Photo of Mark C. Gebhardt,  MD

Mark C. Gebhardt, MD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center
Phone: (617) 667-3940
Fax: (617) 667-2155

Mark C. Gebhardt, MD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Frederic W. and Jane M. Ilfeld Professor, Orthopaedic Surgery, Harvard Medical School
  • Associate Orthopaedic Surgeon, Orthopaedic Surgery, Boston Children's Hospital
  • Chief, Orthopaedic Surgery, Beth Israel Deaconess Medical Center
  • Clinical Associate in Orthopaedic Surgery, Orthopaedic Oncology, Massachusetts General Hospital

Research Abstract

I am involved in the treatment of patients with primary benign and malignant connective tissue tumors of bone and soft tissue in children and adults as well as the care of patients with metastatic carcinoma to bone. I participate in clinical trials to advance the care of patients with these tumors.

Publications from Harvard Catalyst Profiles

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  • Kelly SP, Ramkumar DB, Crawford B, Lozano-Calderon SA, Gebhardt MC, Anderson ME. Management of limb length discrepancy after bone sarcoma resection about the knee in the skeletally immature. J Pediatr Orthop B 2023. PubMed
  • Komarraju A, Van Rilland EZ, Gebhardt MC, Anderson ME, Heincelman C, Wu JS. What is the Value of Radiology Input During a Multidisciplinary Orthopaedic Oncology Conference? Clin Orthop Relat Res 2023. PubMed
  • Lozano-Calderón SA, Albergo JI, Groot OQ, Merchan NA, El Abiad JM, Salinas V, Gomez Mier LC, Montoya CS, Ferrone ML, Ready JE, Linares FJ, Levin AS, Peleteiro Pensado M, Pozo Kreilinger JJ, Ruiz IB, Ortiz-Cruz EJ, Gebhardt MC, Cote GM, Choy E, Spentzos D, Hung YP, Deshpande V, Chebib IA, McCulloch RA, Farfalli G, Aponte Tinao L, Morris CD, Petur Nielsen G, Anderson ME, Jeys LM. Complete tumor necrosis after neoadjuvant chemotherapy defines good responders in patients with Ewing sarcoma. Cancer 2022. PubMed
  • Geiger EJ, Liu W, Srivastava DK, Bernthal NM, Weil BR, Yasui Y, Ness KK, Krull KR, Goldsby RE, Oeffinger KC, Robison LL, Dieffenbach BV, Weldon CB, Gebhardt MC, Howell R, Murphy AJ, Leisenring WM, Armstrong GT, Chow EJ, Wustrack RL. What Are Risk Factors for and Outcomes of Late Amputation After Treatment for Lower Extremity Sarcoma: A Childhood Cancer Survivor Study Report. Clin Orthop Relat Res 2022. PubMed
  • Ramkumar DB, Kelly SP, Ramkumar N, Ercolano LB, Lozano-Calderon S, Gebhardt MC, Anderson ME. Oncological and Functional Outcomes in Joint-sparing Resections of the Proximal Femur for Malignant Primary Bone Tumors. J Pediatr Orthop 2021. PubMed
  • Kaiser CL, Yeung CM, Raskin K, Gebhardt MC, Anderson ME, Lozano-Calderón SA. Tumors of the scapula: A retrospective analysis identifying predictors of malignancy. Surg Oncol 2019; 32:18-22. PubMed
  • Smeland S, Bielack SS, Whelan J, Bernstein M, Hogendoorn P, Krailo MD, Gorlick R, Janeway KA, Ingleby FC, Anninga J, Antal I, Arndt C, Brown KLB, Butterfass-Bahloul T, Calaminus G, Capra M, Dhooge C, Eriksson M, Flanagan AM, Friedel G, Gebhardt MC, Gelderblom H, Goldsby R, Grier HE, Grimer R, Hawkins DS, Hecker-Nolting S, Sundby Hall K, Isakoff MS, Jovic G, Kühne T, Kager L, von Kalle T, Kabickova E, Lang S, Lau CC, Leavey PJ, Lessnick SL, Mascarenhas L, Mayer-Steinacker R, Meyers PA, Nagarajan R, Randall RL, Reichardt P, Renard M, Rechnitzer C, Schwartz CL, Strauss S, Teot L, Timmermann B, Sydes MR, Marina N. Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort. Eur J Cancer 2019; 109:36-50. PubMed
