Photo of Miguel Hernan, MD, DrPH

Miguel Hernan, MD, DrPH

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-0101


miguel_hernan@post.harvard.edu

Photo of Miguel Hernan, MD, DrPH

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-0101


miguel_hernan@post.harvard.edu

Visualize Collaborations

Miguel Hernan, MD, DrPH

Harvard T.H. Chan School Of Public Health

EDUCATIONAL TITLES

  • Professor, Epidemiology, Harvard T.H. Chan School Of Public Health
  • Professor, Biostatistics, Harvard T.H. Chan School Of Public Health

HCC PROGRAM AFFILIATION

Publications from Harvard Catalyst Profiles

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  • Humphreys ABC, Matthews AA, Young JC, Berglund A, Lindahl B, Wettermark B, Dahabreh IJ, Kahan T, Hernán MA. The definition of treatment assignment in observational emulations of target trials - an empirical examination in the Swedish Primary Care Cardiovascular Database. Ann Epidemiol 2025; 108:56-62. PubMed
  • McGee EE, Hernán MA, Giovannucci E, Mucci LA, Chiu YH, Eliassen AH, Dickerman BA. Estimating the effects of lifestyle interventions on mortality among cancer survivors: a methodological framework. Epidemiology 2025. PubMed
  • Shi J, Løberg M, Kalager M, Wieszczy P, Pilonis ND, Adami HO, Kaminski MF, Bretthauer M, Hernán MA, . Effect of colonoscopy screening on risks of colorectal cancer and related death: instrumental variable estimation of per-protocol effects. Eur J Epidemiol 2025. PubMed
  • Gupta A, Hsu G, Kent S, Duffield SJ, Merinopoulou E, Lockhart A, Arora P, Ray J, Wilkinson S, Scheuer N, Ramagopalan SV, Groenwold RHH, Popat S, Hernán MA. Quantitative Bias Analysis for Single-Arm Trials With External Control Arms. JAMA Netw Open 2025; 8:e252152. PubMed
  • García-Albéniz X, Hsu J, Etzioni R, Chan JM, Shi J, Dickerman B, Hernán MA. Prostate-Specific Antigen Screening and Prostate Cancer Mortality: An Emulation of Target Trials in US Medicare. JCO Clin Cancer Inform 2024; 8:e2400094. PubMed
  • Hansford HJ, Cashin AG, Jones MD, Swanson SA, Islam N, Dahabreh IJ, Dickerman BA, Egger M, Garcia-Albeniz X, Golub RM, Lodi S, Moreno-Betancur M, Pearson SA, Schneeweiss S, Sterne J, Sharp MK, Stuart EA, Hernan MA, Lee H, McAuley JH. Development of the TrAnsparent ReportinG of observational studies Emulating a Target trial (TARGET) guideline. BMJ Open 2023; 13:e074626. PubMed
  • Hansford HJ, Cashin AG, Jones MD, Swanson SA, Islam N, Douglas SRG, Rizzo RRN, Devonshire JJ, Williams SA, Dahabreh IJ, Dickerman BA, Egger M, Garcia-Albeniz X, Golub RM, Lodi S, Moreno-Betancur M, Pearson SA, Schneeweiss S, Sterne JAC, Sharp MK, Stuart EA, Hernán MA, Lee H, McAuley JH. Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials: A Systematic Review. JAMA Netw Open 2023; 6:e2336023. PubMed
  • Chiu YH, Wen L, McGrath S, Logan R, Dahabreh IJ, Hernán MA. Evaluating model specification when using the parametric g-formula in the presence of censoring. Am J Epidemiol 2023. PubMed
  • Saesen R, Van Hemelrijck M, Bogaerts J, Booth CM, Cornelissen JJ, Dekker A, Eisenhauer EA, Freitas A, Gronchi A, Hernán MA, Hulstaert F, Ost P, Szturz P, Verkooijen HM, Weller M, Wilson R, Lacombe D, van der Graaf WT. Defining the role of real-world data in cancer clinical research: The position of the European Organisation for Research and Treatment of Cancer. Eur J Cancer 2023; 186:52-61. PubMed
