Photo of Bruno Bockorny,  MD

Bruno Bockorny, MD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center
Phone: (617) 667-2100


bbockorn@bidmc.harvard.edu

Bruno Bockorny, MD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Assistant Professor, Medicine, Harvard Medical School
  • Attending Physician , Gastrointestinal Oncology, Beth Israel Deaconess Medical Center
  • Researcher , Celular Biology , Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

While overall cancer incidence and death rates are declining, the incidence and death rates for pancreatic cancer are increasing. Pancreatic cancer is projected to become the second leading cause of cancer-related death in the United States around 2020. While surgery offers the best chance for survival, fewer than 20 percent of pancreatic cancer cases are diagnosed early enough for surgical intervention. Even with surgery, the disease recurs in approximately 80 percent of these patients, who die within five years of recurrence. Our research efforts focus on early detection of pancreatic cancer as well as new investigational approaches employing organoids to explore the potential of new drugs in the treatment of advanced disease.

Publications from Harvard Catalyst Profiles

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  • Bockorny B, Grossman JE, Hidalgo M. Facts and Hopes in Immunotherapy of Pancreatic Cancer. Clin Cancer Res 2022. PubMed
  • Grossman JE, Muthuswamy L, Huang L, Akshinthala D, Perea S, Gonzalez RS, Tsai LL, Cohen J, Bockorny B, Bullock AJ, Schlechter B, Peters MLB, Conahan C, Narasimhan S, Lim C, Davis RB, Besaw R, Sawhney MS, Pleskow D, Berzin TM, Smith M, Kent TS, Callery M, Muthuswamy SK, Hidalgo M. Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer. Clin Cancer Res 2021. PubMed
  • Bockorny B, Bullock AJ, Abrams TA, Faintuch S, Alsop DC, Goldberg SN, Ahmed M, Miksad RA. Priming of Sorafenib Prior to Radiofrequency Ablation Does Not Increase Treatment Effect in Hepatocellular Carcinoma. Dig Dis Sci 2021. PubMed
  • Bockorny B, Macarulla T, Semenisty V, Borazanci E, Feliu J, Ponz-Sarvise M, Abad DG, Oberstein P, Alistar A, Muñoz A, Geva R, Guillén-Ponce C, Fernandez MS, Peled A, Chaney M, Gliko-Kabir I, Shemesh-Darvish L, Ickowicz D, Sorani E, Kadosh S, Vainstein-Haras A, Hidalgo M. Motixafortide and Pembrolizumab Combined to Nanoliposomal Irinotecan, Fluorouracil, and Folinic Acid in Metastatic Pancreatic Cancer: The COMBAT/KEYNOTE-202 Trial. Clin Cancer Res 2021. PubMed
  • Huang L, Bockorny B, Paul I, Akshinthala D, Frappart PO, Gandarilla O, Bose A, Sanchez-Gonzalez V, Rouse E, Lehoux S, Pandell N, Lim C, Clohessy JG, Grossman JE, Gonzalez RS, Perea S, Daaboul G, Sawhney M, Freedman SD, Kleger A, Cummings RD, Emili A, Muthuswamy L, Hidalgo M, Muthuswamy S. PDX-derived organoids model in vivo drug response and secrete biomarkers. JCI Insight 2020. PubMed
  • Dimitrov-Markov S, Perales-Patón J, Bockorny B, Dopazo A, Muñoz M, Baños N, Bonilla V, Menendez C, Duran Y, Huang L, Perea S, Muthuswamy SK, Al-Shahrour F, Lopez-Casas PP, Hidalgo M. Discovery of new targets to control metastasis in pancreatic cancer by single cell transcriptomics analysis of circulating tumor cells. Mol Cancer Ther 2020. PubMed
  • Bockorny B, Semenisty V, Macarulla T, Borazanci E, Wolpin BM, Stemmer SM, Golan T, Geva R, Borad MJ, Pedersen KS, Park JO, Ramirez RA, Abad DG, Feliu J, Muñoz A, Ponz-Sarvise M, Peled A, Lustig TM, Bohana-Kashtan O, Shaw SM, Sorani E, Chaney M, Kadosh S, Vainstein Haras A, Von Hoff DD, Hidalgo M. BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial. Nat Med 2020; 26:878-885. PubMed
  • Zwicker JI, Roopkumar J, Puligandla M, Schlechter BL, Sharda AV, Peereboom D, Joyce R, Bockorny B, Neuberg D, Bauer KA, Khorana AA. Dose-adjusted enoxaparin thromboprophylaxis in hospitalized cancer patients: a randomized, double-blinded multicenter phase 2 trial. Blood Adv 2020; 4:2254-2260. PubMed
  • Fabre M, Ferrer C, Dominguez-Hormaetxe S, Bockorny B, Murias L, Seifert O, Eisler SA, Kontermann RE, Pfizenmaier K, Lee SY, Vivanco MD, Lopez-Casas PP, Perea S, Abbas M, Richter W, Simón L, Hidalgo M. OMTX705, a Novel FAP-Targeting ADC demonstrates Activity in Chemotherapy and PD1-Resistant Solid Tumors Models. Clin Cancer Res 2020. PubMed
  • Bockorny B, Rusan M, Chen W, Liao RG, Li Y, Piccioni F, Wang J, Tan L, Thorner AR, Li T, Zhang Y, Miao CH, Ovesen T, Shapiro GI, Kwiatkowski DJ, Gray NS, Meyerson M, Hammerman PS, Bass AJ. RAS-MAPK reactivation facilitates acquired resistance in FGFR1-amplified lung cancer and underlies a rationale for upfront FGFR-MEK blockade. Mol Cancer Ther 2018. PubMed
