Photo of Tyler J. VanderWeele,  PhD

Tyler J. VanderWeele, PhD

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health

Tyler J. VanderWeele, PhD

Harvard T.H. Chan School Of Public Health

EDUCATIONAL TITLES

  • Professor, Epidemiology, Harvard T.H. Chan School Of Public Health

DF/HCC PROGRAM AFFILIATION

Research Abstract

The focus of my research is on epidemiologic methods and how we distinguish between association and causation in observational research. I have been applying this work to the study of the role of religion and spirituality in end-of-life cancer care, and to examining the mechanisms governing associations between genetic and environmental risk factors and cancer risk.

Publications from Harvard Catalyst Profiles

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  • VanderWeele TJ. Constructed measures and causal inference: towards a new model of measurement for psychosocial constructs. Epidemiology 2021. PubMed
  • Mathur MB, VanderWeele TJ. Methods to Address Confounding and Other Biases in Meta-Analyses: Review and Recommendations. Annu Rev Public Health 2021. PubMed
  • Nakamura JS, Delaney SW, Diener E, VanderWeele TJ, Kim ES. Are all domains of life satisfaction equal? Differential associations with health and well-being in older adults. Qual Life Res 2021. PubMed
  • Mathur MB, VanderWeele TJ. Meta-Regression Methods to Characterize Evidence Strength Using Meaningful-Effect Percentages Conditional on Study Characteristics. Res Synth Methods 2021. PubMed
  • Smith LH, Mathur MB, VanderWeele TJ. Multiple-bias Sensitivity Analysis Using Bounds. Epidemiology 2021; 32:625-634. PubMed
  • Lee H, Cashin AG, Lamb SE, Hopewell S, Vansteelandt S, VanderWeele TJ, MacKinnon DP, Mansell G, Collins GS, Golub RM, McAuley JH, , Localio AR, van Amelsvoort L, Guallar E, Rijnhart J, Goldsmith K, Fairchild AJ, Lewis CC, Kamper SJ, Williams CM, Henschke N. A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies: The AGReMA Statement. JAMA 2021; 326:1045-1056. PubMed
  • Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, VanderWeele TJ, Higgins JPT, Timpson NJ, Dimou N, Langenberg C, Golub RM, Loder EW, Gallo V, Tybjaerg-Hansen A, Davey Smith G, Egger M, Richards JB. Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement. JAMA 2021; 326:1614-1621. PubMed
  • Skrivankova VW, Richmond RC, Woolf BAR, Davies NM, Swanson SA, VanderWeele TJ, Timpson NJ, Higgins JPT, Dimou N, Langenberg C, Loder EW, Golub RM, Egger M, Davey Smith G, Richards JB. Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration. BMJ 2021; 375:n2233. PubMed
  • Swanson SA, VanderWeele TJ. E-values for Mendelian Randomization. Epidemiology 2020. PubMed
  • Smith LH, VanderWeele TJ. Bounding Bias Due to Selection. Epidemiology 2019; 30:509-516. PubMed
  • Balboni TA, Prigerson HG, Balboni MJ, Enzinger AC, VanderWeele TJ, Maciejewski PK. A scale to assess religious beliefs in end-of-life medical care. Cancer 2019. PubMed
  • VanderWeele TJ. Principles of confounder selection. Eur J Epidemiol 2019; 34:211-219. PubMed
  • Haneuse S, VanderWeele TJ, Arterburn D. Using the E-Value to Assess the Potential Effect of Unmeasured Confounding in Observational Studies. JAMA 2019; 321:602-603. PubMed
  • VanderWeele TJ, Luedtke AR, van der Laan MJ, Kessler RC. Selecting Optimal Subgroups for Treatment Using Many Covariates. Epidemiology 2019; 30:334-341. PubMed
  • Mathur MB, Ding P, Riddell CA, VanderWeele TJ. Website and R Package for Computing E-Values. Epidemiology 2018. PubMed
