Photo of Yangming Ou,  PhD

Yangming Ou, PhD

Boston Children's Hospital

Boston Children's Hospital
Phone: (857) 218-5139


yangming.ou@childrens.harvard.edu

Yangming Ou, PhD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Radiology, Harvard Medical School
  • Affiliated Faculty, Computational Health Informatics Program (CHIP), Boston Children's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

We use image analysis and machine learning to study pediatric brain normal and abnormal development, including injury and tumor, in children and adult survivors. We develop MRI analysis and machine learning algorithms for tumor detection, tumor characterization, outcome prediction, treatment effect quantification in patients and long-term neurocognitive functions in survivors.

Publications

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  • Sotardi S, Gollub RL, Bates SV, Weiss R, Murphy SN, Grant PE, Ou Y. Voxelwise and Regional Brain Apparent Diffusion Coefficient Changes on MRI from Birth to 6 Years of Age. Radiology 2020. PubMed
  • Yang J, Dong X, Hu Y, Peng Q, Tao G, Ou Y, Cai H, Yang X. Fully Automatic Arteriovenous Segmentation in Retinal Images via Topology-Aware Generative Adversarial Networks. Interdiscip Sci 2020; 12:323-334. PubMed
  • Li S, Eshghi M, Khan S, Tian Q, Joutsa J, Ou Y, Wang QM, Kong J, Rosen BR, Ahveninen J, Nummenmaa A. Localizing central swallowing functions by combining non-invasive brain stimulation with neuroimaging. Brain Stimul 2020; 13:1207-1210. PubMed
  • Zöllei L, Iglesias JE, Ou Y, Grant PE, Fischl B. Infant FreeSurfer: An automated segmentation and surface extraction pipeline for T1-weighted neuroimaging data of infants 0-2 years. Neuroimage 2020; 218:116946. PubMed
  • He S, Gollub RL, Murphy SN, Perez JD, Prabhu S, Pienaar R, Robertson RL, Grant PE, Ou Y. BRAIN AGE ESTIMATION USING LSTM ON CHILDREN'S BRAIN MRI. Proc IEEE Int Symp Biomed Imaging 2020; 2020:420-423. PubMed
  • Yu X, Zuk J, Perdue MV, Ozernov-Palchik O, Raney T, Beach SD, Norton ES, Ou Y, Gabrieli JDE, Gaab N. Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills. Hum Brain Mapp 2020. PubMed
  • Zhao J, Lin G, Zhuo M, Fan Z, Miao L, Chen L, Zeng A, Yin R, Ou Y, Shi Z, Yin J, Gao W, Chen J, Zhou X, Zeng Y, Liu X, Xu H, Chen R, Xia X, Carbone DP. Next-generation sequencing based mutation profiling reveals heterogeneity of clinical response and resistance to osimertinib. Lung Cancer 2020; 141:114-118. PubMed
  • Zeng N, Zuo S, Zheng G, Ou Y, Tong T. Editorial: Artificial Intelligence for Medical Image Analysis of Neuroimaging Data. Front Neurosci 2020; 14:480. PubMed
  • Wang H, Han G, Li H, Tao G, Zhuo E, Liu L, Cai H, Ou Y. A Collaborative Dictionary Learning Model for Nasopharyngeal Carcinoma Segmentation on Multimodalities MR Sequences. Comput Math Methods Med 2020; 2020:7562140. PubMed
  • Weiss RJ, Bates SV, Song Y, Zhang Y, Herzberg EM, Chen YC, Gong M, Chien I, Zhang L, Murphy SN, Gollub RL, Grant PE, Ou Y. Mining multi-site clinical data to develop machine learning MRI biomarkers: application to neonatal hypoxic ischemic encephalopathy. J Transl Med 2020; 17:385. PubMed
