Photo of G. Scott Gazelle, MD, MPH, PhD

G. Scott Gazelle, MD, MPH, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-4047
Fax: (617) 726-9414


scott@mgh-ita.org

Photo of G. Scott Gazelle, MD, MPH, PhD

Massachusetts General Hospital
Phone: (617) 726-4047
Fax: (617) 726-9414


scott@mgh-ita.org

Visualize Collaborations

G. Scott Gazelle, MD, MPH, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Radiology, Harvard Medical School
  • Professor, Health Policy and Management, Harvard T.H. Chan School Of Public Health
  • Director, Institute for Technology Assessment, Massachusetts General Hospital
  • Director, Partners Radiology, Massachusetts General Hospital

HCC PROGRAM AFFILIATION

Research Abstract

Dr. Gazelle's research focuses on the evaluating the benefits, costs, and appropriate use of new medical technologies. He also directs the DF/HCC Program in Cancer Outcomes Research Training, which provides fellowship training for individuals interesting in cancer outcomes research.

Publications from Harvard Catalyst Profiles

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  • Ten Haaf K, de Nijs K, Simoni G, Alban A, Cao P, Sun Z, Yong J, Jeon J, Toumazis I, Han SS, Gazelle GS, Kong CY, Plevritis SK, Meza R, de Koning HJ. The Impact of Model Assumptions on Personalized Lung Cancer Screening Recommendations. Med Decis Making 2024. PubMed
  • Potter AL, Xu NN, Senthil P, Srinivasan D, Lee H, Gazelle GS, Chelala L, Zheng W, Fintelmann FJ, Sequist LV, Donington J, Palmer JR, Yang CJ. Pack-Year Smoking History: An Inadequate and Biased Measure to Determine Lung Cancer Screening Eligibility. J Clin Oncol 2024. PubMed
  • Toumazis I, Cao P, de Nijs K, Bastani M, Munshi V, Hemmati M, Ten Haaf K, Jeon J, Tammemägi M, Gazelle GS, Feuer EJ, Kong CY, Meza R, de Koning HJ, Plevritis SK, Han SS. Risk Model-Based Lung Cancer Screening : A Cost-Effectiveness Analysis. Ann Intern Med 2023. PubMed
  • Toumi A, DiGennaro C, Vahdat V, Jalali MS, Gazelle GS, Chhatwal J, Kelz RR, Lubitz CC. Trends in Thyroid Surgery and Guideline-Concordant Care in the United States, 2007-2018. Thyroid 2021. PubMed
  • Bennett DL, Swan JS, Gazelle GS, Saksena M. Music during image-guided breast biopsy reduces patient anxiety levels. Clin Imaging 2020; 65:18-23. PubMed
  • Lee JM, Lowry KP, Cott Chubiz JE, Swan JS, Motazedi T, Halpern EF, Tosteson ANA, Gazelle GS, Donelan K. Breast cancer risk, worry, and anxiety: Effect on patient perceptions of false-positive screening results. Breast 2020; 50:104-112. PubMed
  • White C, Nimeh T, Gazelle GS, Weinstein MC, Loughlin KR. A decision analysis comparing 3 active surveillance protocols for the treatment of patients with low-risk prostate cancer. Cancer 2018. PubMed
  • Lee LK, Reisner AT, Binder WD, Zaheer A, Gunn ML, Linnau KF, Miller CM, Herring MS, Tramontano AC, Kambadakone A, Catalano OA, Harisinghani M, Halpern EF, Donelan K, Gazelle GS, Pandharipande PV. Repeat CT Performed Within One Month of CT Conducted in the Emergency Department for Abdominal Pain: A Secondary Analysis of Data From a Prospective Multicenter Study. AJR Am J Roentgenol 2018. PubMed
  • White C, Weinstein MC, Fingeret AL, Randolph GW, Miyauchi A, Ito Y, Zhan T, Ali A, Gazelle GS, Lubitz CC. Is Less More? A Microsimulation Model Comparing Cost-effectiveness of the Revised American Thyroid Association's 2015 to 2009 Guidelines for the Management of Patients With Thyroid Nodules and Differentiated Thyroid Cancer. Ann Surg 2018. PubMed
  • Lowry KP, Braunstein LZ, Economopoulos KP, Salama L, Lehman CD, Gazelle GS, Halpern EF, Giess CS, Taghian AG, Lee JM. Predictors of surveillance mammography outcomes in women with a personal history of breast cancer. Breast Cancer Res Treat 2018. PubMed
