Photo of Hak Soo Choi, PhD

Hak Soo Choi, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-5784
Fax: (617) 643-2604


mghchoilab@gmail.com

Photo of Hak Soo Choi, PhD

Massachusetts General Hospital
Phone: (617) 726-5784
Fax: (617) 643-2604


mghchoilab@gmail.com

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Hak Soo Choi, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Radiology, Harvard Medical School
  • Director, Bioengineering and Nanomedicine Program, Gordon Center for Medical Imaging, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Hak Soo Choi is a Professor of Radiology at Harvard Medical School and faculty of Dana Farber/Harvard Cancer Center, and Director of the Bioengineering & Nanomedicine Program of Mass General Hospital (https://sites.google.com/view/benmd). Dr. Choi received a Ph.D. in Nanomedicine from Japan Advanced Science and Technology in 2004. After postdoc training in the field of Gene and Drug Delivery, he extended his research into Molecular Imaging at Harvard. Since 2008, his laboratory has focused on developing targeted contrast agents for tissue-specific imaging, which can be used to diagnose and treat human cancer by specifically visualizing the target tissue via “Structure-Inherent Targeting” while avoiding nonspecific uptake in normal background tissues.

Publications from Harvard Catalyst Profiles

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  • Baek MJ, Hur W, Kashiwagi S, Choi HS. Design Considerations for Organ-Selective Nanoparticles. ACS Nano 2025; 19:14605-14626. PubMed
  • Paranjape S, Choi KY, Kashiwagi S, Choi HS. H-Dots: Renal Clearable Zwitterionic Nanocarriers for Disease Diagnosis and Therapy. Langmuir 2025. PubMed
  • Yamashita A, Jang P, Bao K, Kashiwagi S, Frangioni JV, Choi HS. Indocyanine Blue (ICB) as a Functional Alternative to Indocyanine Green (ICG) for Enhanced 700 nm NIR Imaging. Int J Mol Sci 2024. PubMed
  • Pal R, Krishnamoorthy M, Matsui A, Kang H, Morita S, Taniguchi H, Kobayashi T, Morita A, Choi HS, Duda DG, Kumar ATN. Fluorescence Lifetime Imaging Enables In vivo Quantification of PD-L1 Expression and Inter-tumoral Heterogeneity. Cancer Res 2024. PubMed
  • Cui Y, Park SH, Stiles WR, Yamashita A, Dinh J, Kim RS, Zhang Y, Yin X, Baek Y, Wang H, Bao K, Kang H, Choi HS. Renal Clearable H-Dots Leveraging Ligand Complexation for Enhanced Active Tumor Targeting. 2024; 4:2400246. PubMed
  • Raveendran A, Ser J, Park SH, Jang P, Choi HS, Cho H. Lysosome-Targeted Bifunctional Therapeutics Induce Autodynamic Cancer Therapy. Adv Sci (Weinh) 2024. PubMed
  • Jeon OH, Bao K, Kim K, Wang H, Yokomizo S, Park GK, Cho BH, Rho J, Kim C, Choi HS, Kim HK. Precise and safe pulmonary segmentectomy enabled by visualizing cancer margins with dual-channel near-infrared fluorescence. Int J Surg 2024. PubMed
  • Park HS, Yokomizo S, Wang H, Manganiello S, Monaco H, McDonnell R, Kim HJ, Rho J, Ahn S, Jung H, Kang H, Bao K, Kashiwagi S, Choi HS. Bifunctional Tumor-Targeted Bioprobe for Phothotheranosis. Biomater Res 2024; 28:0002. PubMed
