Photo of Francesca Dominici,  PhD

Francesca Dominici, PhD

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-4908
Fax: (617) 432-5619

Francesca Dominici, PhD

Harvard T.H. Chan School Of Public Health


  • Professor, Biostatistics, Harvard T.H. Chan School Of Public Health


Research Abstract

Dr. Dominici’s research has focused on the development of statistical methods for the analysis of large observational data and in particular large administrative data bases such as Medicare and SEER-Medicare. She is an expert in Bayesian methods, longitudinal data analysis, confounding adjustment, causal inference, and Bayesian hierarchical models. She is the PI, together with Dr. Xihong Lin, of a NCI Program Project (P01) entitled “Statistical Informatics for Cancer Research” ( This program project will tackle a series of problems motivated by the analysis of high dimensional data arising in population-based studies of cancer.

Dr. Dominici is has become more involved in comparative effectiveness research collaborating with investigators at Dana Farber Cancer Institute (Dr.. Deborah Schrag and Dr.Nils Arvold). With her colleagues she is developing statistical methods for causal inference and propensity score matching to compare health care delivery systems in end of life cancer, with a special focus on glioblastoma and pancreatic cancer. Dr. Dominici also oversees the management and the analysis of several administrative databases, including Part A CMS files and SEER-Medicare.