  • Kroep S, Heberle CR, Curtius K, Kong CY, Lansdorp-Vogelaar I, Ali A, Wolf WA, Shaheen NJ, Spechler SJ, Rubenstein JH, Nishioka NS, Meltzer SJ, Hazelton WD, van Ballegooijen M, Tramontano AC, Gazelle GS, Luebeck EG, Inadomi JM, Hur C. Impact of Radiofrequency Ablation Treatment of Barrett's Esophagus on Esophageal Adenocarcinoma: A Comparative Modeling Analysis. Clin Gastroenterol Hepatol 2017. PubMed
  • Lubitz C, Ali A, Zhan T, Heberle C, White C, Ito Y, Miyauchi A, Gazelle GS, Kong CY, Hur C. The thyroid cancer policy model: A mathematical simulation model of papillary thyroid carcinoma in The U.S. population. PLoS ONE 2017; 12:e0177068. PubMed
  • Sheehan DF, Criss SD, Gazelle GS, Pandharipande PV, Kong CY. Evaluating lung cancer screening in China: Implications for eligibility criteria design from a microsimulation modeling approach. PLoS ONE 2017; 12:e0173119. PubMed
  • Pandharipande PV, Alabre CI, Coy DL, Zaheer A, Miller CM, Herring MS, Tramontano AC, Dowling EC, Eisenberg JD, Ashar BH, Halpern EF, Donelan K, Gazelle GS. Changes in Physician Decision Making after CT: A Prospective Multicenter Study in Primary Care Settings. Radiology 2016. PubMed
  • Harvey HB, Alkasab TK, Prabhakar AM, Halpern EF, Rosenthal DI, Pandharipande PV, Gazelle GS. Radiologist Peer Review by Group Consensus. J Am Coll Radiol 2016. PubMed
  • Lubitz CC, Economopoulos KP, Sy S, Johanson C, Kunzel HE, Reincke M, Gazelle GS, Weinstein MC, Gaziano TA. Cost-Effectiveness of Screening for Primary Aldosteronism and Subtype Diagnosis in the Resistant Hypertensive Patients. Circ Cardiovasc Qual Outcomes 2015; 8:621-30. PubMed
  • Harvey HB, Alkasab TK, Pandharipande PV, Halpern EF, Prabhakar AM, Oklu R, Rosenthal DI, Hirsch JA, Gazelle GS, Brink JA. Non-Research-Related Physician-Industry Relationships of Radiologists in the United States. J Am Coll Radiol 2015. PubMed
  • Glover M, Khalilzadeh O, Choy G, Prabhakar AM, Pandharipande PV, Gazelle GS. Hospital Evaluations by Social Media: A Comparative Analysis of Facebook Ratings among Performance Outliers. J Gen Intern Med 2015. PubMed
  • Pandharipande PV, Reisner AT, Binder WD, Zaheer A, Gunn ML, Linnau KF, Miller CM, Avery LL, Herring MS, Tramontano AC, Dowling EC, Abujudeh HH, Eisenberg JD, Halpern EF, Donelan K, Gazelle GS. CT in the Emergency Department: A Real-Time Study of Changes in Physician Decision Making. Radiology 2015. PubMed
  • Lee JM, Buist DS, Houssami N, Dowling EC, Halpern EF, Gazelle GS, Lehman CD, Henderson LM, Hubbard RA. Five-year risk of interval-invasive second breast cancer. Journal of the National Cancer Institute 2015. PubMed
  • Niell BL, Bennett D, Sharma A, Gazelle GS. Extramammary Findings on Breast MR Examinations: Frequency, Clinical Relevance, and Patient Outcomes. Radiology 2015. PubMed
  • Lowry KP, Gazelle GS, Gilmore ME, Johanson C, Munshi V, Choi SE, Tramontano AC, Kong CY, McMahon PM. Personalizing annual lung cancer screening for patients with chronic obstructive pulmonary disease: A decision analysis. Cancer 2015. PubMed
  • Harvey HB, Alkasab TK, Pandharipande PV, Zhao J, Halpern EF, Salazar GM, Abujudeh HH, Rosenthal DI, Gazelle GS. Radiologist compliance with institutional guidelines for use of nonroutine communication of diagnostic imaging results. J Am Coll Radiol 2015; 12:376-84. PubMed
  • Romanus D, Cardarella S, Cutler D, Landrum MB, Lindeman NI, Gazelle GS. Cost-effectiveness of multiplexed predictive biomarker screening in non-small-cell lung cancer. J Thorac Oncol 2015; 10:586-94. PubMed
