Photo of Stefan A. Carp, PhD

Stefan A. Carp, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 643-2230


carp@nmr.mgh.harvard.edu

Photo of Stefan A. Carp, PhD

Massachusetts General Hospital
Phone: (617) 643-2230


carp@nmr.mgh.harvard.edu

Visualize Collaborations

Stefan A. Carp, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Radiology, Harvard Medical School
  • Assistant in Biomedical Engineering, Radiology / Martinos Center, Massachusetts General Hospital

HCC PROGRAM AFFILIATION

Research Abstract

My research focuses on the development of novel optical instrumentation for non-invasive tissue monitoring and the translation of these techqniques for clinical use. In particular, I am interested in the application of near-infrared diffuse optical tomography techniques for breast cancer diagnosis and chemotherapy guidance. We have recently shown that dynamic changes in tissue blood volume during fractional mammographic-like compression can be used to assess the early response of malignant lesions to neoadjuvant chemotherapy. I am currently preparing to conduct a follow-up study, that uses a multi-modal optical imaging system combined with digital breast tomosynthesis to characterize the outcome early prediction performance of dynamic optical biomarkers assessed during a multi-stage breast compression maneuver for HER2+ and TNBC patients undergoing NACT.

Publications from Harvard Catalyst Profiles

Powered by Harvard Catalyst
  • Robinson MB, Renna M, Otic N, Kierul OS, Muldoon A, Franceschini MA, Carp SA. Pathlength-selective, interferometric diffuse correlation spectroscopy. IEEE J Sel Top Quantum Electron 2025. PubMed
  • Wang Q, Pan M, Kreiss L, Samaei S, Carp SA, Johansson JD, Zhang Y, Wu M, Horstmeyer R, Diop M, Li DD. A comprehensive overview of diffuse correlation spectroscopy: Theoretical framework, recent advances in hardware, analysis, and applications. Neuroimage 2024; 298:120793. PubMed
  • Deng B, Muldoon A, Cormier J, Mercaldo ND, Niehoff E, Moffett N, Saksena MA, Isakoff SJ, Carp SA. Functional hemodynamic imaging markers for the prediction of pathological outcomes in breast cancer patients treated with neoadjuvant chemotherapy. J Biomed Opt 2024; 29:066001. PubMed
  • Pal R, Lwin TM, Krishnamoorthy M, Collins HR, Chan CD, Prilutskiy A, Nasrallah MP, Dijkhuis TH, Shukla S, Kendall AL, Marshall MS, Carp SA, Hung YP, Shih AR, Martinez-Lage M, Zukerberg L, Sadow PM, Faquin WC, Nahed BV, Feng AL, Emerick KS, Mieog JSD, Vahrmeijer AL, Rajasekaran K, Lee JYK, Rankin KS, Lozano-Calderon S, Varvares MA, Tanabe KK, Kumar ATN. Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients. Nat Biomed Eng 2023. PubMed
  • Muldoon A, Kabeer A, Cormier J, Saksena MA, Fang Q, Carp SA, Deng B. Method to improve the localization accuracy and contrast recovery of lesions in separately acquired X-ray and diffuse optical tomographic breast imaging. Biomed Opt Express 2022; 13:5295-5310. PubMed
  • Thapa B, Mareyam A, Stockmann J, Strasser B, Keil B, Hoecht P, Carp SA, Li X, Wang Z, Chang YV, Dietrich J, Uhlmann E, Cahill DP, Batchelor T, Wald L, Andronesi OC. In Vivo Absolute Metabolite Quantification Using a Multiplexed ERETIC-RX Array Coil for Whole-Brain MR Spectroscopic Imaging. J Magn Reson Imaging 2021. PubMed
  • Cochran JM, Busch DR, Leproux A, Zhang Z, O'Sullivan TD, Cerussi AE, Carpenter PM, Mehta RS, Roblyer D, Yang W, Paulsen KD, Pogue B, Jiang S, Kaufman PA, Chung SH, Schnall M, Snyder BS, Hylton N, Carp SA, Isakoff SJ, Mankoff D, Tromberg BJ, Yodh AG. Tissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days of treatment. J Biomed Opt 2018; 24:1-11. PubMed
  • Leproux, O'Sullivan TD, Cerussi A, Durkin A, Hill B, Hylton N, Yodh AG, Carp SA, Boas D, Jiang S, Paulsen KD, Pogue B, Roblyer D, Yang W, Tromberg BJ. Performance assessment of diffuse optical spectroscopic imaging instruments in a 2-year multicenter breast cancer trial J Biomed Opt 2017; 22:121604. PubMed
  • Zimmermann BB, Deng B, Singh B, Martino M, Selb J, Fang Q, Sajjadi AY, Cormier J, Moore RH, Kopans DB, Boas DA, Saksena MA, Carp SA. Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis. J Biomed Opt 2017; 22:46008. PubMed
  • Sajjadi AY, Isakoff SJ, Deng B, Singh B, Wanyo CM, Fang Q, Specht MC, Schapira L, Moy B, Bardia A, Boas DA, Carp SA. Normalization of compression-induced hemodynamics in patients responding to neoadjuvant chemotherapy monitored by dynamic tomographic optical breast imaging (DTOBI). Biomed Opt Express 2017; 8:555-569. PubMed
  • Kumar AT, Carp SA, Yang J, Ross A, Medarova Z, Ran C. Fluorescence lifetime-based contrast enhancement of indocyanine green-labeled tumors. J Biomed Opt 2017; 22:40501. PubMed
  • Tromberg BJ, Zhang Z, Leproux A, O'Sullivan TD, Cerussi AE, Carpenter PM, Mehta RS, Roblyer D, Yang W, Paulsen KD, Pogue BW, Jiang S, Kaufman PA, Yodh AG, Chung SH, Schnall M, Snyder BS, Hylton N, Boas DA, Carp SA, Isakoff SJ, Mankoff D, . Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging. Cancer Res 2016. PubMed
  • Carp SA, Sajjadi AY, Wanyo CM, Fang Q, Specht MC, Schapira L, Moy B, Bardia A, Boas DA, Isakoff SJ. Hemodynamic signature of breast cancer under fractional mammographic compression using a dynamic diffuse optical tomography system. Biomed Opt Express 2013; 4:2911-24. PubMed
  • Fang Q, Selb J, Carp SA, Boverman G, Miller EL, Brooks DH, Moore RH, Kopans DB, Boas DA. Combined optical and X-ray tomosynthesis breast imaging. Radiology 2011; 258:89-97. PubMed
  • Fang Q,Carp SA,Selb J,Boverman G,Zhang Q,Kopans DB,Moore RH,Miller EL,Brooks DH,Boas DA. Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression. IEEE Trans Med Imaging 2009; 28:30-42. PubMed
  • Boverman G, Fang Q, Carp SA, Miller EL, Brooks DH, Selb J, Moore RH, Kopans DB, Boas DA. Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography. Phys Med Biol 2007; 52:3619-41. PubMed
  • Carp SA, Kauffman T, Fang Q, Rafferty E, Moore R, Kopans D, Boas D. Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements. J Biomed Opt ; 11:064016. PubMed
Hide
Visualize Collaborations