Photo of Brett Bouma,  PhD

Brett Bouma, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-9007
Fax: (617) 726-4103

Brett Bouma, PhD

Massachusetts General Hospital


  • Professor, Health Sciences and Technology, Harvard Medical School
  • Professor, Dermatology, Harvard Medical School
  • Professor, Dermatology/WCP, Massachusetts General Hospital


Research Abstract

Dr. Bouma has extensive experience with the development and translation of novel diagnostic instrumentation for biological and medical applications. His research group at the Massachusetts General Hospital has developed and conducted the first human studies with optical coherence tomography in the gastrointestinal tract (esophagus, stomach, duodenum, colon, and biliary tree) for screening and surveillance roles in detecting early cancer. Patents from this work have resulted in commercially available gastroesophageal imaging systems.

Dr. Bouma’s current work includes the integration of ultrasound and optical imaging technologies, the development of novel high power fiber lasers for biological tissue coagulation and marking, and the innovation of new methods for real-time monitoring of surgical and therapeutic procedures.

Through the Harvard-MIT Division of Health Sciences and Technology, Dr. Bouma teaches graduate courses and supervises MD, MD/PhD, and PhD students.

Publications from Harvard Catalyst Profiles

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  • Villiger M, Lorenser D, McLaughlin RA, Quirk BC, Kirk RW, Bouma BE, Sampson DD. Deep tissue volume imaging of birefringence through fibre-optic needle probes for the delineation of breast tumour. Sci Rep 2016; 6:28771. PubMed
  • Lo WC, Villiger M, Golberg A, Broelsch GF, Khan S, Lian CG, Austen WG, Yarmush M, Bouma BE. Longitudinal, 3D Imaging of Collagen Remodeling in Murine Hypertrophic Scars In Vivo Using Polarization-Sensitive Optical Frequency Domain Imaging. J Invest Dermatol 2016; 136:84-92. PubMed
  • Lo WC, Villiger M, Golberg A, Broelsch GF, Khan S, Lian CG, Austen WG, Yarmush M, Bouma BE. Longitudinal, 3D In Vivo Imaging of Collagen Remodeling in Murine Hypertrophic Scars using Polarization-sensitive Optical Frequency Domain Imaging. J Invest Dermatol 2015. PubMed
  • Suter MJ, Gora MJ, Lauwers GY, Arnason T, Sauk J, Gallagher KA, Kava L, Tan KM, Soomro AR, Gallagher TP, Gardecki JA, Bouma BE, Rosenberg M, Nishioka NS, Tearney GJ. Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study. Gastrointest Endosc 2014. PubMed
  • Sauk J, Coron E, Kava L, Suter M, Gora M, Gallagher K, Rosenberg M, Ananthakrishnan A, Nishioka N, Lauwers G, Woods K, Brugge W, Forcione D, Bouma BE, Tearney G. Interobserver agreement for the detection of Barrett's esophagus with optical frequency domain imaging. Dig Dis Sci 2013; 58:2261-5. PubMed
  • Villiger M, Zhang EZ, Nadkarni SK, Oh WY, Vakoc BJ, Bouma BE. Spectral binning for mitigation of polarization mode dispersion artifacts in catheter-based optical frequency domain imaging. Opt Express 2013; 21:16353-69. PubMed
  • Vakoc BJ, Fukumura D, Jain RK, Bouma BE. Cancer imaging by optical coherence tomography: preclinical progress and clinical potential. Nat Rev Cancer 2012; 12:363-8. PubMed