I am a physician-scientist focused on developing novel diagnostic, preventative, and therapeutic options for pancreatic cancer. To this end, our research group leverages 4 areas of expertise and collaborative resources:
(1) Longitudinal clinical interactions with hereditary pancreatic cancer families at the DFCI Cancer Genetics and Prevention Clinic.
(2) Genome sequencing analysis of families with hereditary pancreatic syndromes to discover novel germline variants with a high effect size on pancreatic cancer risk.
(3) Zebrafish model organisms to allow rapid validation and mechanistic characterization of novel cancer pathways in large populations.
(4) Developmental biology perspective: proficiency in experimental approaches and conceptual paradigms for mechanistically characterizing signaling pathways in cancer through the context of embryonic organogenesis.