Photo of Srinivas Vinod Saladi,  PhD

Srinivas Vinod Saladi, PhD

MASSACHUSETTS EYE AND EAR INSTITUTE

MASSACHUSETTS EYE AND EAR INSTITUTE
Phone: (617) 807-7881


srinivasvinod_saladi@meei.harvard.edu

Srinivas Vinod Saladi, PhD

MASSACHUSETTS EYE AND EAR INSTITUTE

EDUCATIONAL TITLES

  • Instructor, Otology and Laryngology, Harvard Medical School
  • Investigator, Otolaryngology , MASSACHUSETTS EYE AND EAR INSTITUTE
  • Member, Cancer Center, Massachusetts General Hosptial
  • Associated Scientist, 415 Main Street, Broad Institute of MIT and Harvard

DF/HCC PROGRAM AFFILIATION

Research Abstract

Our lab research interests primarily focus on understanding the mechanism by which epigenetic reprogramming contributes to cellular plasticity in tumors. His research aims to define the mechanisms in which deregulated chromatin remodeling or altered chromatin landscape act as oncogenic drivers in cancer. Epigenetic reprogramming is a key oncogenic driver event in multiple cancers, however very little is known about the deregulated epigenetic programs in head and neck squamous cell carcinomas (HNSCC).

We are also interested in delineating oncogenic role of hippo signaling pathway effector, YAP1 in squamous cell carcinomas and melanoma. Hippo pathway was shown to bypass the MAPK oncogenic addiction in advanced stage of multiple cancers contributing to cancer progression.

We integrate genomics, epigenetics, and signaling to dissect the mechanisms contributing to tumor maintenance and progression

Publications

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  • Aras S, Saladi SV, Basuroy T, Marathe HG, Lorès P, de la Serna IL. BAF60A mediates interactions between the microphthalmia-associated transcription factor and the BRG1-containing SWI/SNF complex during melanocyte differentiation. J Cell Physiol 2019; 234:11780-11791. PubMed
  • Tata PR, Chow RD, Saladi SV, Tata A, Konkimalla A, Bara A, Montoro D, Hariri LP, Shih AR, Mino-Kenudson M, Mou H, Kimura S, Ellisen LW, Rajagopal J. Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. Dev Cell 2018; 44:679-693.e5. PubMed
  • Matissek KJ, Onozato ML, Sun S, Zheng Z, Schultz A, Lee J, Patel K, Jerevall PL, Saladi SV, MacLeay A, Tavallai M, Badovinac-Crnjevic T, Barrios C, Beşe N, Chan A, Chavarri-Guerra Y, Debiasi M, Demirdogen E, Egeli U, Gökgöz S, Gomez H, Liedke P, Tasdelen I, Tolunay S, Werutsky G, St Louis J, Horick N, Finkelstein DM, Le LP, Bardia A, Goss PE, Sgroi DC, Iafrate AJ, Ellisen LW. Expressed Gene Fusions as Frequent Drivers of Poor Outcomes in Hormone Receptor Positive Breast Cancer. 2017. PubMed
  • Saladi SV, Ross K, Karaayvaz M, Tata PR, Mou H, Rajagopal J, Ramaswamy S, Ellisen LW. ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell 2017. PubMed
  • Mehrotra A, Saladi SV, Trivedi AR, Aras S, Qi H, Jayanthy A, Setaluri V, de la Serna IL. Modulation of Brahma expression by the mitogen-activated protein kinase/extracellular signal regulated kinase pathway is associated with changes in melanoma proliferation. Arch Biochem Biophys 2018; 563:125-35. PubMed
  • Zhao R, Fallon TR, Saladi SV, Pardo-Saganta A, Villoria J, Mou H, Vinarsky V, Gonzalez-Celeiro M, Nunna N, Hariri LP, Camargo F, Ellisen LW, Rajagopal J. Yap tunes airway epithelial size and architecture by regulating the identity, maintenance, and self-renewal of stem cells. Dev Cell 2014; 30:151-65. PubMed
  • Forster N, Saladi SV, van Bragt M, Sfondouris ME, Jones FE, Li Z, Ellisen LW. Basal cell signaling by p63 controls luminal progenitor function and lactation via NRG1. Dev Cell 2014; 28:147-60. PubMed
  • Ren G, Feng J, Datar I, Yeung AH, Saladi SV, Feng Y, de la Serna I, Yeung KC. A Micro-RNA Connection in BRaf(V600E)-Mediated Premature Senescence of Human Melanocytes. Int J Cell Biol 2018; 2012:913242. PubMed
  • Saladi SV, Keenen B, Marathe HG, Qi H, Chin KV, de la Serna IL. Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness. Mol Cancer 2018; 9:280. PubMed
  • Saladi SV, de la Serna IL. ATP dependent chromatin remodeling enzymes in embryonic stem cells. Stem Cell Rev 2018; 6:62-73. PubMed