Research Abstract
I am an anatomic pathologist with sub-specialty training in gastrointestinal pathology. My research interests include the evaluation and development of biomarkers of diagnostic or prognostic value in gastrointestinal cancers and their precursor conditions, including Barrett's esophagus, colorectal cancer, and inflammatory bowel disease. In collaboration with laboratories at Harvard teaching hospitals (MGH, BWH, and BIDMC) and Harvard School of Public Health, I also participate in studies of the regulation of intestinal T cells in colitis using murine models of colitis and inflammatory bowel disease models, and the role of intestinal microbial ecology in murine models of colitis and colorectal carcinogenesis. In clinical service I direct the gastrointestinal pathology division at Massachusetts General Hospital, with extensive interface with the MGH Gastroenterology and GI Oncology groups. I also have experience in digital pathology applications, and have participated in development and deployment of machine learning algorithms for the analysis of pathology images, in an academic and industry setting I have taught gastrointestinal pathology and pathophysiology to Harvard medical students (in the HST and HMS programs) for approximately 20 years.