  • Dickerman BA, García-Albéniz X, Logan RW, Denaxas S, Hernán MA. Evaluating metformin strategies for cancer prevention: a target trial emulation using electronic health records. Epidemiology 2023. PubMed
  • Dahabreh IJ, Robins JM, Haneuse SJA, Saeed I, Robertson SE, Stuart EA, Hernán MA. Sensitivity analysis using bias functions for studies extending inferences from a randomized trial to a target population. Stat Med 2023. PubMed
  • Boyne DJ, Brenner DR, Gupta A, Mackay E, Arora P, Wasiak R, Cheung WY, Hernán MA. Head-to-head comparison of FOLFIRINOX versus gemcitabine plus nab-paclitaxel in advanced pancreatic cancer: a target trial emulation using real-world data. Ann Epidemiol 2023; 78:28-34. PubMed
  • Hernán MA, Wang W, Leaf DE. Target Trial Emulation: A Framework for Causal Inference From Observational Data. JAMA 2022; 328:2446-2447. PubMed
  • Bretthauer M, Løberg M, Wieszczy P, Kalager M, Emilsson L, Garborg K, Rupinski M, Dekker E, Spaander M, Bugajski M, Holme Ø, Zauber AG, Pilonis ND, Mroz A, Kuipers EJ, Shi J, Hernán MA, Adami HO, Regula J, Hoff G, Kaminski MF, . Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death. N Engl J Med 2022; 387:1547-1556. PubMed
  • Smith LH, García-Albéniz X, Chan JM, Zhao S, Cowan JE, Broering JM, Cooperberg MR, Carroll PR, Hernán MA. Emulation of a target trial with sustained treatment strategies: an application to prostate cancer using both inverse probability weighting and the g-formula. Eur J Epidemiol 2022. PubMed
  • Wen L, Hernán MA, Robins JM. MULTIPLY ROBUST ESTIMATORS OF CAUSAL EFFECTS FOR SURVIVAL OUTCOMES. Scand Stat Theory Appl 2022; 49:1304-1328. PubMed
  • Shahn Z, Hernán MA, Robins JM. A formal causal interpretation of the case-crossover design. Biometrics 2022. PubMed
  • Dahabreh IJ, Robertson SE, Petito LC, Hernán MA, Steingrimsson JA. Efficient and robust methods for causally interpretable meta-analysis: Transporting inferences from multiple randomized trials to a target population. Biometrics 2022. PubMed
  • Bellamy D, Hernán MA, Beam A. A structural characterization of shortcut features for prediction. Eur J Epidemiol 2022; 37:563-568. PubMed
  • Madenci AL, Wanis KN, Cooper Z, Subramanian SV, Haneuse S, Hofman A, Hernán M. Comparison of Mortality Risk With Different Surgeon and Hospital Operative Volumes Among Individuals Undergoing Pancreatectomy by Emulating Target Trials in US Medicare Beneficiaries. JAMA Netw Open 2022; 5:e221766. PubMed
  • McGrath S, Young JG, Hernán MA. Revisiting the g-null paradox. Epidemiology 2021. PubMed
  • Stensrud MJ, Hernán MA, Tchetgen Tchetgen EJ, Robins JM, Didelez V, Young JG. A generalized theory of separable effects in competing event settings. Lifetime Data Analysis 2021; 27:588-631. PubMed
  • Hernán MA. Causal analyses of existing databases: no power calculations required. J Clin Epidemiol 2021. PubMed
  • Shi J, Swanson SA, Kraft P, Rosner B, De Vivo I, Hernán MA. Instrumental variable estimation for a time-varying treatment and a time-to-event outcome via structural nested cumulative failure time models. 2021; 21:258. PubMed
  • Dahabreh IJ, Haneuse SJPA, Robins JM, Robertson SE, Buchanan AL, Stuart EA, Hernán MA. Study Designs for Extending Causal Inferences from a Randomized Trial to a Target Population. Am J Epidemiol 2020. PubMed
