Photo of Sean Lawler,  PhD

Sean Lawler, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 525-5066
Fax: (617) 525-5067


slawler@partners.org

Sean Lawler, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Neurosurgery, Harvard Medical School
  • Assistant Professor, Neurosurgery, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

The overarching goal of my laboratory is to develop and optimize novel therapies for brain tumors through the use of advanced research tools, animal models and collaborative enterprise. The Lawler lab utilizes molecular biological approaches, high-throughput cell-based assays and preclinical immunocompetent and invasive mouse models of glioblastoma and collaborates extensively with investigators in bioinformatics, imaging, immunology, oncolytic viruses, virology and drug design. Our major goal is to provide the foundation to move new therapies forward from bench to bedside; for example clinicaltrials.gov NCT03576612, which was developed based on our data combining local immunostimulation with immune checkpoint blockade. The use of STING agonists would represent an exciting approach for GBM, and we have assembled a team with the strengths and qualities to investigate this in detail using the framework of tools developed in my research laboratory, and a clear path to patient application through our clinical connections at BWH and DFCI Neuro Oncology.

Publications

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  • Peruzzi P, Bronisz A, Nowicki MO, Wang Y, Ogawa D, Price R, Nakano I, Kwon CH, Hayes J, Lawler SE, Ostrowski MC, Chiocca EA, Godlewski J. MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells. 2013. PubMed
  • Levesley J, Steele L, Taylor C, Sinha P, Lawler SE. ABT-263 enhances sensitivity to metformin and 2-deoxyglucose in pediatric glioma by promoting apoptotic cell death. PLoS ONE 2013; 8:e64051. PubMed
  • Alvarez-Breckenridge CA, Yu J, Price R, Wojton J, Pradarelli J, Mao H, Wei M, Wang Y, He S, Hardcastle J, Fernandez SA, Kaur B, Lawler SE, Vivier E, Mandelboim O, Moretta A, Caligiuri MA, Chiocca EA. NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors. Nat Med 2012; 18:1827-34. PubMed
  • Agudelo-Garcia PA, De Jesus JK, Williams SP, Nowicki MO, Chiocca EA, Liyanarachchi S, Li PK, Lannutti JJ, Johnson JK, Lawler SE, Viapiano MS. Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling. Neoplasia 2011; 13:831-40. PubMed
  • Williams SP, Nowicki MO, Liu F, Press R, Godlewski J, Abdel-Rasoul M, Kaur B, Fernandez SA, Chiocca EA, Lawler SE. Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments. Cancer Res 2011; 71:5374-80. PubMed
  • Godlewski J, Nowicki MO, Bronisz A, Nuovo G, Palatini J, De Lay M, Van Brocklyn J, Ostrowski MC, Chiocca EA, Lawler SE. MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. Mol Cell 2010; 37:620-32. PubMed