David R. Spriggs, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-4000

dspriggs@mgh.harvard.edu

Massachusetts General Hospital
Phone: (617) 724-4000

dspriggs@mgh.harvard.edu

David R. Spriggs, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

Professor in Residence, Medicine, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Gynecologic Cancers, Member

Research Abstract

In January of 2018, Dr. Spriggs became the Director of the Gynecologic Oncology Program, replacing Dr. Michael Birrer. Dr. Spriggs has led a variety of trials in Gynecologic Cancer both at MSKCC and now at the MGH, including one of the first Paclitaxel Phase I trials, the discovery of the Gemcitabine / Docetaxel combination for Leiomyosarcoma, a pharmacodynamic Phase III study of long infusion Paclitaxel in Ovarian Cancer (GOG162).

Dr. Spriggs current research interests include the biology of MUC16, the gene encoding CA125 and the Glycobiology of Ovarian Cancer. His current funding includes his position as a co_PI on the DFHCC Ovarian cancer SPORE and a project in the PO1 entitled "Immunological Approaches to Ovarian Cancer" (recently in competing renewal) and independent support from the Department of Defense for a Pilot Program for Implementation of a Human Artificial Chromosome for CAR-T Cells. He holds patents for MUC16 antibodies that have been incorporated into an ongoing CAR T cell clinical trial.

Konstantinopoulos PA, Gockley AA, Xiong N, Krasner C, Horowitz N, Campos S, Wright AA, Liu JF, Shea M, Yeku O, Castro C, Polak M, Lee EK, Sawyer H, Bowes B, Moroney J, Cheng SC, Tayob N, Bouberhan S, Spriggs D, Penson RT, Fleming GF, Nucci MR, Matulonis UA. Evaluation of Treatment With Talazoparib and Avelumab in Patients With Recurrent Mismatch Repair Proficient Endometrial Cancer. JAMA Oncol 2022. PubMed
Rao TD, Xu M, Eng S, Yang G, Manson R, Rosales N, Kumar R, Veillard IE, Zhou Q, Iasonos A, Ouerfelli O, Djaballah H, Spriggs DR, Yeku OO. Dual Fluorescence Isogenic Synthetic Lethal Kinase Screen and High-Content Secondary Screening for MUC16/CA125 Selective Agents. Mol Cancer Ther 2022. PubMed
Russo AL, Lee LJ, Wo JY, Niemierko A, Park D, Alban G, King M, Philp L, Growdon WB, Oliva E, Spriggs DR, Yeku OO. Effect of Mismatch Repair Status on Outcome of Early-Stage Grade 1 to 2 Endometrial Cancer Treated With Vaginal Brachytherapy. Am J Clin Oncol 2022; 45:36-39. PubMed
Zhang S, Yan C, Millar DG, Yang Q, Heather JM, Langenbucher A, Morton LT, Sepulveda S, Alpert E, Whelton LR, Zarrella DT, Guo M, Minogue E, Lawrence MS, Rueda BR, Spriggs DR, Lu W, Langenau DM, Cobbold M. Antibody-Peptide Epitope Conjugates for Personalized Cancer Therapy. Cancer Res 2022; 82:773-784. PubMed
Yang Z, Francisco J, Reese AS, Spriggs DR, Im H, Castro CM. Addressing cervical cancer screening disparities through advances in artificial intelligence and nanotechnologies for cellular profiling. Biophys Rev 2021; 2:011303. PubMed
Stasenko M, Smith E, Yeku O, Park KJ, Laster I, Lee K, Walderich S, Spriggs E, Rueda B, Weigelt B, Zamarin D, Rao TD, Spriggs DR. Targeting galectin-3 with a high-affinity antibody for inhibition of high-grade serous ovarian cancer and other MUC16/CA-125-expressing malignancies. Sci Rep 2021; 11:3718. PubMed
Yeku OO, Rao TD, Laster I, Kononenko A, Purdon TJ, Wang P, Cui Z, Liu H, Brentjens RJ, Spriggs D. Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition. 2021; 12:663379. PubMed
Shimada C, Xu R, Al-Alem L, Stasenko M, Spriggs DR, Rueda BR. Galectins and Ovarian Cancer. Cancers (Basel) 2020. PubMed
LaVigne K, Hyman DM, Zhou QC, Iasonos A, Tew WP, Aghajanian C, Makker V, Hensley ML, Konner J, Grisham RN, Cangemi N, Soldan K, Spriggs DR, Sabbatini PJ, OʼCearbhaill RE. A Randomized Trial of Prophylactic Extended Carboplatin Infusion to Reduce Hypersensitivity Reactions in Recurrent Ovarian Cancer. Int J Gynecol Cancer 2018; 28:1176-1182. PubMed
Yokota T, Bendell J, LoRusso P, Tsushima T, Desai V, Kenmotsu H, Watanabe J, Ono A, Murugesan B, Silva J, Naito T, Greenberg J, Kumar P, Wang Y, Jikoh T, Shiga R, Hyman DM, Ho AL, Spriggs DR, Schwartz GK, Gounder MM. Impact of race on dose selection of molecular-targeted agents in early-phase oncology trials. Br J Cancer 2018; 118:1571-1579. PubMed
Soumerai TE, Donoghue MTA, Bandlamudi C, Srinivasan P, Chang MT, Zamarin D, Cadoo KA, Grisham RN, O'Cearbhaill RE, Tew WP, Konner JA, Hensley ML, Makker V, Sabbatini P, Spriggs DR, Troso-Sandoval TA, Charen AS, Friedman C, Gorsky M, Schweber SJ, Middha S, Murali R, Chiang S, Park KJ, Soslow RA, Ladanyi M, Li BT, Mueller J, Weigelt B, Zehir A, Berger MF, Abu-Rustum NR, Aghajanian C, DeLair DF, Solit DB, Taylor BS, Hyman DM. Clinical Utility of Prospective Molecular Characterization in Advanced Endometrial Cancer. Clin Cancer Res 2018; 24:5939-5947. PubMed