  • Jang P, Ser J, Cardenas K, Kim HJ, Hickey M, Jang J, Gladstone J, Bailey A, Dinh J, Nguyen V, DeMarco E, Srinivas S, Kang H, Kashiwagi S, Bao K, Yamashita A, Choi HS. HSA-ZW800-PEG for Enhanced Optophysical Stability and Tumor Targeting. Int J Mol Sci 2023. PubMed
  • Yamashita A, Park SH, Zeng L, Stiles WR, Ahn S, Bao K, Kim J, Kang H, Choi HS. H-Dot Mediated Nanotherapeutics Mitigate Systemic Toxicity of Platinum-Based Anticancer Drugs. Int J Mol Sci 2023. PubMed
  • Shamim M, Dinh J, Yang C, Nomura S, Kashiwagi S, Kang H, Choi HS, Henary M. Synthesis, Optical Properties, and In Vivo Biodistribution Performance of Polymethine Cyanine Fluorophores. ACS Pharmacol Transl Sci 2023; 6:1192-1206. PubMed
  • Moon HG, Eccles JD, Kim SJ, Kim KH, Kim YM, Rehman J, Lee H, Kanabar P, Christman JW, Ackerman SJ, Ascoli C, Kang H, Choi HS, Kim M, You S, Park GY. Complement C1q essential for aeroallergen sensitization via CSF1R conventional dendritic cells type 2. J Allergy Clin Immunol 2023. PubMed
  • Shin GR, Kim HE, Ju HJ, Kim JH, Choi S, Choi HS, Kim MS. Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer. Mater Today Bio 2022; 16:100386. PubMed
  • Katagiri W, Yokomizo S, Ishizuka T, Yamashita K, Kopp T, Roessing M, Sato A, Iwasaki T, Sato H, Fukuda T, Monaco H, Manganiello S, Nomura S, Ng MR, Feil S, Ogawa E, Fukumura D, Atochin DN, Choi HS, Kashiwagi S. Dual near-infrared II laser modulates the cellular redox state of T cells and augments the efficacy of cancer immunotherapy. FASEB J. 2022; 36:e22521. PubMed
  • Wang H, Kang H, Dinh J, Yokomizo S, Stiles WR, Tully M, Cardenas K, Srinivas S, Ingerick J, Ahn S, Bao K, Choi HS. P800SO3-PEG: a renal clearable bone-targeted fluorophore for theranostic imaging. Biomater Res 2022; 26:51. PubMed
  • Yin X, Cheng Y, Feng Y, Stiles WR, Park SH, Kang H, Choi HS. Phototheranostics for multifunctional treatment of cancer with fluorescence imaging. Adv Drug Deliv Rev 2022; 189:114483. PubMed
  • Yokomizo S, Henary M, Buabeng ER, Fukuda T, Monaco H, Baek Y, Manganiello S, Wang H, Kubota J, Ulumben AD, Lv X, Wang C, Inoue K, Fukushi M, Kang H, Bao K, Kashiwagi S, Choi HS. Topical pH Sensing NIR Fluorophores for Intraoperative Imaging and Surgery of Disseminated Ovarian Cancer. Adv Sci (Weinh) 2022. PubMed
  • Thavornpradit S, Usama SM, Park GK, Dinh J, Choi HS, Burgess K. QuatCy-I and MHI-I in Photodynamic Therapy. 2022; 13:470-474. PubMed
  • Kang H, Shamim M, Yin X, Adluru E, Fukuda T, Yokomizo S, Chang H, Park SH, Cui Y, Moy AJ, Kashiwagi S, Henary M, Choi HS. Tumor-Associated Immune-Cell-Mediated Tumor-Targeting Mechanism with NIR-II Fluorescence Imaging. Adv. Mater. Weinheim 2022; 34:e2106500. PubMed
  • Kang H, Kang MW, Kashiwagi S, Choi HS. NIR fluorescence imaging and treatment for cancer immunotherapy. J Immunother Cancer 2022. PubMed
  • Yin X, Cui Y, Kim RS, Stiles WR, Park SH, Wang H, Ma L, Chen L, Baek Y, Kashiwagi S, Bao K, Ulumben A, Fukuda T, Kang H, Choi HS. Image-guided drug delivery of nanotheranostics for targeted lung cancer therapy. Theranostics 2022; 12:4147-4162. PubMed
