Photo of Monika Vyas,  MD

Monika Vyas, MD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center
Phone: (617) 667-4380

Monika Vyas, MD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Assistant Professor, Pathology, Harvard Medical School
  • Staff Pathologist, Pathology, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

My primary research interests in investigating gastrointestinal/hepatic and pancreaticobiliary malignancies. In addition to determining new histologic prognostic factors for colorectal cancers, I am interesting in defining morphologic features associated with specific genetic/molecular alterations. I am also interested in hereditary/syndromic gastrointestinal malignancies and believe pathologists have a big role in recognizing patients who are at risk and cancer prevention in this group.

Publications from Harvard Catalyst Profiles

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  • Rottmann BG, Patel N, Ahmed M, Deng Y, Ciarleglio M, Vyas M, Jain D, Zhang X. Clinicopathological significance of neutrophil-rich colorectal carcinoma. J Clin Pathol 2021. PubMed
  • Fuller LD, Dunn A, Huber AR, Vyas M, Gonzalez RS. Clinicopathologic Features of Gynecologic Malignancies Presenting Clinically as Colonic Malignancies. Am J Clin Pathol 2021. PubMed
  • Vyas M, Jain D. An update on subtypes of hepatocellular carcinoma: From morphology to molecular. Indian J Pathol Microbiol 2021; 64:S112-S120. PubMed
  • Vyas M, Tang LH, Rekhtman N, Klimstra DS. Alterations in Ki67 Labeling Following Treatment of Poorly Differentiated Neuroendocrine Carcinomas: A Potential Diagnostic Pitfall. Am J Surg Pathol 2021; 45:25-34. PubMed
  • Navale P, Gonzalez RS, Vyas M. Incidental secondary findings in hemorrhoidectomy specimens: A 16-year experience from a single academic center. Hum Pathol 2020. PubMed
  • Vyas M, Firat C, Hechtman JF, Weiser MR, Yaeger R, Vanderbilt C, Benhamida JK, Keshinro A, Zhang L, Ntiamoah P, Gonzalez M, Andrade R, El Dika I, Markowitz AJ, Smith JJ, Garcia-Aguilar J, Vakiani E, Klimstra DS, Stadler ZK, Shia J. Discordant DNA mismatch repair protein status between synchronous or metachronous gastrointestinal carcinomas: frequency, patterns, and molecular etiologies. Fam Cancer 2020. PubMed
  • Vyas M, Celli R, Singh M, Patel N, Aslanian HR, Boffa D, Deng Y, Ciarleglio MM, Laine L, Jain D. Intestinal Metaplasia Around The Gastroesophageal Junction Is Frequently Associated With Antral Reactive Gastropathy: Implications For Carcinoma At The Gastroesophageal Junction. Hum Pathol 2020. PubMed
  • Vyas M, Zhang X. Hepatocellular Carcinoma: Role of Pathology in the Era of Precision Medicine. Clin Liver Dis 2020; 24:591-610. PubMed
  • Patel N, Vyas M, Celli R, Jain D, Zhang X. Adverse Histologic Features in Colorectal Nonpedunculated Malignant Polyps With Nodal Metastasis. Am J Surg Pathol 2020; 44:241-246. PubMed
  • Vyas M, Hechtman JF, Zhang Y, Benayed R, Yavas A, Askan G, Shia J, Klimstra DS, Basturk O. DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma. Mod Pathol 2020; 33:648-656. PubMed
  • Vyas M, Patel N, Celli R, Wajapeyee N, Jain D, Zhang X. Glucose Metabolic Reprogramming and Cell Proliferation Arrest in Colorectal Micropapillary Carcinoma. Gastroenterology Res 2019; 12:128-134. PubMed
  • Liu S, GÓ§nen M, Stadler ZK, Weiser MR, Hechtman JF, Vakiani E, Wang T, Vyas M, Joneja U, Al-Bayati M, Segal NH, Smith JJ, King S, Guercio S, Ntiamoah P, Markowitz AJ, Zhang L, Cercek A, Garcia-Aguilar J, Saltz LB, Diaz LA, Klimstra DS, Shia J. Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas. Mod Pathol 2019; 32:110-121. PubMed
  • Wang T, Lee LH, Vyas M, Zhang L, Ganesh K, Firat C, Segal NH, Desai A, Hechtman JF, Ntiamoah P, Weiser MR, Markowitz AJ, Vakiani E, Klimstra DS, Stadler ZK, Shia J. Colorectal carcinoma with double somatic mismatch repair gene inactivation: clinical and pathological characteristics and response to immune checkpoint blockade. Mod Pathol 2019; 32:1551-1562. PubMed
  • Janostiak R, Vyas M, Cicek AF, Wajapeyee N, Harigopal M. Loss of c-KIT expression in breast cancer correlates with malignant transformation of breast epithelium and is mediated by KIT gene promoter DNA hypermethylation. Exp Mol Pathol 2018; 105:41-49. PubMed
  • Hu ZI, Hellmann MD, Wolchok JD, Vyas M, Shia J, Stadler ZK, Diaz LA, O'Reilly EM. Acquired resistance to immunotherapy in MMR-D pancreatic cancer. J Immunother Cancer 2018; 6:127. PubMed
  • Vyas M, Wong S, Zhang X. Intestinal metaplasia of appendiceal endometriosis is not uncommon and may mimic appendiceal mucinous neoplasm. Pathol Res Pract 2017; 213:39-44. PubMed
  • Prasad ML, Vyas M, Horne MJ, Virk RK, Morotti R, Liu Z, Tallini G, Nikiforova MN, Christison-Lagay ER, Udelsman R, Dinauer CA, Nikiforov YE. NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States. Cancer 2016; 122:1097-107. PubMed
  • Vyas M, Zhang X, Morrow JS, Jain D, Salem RR, West AB. Focal hepatic glycogenosis associated with metastatic insulinoma presenting as mass lesions. Pathol Res Pract 2016; 212:59-62. PubMed
  • Vyas M, Yang X, Zhang X. Gastric Hamartomatous Polyps-Review and Update. Clin Med Insights Gastroenterol 2016; 9:3-10. PubMed
  • Metcalf RA, Monabati A, Vyas M, Roncador G, Gualco G, Bacchi CE, Younes SF, Natkunam Y, Freud AG. Myeloid cell nuclear differentiation antigen is expressed in a subset of marginal zone lymphomas and is useful in the differential diagnosis with follicular lymphoma. Hum Pathol 2014; 45:1730-6. PubMed
  • Vyas M, Menon S, Desai SB. Collision tumor of kidney: A case of renal cell carcinoma with metastases of prostatic adenocarcinoma. Indian J Med Paediatr Oncol 2013; 34:21-3. PubMed
  • Vaideeswar P, Vyas M, Katewa A, Bhaskar M. Piggyback mycosis: pulmonary hydatid cyst with a mycotic co-infection. 2010; 53:265-8. PubMed
  • Vyas M, Deshmukh M, Shet T, Jambhekar N. Splenic angiomatoid nodular transformation in child with inflammatory pseudotumor-like areas. Indian J Pathol Microbiol ; 54:829-31. PubMed
  • Vyas M, Jain D. A practical diagnostic approach to hepatic masses. Indian J Pathol Microbiol ; 61:2-17. PubMed
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