  • Machado I, Toews M, George E, Unadkat P, Essayed W, Luo J, Teodoro P, Carvalho H, Martins J, Golland P, Pieper S, Frisken S, Golby A, Wells Iii W, Ou Y. Deformable MRI-Ultrasound registration using correlation-based attribute matching for brain shift correction: Accuracy and generality in multi-site data. Neuroimage 2019; 202:116094. PubMed
  • Morton SU, Vyas R, Gagoski B, Vu C, Litt J, Larsen RJ, Kuchan MJ, Lasekan JB, Sutton BP, Grant PE, Ou Y. Maternal Dietary Intake of Omega-3 Fatty Acids Correlates Positively with Regional Brain Volumes in 1-Month-Old Term Infants. Cereb Cortex 2019. PubMed
  • Xiao Y, Rivaz H, Chabanas M, Fortin M, Machado I, Ou Y, Heinrich MP, Schnabel JA, Zhong X, Maier A, Wein W, Shams R, Kadoury S, Drobny D, Modat M, Reinertsen I. Evaluation of MRI to ultrasound registration methods for brain shift correction: The CuRIOUS2018 Challenge. IEEE Trans Med Imaging 2019. PubMed
  • Ly KI, Vakulenko-Lagun B, Emblem KE, Ou Y, Da X, Betensky RA, Kalpathy-Cramer J, Duda DG, Jain RK, Chi AS, Plotkin SR, Batchelor TT, Sorensen G, Rosen BR, Gerstner ER. Publisher Correction: Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI. Sci Rep 2019; 9:8721. PubMed
  • Cole AR, Perry DA, Raza A, Nedder AP, Pollack E, Regan WL, van den Bosch SJ, Polizzotti BD, Yang E, Davila D, Afacan O, Warfield SK, Ou Y, Sefton B, Everett AD, Neil JJ, Lidov HGW, Mayer JE, Kheir JN. Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine. JACC Basic Transl Sci 2019; 4:176-187. PubMed
  • Ina Ly K, Vakulenko-Lagun B, Emblem KE, Ou Y, Da X, Betensky RA, Kalpathy-Cramer J, Duda DG, Jain RK, Chi AS, Plotkin SR, Batchelor TT, Sorensen G, Rosen BR, Gerstner ER. Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI. Sci Rep 2018; 8:17062. PubMed
  • Ou Y, Zöllei L, Da X, Retzepi K, Murphy SN, Gerstner ER, Rosen BR, Grant PE, Kalpathy-Cramer J, Gollub RL. Field of View Normalization in Multi-Site Brain MRI. Neuroinformatics 2018. PubMed
  • Davatzikos C, Rathore S, Bakas S, Pati S, Bergman M, Kalarot R, Sridharan P, Gastounioti A, Jahani N, Cohen E, Akbari H, Tunc B, Doshi J, Parker D, Hsieh M, Sotiras A, Li H, Ou Y, Doot RK, Bilello M, Fan Y, Shinohara RT, Yushkevich P, Verma R, Kontos D. Cancer imaging phenomics toolkit: quantitative imaging analytics for precision diagnostics and predictive modeling of clinical outcome. J Med Imaging (Bellingham) 2019; 5:011018. PubMed
  • Bernardis E, Zhang Y, Konukoglu E, Ou Y, Javitz HS, Axel L, Metaxas D, Desjardins B, Pohl KM. eCurves: A Temporal Shape Encoding. 2019; 65:733-744. PubMed
  • Pinto ALR, Ou Y, Sahin M, Grant PE. Quantitative Apparent Diffusion Coefficient Mapping May Predict Seizure Onset in Children With Sturge-Weber Syndrome. Pediatr Neurol 2019; 84:32-38. PubMed
  • Lauer A, Da X, Hansen MB, Boulouis G, Ou Y, Cai X, Liberato Celso Pedrotti A, Kalpathy-Cramer J, Caruso P, Hayden DL, Rost N, Mouridsen K, Eichler FS, Rosen B, Musolino PL. ABCD1 dysfunction alters white matter microvascular perfusion. Brain 2018; 140:3139-3152. PubMed