  • Ji Y, Jones C, Baek Y, Park GK, Kashiwagi S, Choi HS. Near-infrared fluorescence imaging in immunotherapy. Adv Drug Deliv Rev 2020. PubMed
  • Park GK, Lee JH, Soriano E, Choi M, Bao K, Katagiri W, Kim DY, Paik JH, Yun SH, Frangioni JV, Clancy TE, Kashiwagi S, Henary M, Choi HS. Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors. iScience 2020; 23:101006. PubMed
  • Usama SM, Park GK, Nomura S, Baek Y, Choi HS, Burgess K. Role of Albumin in Accumulation and Persistence of Tumor-Seeking Cyanine Dyes. Bioconjug Chem 2020; 31:248-259. PubMed
  • Kim H, Choi HS, Eom JB, Choi Y. Mini-platform for off-on NIR fluorescence imaging using peptide targeting ligands. Bioconjug Chem 2020. PubMed
  • Baart VM, Deken MM, Bordo MW, Bhairosingh SS, Salvatori DCF, Hyun H, Henary M, Choi HS, Sier CFM, Kuppen PJK, van Scheltinga AGTT, March TL, Valentijn ARPM, Frangioni JV, Vahrmeijer AL. Small Molecules for Multi-Wavelength Near-Infrared Fluorescent Mapping of Regional and Sentinel Lymph Nodes in Colorectal Cancer Staging. 2020; 10:586112. PubMed
  • Kang H, Stiles WR, Baek Y, Nomura S, Bao K, Hu S, Park GK, Jo MJ, I H, Coll JL, Rubin BP, Choi HS. Renal Clearable Theranostic Nanoplatforms for Gastrointestinal Stromal Tumors. Adv. Mater. Weinheim 2019. PubMed
  • Kang H, Rho S, Stiles WR, Hu S, Baek Y, Hwang DW, Kashiwagi S, Kim MS, Choi HS. Size-Dependent EPR Effect of Polymeric Nanoparticles on Tumor Targeting. Adv Healthc Mater 2019. PubMed
  • Pal R, Kang H, Choi HS, Kumar ATN. Fluorescence lifetime-based tumor contrast enhancement using an EGFR antibody labeled near infrared fluorophore. Clin Cancer Res 2019. PubMed
  • Ji Y, Wang Z, Bao K, Park GK, Kang H, Hu S, McDonald E, Kim MS, Kashiwagi S, Choi HS. Targeted molecular imaging of TLR4 in hepatocellular carcinoma using zwitterionic near-infrared fluorophores. Quant Imaging Med Surg 2019; 9:1548-1555. PubMed
  • Das P, Santos S, Park GK, Hoseok I, Choi HS. Real-Time Fluorescence Imaging in Thoracic Surgery. Korean J Thorac Cardiovasc Surg 2019; 52:205-220. PubMed
  • Sajedi S, Sabet H, Choi HS. Intraoperative biophotonic imaging systems for image-guided interventions. Nanophotonics 2019; 8:99-116. PubMed
  • Thavornpradit S, Usama SM, Park GK, Shrestha JP, Nomura S, Baek Y, Choi HS, Burgess K. QuatCy: A Heptamethine Cyanine Modification With Improved Characteristics. Theranostics 2019; 9:2856-2867. PubMed
  • Kim H, Cho MH, Choi HS, Lee BI, Choi Y. Zwitterionic near-infrared fluorophore-conjugated epidermal growth factor for fast, real-time, and target-cell-specific cancer imaging. Theranostics 2019; 9:1085-1095. PubMed
  • Kang H, Hu S, Cho MH, Hong SH, Choi Y, Choi HS. Theranostic Nanosystems for Targeted Cancer Therapy. Nano Today 2018; 23:59-72. PubMed
  • Hu S, Kang H, Baek Y, El Fakhri G, Kuang A, Choi HS. Real-Time Imaging of Brain Tumor for Image-Guided Surgery. Adv Healthc Mater 2018. PubMed