  • Mathes DW, Solari MG, Gazelle GS, Butler PE, Wu A, Nazzal A, Nielsen GP, Huang CA, Sachs DH, Lee WP, Randolph MA. Stable mixed hematopoietic chimerism permits tolerance of vascularized composite allografts across a full major histocompatibility mismatch in swine. Transpl Int 2014; 27:1086-96. PubMed
  • Kong CY, Meng L, Omer ZB, Swan JS, Srouji S, Gazelle GS, Fennessy FM. MRI-guided focused ultrasound surgery for uterine fibroid treatment: a cost-effectiveness analysis. AJR Am J Roentgenol 2014; 203:361-71. PubMed
  • Lubitz CC, Kong CY, McMahon PM, Daniels GH, Chen Y, Economopoulos KP, Gazelle GS, Weinstein MC. Annual financial impact of well-differentiated thyroid cancer care in the United States. Cancer 2014; 120:1345-52. PubMed
  • Harvey HB, Gowda V, Gazelle GS, Pandharipande PV. The ephemeral accountable care organization-an unintended consequence of the Medicare shared savings program. J Am Coll Radiol 2014; 11:121-4. PubMed
  • Tramontano AC, Cipriano LE, Kong CY, Shepard JA, Lanuti M, Gazelle GS, McMahon PM. Microsimulation model predicts survival benefit of radiofrequency ablation and stereotactic body radiotherapy versus radiotherapy for treating inoperable stage I non-small cell lung cancer. AJR Am J Roentgenol 2013; 200:1020-7. PubMed
  • Cott Chubiz JE, Lee JM, Gilmore ME, Kong CY, Lowry KP, Halpern EF, McMahon PM, Ryan PD, Gazelle GS. Cost-effectiveness of alternating magnetic resonance imaging and digital mammography screening in BRCA1 and BRCA2 gene mutation carriers. Cancer 2013; 119:1266-76. PubMed
  • Pandharipande PV, Eisenberg JD, Lee RJ, Gilmore ME, Turan EA, Singh S, Kalra MK, Liu B, Kong CY, Gazelle GS. Patients with testicular cancer undergoing CT surveillance demonstrate a pitfall of radiation-induced cancer risk estimates: the timing paradox. Radiology 2013; 266:896-904. PubMed
  • Hartman RI, Chang CY, Wo JY, Eisenberg JD, Hong TS, Harisinghani MG, Gazelle GS, Pandharipande PV. Optimizing adjuvant treatment decisions for stage t2 rectal cancer based on mesorectal node size: a decision analysis. Acad Radiol 2013. PubMed
  • Knudsen AB, Hur C, Gazelle GS, Schrag D, McFarland EG, Kuntz KM. Rescreening of persons with a negative colonoscopy result: results from a microsimulation model. Ann Intern Med 2012; 157:611-20. PubMed
  • McMahon PM, Kong CY, Johnson BE, Weinstein MC, Weeks JC, Tramontano AC, Cipriano LE, Bouzan C, Gazelle GS. Chapter 9: The MGH-HMS lung cancer policy model: tobacco control versus screening. Risk Anal 2012; 32 Suppl 1:S117-24. PubMed
  • Abujudeh HH, Kaewlai R, McMahon PM, Binder W, Novelline RA, Gazelle GS, Thrall JH. Abdominopelvic CT increases diagnostic certainty and guides management decisions: a prospective investigation of 584 patients in a large academic medical center. AJR Am J Roentgenol 2011; 196:238-43. PubMed
  • Miksad RA, Lai KC, Dodson TB, Woo SB, Treister NS, Akinyemi O, Bihrle M, Maytal G, August M, Gazelle GS, Swan JS. Quality of life implications of bisphosphonate-associated osteonecrosis of the jaw. Oncologist 2011; 16:121-32. PubMed
  • Cipriano LE, Romanus D, Earle CC, Neville BA, Halpern EF, Gazelle GS, McMahon PM. Lung cancer treatment costs, including patient responsibility, by disease stage and treatment modality, 1992 to 2003. Value Health 2011; 14:41-52. PubMed
  • Pandharipande PV, Gervais DA, Hartman RI, Harisinghani MG, Feldman AS, Mueller PR, Gazelle GS. Renal mass biopsy to guide treatment decisions for small incidental renal tumors: a cost-effectiveness analysis. Radiology 2010; 256:836-46. PubMed
  • Ho W, Broughton DE, Donelan K, Gazelle GS, Hur C. Analysis of barriers to and patients' preferences for CT colonography for colorectal cancer screening in a nonadherent urban population. AJR Am J Roentgenol 2010; 195:393-7. PubMed