  • Hill KE, Kelly AD, Kuijjer ML, Barry W, Rattani A, Garbutt CC, Kissick H, Janeway K, Perez-Atayde A, Goldsmith J, Gebhardt MC, Arredouani MS, Cote G, Hornicek F, Choy E, Duan Z, Quackenbush J, Haibe-Kains B, Spentzos D. An imprinted non-coding genomic cluster at 14q32 defines clinically relevant molecular subtypes in osteosarcoma across multiple independent datasets. J Hematol Oncol 2017; 10:107. PubMed
  • Chang CD, Wei J, Goldsmith JD, Gebhardt MC, Wu JS. MRI guided needle localization in a patient with recurrence pleomorphic sarcoma and post-operative scarring. Skeletal Radiol 2017. PubMed
  • Marina NM, Smeland S, Bielack SS, Bernstein M, Jovic G, Krailo MD, Hook JM, Arndt C, van den Berg H, Brennan B, Brichard B, Brown KL, Butterfass-Bahloul T, Calaminus G, Daldrup-Link HE, Eriksson M, Gebhardt MC, Gelderblom H, Gerss J, Goldsby R, Goorin A, Gorlick R, Grier HE, Hale JP, Hall KS, Hardes J, Hawkins DS, Helmke K, Hogendoorn PC, Isakoff MS, Janeway KA, Jürgens H, Kager L, Kühne T, Lau CC, Leavey PJ, Lessnick SL, Mascarenhas L, Meyers PA, Mottl H, Nathrath M, Papai Z, Randall RL, Reichardt P, Renard M, Safwat AA, Schwartz CL, Stevens MC, Strauss SJ, Teot L, Werner M, Sydes MR, Whelan JS. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. Lancet Oncol. 2016. PubMed
  • Lozano-Calderón SA, Swaim SO, Federico A, Anderson ME, Gebhardt MC. Predictors of soft-tissue complications and deep infection in allograft reconstruction of the proximal tibia. J Surg Oncol 2016; 113:811-7. PubMed
  • Daw NC, Laack NN, McIlvaine EJ, Krailo M, Womer RB, Granowetter L, Grier HE, Marina NM, Bernstein ML, Gebhardt MC, Marcus KJ, Advani SM, Healey JH, Letson GD, Gorlick RG, Randall RL. Local Control Modality and Outcome for Ewing Sarcoma of the Femur: A Report From the Children's Oncology Group. Ann Surg Oncol 2016. PubMed
  • Bishop MW, Chang YC, Krailo MD, Meyers PA, Provisor AJ, Schwartz CL, Marina NM, Teot LA, Gebhardt MC, Gorlick R, Janeway KA, Chou AJ. Assessing the Prognostic Significance of Histologic Response in Osteosarcoma: A Comparison of Outcomes on CCG-782 and INT0133-A Report From the Children's Oncology Group Bone Tumor Committee. Pediatr Blood Cancer 2016. PubMed
  • Yeung CM, Lozano-Calderón SA, Allar B, Naqvi M, Gebhardt MC, Anderson ME. Ipsilateral Nonvascularized Autograft and Periosteal Repair for the Treatment of Pediatric Tumors of the Distal Fibula. Orthopedics 2016. PubMed
  • Schwartz CL, Wexler LH, Krailo MD, Teot LA, Devidas M, Steinherz LJ, Goorin AM, Gebhardt MC, Healey JH, Sato JK, Meyers PA, Grier HE, Bernstein ML, Lipshultz SE. Intensified Chemotherapy With Dexrazoxane Cardioprotection in Newly Diagnosed Nonmetastatic Osteosarcoma: A Report From the Children's Oncology Group. Pediatr Blood Cancer 2015. PubMed
  • Damron TA, Nazarian A, Entezari V, Brown C, Grant W, Calderon N, Zurakowski D, Terek RM, Anderson ME, Cheng EY, Aboulafia AJ, Gebhardt MC, Snyder BD. CT-based Structural Rigidity Analysis Is More Accurate Than Mirels Scoring for Fracture Prediction in Metastatic Femoral Lesions. Clin Orthop Relat Res 2015. PubMed
