Photo of Jamie M. Jacobs,  PhD

Jamie M. Jacobs, PhD

Massachusetts General Hospital

Massachusetts General Hospital

Photo of Jamie M. Jacobs,  PhD

Massachusetts General Hospital

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Jamie M. Jacobs, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor of Psychology, Psychiatry, Harvard Medical School
  • Director, Caregiver Research, Cancer Outcomes Research Program, Massachusetts General Hospital

HCC PROGRAM AFFILIATION

Research Abstract

Dr. Jamie Jacobs is a Clinical Assistant in Psychology at the Massachusetts General Hospital (MGH), an Assistant Professor of Psychology at Harvard Medical School (HMS), and the Director of Caregiver Research in the MGH Cancer Outcomes Research Program (CORe). In addition to the MGH CORe Program, she holds appointments in the MGH Center for Psychiatric Oncology and Behavioral Sciences, the MGH Behavioral Medicine Service, and the Mongan Institute Health Policy Center. She has expertise developing and testing supportive, evidence-based, caregiver-directed, and patient-centered interventions in behavioral oncology, with a focus on study design, methodology, and implementation of randomized controlled trials (RCTs). Currently, she is the Principal Investigator on a Career Development Award (K07) from the National Cancer Institute (NCI) to develop and test a patient-centered, evidence-based, telehealth intervention to enhance adherence to adjuvant endocrine therapy, reduce distress, and improve symptom management for early-stage hormone receptor-positive breast cancer survivors. She is also the Co-Investigator on two funded-RCTs to develop and test an evidence-based psychosocial intervention for managing symptoms of stress and burden in caregivers of patients with advanced cancer. Dr. Jacobs is a Lecturer at Harvard University, for which she instructs a seminar course in Psycho-Oncology.

