bashir MR, Beskow L, Blanco R, Califf R, Campbell P, Carin L, Christian V, Cousins S, Das M, Dockery M, Douglas PS, Dunham A, Eckstrand J, Fleischmann D, Ford E, Fraulo E, French J, Gambhir SS, Ginsburg GS, Green RC, Haddad F, Hernandez A, Hernandez J, Huang ES, Jaffe G, King D, Koweek LH, Langlotz C, Liao YJ, Mahaffey KW, Marcom K, Marks WJ, Maron D, McCabe R, McCall S, McCue R, Mega J, Miller D, Muhlbaier LH, Munshi R, Newby LK, Pak-Harvey E, Patrick-Lake B, Pencina M, Peterson ED, Rodriguez F, Shore S, Shah S, Shipes S, Sledge G, Spielman S, Spitler R, Schaack T, Swamy G, Willemink MJ, Wong CA. The Project Baseline Health Study: a step towards a broader mission to map human health. NPJ Digit Med 2020; 3:84. PubMed
  • Baudhuin LM, Biesecker LG, Burke W, Green ED, Green RC. Predictive and Precision Medicine with Genomic Data. Clin Chem 2019. PubMed
  • Lu CY, Hendricks-Sturrup RM, Mazor KM, McGuire AL, Green RC, Rehm HL. The case for implementing sustainable routine, population-level genomic reanalysis. Genet Med 2019. PubMed
  • Robinson JO, Wynn J, Biesecker B, Biesecker LG, Bernhardt B, Brothers KB, Chung WK, Christensen KD, Green RC, McGuire AL, Hart MR, Griesemer I, Patrick DL, Rini C, Veenstra D, Cronin AM, Gray SW. Psychological outcomes related to exome and genome sequencing result disclosure: a meta-analysis of seven Clinical Sequencing Exploratory Research (CSER) Consortium studies. Genet Med 2019. PubMed
  • Zoltick ES, Linderman MD, McGinniss MA, Ramos E, Ball MP, Church GM, Leonard DGB, Pereira S, McGuire AL, Caskey CT, Sanderson SC, Schadt EE, Nielsen DE, Crawford SD, Green RC, . Predispositional genome sequencing in healthy adults: design, participant characteristics, and early outcomes of the PeopleSeq Consortium. Genome Med 2019; 11:10. PubMed
  • Hart MR, Biesecker BB, Blout CL, Christensen KD, Amendola LM, Bergstrom KL, Biswas S, Bowling KM, Brothers KB, Conlin LK, Cooper GM, Dulik MC, East KM, Everett JN, Finnila CR, Ghazani AA, Gilmore MJ, Goddard KAB, Jarvik GP, Johnston JJ, Kauffman TL, Kelley WV, Krier JB, Lewis KL, McGuire AL, McMullen C, Ou J, Plon SE, Rehm HL, Richards CS, Romasko EJ, Miren Sagardia A, Spinner NB, Thompson ML, Turbitt E, Vassy JL, Wilfond BS, Veenstra DL, Berg JS, Green RC, Biesecker LG, Hindorff LA. Secondary findings from clinical genomic sequencing: prevalence, patient perspectives, family history assessment, and health-care costs from a multisite study. Genet Med 2019; 21:1100-1110. PubMed
  • Brothers KB, Vassy JL, Green RC. Reconciling Opportunistic and Population Screening in Clinical Genomics. Mayo Clin. Proc. 2019; 94:103-109. PubMed
  • Wolf SM, Scholtes E, Koenig BA, Petersen GM, Berry SA, Beskow LM, Daly MB, Fernandez CV, Green RC, LeRoy BS, Lindor NM, O'Rourke PP, Breitkopf CR, Rothstein MA, Van Ness B, Wilfond BS. Pragmatic Tools for Sharing Genomic Research Results with the Relatives of Living and Deceased Research Participants. J Law Med Ethics 2018; 46:87-109. PubMed
  • Roberts JS, Robinson JO, Diamond PM, Bharadwaj A, Christensen KD, Lee KB, Green RC, McGuire AL, . Patient understanding of, satisfaction with, and perceived utility of whole-genome sequencing: findings from the MedSeq Project. Genet Med 2018; 20:1069-1076. PubMed
  • Vassy JL, Davis JK, Kirby C, Richardson IJ, Green RC, McGuire AL, Ubel PA. How Primary Care Providers Talk to Patients about Genome Sequencing Results: Risk, Rationale, and Recommendation. J Gen Intern Med 2018; 33:877-885. PubMed
  • Landry L, Nielsen DE, Carere DA, Roberts JS, Green RC, . Racial minority group interest in direct-to-consumer genetic testing: findings from the PGen study. J Community Genet 2017; 8:293-301. PubMed
  • Marshall DA, MacDonald KV, Robinson JO, Barcellos LF, Gianfrancesco M, Helm M, McGuire A, Green RC, Douglas MP, Goldman MA, Phillips KA. The price of whole-genome sequencing may be decreasing, but who will be sequenced? Per Med 2017; 14:203-211. PubMed
  • Han PKJ, Umstead KL, Bernhardt BA, Green RC, Joffe S, Koenig B, Krantz I, Waterston LB, Biesecker LG, Biesecker BB. A taxonomy of medical uncertainties in clinical genome sequencing. Genet Med 2017; 19:918-925. PubMed
  • Arora NS, Davis JK, Kirby C, McGuire AL, Green RC, Blumenthal-Barby JS, Ubel PA, . Communication challenges for nongeneticist physicians relaying clinical genomic results. Per Med 2016; 14:423-431. PubMed
  • Jamal L, Robinson JO, Christensen KD, Blumenthal-Barby J, Slashinski MJ, Perry DL, Vassy JL, Wycliff J, Green RC, McGuire AL. When bins blur: Patient perspectives on categories of results from clinical whole genome sequencing. AJOB Empir Bioeth ; 8:82-88. PubMed