  • Zhou C, Chen T, Xie Z, Qin Y, Ou Y, Zhang J, Li S, Chen R, Zhong N. RACK1 forms a complex with FGFR1 and PKM2, and stimulates the growth and migration of squamous lung cancer cells. Mol Carcinog 2017; 56:2391-2399. PubMed
  • Dinh CV, Steenbergen P, Ghobadi G, van der Poel H, Heijmink SW, de Jong J, Isebaert S, Haustermans K, Lerut E, Oyen R, Ou Y, Christos D, van der Heide UA. Multicenter validation of prostate tumor localization using multiparametric MRI and prior knowledge. Med Phys 2017; 44:949-961. PubMed
  • Tu X, Xie M, Gao J, Ma Z, Chen D, Wang Q, Finlayson SG, Ou Y, Cheng JZ. Automatic Categorization and Scoring of Solid, Part-Solid and Non-Solid Pulmonary Nodules in CT Images with Convolutional Neural Network. Sci Rep 2019; 7:8533. PubMed
  • Ou Y, Zöllei L, Retzepi K, Castro V, Bates SV, Pieper S, Andriole KP, Murphy SN, Gollub RL, Grant PE. Using clinically acquired MRI to construct age-specific ADC atlases: Quantifying spatiotemporal ADC changes from birth to 6-year old. Hum Brain Mapp 2018; 38:3052-3068. PubMed
  • Kalpathy-Cramer J, Chandra V, Da X, Ou Y, Emblem KE, Muzikansky A, Cai X, Douw L, Evans JG, Dietrich J, Chi AS, Wen PY, Stufflebeam S, Rosen B, Duda DG, Jain RK, Batchelor TT, Gerstner ER. Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma. J. Neurooncol. 2016. PubMed
  • Doshi J, Erus G, Ou Y, Resnick SM, Gur RC, Gur RE, Satterthwaite TD, Furth S, Davatzikos C, . MUSE: MUlti-atlas region Segmentation utilizing Ensembles of registration algorithms and parameters, and locally optimal atlas selection. Neuroimage 2019; 127:186-195. PubMed
  • Ou Y, Gollub RL, Retzepi K, Reynolds N, Pienaar R, Pieper S, Murphy SN, Grant PE, Zöllei L. Brain extraction in pediatric ADC maps, toward characterizing neuro-development in multi-platform and multi-institution clinical images. Neuroimage 2019; 122:246-61. PubMed
  • Rojas KD, Montero ML, Yao J, Messing E, Fazili A, Joseph J, Ou Y, Rubens DJ, Parker KJ, Davatzikos C, Castaneda B. Methodology to study the three-dimensional spatial distribution of prostate cancer and their dependence on clinical parameters. J Med Imaging (Bellingham) 2018; 2:037502. PubMed
  • Ou Y, Weinstein SP, Conant EF, Englander S, Da X, Gaonkar B, Hsieh MK, Rosen M, DeMichele A, Davatzikos C, Kontos D. Deformable registration for quantifying longitudinal tumor changes during neoadjuvant chemotherapy. Magn Reson Med 2018; 73:2343-56. PubMed
  • Petitjean C, Zuluaga MA, Bai W, Dacher JN, Grosgeorge D, Caudron J, Ruan S, Ayed IB, Cardoso MJ, Chen HC, Jimenez-Carretero D, Ledesma-Carbayo MJ, Davatzikos C, Doshi J, Erus G, Maier OM, Nambakhsh CM, Ou Y, Ourselin S, Peng CW, Peters NS, Peters TM, Rajchl M, Rueckert D, Santos A, Shi W, Wang CW, Wang H, Yuan J. Right ventricle segmentation from cardiac MRI: a collation study. Med Image Anal 2017; 19:187-202. PubMed
  • Ou Y, Akbari H, Bilello M, Da X, Davatzikos C. Comparative evaluation of registration algorithms in different brain databases with varying difficulty: results and insights. IEEE Trans Med Imaging 2019; 33:2039-65. PubMed
