Photo of Sheheryar Kabraji,  MB, ChB

Sheheryar Kabraji, MB, ChB

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute


sheheryar_kabraji@dfci.harvard.edu

Sheheryar Kabraji, MB, ChB

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Instructor, Medicine, Harvard Medical School
  • Physician, Medical Oncology, Dana-Farber Cancer Institute

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr Kabraji is a physician-scientist using single cell approaches to understand how cell cycle states contribute to drug resistance and cancer relapse in cancer. He has developed novel approaches to measuring cell cycle states in tissues from mouse models and human tumors. Current efforts are focused on translational validation and mechanistic understanding of quiescent cancer cell heterogeneity within untreated and treated tumors. As a physician at Dana Farber Cancer Institute, Dr Kabraji specializes in the treatment of patients with breast cancer brain metastases.

Publications from Harvard Catalyst Profiles

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  • Ni J, Kabraji S, Xie S, Wang Y, Pan P, He X, Liu Z, Leone JP, Long HW, Brown MA, Winer EP, Dillon DAR, Lin NU, Zhao JJ. p16-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases. Nat Commun 2022; 13:1473. PubMed
  • Gaglia G, Kabraji S, Rammos D, Dai Y, Verma A, Wang S, Mills CE, Chung M, Bergholz JS, Coy S, Lin JR, Jeselsohn R, Metzger O, Winer EP, Dillon DA, Zhao JJ, Sorger PK, Santagata S. Temporal and spatial topography of cell proliferation in cancer. Nat Cell Biol 2022; 24:316-326. PubMed
  • Bergholz JS, Wang Q, Kabraji S, Zhao JJ. Integrating immunotherapy and targeted therapy in cancer treatment: Mechanistic insights and clinical implications. Clin Cancer Res 2020. PubMed
  • Liu Z, Wang Y, Kabraji S, Xie S, Pan P, Liu Z, Ni J, Zhao JJ. Improving orthotopic mouse models of patient-derived breast cancer brain metastases by a modified intracarotid injection method. Sci Rep 2019; 9:622. PubMed
  • Kabraji S, Sole X, Huang Y, Bango C, Sgroi D, Loda M, Ramaswamy S. AKT1 quiescent cancer cells in ductal carcinoma in situ of the breast. NPJ Breast Cancer 2019; 5:10. PubMed
  • Kabraji S, Ni J, Lin NU, Xie S, Winer EP, Zhao JJ. Drug Resistance in HER2-Positive Breast Cancer Brain Metastases: Blame the Barrier or the Brain? Clin Cancer Res 2018. PubMed
  • Alves CP, Dey-Guha I, Kabraji S, Yeh AC, Talele NP, Solé X, Chowdhury J, Mino-Kenudson M, Loda M, Sgroi D, Borresen-Dale AL, Russnes HG, Ross KN, Ramaswamy S. AKT1low Quiescent Cancer Cells Promote Solid Tumor Growth. Mol Cancer Ther 2018; 17:254-263. PubMed
  • Kabraji S, Solé X, Huang Y, Bango C, Bowden M, Bardia A, Sgroi D, Loda M, Ramaswamy S. AKT1(low) quiescent cancer cells persist after neoadjuvant chemotherapy in triple negative breast cancer. Breast Cancer Res 2017; 19:88. PubMed
  • Kabraji S. Progress requires scientific thinking at all levels. Nature 2004; 432:949. PubMed