  • Tran BNN, Angelo JP, Lee JH, Ruan QZ, Laurence RG, Choi HS, Lee BT, Singhal D. A novel pilot animal model for the surgical prevention of lymphedema: the power of optical imaging. J Surg Res 2018; 221:285-292. PubMed
  • Park GK, Hoseok, Kim GS, Hwang NS, Choi HS. Optical spectroscopic imaging for cell therapy and tissue engineering. Appl Spectrosc Rev 2018; 53:360-375. PubMed
  • Bao K, Lee JH, Kang H, Park GK, El Fakhri G, Choi HS. PSMA-targeted contrast agents for intraoperative imaging of prostate cancer. Chem Commun (Camb) 2017; 53:1611-1614. PubMed
  • Wada H, Hyun H, Kang H, Gravier J, Henary M, Bordo MW, Choi HS, Frangioni JV. Intraoperative Near-Infrared Fluorescence Imaging of Thymus in Preclinical Models. Ann Thorac Surg 2016. PubMed
  • Ashitate Y, Levitz A, Park MH, Hyun H, Venugopal V, Park G, El Fakhri G, Henary M, Gioux S, Frangioni JV, Choi HS. Endocrine-specific NIR fluorophores for adrenal gland targeting. Chem Commun (Camb) 2016; 52:10305-8. PubMed
  • Kang H, Mintri S, Menon AV, Lee HY, Choi HS, Kim J. Pharmacokinetics, pharmacodynamics and toxicology of theranostic nanoparticles. Nanoscale 2015; 7:18848-62. PubMed
  • Owens EA, Lee S, Choi J, Henary M, Choi HS. NIR fluorescent small molecules for intraoperative imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2015. PubMed
  • Wada H, Hyun H, Vargas C, Genega EM, Gravier J, Gioux S, Frangioni JV, Choi HS. Sentinel Lymph Node Mapping of Liver. Ann Surg Oncol 2015. PubMed
  • Njiojob CN, Owens EA, Narayana L, Hyun H, Choi HS, Henary M. Tailored near-infrared contrast agents for image guided surgery. J Med Chem 2015. PubMed
  • Hyun H, Park MH, Owens EA, Wada H, Henary M, Handgraaf HJ, Vahrmeijer AL, Frangioni JV, Choi HS. Structure-inherent targeting of near-infrared fluorophores for parathyroid and thyroid gland imaging. Nat Med 2015; 21:192-7. PubMed
  • Kim S, Jung UT, Kim SK, Lee JH, Choi HS, Kim CS, Jeong MY. Nanostructured multifunctional surface with antireflective and antimicrobial characteristics. 2015; 7:326-31. PubMed
  • Wada H, Hyun H, Vargas C, Gravier J, Park G, Gioux S, Frangioni JV, Henary M, Choi HS. Pancreas-targeted NIR fluorophores for dual-channel image-guided abdominal surgery. Theranostics 2015; 5:1-11. PubMed
  • Jee JE, Lim J, Hyun H, Oon J, Ong YS, Massif C, Chang YT, Choi HS, Lee SS. Investigating fluorescent dyes in fluorescence-assisted screenings. Chem Commun (Camb) 2014. PubMed
  • Verbeek FP, van der Vorst JR, Tummers QR, Boonstra MC, de Rooij KE, Löwik CW, Valentijn AR, van de Velde CJ, Choi HS, Frangioni JV, Vahrmeijer AL. Near-infrared fluorescence imaging of both colorectal cancer and ureters using a low-dose integrin targeted probe. Ann Surg Oncol 2014. PubMed
  • Chung JE, Tan S, Gao SJ, Yongvongsoontorn N, Kim SH, Lee JH, Choi HS, Yano H, Zhuo L, Kurisawa M, Ying JY. Self-assembled micellar nanocomplexes comprising green tea catechin derivatives and protein drugs for cancer therapy. Nat Nanotechnol 2014. PubMed