Rao TD, Fernández-Tejada A, Axelrod A, Rosales N, Yan X, Thapi S, Wang A, Park KJ, Nemieboka B, Xiang J, Lewis JS, Olvera N, Levine DA, Danishefsky SJ, Spriggs DR. Antibodies Against Specific MUC16 Glycosylation Sites Inhibit Ovarian Cancer Growth. ACS Chem Biol 2017; 12:2085-2096. PubMed
Rao TD, Tian H, Ma X, Yan X, Thapi S, Schultz N, Rosales N, Monette S, Wang A, Hyman DM, Levine DA, Solit D, Spriggs DR. Expression of the Carboxy-Terminal Portion of MUC16/CA125 Induces Transformation and Tumor Invasion. PLoS ONE 2015; 10:e0126633. PubMed
Rao TD, Rosales N, Spriggs DR. Dual-fluorescence isogenic high-content screening for MUC16/CA125 selective agents. Mol Cancer Ther 2011; 10:1939-48. PubMed
Dharma Rao T, Park KJ, Smith-Jones P, Iasonos A, Linkov I, Soslow RA, Spriggs DR. Novel monoclonal antibodies against the proximal (carboxy-terminal) portions of MUC16. Appl. Immunohistochem. Mol. Morphol. 2010; 18:462-72. PubMed
Chekmasova AA, Rao TD, Nikhamin Y, Park KJ, Levine DA, Spriggs DR, Brentjens RJ. Successful eradication of established peritoneal ovarian tumors in SCID-Beige mice following adoptive transfer of T cells genetically targeted to the MUC16 antigen. Clin Cancer Res 2010; 16:3594-606. PubMed
Nemieboka B, Sharma SK, Rao TD, Edwards KJ, Yan S, Wang P, Ragupathi A, Piersigilli A, Spriggs DR, Lewis JS. Radiopharmacologic screening of antibodies to the unshed ectodomain of MUC16 in ovarian cancer identifies a lead candidate for clinical translation. Nucl Med Biol ; 86-87:9-19. PubMed

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David R. Spriggs, MD

Massachusetts General Hospital

Similar Members

Similar Members

David R. Spriggs, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

DF/HCC PROGRAM AFFILIATION

Research Abstract

Publications from Harvard Catalyst Profiles

Similar Members

Similar Members