Photo of Lev T. Perelman, PhD

Lev T. Perelman, PhD

Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center

Photo of Lev T. Perelman, PhD

Beth Israel Deaconess Medical Center

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Lev T. Perelman, PhD

Beth Israel Deaconess Medical Center

EDUCATIONAL TITLES

  • Professor, Medicine, Harvard Medical School
  • Director, Center for Advanced Biomedical Imaging and Photonics, Beth Israel Deaconess Medical Center

DF/HCC PROGRAM AFFILIATION

Research Abstract

Biomedical light scattering spectroscopy (LSS) we have developed, relates spectroscopic properties of light elastically scattered by cellular organelles and other intracellular substructures, as well as collagen fiber network of the extracellular matrix to their size, shape and refractive index. The LSS has been successfully used for early cancer detection in various organs of the digestive system, such as identifying precancerous and early cancerous changes in the esophagus and pancreas.

Publications from Harvard Catalyst Profiles

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  • Pleskow DK, Sawhney MS, Upputuri PK, Berzin TM, Coughlan MF, Khan U, Glyavina M, Zhang X, Chen L, Sheil CJ, Cohen JM, Vitkin E, Zakharov YN, Itzkan I, Zhang L, Qiu L, Perelman LT. In vivo detection of bile duct pre-cancer with endoscopic light scattering spectroscopy. Nat Commun 2023; 14:109. PubMed
  • Pettinato G, Perelman LT, Fisher RA. Development of a Scalable Three-Dimensional Culture of Human Induced Pluripotent Stem Cells-Derived Liver Organoids. Methods Mol Biol 2022; 2455:131-147. PubMed
  • Qiu L, Zhang L, Horowitz GL, Turzhitsky V, Coughlan MF, Glyavina M, Khan U, Zakharov YN, Vitkin E, Itzkan I, Perelman LT. Rapid detection and identification of bacteria directly from whole blood with light scattering spectroscopy based biosensor. 2021. PubMed
  • Pettinato G, Coughlan MF, Zhang X, Chen L, Khan U, Glyavina M, Sheil CJ, Upputuri PK, Zakharov YN, Vitkin E, D'Assoro AB, Fisher RA, Itzkan I, Zhang L, Qiu L, Perelman LT. Spectroscopic label-free microscopy of changes in live cell chromatin and biochemical composition in transplantable organoids. Sci Adv 2021. PubMed
  • Pleskow DK, Zhang L, Turzhitsky V, Coughlan MF, Khan U, Zhang X, Sheil CJ, Glyavina M, Chen L, Shinagare S, Zakharov YN, Vitkin E, Itzkan I, Perelman LT, Qiu L. Coherent confocal light scattering spectroscopic microscopy evaluates cancer progression and aggressiveness in live cells and tissue. ACS Photonics 2021; 8:2050-2059. PubMed
  • Sheil CJ, Khan U, Zakharov YN, Coughlan MF, Pleskow DK, Sawhney MS, Berzin TM, Cohen JM, Glyavina M, Zhang L, Itzkan I, Perelman LT, Qiu L. Two-photon polymerization nanofabrication of ultracompact light scattering spectroscopic probe for detection of pre-cancer in pancreatic cyst. Opt Lasers Eng 2021. PubMed
  • Qiu L, Chuttani R, Pleskow DK, Turzhitsky V, Khan U, Zakharov YN, Zhang L, Berzin TM, Yee EU, Sawhney MS, Li Y, Vitkin E, Goldsmith JD, Itzkan I, Perelman LT. Multispectral light scattering endoscopic imaging of esophageal precancer. Light Sci Appl 2018; 7:17174. PubMed
  • Zhang L, Pleskow DK, Turzhitsky V, Yee EU, Berzin TM, Sawhney M, Shinagare S, Vitkin E, Zakharov Y, Khan U, Wang F, Goldsmith JD, Goldberg S, Chuttani R, Itzkan I, Qiu L, Perelman LT. Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy. Nat Biomed Eng 2017. PubMed
  • Melo SA, Sugimoto H, O'Connell JT, Kato N, Villanueva A, Vidal A, Qiu L, Vitkin E, Perelman LT, Melo CA, Lucci A, Ivan C, Calin GA, Kalluri R. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell 2014; 26:707-21. PubMed
  • Vitkin E, Turzhitsky V, Qiu L, Guo L, Itzkan I, Hanlon EB, Perelman LT. Photon diffusion near the point-of-entry in anisotropically scattering turbid media. Nat Commun 2011; 2:587. PubMed
  • Itzkan I, Qiu L, Fang H, Zaman MM, Vitkin E, Ghiran IC, Salahuddin S, Modell M, Andersson C, Kimerer LM, Cipolloni PB, Lim KH, Freedman SD, Bigio I, Sachs BP, Hanlon EB, Perelman LT. Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels. Proc Natl Acad Sci U S A 2007; 104:17255-60. PubMed
  • Qiu L, Pleskow D, Chuttani R, Vitkin E, Leyden J, Ozden N, Itani S, Guo LY, Sacks A, Goldsmith JD, Modell MD, Hanlon EB, Itzkan I, & Perelman LT. Multispectral Scanning during Endoscopy Guides Biopsy of Dysplasia in Barrett’s Esophagus Nat Med 2000.
  • Zhang L, Pleskow DK, Turzhitsky V, Yee EU, Berzin TM, Sawhney M, Shinagare S, Vitkin E, Zakharov Y, Khan U, Wang F, Goldsmith JD, Goldberg S, Chuttani R, Itzkan I, Qiu L & Perelman LT. Light scattering spectroscopy identifies malignant potential of pancreatic cysts during endoscopy Nat Biomed Eng ; 1:40.
  • Gurjar R, Backman V, Perelman LT, Georgakoudi I, Badizadegan K, Itzkan I, Dasari RR, Feld MS. Functional Imaging of Epithelial Tissues with Polarized Light Scattering Spectroscopy Nat Med ; 7:1245–1248.
  • Backman V, Wallace M, Perelman LT, Arendt JT, Gurjar R, Müller MG, Zhang Q, Zonios G, Kline K, McGillican T, Shapshay S, Valdez T, Badizadegan K, Crawford JM, Fitzmaurice M, Kabani S, Levin HS, Seiler M, Dasari RR, Itzkan I, Van Dam J, Feld MS. Early-Warning Changes in Precancerous Epithelial Cells Can Now be Spotted In Situ Nature ; 406:35-36.
  • Kneipp K, Wang Y, Kneipp H, Perelman LT, Itzkan I, Dasari RR, Feld MS. Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS) Phys Rev Lett ; 78:1667-1670.
  • Perelman LT, Backman V, Wallace M, Zonios G, Manoharan R, Nusrat A, Shields S, Seiler M, Lima C, Hamano T, Itzkan I, Van Dam J, Crawford JM, Feld MS. Observation of Periodic Fine Structure in Reflectance from Biological Tissue: A New Technique for Measuring Nuclear Size Distribution Phys Rev Lett ; 80:627-630.
  • Qiu L, Zhang L, Turzhitsky V, Khan U, Zakharov Y, Kantekure K, Vitkin E, Itzkan I, Pleskow DK, Sawhney M, Berzin TM, Goldsmith JD, Perelman LT. Multispectral Endoscopy with Light Gating for Early Cancer Detection. IEEE J Sel Top Quantum Electron . PubMed
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DF/HCC members that share similar concepts* with Lev T. Perelman, PhD but have yet to coauthor a publication with this researcher.

* Concepts are MeSH terms, automatically derived from member publications

Similar Members