  • Inoue K, Gibbs SL, Liu F, Lee JH, Xie Y, Ashitate Y, Fujii H, Frangioni JV, Choi HS. Microscopic validation of macroscopic in vivo images enabled by same-slide optical and nuclear fusion. J Nucl Med 2014. PubMed
  • Salim MM, Owens EA, Gao T, Lee JH, Hyun H, Choi HS, Henary M. Hydroxylated near-infrared BODIPY fluorophores as intracellular pH sensors. Analyst 2014; 139:4862-73. PubMed
  • Hyun H, Wada H, Bao K, Gravier J, Yadav Y, Laramie M, Henary M, Frangioni JV, Choi HS. Phosphonated near-infrared fluorophores for biomedical imaging of bone. Angew Chem Int Ed Engl 2014; 53:10668-72. PubMed
  • Choi HS. Nanoparticle assembly: building blocks for tumour delivery. Nat Nanotechnol 2014; 9:93-4. PubMed
  • Ashitate Y, Hyun H, Kim SH, Lee JH, Henary M, Frangioni JV, Choi HS. Simultaneous mapping of pan and sentinel lymph nodes for real-time image-guided surgery. Theranostics 2014; 4:693-700. PubMed
  • Yeo SJ, Huong DT, Hong NN, Li CY, Choi K, Yu K, Choi DY, Chong CK, Choi HS, Mallik SK, Kim HS, Sung HW, Park H. Rapid and quantitative detection of zoonotic influenza A virus infection utilizing coumarin-derived dendrimer-based fluorescent immunochromatographic strip test (FICT). Theranostics 2014; 4:1239-49. PubMed
  • Park MH, Hyun H, Ashitate Y, Wada H, Park G, Lee JH, Njiojob C, Henary M, Frangioni JV, Choi HS. Prototype nerve-specific near-infrared fluorophores. Theranostics 2014; 4:823-33. PubMed
  • Huang X, Zhang F, Zhu L, Choi KY, Guo N, Guo J, Tackett K, Anilkumar P, Liu G, Quan Q, Choi HS, Niu G, Sun YP, Lee S, Chen X. Effect of injection routes on the biodistribution, clearance, and tumor uptake of carbon dots. ACS Nano 2013; 7:5684-93. PubMed
  • Ashitate Y, Lee BT, Laurence RG, Lunsford E, Hutteman M, Oketokoun R, Choi HS, Frangioni JV. Intraoperative prediction of postoperative flap outcome using the near-infrared fluorophore methylene blue. Ann Plast Surg 2013. PubMed
  • Huang X, Zhang F, Wang H, Niu G, Choi KY, Swierczewska M, Zhang G, Gao H, Wang Z, Zhu L, Choi HS, Lee S, Chen X. Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery. Biomaterials 2013; 34:1772-80. PubMed
  • Kim SH, Park G, Hyun H, Lee JH, Ashitate Y, Choi J, Hong GH, Owens EA, Henary M, Choi HS. Near-infrared lipophilic fluorophores for tracing tissue growth. 2013; 8:014110. PubMed
  • Choi HS, Gibbs SL, Lee JH, Kim SH, Ashitate Y, Liu F, Hyun H, Park G, Xie Y, Bae S, Henary M, Frangioni JV. Targeted zwitterionic near-infrared fluorophores for improved optical imaging. Nat Biotechnol 2013; 31:148-53. PubMed
  • Owens EA, Hyun H, Kim SH, Lee JH, Park G, Ashitate Y, Choi J, Hong GH, Alyabyev S, Lee SJ, Khang G, Henary M, Choi HS. Highly charged cyanine fluorophores for trafficking scaffold degradation. 2013; 8:014109. PubMed
  • Kim SH, Lee JH, Hyun H, Ashitate Y, Park G, Robichaud K, Lunsford E, Lee SJ, Khang G, Choi HS. Near-infrared fluorescence imaging for noninvasive trafficking of scaffold degradation. Sci Rep 2013; 3:1198. PubMed
  • Lee JH, Park G, Hong GH, Choi J, Choi HS. Design considerations for targeted optical contrast agents. Quant Imaging Med Surg 2012; 2:266-73. PubMed
