Research Abstract

Our lab advances multiscale network biology by using computational and experimental methods to understand how mammalian cell signaling and regulation integrate across multiple scales, from the molecular to whole-body level. We combine multiplexed measurements with in vivo imaging and mathematical modeling to distill principles of cellular communication. We particularly focus on inflammation and cancer, where abnormal signals in multiple cell types promote disease progression and are therapeutically targeted. We have applied this approach to study the combined transport and action of both traditional drugs in the treatment of cancer, as well as therapies that use engineered materials such as nanoparticles to probe and exploit features of the tumor microenvironment.