  • Abujudeh HH, Boland GW, Kaewlai R, Rabiner P, Halpern EF, Gazelle GS, Thrall JH. Abdominal and pelvic computed tomography (CT) interpretation: discrepancy rates among experienced radiologists. Eur Radiol 2010; 20:1952-7. PubMed
  • Hayeck TJ, Kong CY, Spechler SJ, Gazelle GS, Hur C. The prevalence of Barrett's esophagus in the US: estimates from a simulation model confirmed by SEER data. 2010; 23:451-7. PubMed
  • Blankstein R, Murphy MK, Nasir K, Gazelle GS, Batlle JC, Al-Mallah M, Shturman L, Hoffmann U, Cury RC, Abbara S, Brady TJ, Lee TH. Perceived usefulness of cardiac computed tomography as assessed by referring physicians and its effect on patient management. Am J Cardiol 2010; 105:1246-53. PubMed
  • Huang ES, Gazelle GS, Hur C. Consensus Guidelines in the Management of Branch Duct Intraductal Papillary Mucinous Neoplasm: A Cost-Effectiveness Analysis. Dig Dis Sci 2010; 55:852-60. PubMed
  • Lee JM, McMahon PM, Kong CY, Kopans DB, Ryan PD, Ozanne EM, Halpern EF, Gazelle GS. Cost-effectiveness of breast MR imaging and screen-film mammography for screening BRCA1 gene mutation carriers. Radiology 2010; 254:793-800. PubMed
  • Hur C, Hayeck TJ, Yeh JM, Richards EB, Spechler SJ, Gazelle GS, Kong CY. Development, calibration, and validation of a U.S. white male population-based simulation model of esophageal adenocarcinoma. PLoS ONE 2010; 5:e9483. PubMed
  • Ladapo JA, Jaffer FA, Hoffmann U, Thomson CC, Bamberg F, Dec W, Cutler DM, Weinstein MC, Gazelle GS. Clinical outcomes and cost-effectiveness of coronary computed tomography angiography in the evaluation of patients with chest pain. J Am Coll Cardiol 2009; 54:2409-22. PubMed
  • Pandharipande PV, Gazelle GS. Comparative effectiveness research: what it means for radiology. Radiology 2009; 253:600-5. PubMed
  • Lee JM, Halpern EF, Rafferty EA, Gazelle GS. Evaluating the correlation between film mammography and MRI for screening women with increased breast cancer risk. Acad Radiol 2009; 16:1323-8. PubMed
  • Greenblatt WH, Hur C, Knudsen AB, Evans JA, Chung DC, Gazelle GS. Cost-effectiveness of prophylactic surgery for duodenal cancer in familial adenomatous polyposis. Cancer Epidemiol Biomarkers Prev 2009; 18:2677-84. PubMed
  • Hur C,Broughton DE,Kong CY,Ozanne EM,Richards EB,Truong T,Gazelle GS. Patient Preferences for the Chemoprevention of Colorectal Cancer. Dig Dis Sci 2009; 54:2207-14. PubMed
  • Pandharipande PV, Mora JT, Uppot RN, Goehler A, Braschi M, Halpern EF, Gazelle GS, Harisinghani MG. Lymphotropic nanoparticle-enhanced MRI for independent prediction of lymph node malignancy: a logistic regression model. AJR Am J Roentgenol 2009; 193:W230-7. PubMed
  • Kahlon P, McCullough K, Gazelle GS. Enhancing patient safety: standardization of CT contrast media practices. J Am Coll Radiol 2009; 6:562-6. PubMed
  • Geisler BP, van Dam RM, Gazelle GS, Goehler A. Risk of bias in meta-analysis on erythropoietin-stimulating agents in heart failure. Heart 2009; 95:1278-9; author reply 1279. PubMed
  • Kong CY, McMahon PM, Gazelle GS. Calibration of disease simulation model using an engineering approach. Value Health 2009; 12:521-9. PubMed
  • Pandharipande PV,Choy G,del Carmen MG,Gazelle GS,Russell AH,Lee SI. MRI and PET/CT for triaging stage IB clinically operable cervical cancer to appropriate therapy: decision analysis to assess patient outcomes. AJR Am J Roentgenol 2009; 192:802-14. PubMed
  • McMahon PM, Kong CY, Weinstein MC, Tramontano AC, Cipriano LE, Johnson BE, Weeks JC, Gazelle GS. Adopting helical CT screening for lung cancer : potential health consequences during a 15-year period. Cancer 2008; 113:3440-9. PubMed