  • Suzuki E, VanderWeele TJ. Mechanisms and uncertainty in randomized controlled trials: A commentary on Deaton and Cartwright. Soc Sci Med 2018. PubMed
  • VanderWeele TJ. On well-defined hypothetical interventions in the potential outcomes framework. Epidemiology 2018. PubMed
  • Jackson JW, VanderWeele TJ. Decomposition Analysis to Identify Intervention Targets for Reducing Disparities. Epidemiology 2018; 29:825-835. PubMed
  • Spiegelman D, Khudyakov P, Wang M, Vanderweele TJ. Evaluating Public Health Interventions: 7. Let the Subject Matter Choose the Effect Measure: Ratio, Difference, or Something Else Entirely. Am J Public Health 2018; 108:73-76. PubMed
  • Liu L, Nevo D, Nishihara R, Cao Y, Song M, Twombly TS, Chan AT, Giovannucci EL, VanderWeele TJ, Wang M, Ogino S. Utility of inverse probability weighting in molecular pathological epidemiology. Eur J Epidemiol 2017. PubMed
  • Barfield R, Shen J, Just AC, Vokonas PS, Schwartz J, Baccarelli AA, VanderWeele TJ, Lin X. Testing for the indirect effect under the null for genome-wide mediation analyses. Genet Epidemiol 2017; 41:824-833. PubMed
  • Lin SH, Young JG, Logan R, VanderWeele TJ. Mediation analysis for a survival outcome with time-varying exposures, mediators, and confounders. Stat Med 2017; 36:4153-4166. PubMed
  • VanderWeele TJ. On a Square-Root Transformation of the Odds Ratio for a Common Outcome. Epidemiology 2017; 28:e58-e60. PubMed
  • Keogh RH, Daniel RM, Vanderweele TJ, Vansteelandt S. Analysis of longitudinal studies with repeated outcome measures: adjusting for time-dependent confounding using conventional methods. Am J Epidemiol 2017. PubMed
  • VanderWeele TJ, Ding P. Sensitivity Analysis in Observational Research: Introducing the E-Value. Ann Intern Med 2017; 167:268-274. PubMed
  • Balboni MJ, Sullivan A, Smith PT, Zaidi D, Mitchell C, Tulsky JA, Sulmasy D, VanderWeele TJ, Balboni TA. The Views of Clergy Regarding Ethical Controversies in Care at the End of Life. J Pain Symptom Manage 2017. PubMed
  • VanderWeele TJ, Balboni TA, Koh HK. Health and Spirituality. JAMA 2017; 318:519-520. PubMed
  • VanderWeele TJ. On the promotion of human flourishing. Proc Natl Acad Sci U S A 2017; 114:8148-8156. PubMed
  • Spiegelman D, VanderWeele TJ. Evaluating Public Health Interventions: 6. Modeling Ratios or Differences? Let the Data Tell Us. Am J Public Health 2017; 107:1087-1091. PubMed
  • VanderWeele TJ, Tchetgen Tchetgen EJ. Mediation analysis with time varying exposures and mediators. J R Stat Soc Series B Stat Methodol 2017; 79:917-938. PubMed
  • Maas P, Barrdahl M, Joshi AD, Auer PL, Gaudet MM, Milne RL, Schumacher FR, Anderson WF, Check D, Chattopadhyay S, Baglietto L, Berg CD, Chanock SJ, Cox DG, Figueroa JD, Gail MH, Graubard BI, Haiman CA, Hankinson SE, Hoover RN, Isaacs C, Kolonel LN, Le Marchand L, Lee IM, Lindström S, Overvad K, Romieu I, Sanchez MJ, Southey MC, Stram DO, Tumino R, VanderWeele TJ, Willett WC, Zhang S, Buring JE, Canzian F, Gapstur SM, Henderson BE, Hunter DJ, Giles GG, Prentice RL, Ziegler RG, Kraft P, Garcia-Closas M, Chatterjee N. Breast Cancer Risk From Modifiable and Nonmodifiable Risk Factors Among White Women in the United States. JAMA Oncol 2016. PubMed
  • Ogino S, Nishihara R, VanderWeele TJ, Wang M, Nishi A, Lochhead P, Qian ZR, Zhang X, Wu K, Nan H, Yoshida K, Milner DA, Chan AT, Field AE, Camargo CA, Williams MA, Giovannucci EL. The Role of Molecular Pathological Epidemiology in the Study of Neoplastic and Non-Neoplastic Diseases in the Era of Precision Medicine. Epidemiology 2016. PubMed
