Photo of Wilfred Ngwa,  MS, PhD

Wilfred Ngwa, MS, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 582-9300


wngwa@lroc.harvard.edu

Wilfred Ngwa, MS, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Radiation Oncology, Harvard Medical School
  • Medical Physicist, , Radiation Oncology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr Ngwa's research is focused on clinical translation of technologies/approaches that can increase access to quality cancer treatment. This includes smart radiotherapy biomaterials (Tiny drones to Target cancer or nanoparticle drones) and PhytoMedicines. The award-winning drone technologies are designed to help eliminate both local and metastatic tumors with minimal collateral damage or side effects. The drones can be employed to sustainably deliver different drug payloads (including immunotherapy/chemotherapy drugs or cannabinoids) precisely to disease sites or targets, with greater therapeutic efficacy. This work leverages the abscopal effect and the biomaterials drone technology in research to significantly increase survival and quality of life for patients.

Publications

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  • Schuemann J, Bagley A, Berbeco R, Bromma K, Butterworth KT, Byrne H, Chithrani DB, Cho SH, Cook JR, Favaudon V, Gholami YH, Gargioni E, Hainfeld JF, Hespeels F, Heuskin AC, Ibeh UM, Kuncic Z, Kunjachan S, Lacombe S, Lucas S, Lux F, McMahon SJ, Nevozhay D, Ngwa W, Payne JD, Penninckx S, Porcel E, Prise KM, Rabus H, Ridwan SM, Rudek B, Sanche L, Singh B, Smilowitz HM, Sokolov KV, Sridhar S, Stanishevskiy Y, Sung W, Tillement O, Virani NA, Yantasee W, Krishnan S. Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions. Phys Med Biol 2020. PubMed
  • Wood J, Yasmin-Karim S, Mueller R, Viswanathan AN, Ngwa W. Single Radiotherapy Fraction with Local Anti-CD40 Therapy Generates Effective Abscopal Responses in Mouse Models of Cervical Cancer. Cancers (Basel) 2020. PubMed
  • Irabor OC, Swanson W, Shaukat F, Wirtz J, Mallum AA, Ngoma T, Elzawawy A, Nguyen P, Incrocci L, Ngwa W. Can the Adoption of Hypofractionation Guidelines Expand Global Radiotherapy Access? An Analysis for Breast and Prostate Radiotherapy. JCO Glob Oncol 2020; 6:667-678. PubMed
  • Boateng F, Ngwa W. Delivery of Nanoparticle-Based Radiosensitizers for Radiotherapy Applications. Int J Mol Sci 2020. PubMed
  • Boateng F, Ngwa W. Novel bioerodable eluting-spacers for radiotherapy applications with dose painting. Br J Radiol 2019; 92:20180745. PubMed
  • Torres-Luquis O, Madden K, N'dri NM, Berg R, Olopade OF, Ngwa W, Abuidris D, Mittal S, Lyn-Cook B, Mohammed SI. LXR/RXR pathway signaling associated with triple-negative breast cancer in African American women. Breast Cancer (Dove Med Press) 2018; 11:1-12. PubMed
  • Moreau M, Ibeh U, Decosmo K, Bih N, Yasmin-Karim S, Toyang N, Lowe H, Ngwa W. Flavonoid Derivative of Demonstrates Therapeutic Potential in Preclinical Models of Metastatic Pancreatic Cancer. 2019; 9:660. PubMed
  • Ngwa W. Systemic immune effects boost radiotherapy. Nat Biomed Eng 2019; 2:562-563. PubMed
  • Tayyari F, Gowda GAN, Olopade OF, Berg R, Yang HH, Lee MP, Ngwa WF, Mittal SK, Raftery D, Mohammed SI. Metabolic profiles of triple-negative and luminal A breast cancer subtypes in African-American identify key metabolic differences. 2018; 9:11677-11690. PubMed
  • Ngwa W, Irabor OC, Schoenfeld JD, Hesser J, Demaria S, Formenti SC. Using immunotherapy to boost the abscopal effect. Nat Rev Cancer 2018. PubMed
  • Yasmin-Karim S, Moreau M, Mueller R, Sinha N, Dabney R, Herman A, Ngwa W. Enhancing the Therapeutic Efficacy of Cancer Treatment With Cannabinoids. 2018; 8:114. PubMed
  • Yasmin-Karim S, Bruck PT, Moreau M, Kunjachan S, Chen GZ, Kumar R, Grabow S, Dougan SK, Ngwa W. Radiation and Local Anti-CD40 Generate an Effective Vaccine in Preclinical Models of Pancreatic Cancer. 2018; 9:2030. PubMed