  • Pearson SD,Knudsen AB,Scherer RW,Weissberg J,Gazelle GS. Assessing the comparative effectiveness of a diagnostic technology: CT colonography. Health Aff (Millwood) 2008; 27:1503-14. PubMed
  • Pandharipande PV,Harisinghani MG,Ozanne EM,Specht MC,Hur C,Lee JM,Gazelle GS. Staging MR lymphangiography of the axilla for early breast cancer: cost-effectiveness analysis. AJR Am J Roentgenol 2008; 191:1308-19. PubMed
  • Hur C,Broughton DE,Ozanne E,Yachimski P,Nishioka NS,Gazelle GS. Patient preferences for the chemoprevention of esophageal adenocarcinoma in Barrett's esophagus. Am J Gastroenterol 2008; 103:2432-42. PubMed
  • Lee JM,Georgian-Smith D,Gazelle GS,Halpern EF,Rafferty EA,Moore RH,Yeh ED,D'Alessandro HA,Hitt RA,Kopans DB. Detecting nonpalpable recurrent breast cancer: the role of routine mammographic screening of transverse rectus abdominis myocutaneous flap reconstructions. Radiology 2008; 248:398-405. PubMed
  • Pandharipande PV, Gervais DA, Mueller PR, Hur C, Gazelle GS. Radiofrequency Ablation versus Nephron-sparing Surgery for Small Unilateral Renal Cell Carcinoma: Cost-effectiveness Analysis. Radiology 2008; 248:169-78. PubMed
  • McMahon PM, Kong CY, Johnson BE, Weinstein MC, Weeks JC, Kuntz KM, Shepard JA, Swensen SJ, Gazelle GS. Estimating Long-term Effectiveness of Lung Cancer Screening in the Mayo CT Screening Study. Radiology 2008; 248:278-87. PubMed
  • Lee JM, Kopans DB, McMahon PM, Halpern EF, Ryan PD, Weinstein MC, Gazelle GS. Breast cancer screening in BRCA1 mutation carriers: effectiveness of MR imaging--Markov Monte Carlo decision analysis. Radiology 2008; 246:763-71. PubMed
  • Gazelle G. Understanding hospice--an underutilized option for life's final chapter. N Engl J Med 2007; 357:321-4. PubMed
  • Hur C, Chung DC, Schoen RE, Gazelle GS. The management of small polyps found by virtual colonoscopy: results of a decision analysis. Clin Gastroenterol Hepatol 2007; 5:237-44. PubMed
  • Knudsen AB, McMahon PM, Gazelle GS. Use of modeling to evaluate the cost-effectiveness of cancer screening programs. J Clin Oncol 2007; 25:203-8. PubMed
  • McMahon PM, Zaslavsky AM, Weinstein MC, Kuntz KM, Weeks JC, Gazelle GS. Estimation of mortality rates for disease simulation models using Bayesian evidence synthesis. Med Decis Making 2006; 26:497-511. PubMed
  • Hur C, Wittenberg E, Nishioka NS, Gazelle GS. Quality of life in patients with various Barretts esophagus associated health states. Health Qual Life Outcomes 2006; 4:45. PubMed
  • Rodríguez JR, Germes SS, Pandharipande PV, Gazelle GS, Thayer SP, Warshaw AL, Fernández-del Castillo C. Implications and cost of pancreatic leak following distal pancreatic resection. Arch Surg 2006; 141:361-5; discussion 366. PubMed
  • Sahani DV, Kadavigere R, Blake M, Fernandez-Del Castillo C, Lauwers GY, Hahn PF. Intraductal papillary mucinous neoplasm of pancreas: multi-detector row CT with 2D curved reformations--correlation with MRCP. Radiology 2006; 238:560-9. PubMed
  • Hur C, Wittenberg E, Nishioka NS, Gazelle GS. Patient preferences for the management of high-grade dysplasia in Barrett's esophagus. Dig Dis Sci 2005; 50:116-25. PubMed
  • Geisler BP,Siebert U,Gazelle GS,Cohen DJ,Gohler A. Deterministic Sensitivity Analysis for First-Order Monte Carlo Simulations: A Technical Note. Value Health ; 12:96-7. PubMed
  • Ladapo JA, Horwitz JR, Weinstein MC, Gazelle GS, Cutler DM. Adoption and spread of new imaging technology: a case study. Health Aff (Millwood) ; 28:w1122-32. PubMed
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