  • Dickerman BA, García-Albéniz X, Logan RW, Denaxas S, Hernán MA. Emulating a target trial in case-control designs: an application to statins and colorectal cancer. Int J Epidemiol 2020. PubMed
  • Dahabreh IJ, Robins JM, Hernán MA. Benchmarking Observational Methods by Comparing Randomized Trials and Their Emulations. Epidemiology 2020; 31:614-619. PubMed
  • García-Albéniz X, Hernán MA, Hsu J. Continuation of Annual Screening Mammography and Breast Cancer Mortality in Women Older Than 70 Years. Ann Intern Med 2020; 173:247. PubMed
  • Dickerman BA, Hernán MA. Counterfactual prediction is not only for causal inference. Eur J Epidemiol 2020; 35:615-617. PubMed
  • Sarvet AL, Wanis KN, Stensrud MJ, Hernán MA. A Graphical Description of Partial Exchangeability. Epidemiology 2020; 31:365-368. PubMed
  • Young JG, Stensrud MJ, Tchetgen Tchetgen EJ, Hernán MA. A causal framework for classical statistical estimands in failure-time settings with competing events. Stat Med 2020; 39:1199-1236. PubMed
  • Stensrud MJ, Hernán MA. Why Test for Proportional Hazards? JAMA 2020. PubMed
  • Petito LC, García-Albéniz X, Logan RW, Howlader N, Mariotto AB, Dahabreh IJ, Hernán MA. Estimates of Overall Survival in Patients With Cancer Receiving Different Treatment Regimens: Emulating Hypothetical Target Trials in the Surveillance, Epidemiology, and End Results (SEER)-Medicare Linked Database. JAMA Netw Open 2020; 3:e200452. PubMed
  • Dahabreh IJ, Petito LC, Robertson SE, Hernán MA, Steingrimsson JA. Toward Causally Interpretable Meta-analysis: Transporting Inferences from Multiple Randomized Trials to a New Target Population. Epidemiology 2020. PubMed
  • García-Albéniz X, Hernán MA, Logan RW, Price M, Armstrong K, Hsu J. Continuation of Annual Screening Mammography and Breast Cancer Mortality in Women Older Than 70 Years. Ann Intern Med 2020. PubMed
  • Dahabreh IJ, Robertson SE, Hernán MA. On the Relation Between G-formula and Inverse Probability Weighting Estimators for Generalizing Trial Results. Epidemiology 2019; 30:807-812. PubMed
  • Galea S, Hernán MA. Win-win: Reconciling Social Epidemiology and Causal Inference. Am J Epidemiol 2019. PubMed
  • Dickerman BA, García-Albéniz X, Logan RW, Denaxas S, Hernán MA. Avoidable flaws in observational analyses: an application to statins and cancer. Nat Med 2019; 25:1601-1606. PubMed
  • Jain P, Danaei G, Manson JE, Robins JM, Hernán MA. Weight gain after smoking cessation and lifestyle strategies to reduce it. Epidemiology 2019. PubMed
  • Young JG, Vatsa R, Murray EJ, Hernán MA. Interval-cohort designs and bias in the estimation of per-protocol effects: a simulation study. Trials 2019; 20:552. PubMed
  • Dahabreh IJ, Hernán MA. Extending inferences from a randomized trial to a target population. Eur J Epidemiol 2019; 34:719-722. PubMed
  • García-Albéniz X, Hsu J, Bretthauer M, Hernán MA. Estimating the Effect of Preventive Services with Databases of Administrative Claims: Reasons to Be Concerned. Am J Epidemiol 2019. PubMed
  • Young JG, Logan RW, Robins JM, Hernán MA. Inverse probability weighted estimation of risk under representative interventions in observational studies. Journal of the American Statistical Association 2019; 114:938-947. PubMed