  • Shen X, Liu S, Li R, Ou Y. Experimental study on the impact of temperature on the dissipation process of supersaturated total dissolved gas. J Environ Sci (China) 2014; 26:1874-8. PubMed
  • Litjens G, Toth R, van de Ven W, Hoeks C, Kerkstra S, van Ginneken B, Vincent G, Guillard G, Birbeck N, Zhang J, Strand R, Malmberg F, Ou Y, Davatzikos C, Kirschner M, Jung F, Yuan J, Qiu W, Gao Q, Edwards PE, Maan B, van der Heijden F, Ghose S, Mitra J, Dowling J, Barratt D, Huisman H, Madabhushi A. Evaluation of prostate segmentation algorithms for MRI: the PROMISE12 challenge. Med Image Anal 2018; 18:359-73. PubMed
  • Serpa MH, Ou Y, Schaufelberger MS, Doshi J, Ferreira LK, Machado-Vieira R, Menezes PR, Scazufca M, Davatzikos C, Busatto GF, Zanetti MV. Neuroanatomical classification in a population-based sample of psychotic major depression and bipolar I disorder with 1 year of diagnostic stability. Biomed Res Int 2018; 2014:706157. PubMed
  • Da X, Toledo JB, Zee J, Wolk DA, Xie SX, Ou Y, Shacklett A, Parmpi P, Shaw L, Trojanowski JQ, Davatzikos C, . Integration and relative value of biomarkers for prediction of MCI to AD progression: spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers. Neuroimage Clin 2018; 4:164-73. PubMed
  • Doshi J, Erus G, Ou Y, Gaonkar B, Davatzikos C. Multi-atlas skull-stripping. Acad Radiol 2018; 20:1566-76. PubMed
  • Zanetti MV, Schaufelberger MS, Doshi J, Ou Y, Ferreira LK, Menezes PR, Scazufca M, Davatzikos C, Busatto GF. Neuroanatomical pattern classification in a population-based sample of first-episode schizophrenia. 2015; 43:116-25. PubMed
  • Ou Y, Ye DH, Pohl KM, Davatzikos C. Validation of DRAMMS among 12 Popular Methods in Cross-Subject Cardiac MRI Registration. Biomed Image Regist Proc 2019; 7359:209-219. PubMed
  • Bernardis E, Konukoglu E, Ou Y, Metaxas DN, Desjardins B, Pohl KM. Temporal shape analysis via the spectral signature. Med Image Comput Comput Assist Interv 2019; 15:49-56. PubMed
  • Ou Y, Sotiras A, Paragios N, Davatzikos C. DRAMMS: Deformable registration via attribute matching and mutual-saliency weighting. Med Image Anal 2018; 15:622-39. PubMed
  • Sotiras A, Ou Y, Glocker B, Davatzikos C, Paragios N. Simultaneous geometric--iconic registration. Med Image Comput Comput Assist Interv 2019; 13:676-83. PubMed
  • Ou Y, Shen D, Zeng J, Sun L, Moul J, Davatzikos C. Sampling the spatial patterns of cancer: optimized biopsy procedures for estimating prostate cancer volume and Gleason Score. Med Image Anal 2018; 13:609-20. PubMed
  • Ou Y, Davatzikos C. DRAMMS: deformable registration via attribute matching and mutual-saliency weighting. Inf Process Med Imaging 2019; 21:50-62. PubMed
  • Verma R, Zacharaki EI, Ou Y, Cai H, Chawla S, Lee SK, Melhem ER, Wolf R, Davatzikos C. Multiparametric tissue characterization of brain neoplasms and their recurrence using pattern classification of MR images. Acad Radiol 2018; 15:966-77. PubMed
  • Zhan Y, Ou Y, Feldman M, Tomaszeweski J, Davatzikos C, Shen D. Registering histologic and MR images of prostate for image-based cancer detection. Acad Radiol 2018; 14:1367-81. PubMed
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