Publications from Harvard Catalyst Profiles

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  • Boulanger MC, Lo SB, Centracchio JA, Jewett B, Freese M, Holtze M, Jacobs JM, Petrillo LA, Bauman J, El-Jawahri A, Temel JS, Greer JA. Pilot Feasibility Trial of a Supportive Care Digital Application for Patients with Advanced Nonsmall Cell Lung Cancer. J Palliat Med 2025. PubMed
  • Jacobs JM, Traeger L, Freese M, Barata A, Newcomb R, Rabideau D, Horick N, DeFilipp Z, Chen YB, Gray T, Pepper J, Caruso E, Amonoo HL, Lee SJ, Greer JA, Temel JS, El-Jawahri A. BMT-CARE App: A Randomized Controlled Trial of a Psychosocial Digital Application for Caregivers of Patients Undergoing Hematopoietic Stem-Cell Transplantation. J Clin Oncol 2025. PubMed
  • Willis KD, Barata A, Freese M, Applebaum AJ, Nelson A, Traeger LN, Horick NK, Rabideau DJ, Temel JS, Greer JA, Jacobs JM, El-Jawahri A. Randomised controlled trial of a psychosocial digital health application to promote coping for caregivers of patients undergoing haematopoietic stem cell transplantation: a study protocol for the BMT-CARE app. BMJ Open 2025; 15:e092371. PubMed
  • Walsh LE, Dunderdale L, Horick N, Temel JS, Greer JA, Jacobs JM. Intervention-Related Changes in Coping Ability Drives Improvements in Mood and Quality of Life for Patients Taking Adjuvant Endocrine Therapy. 2024; 33:e70049. PubMed
  • Forst DA, Podgurski AF, Strander SM, Whitman JD, Datta S, Pintro K, Horick NK, Willis KD, Sannes TS, Greer JA, El-Jawahri A, Jacobs JM, Temel JS. NeuroCARE: A Randomized Controlled Trial of a Psychological Intervention for Caregivers of Patients With Primary Malignant Brain Tumors. J Clin Oncol 2024. PubMed
  • Willis KD, Walsh EA, Dunderdale LE, Post K, Horick N, Antoni MH, Safren SA, Partridge AH, Peppercorn J, Park ER, Temel JS, Greer JA, Jacobs JM. Effects of Adjuvant Endocrine Therapy-Specific Perceptions on Response to a Behavioral Intervention for Adjuvant Endocrine Therapy Adherence in Patients With Breast Cancer. JCO Oncol Pract 2024. PubMed
  • Walsh EA, Walsh LE, Hernand M, Horick N, Antoni MH, Temel JS, Greer JA, Jacobs JM. Concurrent factors associated with adherence to adjuvant endocrine therapy among women with non-metastatic breast cancer. J Cancer Surviv 2024. PubMed
  • Walsh EA, Post K, Massad K, Horick N, Antoni MH, Penedo FJ, Safren SA, Partridge AH, Peppercorn J, Park ER, Temel JS, Greer JA, Jacobs JM. Identification of patient subgroups who benefit from a behavioral intervention to improve adjuvant endocrine therapy adherence: a randomized-controlled trial. Breast Cancer Res Treat 2024. PubMed
  • Fava M, Sorg E, Jacobs JM, Leadbetter R, Guidi J. Distinguishing and treating demoralization syndrome in cancer: A review. Gen Hosp Psychiatry 2023; 85:185-190. PubMed
  • Steinhilber KM, Chabria RS, Clara A, Temel JS, Greer JA, Traeger L, Jacobs JM. Shifting behavioral intervention research to virtual methods: Challenges and solutions in practice, during and after the COVID-19 pandemic. J Telemed Telecare 2023. PubMed
  • Waldman LP, Centracchio JA, Jacobs JM, Petrillo LA, El-Jawahri AR, Temel JS, Greer JA. Study protocol for a randomized trial of a supportive care mobile application to improve symptoms, coping, and quality of life in patients with advanced non-small cell lung cancer. Front Psychol 2023; 14:1184482. PubMed
  • Applebaum AJ, Loschiavo M, Morgan K, Mennin DS, Fresco DM, Hoyt MA, Schofield E, O'Toole MS, Cohn J, Jacobs JM. A randomized controlled trial of emotion regulation therapy for cancer caregivers: A mechanism-targeted approach to addressing caregiver distress. Contemp Clin Trials 2022; 122:106923. PubMed
  • Walsh EA, Chabria R, Vranceanu AM, Park ER, Post K, Peppercorn J, Temel JS, Greer JA, Jacobs JM. Understanding pain related to adjuvant endocrine therapy after breast cancer: A qualitative report. Eur J Cancer Care (Engl) 2022. PubMed