  • Dickerman BA, Giovannucci E, Pernar CH, Mucci LA, Hernán MA. Guideline-Based Physical Activity and Survival Among US Men With Nonmetastatic Prostate Cancer. Am J Epidemiol 2018. PubMed
  • Murray EJ, Caniglia EC, Swanson SA, Hernández-Díaz S, Hernán MA. Patients and investigators preferred measures of absolute risk in subgroups for pragmatic randomized trials. J Clin Epidemiol 2018. PubMed
  • Holme Ø, Løberg M, Kalager M, Bretthauer M, Hernán MA, Aas E, Eide TJ, Skovlund E, Lekven J, Schneede J, Tveit KM, Vatn M, Ursin G, Hoff G, . Long-Term Effectiveness of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality in Women and Men: A Randomized Trial. Ann Intern Med 2018; 168:775-782. PubMed
  • Emilsson L, García-Albéniz X, Hernan MA. Association of Statin Use With Overall and Cancer Survival-Reply. JAMA Oncol 2018. PubMed
  • Swanson SA, Labrecque J, Hernán MA. Causal null hypotheses of sustained treatment strategies: What can be tested with an instrumental variable? Eur J Epidemiol 2018. PubMed
  • Hernán MA. The C-Word: Scientific Euphemisms Do Not Improve Causal Inference From Observational Data. Am J Public Health 2018; 108:616-619. PubMed
  • Swanson SA, Hernán MA, Miller M, Robins JM, Richardson TS. Partial Identification of the Average Treatment Effect Using Instrumental Variables: Review of Methods for Binary Instruments, Treatments, and Outcomes. Journal of the American Statistical Association 2018; 113:933-947. PubMed
  • Lash TL, Kaufman JS, Hernán MA. Correspondence Between Results and Aims of Funding Support in EPIDEMIOLOGY Articles. Epidemiology 2018; 29:1-4. PubMed
  • Hernán MA. How to estimate the effect of treatment duration on survival outcomes using observational data. BMJ 2018; 360:k182. PubMed
  • Emilsson L, García-Albéniz X, Logan RW, Caniglia EC, Kalager M, Hernán MA. Examining Bias in Studies of Statin Treatment and Survival in Patients With Cancer. JAMA Oncol 2017. PubMed
  • García-Albéniz X, Hsu J, Hernán MA. The value of explicitly emulating a target trial when using real world evidence: an application to colorectal cancer screening. Eur J Epidemiol 2017. PubMed
  • Murray EJ, Robins JM, Seage GR, Freedberg KA, Hernán MA. A Comparison of Agent-Based Models and the Parametric G-Formula for Causal Inference. Am J Epidemiol 2017; 186:131-142. PubMed
  • Swanson SA, Tiemeier H, Ikram MA, Hernán MA. Nature as a trialist? Deconstructing the analogy between Mendelian Randomization and randomized trials. Epidemiology 2017. PubMed
  • García-Albéniz X, Hsu J, Bretthauer M, Hernán MA. Screening Colonoscopy to Prevent Colorectal Cancer Among Medicare Beneficiaries Aged 70 to 79 Years. Ann Intern Med 2017; 166:758-759. PubMed
  • Hernán MA, Robins JM. Per-Protocol Analyses of Pragmatic Trials. N Engl J Med 2017; 377:1391-1398. PubMed
  • García-Albéniz X, Hsu J, Bretthauer M, Hernán MA. Effectiveness of Screening Colonoscopy to Prevent Colorectal Cancer Among Medicare Beneficiaries Aged 70 to 79 Years: A Prospective Observational Study. Ann Intern Med 2016. PubMed
  • García-Albéniz X, Hsu J, Lipsitch M, Bretthauer M, Logan RW, Hernández-Díaz S, Hernán MA. Colonoscopy and Risk of Infective Endocarditis in the Elderly. J Am Coll Cardiol 2016; 68:570-1. PubMed