  • Rusan M, Li K, Li Y, Christensen CL, Abraham BJ, Kwiatkowski N, Buczkowski KA, Bockorny B, Chen T, Li S, Rhee K, Zhang H, Chen W, Terai H, Tavares T, Leggett AL, Li T, Wang Y, Zhang T, Kim TJ, Hong SH, Poudel-Neupane N, Silkes M, Mudianto T, Tan L, Shimamura T, Meyerson M, Bass AJ, Watanabe H, Gray NS, Young RA, Wong KK, Hammerman PS. Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression. 2018; 8:59-73. PubMed
  • Bockorny B, Pectasides E. The emerging role of immunotherapy in gastric and esophageal adenocarcinoma. Future Oncol 2016; 12:1833-46. PubMed
  • Webb BJ, Dascomb K, Stenehjem E, Vikram HR, Agrwal N, Sakata K, Williams K, Bockorny B, Bagavathy K, Mirza S, Metersky M, Dean NC. Derivation and Multicenter Validation of the Drug Resistance in Pneumonia Clinical Prediction Score. Antimicrob Agents Chemother 2016; 60:2652-63. PubMed
  • Dasanu CA, Bockorny B, Alexandrescu DT. Pyoderma gangrenosum due to lenalidomide use for multiple myeloma. J Oncol Pharm Pract 2015; 21:471-3. PubMed
  • Dasanu CA, Bockorny B. Recurrent pseudocellulitis due to gemcitabine: underrecognized and underreported? J Oncol Pharm Pract 2015; 21:377-9. PubMed
  • Dasanu CA, Bockorny B, Grabska J, Codreanu I. Prevalence and Pattern of Autoimmune Conditions in Patients with Marginal Zone Lymphoma: A Single Institution Experience. Conn Med 2015; 79:197-200. PubMed
  • Atienza J, Bockorny B, Dadla A, Codreanu I, Dasanu CA. Inflammatory and immune-related conditions associated with Waldenström macroglobulinemia: a single center experience. Leuk Lymphoma 2015; 56:1179-80. PubMed
  • Bockorny B, Dasanu CA. HMG-CoA reductase inhibitors as adjuvant treatment for hematologic malignancies: what is the current evidence? Ann. Hematol. 2015; 94:1-12. PubMed
  • Habibi H, Bockorny B, Bagavathy K, Senatore F, Gorusu M. Epithelioid hemangioendothelioma presenting as malignant biliary stricture. J Gastrointest Cancer 2014; 45 Suppl 1:275-7. PubMed
  • Bockorny B, Atienza JA, Dasanu CA. Autoimmune manifestations in patients with Waldenström macroglobulinemia. Clin Lymphoma Myeloma Leuk 2014; 14:456-9. PubMed
  • Majumder S, Bockorny B, Baker WL, Dasanu CA. Association between HBsAg positivity and pancreatic cancer: a meta-analysis. J Gastrointest Cancer 2014; 45:347-52. PubMed
  • Bockorny B, Codreanu I, Dasanu CA. Prevalence of autoimmune hematologic and non-hematologic conditions in large granular lymphocytic leukemia: exploratory analysis of a series of consecutive patients. Leuk Lymphoma 2014; 55:1399-401. PubMed
  • Joseph R, Bockorny B, Dasanu CA. Methotrexate therapy leading to a rapid progression of a previously indolent prostate cancer: is immunosuppression to blame? J Oncol Pharm Pract 2014; 20:149-53. PubMed
  • Gorgan M, Bockorny B, Lawlor M, Volpe J, Fiel-Gan M. Pulmonary hemorrhage with capillaritis secondary to mycophenolate mofetil in a heart-transplant patient. Arch Pathol Lab Med 2013; 137:1684-7. PubMed
  • Bockorny B, Dasanu CA. Intrinsic immune alterations in renal cell carcinoma and emerging immunotherapeutic approaches. Expert Opin Biol Ther 2013; 13:911-25. PubMed
  • Bockorny B, Conlon M, Dasanu CA. Peripheral blood immunophenotypic analysis as a diagnostic tool for large granular lymphocyte leukemia. Leuk Lymphoma 2013; 54:435-7. PubMed
  • Bockorny B, Dasanu CA. Autoimmune manifestations in large granular lymphocyte leukemia. Clin Lymphoma Myeloma Leuk 2012; 12:400-5. PubMed
  • Bockorny B, Posteraro A, Bilgrami S. Bilateral spontaneous adrenal hemorrhage during pregnancy. Obstet Gynecol 2012; 120:377-81. PubMed
  • Bockorny B, Dasanu CA. Syndrome of inappropriate antidiuretic hormone secretion due to marginal zone lymphoma: responding to rituximab. Clin Lymphoma Myeloma Leuk 2012; 12:220-2. PubMed
  • Bockorny M, Kourelis T, Bockorny B. Superior vena cava syndrome caused by colon adenocarcinoma metastasis: a case report and review of literature. Conn Med 2012; 76:77-80. PubMed
  • Bockorny B, Codreanu I, Dasanu CA. Hodgkin lymphoma as Richter transformation in chronic lymphocytic leukaemia: a retrospective analysis of world literature. British Journal of Haematology 2012; 156:50-66. PubMed
  • Bockorny M, Chakravarty S, Schulman P, Bockorny B, Bona R. Severe heart failure after bortezomib treatment in a patient with multiple myeloma: a case report and review of the literature. Acta Haematol 2012; 128:244-7. PubMed
  • Alves A, Martins A, Adolphsson S, Bockorny B, Carleti G, Cabral G, Souza AC, Vianna A. [Severe imported malaria: case report]. Rev Bras Ter Intensiva 2007; 19:231-6. PubMed
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