Research Abstract

I am a physician-scientist with an interest in pursuing questions at the interface of basic discovery biology and the clinical care of patients with genitourinary cancers. My laboratory is centered on the mechanistic study of pathways that underlie cancer initiaiton, progression, and drug resistance, with a focus on cancers of the prostate and kidney. Our work involves integrating genomic profiling of primary tissue specimens with large-scale functional genetic approaches in in vitro and in vivo systems. Our goal is to characterize the molecular drivers and vulnerabilities of prostate and kidney cancers with the goal of identifying pathways that are dysregulated in these cancers and delineating how they can be modulated for therapeutic benefit.