Our lab research interests primarily focus on understanding the mechanism by which epigenetic reprogramming contributes to cellular plasticity in tumors. His research aims to define the mechanisms in which deregulated chromatin remodeling or altered chromatin landscape act as oncogenic drivers in cancer. Epigenetic reprogramming is a key oncogenic driver event in multiple cancers, however very little is known about the deregulated epigenetic programs in head and neck squamous cell carcinomas (HNSCC).
We are also interested in delineating oncogenic role of hippo signaling pathway effector, YAP1 in squamous cell carcinomas and melanoma. Hippo pathway was shown to bypass the MAPK oncogenic addiction in advanced stage of multiple cancers contributing to cancer progression.
We integrate genomics, epigenetics, and signaling to dissect the mechanisms contributing to tumor maintenance and progression