  • Moreau M, Yasmin-Karim S, Kunjachan S, Sinha N, Gremse F, Kumar R, Chow KF, Ngwa W. Priming the Abscopal Effect Using Multifunctional Smart Radiotherapy Biomaterials Loaded with Immunoadjuvants. 2018; 8:56. PubMed
  • Irabor OC, Kerry VB, Matton J, Ngwa W. Leveraging the Global Health Service Partnership Model for Workforce Development in Global Radiation Oncology. J Glob Oncol 2017. PubMed
  • Ngwa W, Ikhile E, Ntekim A, Lasebikan N, Alabi A, Shagaya UN, Omolara F, Ali-Gombe M, Bojude AD, Ngoma M, Ngoma T, Bhagwat M, Irabor OC, Schoenfeld J, Nguyen P, Sajo E, Laurie F, Moni J, Fitzgerald TJ. Potential Role of the Quality Assurance Review Center Platform in Global Radiation Oncology. Int J Radiat Oncol Biol Phys 2017; 99:956-962. PubMed
  • Boateng F, Ngwa W. Modeling Gold Nanoparticle-Eluting Spacer Degradation during Brachytherapy Application with in situ Dose-painting. Br J Radiol 2017. PubMed
  • Balogun O, Rodin D, Ngwa W, Grover S, Longo J. Challenges and Prospects for Providing Radiation Oncology Services in Africa. Semin Radiat Oncol 2017; 27:184-188. PubMed
  • Ngwa W, Boateng F, Kumar R, Irvine DJ, Formenti S, Ngoma T, Herskind C, Veldwijk MR, Hildenbrand GL, Hausmann M, Wenz F, Hesser J. Smart Radiation Therapy Biomaterials. Int J Radiat Oncol Biol Phys 2017; 97:624-637. PubMed
  • Ngwa W, Kumar R, Moreau M, Dabney R, Herman A. Nanoparticle Drones to Target Lung Cancer with Radiosensitizers and Cannabinoids. 2017; 7:208. PubMed
  • Ngwa W, Ouyang Z. Following the Preclinical Data: Leveraging the Abscopal Effect More Efficaciously. 2017; 7:66. PubMed
  • Hao Y, Yasmin-Karim S, Moreau M, Sinha N, Sajo E, Ngwa W. Enhancing radiotherapy for lung cancer using immunoadjuvants delivered in situ from new design radiotherapy biomaterials: a preclinical study. Phys Med Biol 2016; 61:N697-N707. PubMed
  • Ouyang Z, Liu B, Yasmin-Karim S, Sajo E, Ngwa W. Nanoparticle-aided external beam radiotherapy leveraging the ńĆerenkov effect. 2016; 32:944-7. PubMed
  • Ouyang Z, Mainali MK, Sinha N, Strack G, Altundal Y, Hao Y, Winningham TA, Sajo E, Celli J, Ngwa W. Potential of using cerium oxide nanoparticles for protecting healthy tissue during accelerated partial breast irradiation (APBI). 2016. PubMed
  • Ngwa W, Ngoma T, Zietman A, Mayr N, Elzawawy A, Winningham TA, Balogun O, Enwerem-Bromson N, Ntizimira C, Olopade OI, Oluwole D, Odedina F, Williams M, Flanigan J, Asana L, Ngwa K, Avery S, Pollard JM, Roland T, Funwi-Gabga N, Mbarika V, Hardenbergh P, Winkfield K, Pipman Y, Stefan C, Ngoma M, Mohammed S, Katz M, Erno S, Moni J, Fitzgerald T, Tonlaar N, Efstathiou J, Gierga D, Ayo C, Knaul F, Gospodarowicz M, Makrigiorgos GM, Nguyen PL. Closing the Cancer Divide Through Ubuntu: Information and Communication Technology-Powered Models for Global Radiation Oncology. Int J Radiat Oncol Biol Phys 2016; 94:440-9. PubMed
  • Hao Y, Altundal Y, Moreau M, Sajo E, Kumar R, Ngwa W. Potential for enhancing external beam radiotherapy for lung cancer using high-Z nanoparticles administered via inhalation. Phys Med Biol 2015; 60:7035-43. PubMed
  • Ngwa W, Sajo E, Ngoma T, Bortfeld T, Gierga D, White KB, Akinwande B, Enwerem-Bromson MM, Teboh Forbang R, Winningham TA, Court LE, Odedina FT, Wu R, Makrigiorgos M, Nguyen PL. Potential for information and communication technologies to catalyze global collaborations in radiation oncology. Int J Radiat Oncol Biol Phys 2015; 91:444-7. PubMed
  • Altundal Y, Cifter G, Detappe A, Sajo E, Tsiamas P, Zygmanski P, Berbeco R, Cormack RA, Makrigiorgos M, Ngwa W. New potential for enhancing concomitant chemoradiotherapy with FDA approved concentrations of cisplatin via the photoelectric effect. 2015; 31:25-30. PubMed
  • Sinha N, Cifter G, Sajo E, Kumar R, Sridhar S, Nguyen PL, Cormack RA, Makrigiorgos GM, Ngwa W. Brachytherapy application with in situ dose painting administered by gold nanoparticle eluters. Int J Radiat Oncol Biol Phys 2015; 91:385-92. PubMed