  • Jacobs JM, Post K, Massad K, Horick NK, Walsh EA, Cohn J, Rapoport CS, Clara AJ, Antoni MH, Safren SA, Partridge AH, Peppercorn JM, Park ER, Temel JS, Greer JA. A telehealth intervention for symptom management, distress, and adherence to adjuvant endocrine therapy: A randomized controlled trial. Cancer 2022. PubMed
  • Forst DA, Kaslow-Zieve ER, Hansen A, Mesa M, Landay SL, Quain KM, Sereno I, El-Jawahri A, Greer JA, Temel JS, Jacobs JM. Characterizing Distress and Identifying Modifiable Intervention Targets for Family Caregivers of Patients with Malignant Gliomas. J Palliat Med 2022. PubMed
  • Weingarden H, Wilhelm S, Jacobs JM, Carrellas J, Cetrulo C, Austen WG, Colwell AS. Prospective examination of psychological risk and maintenance factors for body image distress after mastectomy with immediate breast reconstruction. 2022; 42:120-125. PubMed
  • Forst DA, Podgurski AF, Quain KM, Landay SL, Anand M, Kaslow-Zieve E, Mesa MM, Jacobs JM, Dietrich J, Parsons MW, Horick N, Greer JA, Batchelor TT, Jackson VA, El-Jawahri A, Temel JS. Factors associated with psychological distress in caregivers of patients with malignant gliomas. Support Care Cancer 2022. PubMed
  • Ream ME, Walsh EA, Jacobs JM, Taub C, Lippman M, Schaefer-Solle N, Safren SA, Antoni MH. Brief relaxation training is associated with long-term endocrine therapy adherence among women with breast cancer: post hoc analysis of a randomized controlled trial. Breast Cancer Res Treat 2021; 190:79-88. PubMed
  • Waldman LP, Nelson AM, Jacobs JM, Gray TF, Clay M, Jagielo AD, Rice J, Traeger L, El-Jawahri A. Anxiety and Depression Symptoms in Caregivers Prior to Hematopoietic Stem Cell Transplantation (HCT). Transplant Cell Ther 2021. PubMed
  • Jacobs JM, Rapoport CS, Horenstein A, Clay M, Walsh EA, Peppercorn J, Temel JS, Greer JA. Study protocol for a randomised controlled feasibility trial of a virtual intervention (STRIDE) for symptom management, distress and adherence to adjuvant endocrine therapy after breast cancer. BMJ Open 2021; 11:e041626. PubMed
  • Jacobs JM, Nelson AM, Traeger L, Waldman L, Nicholson S, Jagielo AD, D'Alotto J, Greer JA, Temel JS, El-Jawahri A. Enhanced coping and self-efficacy in caregivers of stem cell transplant recipients: Identifying mechanisms of a multimodal psychosocial intervention. Cancer 2020; 126:5337-5346. PubMed
  • Jacobs JM, Walsh EA, Rapoport CS, Antoni MH, Park ER, Post K, Comander A, Peppercorn J, Safren SA, Temel JS, Greer JA. Development and Refinement of a Telehealth Intervention for Symptom Management, Distress, and Adherence to Adjuvant Endocrine Therapy after Breast Cancer. J Clin Psychol Med Settings 2020. PubMed
  • Forst DA, Quain K, Landay SL, Anand M, Kaslow-Zieve E, Mesa MM, Jacobs JM, Dietrich J, Parsons MW, Horick N, Greer JA, Batchelor TT, Jackson VA, El-Jawahri A, Temel JS. Perceptions of prognosis and goal of treatment in patients with malignant gliomas and their caregivers. Neurooncol Pract 2020; 7:490-497. PubMed
  • Brunelle CL, Roberts SA, Horick NK, Gillespie TC, Jacobs JM, Daniell KM, Naoum GE, Taghian AG. Integrating Systems Into the Diagnostic Criteria for Breast Cancer-Related Lymphedema: Applying Results From a Prospective Surveillance Program. Phys Ther 2020. PubMed
  • Jacobs JM, Walsh EA, Park ER, Berger J, Peppercorn J, Partridge A, Horick N, Safren SA, Temel JS, Greer JA. The Patient's Voice: Adherence, Symptoms, and Distress Related to Adjuvant Endocrine Therapy After Breast Cancer. Int J Behav Med 2020. PubMed
  • El-Jawahri A, Jacobs JM, Nelson AM, Traeger L, Greer JA, Nicholson S, Waldman LP, Fenech AL, Jagielo AD, D'Alotto J, Horick N, Spitzer T, DeFilipp Z, Chen YA, Temel JS. Multimodal psychosocial intervention for family caregivers of patients undergoing hematopoietic stem cell transplantation: A randomized clinical trial. Cancer 2020; 126:1758-1765. PubMed
  • Greer JA, Jacobs JM, Pensak N, Nisotel LE, Fishbein JN, MacDonald JJ, Ream ME, Walsh EA, Buzaglo J, Muzikansky A, Lennes IT, Safren SA, Pirl WF, Temel JS. Randomized Trial of a Smartphone Mobile App to Improve Symptoms and Adherence to Oral Therapy for Cancer. J Natl Compr Canc Netw 2020; 18:133-141. PubMed