Publications from Harvard Catalyst Profiles

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  • Antonelli J, Papadogeorgou G, Dominici F. Causal inference in high dimensions: A marriage between Bayesian modeling and good frequentist properties. Biometrics 2020. PubMed
  • Mezzetti M, Palli D, Dominici F. Combining individual and aggregated data to investigate the role of socioeconomic disparities on cancer burden in Italy. Stat Med 2020; 39:26-44. PubMed
  • Haneuse S, Dominici F, Normand SL, Schrag D. Assessment of Between-Hospital Variation in Readmission and Mortality After Cancer Surgical Procedures. JAMA Netw Open 2018; 1:e183038. PubMed
  • Cutler D, Dominici F. A Breath of Bad Air: Cost of the Trump Environmental Agenda May Lead to 80 000 Extra Deaths per Decade. JAMA 2018; 319:2261-2262. PubMed
  • Braun D, Gorfine M, Parmigiani G, Arvold ND, Dominici F, Zigler C. Propensity scores with misclassified treatment assignment: a likelihood-based adjustment. Biostatistics 2017. PubMed
  • Cefalu M, Dominici F, Arvold N, Parmigiani G. Model averaged double robust estimation. Biometrics 2016. PubMed
  • Arvold ND, Cefalu M, Wang Y, Zigler C, Schrag D, Dominici F. Comparative effectiveness of radiotherapy with vs. without temozolomide in older patients with glioblastoma. J. Neurooncol. 2016. PubMed
  • Lee KH, Haneuse S, Schrag D, Dominici F. Bayesian Semi-parametric Analysis of Semi-competing Risks Data: Investigating Hospital Readmission after a Pancreatic Cancer Diagnosis. 2015; 64:253-273. PubMed
  • Obermeyer Z, Makar M, Abujaber S, Dominici F, Block S, Cutler DM. Association between the Medicare hospice benefit and health care utilization and costs for patients with poor-prognosis cancer. JAMA 2014; 312:1888-96. PubMed
  • Arvold ND, Wang Y, Zigler C, Schrag D, Dominici F. Hospitalization burden and survival among older glioblastoma patients. 2014. PubMed
  • Dominici F, Greenstone M, Sunstein CR. Science and regulation. Particulate matter matters. Science 2014; 344:257-9. PubMed
  • Wang Y, Schrag D, Brooks GA, Dominici F. National trends in pancreatic cancer outcomes and pattern of care among Medicare beneficiaries, 2000 through 2010. Cancer 2014. PubMed
  • Zigler CM, Dominici F. Uncertainty in Propensity Score Estimation: Bayesian Methods for Variable Selection and Model Averaged Causal Effects. Journal of the American Statistical Association 2014; 109:95-107. PubMed
  • Anderson GB, Dominici F, Wang Y, McCormack MC, Bell ML, Peng RD. Heat-related emergency hospitalizations for respiratory diseases in the Medicare population. Am J Respir Crit Care Med 2013; 187:1098-103. PubMed
  • Zigler CM, Watts K, Yeh RW, Wang Y, Coull BA, Dominici F. Model feedback in Bayesian propensity score estimation. Biometrics 2013; 69:263-73. PubMed
  • Correia AW, Pope CA, Dockery DW, Wang Y, Ezzati M, Dominici F. Effect of air pollution control on life expectancy in the United States: an analysis of 545 U.S. counties for the period from 2000 to 2007. Epidemiology 2013; 24:23-31. PubMed
  • Barr CD, Diez DM, Wang Y, Dominici F, Samet JM. Comprehensive smoking bans and acute myocardial infarction among Medicare enrollees in 387 US counties: 1999-2008. Am J Epidemiol 2012; 176:642-8. PubMed
  • Wang C, Parmigiani G, Dominici F. Bayesian effect estimation accounting for adjustment uncertainty. Biometrics 2012. PubMed
  • Dominici F, Mittleman MA. China's air quality dilemma: reconciling economic growth with environmental protection. JAMA 2012; 307:2100-2. PubMed
  • Brooke BS, Dominici F, Pronovost PJ, Makary MA, Schneider E, Pawlik TM. Variations in surgical outcomes associated with hospital compliance with safety practices. Surgery 2012; 151:651-9. PubMed
  • Zigler CM, Dominici F, Wang Y. Estimating causal effects of air quality regulations using principal stratification for spatially correlated multivariate intermediate outcomes. Biostatistics 2012; 13:289-302. PubMed
  • Yeh RW, Normand SL, Wang Y, Barr CD, Dominici F. Geographic disparities in the incidence and outcomes of hospitalized myocardial infarction: does a rising tide lift all boats? Circ Cardiovasc Qual Outcomes 2012; 5:197-204. PubMed
  • Bobb JF, Dominici F, Peng RD. A Bayesian model averaging approach for estimating the relative risk of mortality associated with heat waves in 105 U.S. cities. Biometrics 2011; 67:1605-16. PubMed
  • Chang HH, Peng RD, Dominici F. Estimating the acute health effects of coarse particulate matter accounting for exposure measurement error. Biostatistics 2011; 12:637-52. PubMed
  • Pham JC, Colantuoni E, Dominici F, Shore A, Macrae C, Scobie S, Fletcher M, Cleary K, Goeschel CA, Pronovost PJ. The harm susceptibility model: a method to prioritise risks identified in patient safety reporting systems. Qual Saf Health Care 2010; 19:440-5. PubMed
  • Makary MA, Clark JM, Clarke JM, Shore AD, Magnuson TH, Richards T, Bass EB, Dominici F, Weiner JP, Wu AW, Segal JB. Medication utilization and annual health care costs in patients with type 2 diabetes mellitus before and after bariatric surgery. Arch Surg 2010; 145:726-31. PubMed
  • Janes H, Dominici F, Zeger S. On quantifying the magnitude of confounding. Biostatistics 2010; 11:572-82. PubMed
  • Zeger SL, Dominici F, McDermott A, Samet JM. Mortality in the Medicare population and chronic exposure to fine particulate air pollution in urban centers (2000-2005). Environ Health Perspect 2008; 116:1614-9. PubMed
  • Dominici F, Wang C, Crainiceanu C, Parmigiani G. Model selection and health effect estimation in environmental epidemiology. Epidemiology 2008; 19:558-60. PubMed
  • Peng RD, Chang HH, Bell ML, McDermott A, Zeger SL, Samet JM, Dominici F. Coarse particulate matter air pollution and hospital admissions for cardiovascular and respiratory diseases among Medicare patients. JAMA 2008; 299:2172-9. PubMed
  • Eftim SE, Samet JM, Janes H, McDermott A, Dominici F. Fine particulate matter and mortality: a comparison of the six cities and American Cancer Society cohorts with a medicare cohort. Epidemiology 2008; 19:209-16. PubMed
  • Peng RD, Dominici F, Zeger SL. Reproducible epidemiologic research. Am J Epidemiol 2006; 163:783-9. PubMed
  • Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, Samet JM. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA 2006; 295:1127-34. PubMed
  • Bobb JF, Obermeyer Z, Wang Y, Dominici F. Cause-specific risk of hospital admission related to extreme heat in older adults. JAMA ; 312:2659-67. PubMed