  • Ashitate Y, Stockdale A, Choi HS, Laurence RG, Frangioni JV. Real-time simultaneous near-infrared fluorescence imaging of bile duct and arterial anatomy. J Surg Res 2012. PubMed
  • Ashitate Y, Kim SH, Tanaka E, Henary M, Choi HS, Frangioni JV, Flaumenhaft R. Two-wavelength near-infrared fluorescence for the quantitation of drug antiplatelet effects in large animal model systems. J. Vasc. Surg. 2012; 56:171-80. PubMed
  • Huang X, Zhang F, Lee S, Swierczewska M, Kiesewetter DO, Lang L, Zhang G, Zhu L, Gao H, Choi HS, Niu G, Chen X. Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes. Biomaterials 2012; 33:4370-8. PubMed
  • Liu F, Lunsford EP, Tong J, Ashitate Y, Gibbs SL, Yu J, Choi HS, Henske EP, Frangioni JV. Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex. PLoS ONE 2012; 7:e38589. PubMed
  • Zhu L, Guo N, Li Q, Ma Y, Jacboson O, Lee S, Choi HS, Mansfield JR, Niu G, Chen X. Dynamic PET and Optical Imaging and Compartment Modeling using a Dual-labeled Cyclic RGD Peptide Probe. Theranostics 2012; 2:746-56. PubMed
  • Mieog JS, Troyan SL, Hutteman M, Donohoe KJ, van der Vorst JR, Stockdale A, Liefers GJ, Choi HS, Gibbs-Strauss SL, Putter H, Gioux S, Kuppen PJ, Ashitate Y, Löwik CW, Smit VT, Oketokoun R, Ngo LH, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer. Ann Surg Oncol 2011. PubMed
  • Choi HS, Nasr K, Alyabyev S, Feith D, Lee JH, Kim SH, Ashitate Y, Hyun H, Patonay G, Strekowski L, Henary M, Frangioni JV. Synthesis and in vivo fate of zwitterionic near-infrared fluorophores. Angew Chem Int Ed Engl 2011; 50:6258-63. PubMed
  • Lee JH, Choi HS, Nasr KA, Ha M, Kim Y, Frangioni JV. High-throughput small molecule identification using MALDI-TOF and a nanolayered substrate. Anal Chem 2011; 83:5283-9. PubMed
  • Ashitate Y, Tanaka E, Stockdale A, Choi HS, Frangioni JV. Near-infrared fluorescence imaging of thoracic duct anatomy and function in open surgery and video-assisted thoracic surgery. J Thorac Cardiovasc Surg 2011; 142:31-8.e1-2. PubMed
  • Hutteman M, Choi HS, Mieog JS, van der Vorst JR, Ashitate Y, Kuppen PJ, van Groningen MC, Löwik CW, Smit VT, van de Velde CJ, Frangioni JV, Vahrmeijer AL. Clinical translation of ex vivo sentinel lymph node mapping for colorectal cancer using invisible near-infrared fluorescence light. Ann Surg Oncol 2011; 18:1006-14. PubMed
  • Choi HS, Frangioni JV. Nanoparticles for biomedical imaging: fundamentals of clinical translation. Mol Imaging 2010; 9:291-310. PubMed
  • Choi HS, Ashitate Y, Lee JH, Kim SH, Matsui A, Insin N, Bawendi MG, Semmler-Behnke M, Frangioni JV, Tsuda A. Rapid translocation of nanoparticles from the lung airspaces to the body. Nat Biotechnol 2010; 28:1300-3. PubMed
  • Gioux S, Choi HS, Frangioni JV. Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation. Mol Imaging 2010; 9:237-55. PubMed
  • Matsui A, Tanaka E, Choi HS, Kianzad V, Gioux S, Lomnes SJ, Frangioni JV. Real-time, near-infrared, fluorescence-guided identification of the ureters using methylene blue. Surgery 2010; 148:78-86. PubMed