  • Nazarian A, Entezari V, Zurakowski D, Calderon N, Hipp JA, Villa-Camacho JC, Lin PP, Cheung FH, Aboulafia AJ, Turcotte R, Anderson ME, Gebhardt MC, Cheng EY, Terek RM, Yaszemski M, Damron TA, Snyder BD. Treatment Planning and Fracture Prediction in Patients with Skeletal Metastasis with CT-Based Rigidity Analysis. Clin Cancer Res 2015. PubMed
  • Nazarian A, Entezari V, Villa-Camacho JC, Zurakowski D, Katz JN, Hochman M, Baldini EH, Vartanians V, Rosen MP, Gebhardt MC, Terek RM, Damron TA, Yaszemski MJ, Snyder BD. Does CT-based Rigidity Analysis Influence Clinical Decision-making in Simulations of Metastatic Bone Disease? Clin Orthop Relat Res 2015. PubMed
  • DuBois SG, Krailo MD, Gebhardt MC, Donaldson SS, Marcus KJ, Dormans J, Shamberger RC, Sailer S, Nicholas RW, Healey JH, Tarbell NJ, Randall RL, Devidas M, Meyer JS, Granowetter L, Womer RB, Bernstein M, Marina N, Grier HE. Comparative evaluation of local control strategies in localized Ewing sarcoma of bone: a report from the Children's Oncology Group. Cancer 2015. PubMed
  • Bae DS, Kim JM, Reidler JS, Das De S, Gebhardt MC. Surgical treatment of osteochondroma of the proximal humerus: radiographic and early clinical results. J Pediatr Orthop 2013. PubMed
  • Croteau SE, Henderson ER, Billett AL, Gebhardt MC, Voss SD. Resolving bony abnormality evolves to diffuse large B-cell lymphoma. Pediatr Blood Cancer 2013; 60:E113-5. PubMed
  • Henderson ER, Jacobsen CM, Pohlmann RA, Kozakewich HP, Holm IA, Gebhardt MC. Proximal tibial pain in a child. Skeletal Radiol 2013. PubMed
  • Henderson ER, Pohlmann RA, Hollowell ML, Gebhardt MC. Epiphyseal lesion of the humerus in a child. Solitary epiphyseal enchondroma of the humeral greater tuberosity. Skeletal Radiol 2013. PubMed
  • Henderson ER, Jacobsen CM, Pohlmann RA, Kozakewich HP, Holm IA, Gebhardt MC. Proximal tibial pain in a child. Skeletal Radiol 2013. PubMed
  • Henderson ER, Pohlmann RA, Hollowell ML, Gebhardt MC. Epiphyseal lesion of the humerus in a child. Skeletal Radiol 2013. PubMed
  • Kelly AD, Haibe-Kains B, Janeway KA, Hill KE, Howe E, Goldsmith J, Kurek K, Perez-Atayde AR, Francoeur N, Fan JB, April C, Schneider H, Gebhardt MC, Culhane A, Quackenbush J, Spentzos D. MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32. Genome Med 2013; 5:2. PubMed
  • Evans CH, Liu F, Porter RM, O'Sullivan RP, Merghoub T, Lunsford EP, Robichaud K, Van Valen F, Lessnick SL, Gebhardt MC, Wells JW. EWS-FLI-1-targeted cytotoxic T-cell killing of multiple tumor types belonging to the Ewing sarcoma family of tumors. Clin Cancer Res 2012; 18:5341-51. PubMed
  • Fountzilas E, Kelly AD, Perez-Atayde AR, Goldsmith J, Konstantinopoulos PA, Francoeur N, Correll M, Rubio R, Hu L, Gebhardt MC, Quackenbush J, Spentzos D. A microRNA activity map of human mesenchymal tumors: connections to oncogenic pathways; an integrative transcriptomic study. BMC Genomics 2012; 13:332. PubMed
  • Sawamura C, Springfield DS, Marcus KJ, Perez-Atayde AR, Gebhardt MC. Factors predicting local recurrence, metastasis, and survival in pediatric soft tissue sarcoma in extremities. Clin Orthop Relat Res 2010; 468:3019-27. PubMed
  • Healey JH, O'Connor MI, Gebhardt MC. Highlights of the ISOLS/MSTS 2009 meeting: editorial comment. Clin Orthop Relat Res 2010; 468:2829-30. PubMed