  • Epstein-Peterson ZD, Sullivan AJ, Enzinger AC, Trevino KM, Zollfrank AA, Balboni MJ, VanderWeele TJ, Balboni TA. Examining Forms of Spiritual Care Provided in the Advanced Cancer Setting. Am J Hosp Palliat Care 2015. PubMed
  • Valeri L, Chen JT, Garcia-Albeniz X, Krieger N, VanderWeele TJ, Coull BA. The role of stage at diagnosis in colorectal cancer black-white survival disparities: a counterfactual causal inference approach. Cancer Epidemiol Biomarkers Prev 2015. PubMed
  • Nishihara R, VanderWeele TJ, Shibuya K, Mittleman MA, Wang M, Field AE, Giovannucci E, Lochhead P, Ogino S. Molecular pathological epidemiology gives clues to paradoxical findings. Eur J Epidemiol 2015; 30:1129-35. PubMed
  • Rodin D, Balboni M, Mitchell C, Smith PT, VanderWeele TJ, Balboni TA. Whose role? Oncology practitioners' perceptions of their role in providing spiritual care to advanced cancer patients. Support Care Cancer 2015. PubMed
  • Carere DA, VanderWeele T, Moreno TA, Mountain JL, Roberts JS, Kraft P, Green RC, . The impact of direct-to-consumer personal genomic testing on perceived risk of breast, prostate, colorectal, and lung cancer: findings from the PGen study. BMC Med Genomics 2015; 8:63. PubMed
  • Joshi AD, Lindström S, Hüsing A, Barrdahl M, VanderWeele TJ, Campa D, Canzian F, Gaudet MM, Figueroa JD, Baglietto L, Berg CD, Buring JE, Chanock SJ, Chirlaque MD, Diver WR, Dossus L, Giles GG, Haiman CA, Hankinson SE, Henderson BE, Hoover RN, Hunter DJ, Isaacs C, Kaaks R, Kolonel LN, Krogh V, Le Marchand L, Lee IM, Lund E, McCarty CA, Overvad K, Peeters PH, Riboli E, Schumacher F, Severi G, Stram DO, Sund M, Thun MJ, Travis RC, Trichopoulos D, Willett WC, Zhang S, Ziegler RG, Kraft P, . Additive interactions between susceptibility single-nucleotide polymorphisms identified in genome-wide association studies and breast cancer risk factors in the Breast and Prostate Cancer Cohort Consortium. Am J Epidemiol 2014. PubMed
  • Balboni MJ, Sullivan A, Enzinger AC, Epstein-Peterson ZD, Tseng YD, Mitchell C, Niska J, Zollfrank A, VanderWeele TJ, Balboni TA. Nurse and physician barriers to spiritual care provision at the end of life. J Pain Symptom Manage 2014. PubMed
  • VanderWeele TJ, Tchetgen Tchetgen EJ, Cornelis M, Kraft P. Methodological challenges in mendelian randomization. Epidemiology 2014; 25:427-35. PubMed
  • Huang YT, Vanderweele TJ, Lin X. JOINT ANALYSIS OF SNP AND GENE EXPRESSION DATA IN GENETIC ASSOCIATION STUDIES OF COMPLEX DISEASES. Ann Appl Stat 2014; 8:352-376. PubMed
  • Vanderweele TJ, Ko YA, Mukherjee B. Environmental confounding in gene-environment interaction studies. Am J Epidemiol 2013; 178:144-52. PubMed
  • Balboni TA, Balboni M, Enzinger AC, Gallivan K, Paulk ME, Wright A, Steinhauser K, VanderWeele TJ, Prigerson HG. Provision of spiritual support to patients with advanced cancer by religious communities and associations with medical care at the end of life. JAMA Intern Med 2013; 173:1109-17. PubMed
  • Balboni MJ, Sullivan A, Amobi A, Phelps AC, Gorman DP, Zollfrank A, Peteet JR, Prigerson HG, Vanderweele TJ, Balboni TA. Why is spiritual care infrequent at the end of life? Spiritual care perceptions among patients, nurses, and physicians and the role of training. J Clin Oncol 2013; 31:461-7. PubMed
  • VanderWeele TJ. Policy-relevant proportions for direct effects. Epidemiology 2013; 24:175-6. PubMed