  • Jacobs JM, Fishman S, Sommer R, Sereno I, Fenech A, Jankowski AL, Traeger L, Greer JA, Vanderklish J, Hunnewell C, Saylor M, Chen YB, Spitzer T, DeFilipp Z, Temel JS, El-Jawahri A. Coping and modifiable psychosocial factors are associated with mood and quality of life in patients with chronic graft-versus-host-disease (GVHD). Biol Blood Marrow Transplant 2019. PubMed
  • Jacobs JM, Ream ME, Pensak N, Nisotel LE, Fishbein JN, MacDonald JJ, Buzaglo J, Lennes IT, Safren SA, Pirl WF, Temel JS, Greer JA. Patient Experiences With Oral Chemotherapy: Adherence, Symptoms, and Quality of Life. J Natl Compr Canc Netw 2019; 17:221-228. PubMed
  • Greer JA, Jacobs J, Pensak N, MacDonald JJ, Fuh CX, Perez GK, Ward A, Tallen C, Muzikansky A, Traeger L, Penedo FJ, El-Jawahri A, Safren SA, Pirl WF, Temel JS. Randomized Trial of a Tailored Cognitive-Behavioral Therapy Mobile Application for Anxiety in Patients with Incurable Cancer. Oncologist 2019. PubMed
  • Greer JA, Jacobs JM, El-Jawahri A, Nipp RD, Gallagher ER, Pirl WF, Park ER, Muzikansky A, Jacobsen JC, Jackson VA, Temel JS. Role of Patient Coping Strategies in Understanding the Effects of Early Palliative Care on Quality of Life and Mood. J Clin Oncol 2018; 36:53-60. PubMed
  • Wang AW, Bouchard LC, Gudenkauf LM, Jutagir DR, Fisher HM, Jacobs JM, Blomberg BB, Lechner SC, Carver CS, Antoni MH. Differential psychological effects of cognitive-behavioral stress management among breast cancer patients with high and low initial cancer-specific distress. J Psychosom Res 2018; 113:52-57. PubMed
  • Jacobs JM, Traeger L, Eusebio J, Simon NM, Sequist LV, Greer JA, Temel JS, Pirl WF. Depression, inflammation, and epidermal growth factor receptor (EGFR) status in metastatic non-small cell lung cancer: A pilot study. J Psychosom Res 2017; 99:28-33. PubMed
  • Jutagir DR, Blomberg BB, Carver CS, Lechner SC, Timpano KR, Bouchard LC, Gudenkauf LM, Jacobs JM, Diaz A, Lutgendorf SK, Cole SW, Heller AS, Antoni MH. Social well-being is associated with less pro-inflammatory and pro-metastatic leukocyte gene expression in women after surgery for breast cancer. Breast Cancer Res Treat 2017; 165:169-180. PubMed
  • Jacobs JM, Pensak NA, Sporn NJ, MacDonald JJ, Lennes IT, Safren SA, Pirl WF, Temel JS, Greer JA. Treatment Satisfaction and Adherence to Oral Chemotherapy in Patients With Cancer. J Oncol Pract 2017. PubMed
  • Jacobs JM, Shaffer KM, Nipp RD, Fishbein JN, MacDonald J, El-Jawahri A, Pirl WF, Jackson VA, Park ER, Temel JS, Greer JA. Distress is Interdependent in Patients and Caregivers with Newly Diagnosed Incurable Cancers. Ann Behav Med 2017. PubMed
  • Fisher HM, Jacobs JM, Taub CJ, Lechner SC, Lewis JE, Carver CS, Blomberg BB, Antoni MH. How changes in physical activity relate to fatigue interference, mood, and quality of life during treatment for non-metastatic breast cancer. Gen Hosp Psychiatry 2017; 49:37-43. PubMed
  • Stagl JM, Lechner SC, Carver CS, Bouchard LC, Gudenkauf LM, Jutagir DR, Diaz A, Yu Q, Blomberg BB, Ironson G, Glück S, Antoni MH. A randomized controlled trial of cognitive-behavioral stress management in breast cancer: survival and recurrence at 11-year follow-up. Breast Cancer Res Treat 2015; 154:319-28. PubMed
  • Stagl JM, Bouchard LC, Lechner SC, Blomberg BB, Gudenkauf LM, Jutagir DR, Glück S, Derhagopian RP, Carver CS, Antoni MH. Long-term psychological benefits of cognitive-behavioral stress management for women with breast cancer: 11-year follow-up of a randomized controlled trial. Cancer 2015; 121:1873-81. PubMed
  • Antoni MH, Jacobs JM, Bouchard LC, Lechner SC, Jutagir DR, Gudenkauf LM, Blomberg BB, Glück S, Carver CS. Post-surgical depressive symptoms and long-term survival in non-metastatic breast cancer patients at 11-year follow-up. Gen Hosp Psychiatry ; 44:16-21. PubMed
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