  • Bretthauer M, Kaminski MF, Løberg M, Zauber AG, Regula J, Kuipers EJ, Hernán MA, McFadden E, Sunde A, Kalager M, Dekker E, Lansdorp-Vogelaar I, Garborg K, Rupinski M, Spaander MC, Bugajski M, Høie O, Stefansson T, Hoff G, Adami HO, . Population-Based Colonoscopy Screening for Colorectal Cancer: A Randomized Clinical Trial. JAMA Intern Med 2016; 176:894-902. PubMed
  • Hernán MA, Sauer BC, Hernández-Díaz S, Platt R, Shrier I. Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses. J Clin Epidemiol 2016. PubMed
  • Jover R, Bretthauer M, Dekker E, Holme Ø, Kaminski MF, Løberg M, Zauber AG, Hernán MA, Lansdorp-Vogelaar I, Sunde A, McFadden E, Castells A, Regula J, Quintero E, Pellisé M, Senore C, Kalager M, Dinis-Ribeiro M, Emilsson L, Ransohoff DF, Hoff G, Adami HO. Rationale and design of the European Polyp Surveillance (EPoS) trials. Endoscopy 2016. PubMed
  • Adami HO, Bretthauer M, Emilsson L, Hernán MA, Kalager M, Ludvigsson JF, Ekbom A. The continuing uncertainty about cancer risk in inflammatory bowel disease. Gut 2016. PubMed
  • Hernán MA, Robins JM. Using Big Data to Emulate a Target Trial When a Randomized Trial Is Not Available. Am J Epidemiol 2016. PubMed
  • Huitfeldt A, Hernan MA, Kalager M, Robins JM. Comparative Effectiveness Research Using Observational Data: Active Comparators to Emulate Target Trials with Inactive Comparators. EGEMS (Wash DC) 2016; 4:1234. PubMed
  • García-Albéniz X, Hsu J, Lipsitch M, Logan RW, Hernández-Díaz S, Hernán MA. Infective endocarditis and cancer in the elderly. Eur J Epidemiol 2016; 31:41-9. PubMed
  • Hernán MA. Counterpoint: Epidemiology to Guide Decision-Making: Moving Away From Practice-Free Research. Am J Epidemiol 2015; 182:834-9. PubMed
  • Huitfeldt A, Kalager M, Robins JM, Hoff G, Hernán MA. Methods to Estimate the Comparative Effectiveness of Clinical Strategies that Administer the Same Intervention at Different Times. Curr Epidemiol Rep 2015; 2:149-161. PubMed
  • García-Albéniz X, Maurel J, Hernán MA. Why post-progression survival and post-relapse survival are not appropriate measures of efficacy in cancer randomized clinical trials. Int J Cancer 2015; 136:2444-7. PubMed
  • Swanson SA, Miller M, Robins JM, Hernán MA. Definition and evaluation of the monotonicity condition for preference-based instruments. Epidemiology 2015; 26:414-20. PubMed
  • Swanson SA, Robins JM, Miller M, Hernán MA. Selecting on treatment: a pervasive form of bias in instrumental variable analyses. Am J Epidemiol 2015; 181:191-7. PubMed
  • Gruber S, Logan RW, Jarrín I, Monge S, Hernán MA. Ensemble learning of inverse probability weights for marginal structural modeling in large observational datasets. Stat Med 2015; 34:106-17. PubMed
  • Swanson SA, Holme Ø, Løberg M, Kalager M, Bretthauer M, Hoff G, Aas E, Hernán MA. Bounding the per-protocol effect in randomized trials: an application to colorectal cancer screening. Trials 2015; 16:541. PubMed
  • Holme Ø, Løberg M, Kalager M, Bretthauer M, Hernán MA, Aas E, Eide TJ, Skovlund E, Schneede J, Tveit KM, Hoff G. Effect of flexible sigmoidoscopy screening on colorectal cancer incidence and mortality: a randomized clinical trial. JAMA 2014; 312:606-15. PubMed
  • Hernán MA, Hernández-Díaz S, Robins JM. Randomized trials analyzed as observational studies. Ann Intern Med 2013; 159:560-2. PubMed
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