  • Leong NL, Anderson ME, Gebhardt MC, Snyder BD. Computed tomography-based structural analysis for predicting fracture risk in children with benign skeletal neoplasms: comparison of specificity with that of plain radiographs. J Bone Joint Surg Am 2010; 92:1827-33. PubMed
  • Kim B, Chen YL, Kirsch DG, Goldberg SI, Kobayashi W, Hyun Kung J, Wolfgang JA, Doppke K, Rosenberg AE, Nielsen GP, Raskin KA, Springfield DS, Schwab JH, Gebhardt MC, Yoon SS, Hornicek FJ, Delaney TF. An Effective Preoperative Three-Dimensional Radiotherapy Target Volume for Extremity Soft Tissue Sarcoma and the Effect of Margin Width on Local Control. Int J Radiat Oncol Biol Phys 2010; 77:843-50. PubMed
  • Konstantinopoulos PA, Fountzilas E, Goldsmith JD, Bhasin M, Pillay K, Francoeur N, Libermann TA, Gebhardt MC, Spentzos D. Analysis of multiple sarcoma expression datasets: implications for classification, oncogenic pathway activation and chemotherapy resistance. PLoS ONE 2010; 5:e9747. PubMed
  • Sung AD,Anderson ME,Zurakowski D,Hornicek FJ,Gebhardt MC. Unicameral bone cyst: a retrospective study of three surgical treatments. Clin Orthop Relat Res 2008; 466:2519-26. PubMed
  • Sawamura C, Hornicek FJ, Gebhardt MC. Complications and Risk Factors for Failure of Rotationplasty: Review of 25 Patients. Clin Orthop Relat Res 2008; 466:1302-8. PubMed
  • Kocher MS, Dichtel L, Kasser JR, Gebhardt MC, Katz JN. Orthopedic board certification and physician performance: an analysis of medical malpractice, hospital disciplinary action, and state medical board disciplinary action rates. Am J Orthop 2008; 37:73-5. PubMed
  • Meyers PA, Schwartz CL, Krailo MD, Healey JH, Bernstein ML, Betcher D, Ferguson WS, Gebhardt MC, Goorin AM, Harris M, Kleinerman E, Link MP, Nadel H, Nieder M, Siegal GP, Weiner MA, Wells RJ, Womer RB, Grier HE,. Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology Group. J Clin Oncol 2008; 26:633-8. PubMed
  • Miser JS, Goldsby RE, Chen Z, Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, Gebhardt MC, Dickman PS, Perlman EJ, Meyers PA, Donaldson SS, Moore SG, Rausen AR, Vietti TJ, Grier HE. Treatment of metastatic Ewing sarcoma/primitive neuroectodermal tumor of bone: evaluation of increasing the dose intensity of chemotherapy--a report from the Children's Oncology Group. Pediatr Blood Cancer 2007; 49:894-900. PubMed
  • Buecker PJ, Gebhardt MC. Are fibula strut allografts a reliable alternative for periarticular reconstruction after curettage for bone tumors? Clin Orthop Relat Res 2007; 461:170-4. PubMed
  • Kattapuram TM, Ozhathil DK, Hornicek FJ, Gebhardt MC, Mankin HJ, Rosenberg AE, Kattapuram SV. Imaging of pseudoneoplastic masses associated with allografts. Skeletal Radiol 2007; 36:747-53. PubMed
  • Gleason BC, Kleinman PK, Debelenko LV, Rahbar R, Gebhardt MC, Perez-Atayde AR. Novel karyotypes in giant cell-rich lesions of bone. Am J Surg Pathol 2007; 31:926-32. PubMed
  • Gebhardt MC, Testani-Dufour L. The role of the nurse academician in promoting evidence-based practice in a brain injury rehabilitation unit. J Neurosci Nurs 2007; 39:190-1. PubMed
  • Buecker PJ, Berenstein M, Gebhardt MC, Hornicek FJ, Mankin HJ. Locking versus standard plates for allograft fixation after tumor resection in children and adolescents. J Pediatr Orthop 2006; 26:680-5. PubMed
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