  • Winer JH, Choi HS, Gibbs-Strauss SL, Ashitate Y, Colson YL, Frangioni JV. Intraoperative localization of insulinoma and normal pancreas using invisible near-infrared fluorescent light. Ann Surg Oncol 2010; 17:1094-100. PubMed
  • Matsui A, Tanaka E, Choi HS, Winer JH, Kianzad V, Gioux S, Laurence RG, Frangioni JV. Real-time intra-operative near-infrared fluorescence identification of the extrahepatic bile ducts using clinically available contrast agents. Surgery 2010. PubMed
  • Choi HS, Liu W, Liu F, Nasr K, Misra P, Bawendi MG, Frangioni JV. Design considerations for tumour-targeted nanoparticles. Nat Nanotechnol 2010; 5:42-7. PubMed
  • Choi HS,Ipe BI,Misra P,Lee JH,Bawendi MG,Frangioni JV. Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots. Nano Lett 2009; 9:2354-9. PubMed
  • Yuan TL,Choi HS,Matsui A,Benes C,Lifshits E,Luo J,Frangioni JV,Cantley LC. Class 1A PI3K regulates vessel integrity during development and tumorigenesis. Proc Natl Acad Sci U S A 2008; 105:9739-44. PubMed
  • Tanaka E,Choi HS,Humblet V,Ohnishi S,Laurence RG,Frangioni JV. Real-time intraoperative assessment of the extrahepatic bile ducts in rats and pigs using invisible near-infrared fluorescent light. Surgery 2008; 144:39-48. PubMed
  • Gioux S, Kianzad V, Ciocan R, Choi HS, Nelson C, Thumm J, Filkins RJ, Lomnes SJ, Frangioni JV. A low-cost, linear, DC - 35 MHz, high-power LED driver for continuous wave (CW) and fluorescence lifetime imaging (FLIM). Proc Soc Photo Opt Instrum Eng 2008; 6848:684807. PubMed
  • Liu W, Choi HS, Zimmer JP, Tanaka E, Frangioni JV, Bawendi M. Compact cysteine-coated CdSe(ZnCdS) quantum dots for in vivo applications. J Am Chem Soc 2007; 129:14530-1. PubMed
  • Tanaka E, Ohnishi S, Laurence RG, Choi HS, Humblet V, Frangioni JV. Real-time intraoperative ureteral guidance using invisible near-infrared fluorescence. J Urol 2007; 178:2197-202. PubMed
  • Choi HS, Liu W, Misra P, Tanaka E, Zimmer JP, Itty Ipe B, Bawendi MG, Frangioni JV. Renal clearance of quantum dots. Nat Biotechnol 2007; 25:1165-70. PubMed
  • Tanaka E, Choi HS, Fujii H, Bawendi MG, Frangioni JV. Image-guided oncologic surgery using invisible light: completed pre-clinical development for sentinel lymph node mapping. Ann Surg Oncol 2006; 13:1671-81. PubMed
  • Loethen S, Ooya T, Choi HS, Yui N, Thompson DH. Synthesis, characterization, and pH-triggered dethreading of alpha-cyclodextrin-poly(ethylene glycol) polyrotaxanes bearing cleavable endcaps. Biomacromolecules 2006; 7:2501-6. PubMed
  • Choi HS, Hirasawa A, Ooya T, Kajihara D, Hohsaka T, Yui N. pH-sensitive locomotion of cyclodextrins in a block-selective mobile polyrotaxane. 2006; 7:1671-3. PubMed
  • Choi HS, Takahashi A, Ooya T, Yui N. Molecular-recognition and binding properties of cyclodextrin-conjugated polyrotaxanes. 2006; 7:1668-70. PubMed
  • Ooya T, Inoue D, Choi HS, Kobayashi Y, Loethen S, Thompson DH, Ko YH, Kim K, Yui N. pH-responsive movement of cucurbit[7]uril in a diblock polypseudorotaxane containing dimethyl beta-cyclodextrin and cucurbit[7]uril. Org Lett 2006; 8:3159-62. PubMed