  • Ogburn EL, Vanderweele TJ. Bias attenuation results for nondifferentially mismeasured ordinal and coarsened confounders. Biometrika 2013; 100:241-248. PubMed
  • Vansteelandt S, Vanderweele TJ. Natural direct and indirect effects on the exposed: effect decomposition under weaker assumptions. Biometrics 2012; 68:1019-27. PubMed
  • Pierce BL, VanderWeele TJ. The effect of non-differential measurement error on bias, precision and power in Mendelian randomization studies. Int J Epidemiol 2012; 41:1383-93. PubMed
  • Vanderweele TJ, Mukherjee B, Chen J. Sensitivity analysis for interactions under unmeasured confounding. Stat Med 2012; 31:2552-64. PubMed
  • Ogburn EL, VanderWeele TJ. Analytic results on the bias due to nondifferential misclassification of a binary mediator. Am J Epidemiol 2012; 176:555-61. PubMed
  • Phelps AC, Lauderdale KE, Alcorn S, Dillinger J, Balboni MT, Van Wert M, Vanderweele TJ, Balboni TA. Addressing spirituality within the care of patients at the end of life: perspectives of patients with advanced cancer, oncologists, and oncology nurses. J Clin Oncol 2012; 30:2538-44. PubMed
  • VanderWeele TJ, Valeri L, Ogburn EL. The role of measurement error and misclassification in mediation analysis: mediation and measurement error. Epidemiology 2012; 23:561-4. PubMed
  • VanderWeele TJ, Hernán MA. Results on differential and dependent measurement error of the exposure and the outcome using signed directed acyclic graphs. Am J Epidemiol 2012; 175:1303-10. PubMed
  • Vanderweele TJ. Inference for additive interaction under exposure misclassification. Biometrika 2012; 99:502-508. PubMed
  • VanderWeele TJ, Asomaning K, Tchetgen Tchetgen EJ, Han Y, Spitz MR, Shete S, Wu X, Gaborieau V, Wang Y, McLaughlin J, Hung RJ, Brennan P, Amos CI, Christiani DC, Lin X. Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction. Am J Epidemiol 2012. PubMed
  • Vanderweele TJ, Tan Z. Directed acyclic graphs with edge-specific bounds. Biometrika 2012; 99:115-126. PubMed
  • VanderWeele TJ, Adami HO, Tamimi RM. Mammographic density as a mediator for breast cancer risk: analytic approaches. Breast Cancer Res 2012; 14:317. PubMed
  • Balboni T, Balboni M, Paulk ME, Phelps A, Wright A, Peteet J, Block S, Lathan C, Vanderweele T, Prigerson H. Support of cancer patients' spiritual needs and associations with medical care costs at the end of life. Cancer 2011; 117:5383-91. PubMed
  • Winkelman WD, Lauderdale K, Balboni MJ, Phelps AC, Peteet JR, Block SD, Kachnic LA, VanderWeele TJ, Balboni TA. The relationship of spiritual concerns to the quality of life of advanced cancer patients: preliminary findings. J Palliat Med 2011; 14:1022-8. PubMed
  • Balboni MJ, Babar A, Dillinger J, Phelps AC, George E, Block SD, Kachnic L, Hunt J, Peteet J, Prigerson HG, VanderWeele TJ, Balboni TA. "It depends": viewpoints of patients, physicians, and nurses on patient-practitioner prayer in the setting of advanced cancer. J Pain Symptom Manage 2011. PubMed
  • Vallurupalli M, Lauderdale K, Balboni MJ, Phelps AC, Block SD, Ng AK, Kachnic LA, Vanderweele TJ, Balboni TA. The role of spirituality and religious coping in the quality of life of patients with advanced cancer receiving palliative radiation therapy. J Support Oncol ; 10:81-7. PubMed
  • Rice MS, Bertrand KA, VanderWeele TJ, Rosner BA, Liao X, Adami HO, Tamimi RM. Mammographic density and breast cancer risk: a mediation analysis. Breast Cancer Res ; 18:94. PubMed
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