  • Kumar R, Korideck H, Ngwa W, Berbeco RI, Makrigiorgos GM, Sridhar S. Third generation gold nanoplatform optimized for radiation therapy. Transl Cancer Res 2014. PubMed
  • Detappe A, Tsiamas P, Ngwa W, Zygmanski P, Makrigiorgos M, Berbeco R. The effect of flattening filter free delivery on endothelial dose enhancement with gold nanoparticles. Med Phys 2013; 40:031706. PubMed
  • Tsiamas P, Liu B, Cifter F, Ngwa WF, Berbeco RI, Kappas C, Theodorou K, Marcus K, Makrigiorgos MG, Sajo E, Zygmanski P. Impact of beam quality on megavoltage radiotherapy treatment techniques utilizing gold nanoparticles for dose enhancement. Phys Med Biol 2013; 58:451-64. PubMed
  • Ngwa W, Korideck H, Kassis AI, Kumar R, Sridhar S, Makrigiorgos GM, Cormack RA. In vitro radiosensitization by gold nanoparticles during continuous low-dose-rate gamma irradiation with I-125 brachytherapy seeds. 2012. PubMed
  • Berbeco RI, Korideck H, Ngwa W, Kumar R, Patel J, Sridhar S, Johnson S, Price BD, Kimmelman A, Makrigiorgos GM. DNA damage enhancement from gold nanoparticles for clinical MV photon beams. Radiat Res 2012. PubMed
  • Ngwa W, Makrigiorgos GM, Berbeco RI. Gold nanoparticle enhancement of stereotactic radiosurgery for neovascular age-related macular degeneration. Phys Med Biol 2012; 57:6371-80. PubMed
  • Ngwa W, Tsiamas P, Zygmanski P, Makrigiorgos GM, Berbeco RI. A multipurpose quality assurance phantom for the small animal radiation research platform (SARRP). Phys Med Biol 2012; 57:2575-86. PubMed
  • Ngwa W, Makrigiorgos GM, Berbeco RI. Gold nanoparticle-aided brachytherapy with vascular dose painting: estimation of dose enhancement to the tumor endothelial cell nucleus. Med Phys 2012; 39:392-8. PubMed
  • Ngwa W, Korideck H, Chin LM, Makrigiorgos GM, Berbeco RI. MOSFET assessment of radiation dose delivered to mice using the Small Animal Radiation Research Platform (SARRP). Radiat Res 2011. PubMed
  • Berbeco RI, Ngwa W, Makrigiorgos GM. Localized Dose Enhancement to Tumor Blood Vessel Endothelial Cells via Megavoltage X-rays and Targeted Gold Nanoparticles: New Potential for External Beam Radiotherapy. Int J Radiat Oncol Biol Phys 2010. PubMed
  • Ngwa W, Makrigiorgos GM, Berbeco RI. Applying gold nanoparticles as tumor-vascular disrupting agents during brachytherapy: estimation of endothelial dose enhancement. Phys Med Biol 2010; 55:6533-48. PubMed
  • Waghorn BJ, Shah AP, Ngwa W, Meeks SL, Moore JA, Siebers JV, Langen KM. A computational method for estimating the dosimetric effect of intra-fraction motion on step-and-shoot IMRT and compensator plans. Phys Med Biol 2010; 55:4187-202. PubMed
  • Ngwa W, Meeks SL, Kupelian PA, Schnarr E, Langen KM. Validation of a computational method for assessing the impact of intra-fraction motion on helical tomotherapy plans. Phys Med Biol 2009; 54:6611-21. PubMed
  • Langen KM, Lu W, Ngwa W, Willoughby TR, Chauhan B, Meeks SL, Kupelian PA, Olivera G. Correlation between dosimetric effect and intrafraction motion during prostate treatments delivered with helical tomotherapy. Phys Med Biol 2008; 53:7073-86. PubMed
  • Kamanyi A, Ngwa W, Betz T, Wannemacher R, Grill W. Combined phase-sensitive acoustic microscopy and confocal laser scanning microscopy. Ultrasonics 2007; 44 Suppl 1:e1295-300. PubMed
  • Laforsch C, Ngwa W, Grill W, Tollrian R. An acoustic microscopy technique reveals hidden morphological defenses in Daphnia. Proc Natl Acad Sci U S A 2004; 101:15911-4. PubMed
  • Schiller J, Naji L, Trampel R, Ngwa W, Knauss R, Arnold K. Pulsed-field gradient-nuclear magnetic resonance (PFG NMR) to measure the diffusion of ions and polymers in cartilage: applications in joint diseases. Methods Mol. Med. 2004; 101:287-302. PubMed
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