  • Choi HS, Ooya T, Yui N. One-pot synthesis of a polyrotaxane via selective threading of a PEI-b-PEG-b-PEI copolymer. 2006; 6:420-4. PubMed
  • Ooya T, Choi HS, Yamashita A, Yui N, Sugaya Y, Kano A, Maruyama A, Akita H, Ito R, Kogure K, Harashima H. Biocleavable polyrotaxane-plasmid DNA polyplex for enhanced gene delivery. J Am Chem Soc 2006; 128:3852-3. PubMed
  • Yamashita A, Choi HS, Ooya T, Yui N, Akita H, Kogure K, Harashima H. Improved cell viability of linear polyethylenimine through gamma-cyclodextrin inclusion for effective gene delivery. Chembiochem 2006; 7:297-302. PubMed
  • Choi HS, Yamashita A, Ooya T, Yui N, Akita H, Kogure K, Ito R, Harashima H. Sunflower-shaped cyclodextrin-conjugated poly(epsilon-lysine) polyplex as a controlled intracellular trafficking device. Chembiochem 2005; 6:1986-90. PubMed
  • Choi HS, Yamamoto K, Ooya T, Yui N. Synthesis of poly(epsilon-lysine)-grafted dextrans and their pH- and thermosensitive hydrogelation with cyclodextrins. 2005; 6:1081-6. PubMed
  • Choi HS, Ooya T, Sasaki S, Yui N, Kurisawa M, Uyama H, Kobayashi S. Spontaneous change of physical state from hydrogels to crystalline precipitates during poly-pseudorotaxane formation. 2004; 5:1431-4. PubMed
  • Choi HS, Huh KM, Ooya T, Yui N. pH- and thermosensitive supramolecular assembling system: rapidly responsive properties of beta-cyclodextrin-conjugated poly(epsilon-lysine). J Am Chem Soc 2003; 125:6350-1. PubMed
  • Seo SA, Choi HS, Khang G, Rhee JM, Lee HB. A local delivery system for fentanyl based on biodegradable poly(L-lactide-co-glycolide) oligomer. Int J Pharm 2002; 239:93-101. PubMed
  • Choi HS, Seo SA, Khang G, Rhee JM, Lee HB. Preparation and characterization of fentanyl-loaded PLGA microspheres: in vitro release profiles. Int J Pharm 2002; 234:195-203. PubMed
  • Lee JH, Bao K, Frangioni JV, Choi HS. Screening of Small Molecule Microarrays for Ligands Targeted to the Extracellular Epitopes of Living Cells. Microarrays (Basel) ; 4:53-63. PubMed
  • Ashitate Y, Vooght CS, Hutteman M, Oketokoun R, Choi HS, Frangioni JV. Simultaneous assessment of luminal integrity and vascular perfusion of the gastrointestinal tract using dual-channel near-infrared fluorescence. ; 11:301-8. PubMed
  • Hyun H, Bordo MW, Nasr K, Feith D, Lee JH, Kim SH, Ashitate Y, Moffitt LA, Rosenberg M, Henary M, Choi HS, Frangioni JV. cGMP-Compatible preparative scale synthesis of near-infrared fluorophores. Contrast Media Mol Imaging ; 7:516-24. PubMed
  • Choi HS, Ooya T, Huh KM, Yui N. pH-triggered changes in assembling properties of beta-cyclodextrin-conjugated poly(epsilon-lysine) complexes. Biomacromolecules ; 6:1200-4. PubMed
  • Gioux S, Lomnes SJ, Choi HS, Frangioni JV. Low-frequency wide-field fluorescence lifetime imaging using a high-power near-infrared light-emitting diode light source. J Biomed Opt ; 15:026005. PubMed
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