Photo of Barbara Wegiel, PhD

Barbara Wegiel, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 735-2846


bwegiel@bidmc.harvard.edu

Photo of Barbara Wegiel, PhD

Harvard Medical School
Phone: (617) 735-2846


bwegiel@bidmc.harvard.edu

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Barbara Wegiel, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • Associate Professor, Surgery, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

A major interest of our laboratory is the role of heme degradation enzymes: heme oxygenase-1 (HO-1) and biliverdin reductase (BVR) in inflammation and tumor biology. We have demonstrated that HO-1 and its product carbon monoxide (CO) are critical regulators of DNA repair pathway (PNAS, 2011) as well as myeloid cell maturation (CDD, 2014). CO at low non-toxic doses blocks tumor growth and accelerates responses to current chemotherapy (Can Res, 2013). Further, we have uncovered novel properties of BVR to act as a signaling molecule and mediate anti-inflammatory effects of biliverdin in myeloid cells (JBC, 2009; PNAS 2011). We continue to explore a role of BVR and HO-1 using our newly generated BVR and HO-1 conditional knockout mice as well as transgenic models of carcinogenesis.

Publications from Harvard Catalyst Profiles

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  • Koikawa K, Kibe S, Suizu F, Sekino N, Kim N, Manz TD, Pinch BJ, Akshinthala D, Verma A, Gaglia G, Nezu Y, Ke S, Qiu C, Ohuchida K, Oda Y, Lee TH, Wegiel B, Clohessy JG, London N, Santagata S, Wulf GM, Hidalgo M, Muthuswamy SK, Nakamura M, Gray NS, Zhou XZ, Lu KP. Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. Cell 2021. PubMed
  • Canesin G, Muralidharan AM, Swanson KD, Wegiel B. HO-1 and Heme: G-Quadruplex Interaction Choreograph DNA Damage Responses and Cancer Growth. Cells 2021. PubMed
  • Canesin G, Janovicova L, Wegiel B. Measurement of labile and protein-bound heme in fixed prostate cancer cells and in cellular fractions. STAR Protoc 2021; 2:100491. PubMed
  • Canesin G, Di Ruscio A, Li M, Ummarino S, Hedblom A, Choudhury R, Krzyzanowska A, Csizmadia E, Palominos M, Stiehm A, Ebralidze A, Chen SY, Bassal MA, Zhao P, Tolosano E, Hurley L, Bjartell A, Tenen DG, Wegiel B. Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases. Cell Rep 2020; 32:108181. PubMed
  • Lilljebjörn LV, Csizmadia E, Hedblom A, Canesin G, Kalbasi A, Li M, Kramer F, Bornfeldt KE, Wegiel B. A Role of the Heme Degradation Pathway in Shaping Prostate Inflammatory Responses and Lipid Metabolism. Am J Pathol 2020. PubMed
  • Canesin G, Hejazi SM, Swanson KD, Wegiel B. Heme-Derived Metabolic Signals Dictate Immune Responses. 2020; 11:66. PubMed
  • Bisht K, Canesin G, Cheytan T, Li M, Nemeth Z, Csizmadia E, Woodruff TM, Stec DE, Bulmer AC, Otterbein LE, Wegiel B. Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a--C5aR1 Pathway. J Immunol 2019. PubMed
  • Daneshmandi S, Wegiel B, Seth P. Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma. Cancers (Basel) 2019. PubMed
  • Hedblom A, Hejazi SM, Canesin G, Choudhury R, Hanafy KA, Csizmadia E, Persson JL, Wegiel B. Heme detoxification by heme oxygenase-1 reinstates proliferative and immune balances upon genotoxic tissue injury. Cell Death Dis 2019; 10:72. PubMed
  • Wegiel B, Vuerich M, Daneshmandi S, Seth P. Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy. 2018; 8:284. PubMed
  • Seth P, Csizmadia E, Hedblom A, Vuerich M, Xie H, Li M, Longhi MS, Wegiel B. Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity. Cancer Res 2017; 77:3632-3643. PubMed
  • Wang Y, Hedblom A, Koerner SK, Li M, Jernigan FE, Wegiel B, Sun L. Novel synthetic chalcones induce apoptosis in the A549 non-small cell lung cancer cells harboring a KRAS mutation. Bioorg Med Chem Lett 2016; 26:5703-5706. PubMed
  • Wegiel B, Wang Y, Li M, Jernigan F, Sun L. Novel indolyl-chalcones target stathmin to induce cancer cell death. Cell Cycle 2016. PubMed
  • Nemeth Z, Csizmadia E, Vikstrom L, Li M, Bisht K, Feizi A, Otterbein S, Zuckerbraun B, Costa DB, Pandolfi PP, Fillinger J, Döme B, Otterbein LE, Wegiel B. Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth. 2016. PubMed
  • Nemeth Z, Li M, Csizmadia E, Döme B, Johansson M, Persson JL, Seth P, Otterbein L, Wegiel B. Heme oxygenase-1 in macrophages controls prostate cancer progression. 2015. PubMed
  • Eguchi T, Prince T, Wegiel B, Calderwood SK. Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer. J Cell Biochem 2015. PubMed
  • Bisht K, Wegiel B, Tampe J, Neubauer O, Wagner KH, Otterbein LE, Bulmer AC. Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling. Biochem Biophys Res Commun 2014; 449:94-9. PubMed
  • Wegiel B, Gallo D, Csizmadia E, Harris C, Belcher J, Vercellotti GM, Penacho N, Seth P, Sukhatme V, Ahmed A, Pandolfi PP, Helczynski L, Bjartell A, Persson JL, Otterbein LE. Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth. Cancer Res 2013; 73:7009-21. PubMed
  • Wegiel B, Hanto DW, Otterbein LE. The social network of carbon monoxide in medicine. Trends Mol Med 2013; 19:3-11. PubMed
  • Wegiel B, Gallo D, Csizmadia E, Roger T, Kaczmarek E, Harris C, Zuckerbraun BS, Otterbein LE. Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase. Proc Natl Acad Sci U S A 2011; 108:18849-54. PubMed
  • Otterbein LE, Hedblom A, Harris C, Csizmadia E, Gallo D, Wegiel B. Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein. Proc Natl Acad Sci U S A 2011; 108:14491-6. PubMed
  • Wegiel B, Bjartell A, Tuomela J, Dizeyi N, Tinzl M, Helczynski L, Nilsson E, Otterbein LE, Härkönen P, Persson JL. Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. Journal of the National Cancer Institute 2008; 100:1022-36. PubMed
  • Wegiel B, Chin BY, Otterbein LE. Inhale to survive, cycle or die? Carbon monoxide and cellular proliferation. Cell Cycle 2008; 7:1379-84. PubMed
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DF/HCC members that share similar concepts* with Barbara Wegiel, PhD but have yet to coauthor a publication with this researcher.

* Concepts are MeSH terms, automatically derived from member publications

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