Photo of Florian J. Fintelmann, MD

Florian J. Fintelmann, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-4254


fintelmann@mgh.harvard.edu

Photo of Florian J. Fintelmann, MD

Massachusetts General Hospital
Phone: (617) 724-4254


fintelmann@mgh.harvard.edu

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Florian J. Fintelmann, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Radiology, Harvard Medical School
  • Head, Thoracic Imaging Percutaneous Thermal Ablation, Radiology, Massachusetts General Hospital
  • Officer, Visiting Research Fellowships, Radiology, Massachusetts General Hospital
  • Cachexia Research Group, Radiology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My group is working on improving lung cancer care through early detection (lung cancer screening with chest CT), treatment with image-guided percutaneous ablation (cryoablation, microwave ablation), and risk stratification for other therapies using body composition analysis.

Publications from Harvard Catalyst Profiles

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  • Petranovic M, McDermott S, Mercaldo S, Little BP, Graur A, Huang K, Fintelmann FJ, Digumarthy SR, Gainor JF. Impact of Baseline Interstitial Lung Abnormalities on Pneumonitis Risk in Patients Receiving Immune Checkpoint Inhibitors for Non-Small-Cell Lung Cancer. Clin Lung Cancer 2023; 24:682-688.e5. PubMed
  • Fintelmann FJ, Graur A, Oueidat K, Simon J, Harvey Barnes JM, McDermott S, Genshaft SJ, Healey TT, Suh RD, Maxwell AWP, Abtin F. Ablation of Stage I-II Non-Small Cell Lung Cancer in Patients With Interstitial Lung Disease: A Multicenter Retrospective Study. AJR Am J Roentgenol 2023. PubMed
  • Adams SJ, Mikhael P, Wohlwend J, Barzilay R, Sequist LV, Fintelmann FJ. Artificial Intelligence and Machine Learning in Lung Cancer Screening. Thorac Surg Clin 2023; 33:401-409. PubMed
  • Simon J, Mikhael P, Tahir I, Graur A, Ringer S, Fata A, Jeffrey YC, Shepard JA, Jacobson F, Barzilay R, Sequist LV, Pace LE, Fintelmann FJ. Role of sex in lung cancer risk prediction based on single low-dose chest computed tomography. Sci Rep 2023; 13:18611. PubMed
  • Som A, Rosenboom JG, Wehrenberg-Klee E, Chandler A, Ndakwah G, Chen E, Morimoto J, Kim J, Mustafa AR, Marcos-Vidal A, Fintelmann FJ, Basu A, Langer R, Traverso G, Mahmood U. Percutaneous Intratumoral Immunoadjuvant Gel Increases The Abscopal Effect of Cryoablation for Checkpoint Inhibitor Resistant Cancer. Adv Healthc Mater 2023. PubMed
  • Saenger JA, Tahir I, Födinger M, Cote GM, Muniappan A, Fintelmann FJ. Multimodality local ablative therapy of 23 lung metastases with surgical resection and percutaneous cryoablation in a patient with Li-Fraumeni Syndrome: A case report. Radiol Case Rep 2023; 18:3586-3591. PubMed
  • Tonnesen PE, Mercaldo ND, Tahir I, Dietrich AW, Amayri W, Graur A, Allaire B, Bouxsein ML, Samelson EJ, Kiel DP, Fintelmann FJ. Muscle Reference Values From Thoracic and Abdominal CT for Sarcopenia Assessment: The Framingham Heart Study. Invest Radiol 2023. PubMed
  • Saraf A, Tahir I, Hu B, Dietrich AW, Tonnesen PE, Sharp GC, Tillman G, Roeland EJ, Nipp RD, Comander A, Peppercorn J, Fintelmann FJ, Jimenez RB. Association of Sarcopenia With Toxicity-Related Discontinuation of Adjuvant Endocrine Therapy in Women With Early-Stage Hormone Receptor-Positive Breast Cancer. Int J Radiat Oncol Biol Phys 2023. PubMed
  • Dagogo-Jack I, Manoogian A, Jessop N, Georgantas NZ, Fintelmann FJ, Farahani A, Digumarthy SR, Price MC, Folch EE, Keyes CM, Do A, Peterson JL, Mino-Kenudson M, Pitman M, Rivera M, Nardi V, Dias-Santagata D, Le LP, Iafrate AJ, Heist RS, Ritterhouse LR, Lennerz JK. Integrated Radiology, Pathology, and Pharmacy Program to Accelerate Access to Osimertinib. JCO Oncol Pract 2023. PubMed
  • Sänger JA, Graur A, Tahir I, Price MC, Keane FK, Lanuti M, Sharma A, Fintelmann FJ. Outcomes following cryoablation of stage IA non-small cell lung cancer in patients with and without interstitial lung disease: A retrospective single-center cohort study. Lung Cancer 2023; 181:107231. PubMed
  • Schmeusser BN, Ali AA, Fintelmann FJ, Garcia JM, Williams GR, Master VA, Psutka SP. Imaging Techniques to Determine Degree of Sarcopenia and Systemic Inflammation in Advanced Renal Cell Carcinoma. Current Urology Reports 2023; 24:317-334. PubMed
  • Maxwell AWP, Abtin F, Fintelmann FJ, Baird GL, Suh RD, Sofocleous CT, Solomon SB. Transthoracic Needle Biopsy Is a Safe and Effective Diagnostic Procedure. J Am Coll Radiol 2023. PubMed
  • Murphy DJ, Mayoral M, Larici AR, Ginsberg MS, Cicchetti G, Fintelmann FJ, Marom EM, Truong MT, Gill RR. Imaging Follow-Up of Nonsurgical Therapies for Lung Cancer: Expert Panel Narrative Review. AJR Am J Roentgenol 2023. PubMed
  • Abrishami Kashani M, Murphy MC, Saenger JA, Wrobel MM, Tahir I, Mrah S, Ringer S, Bunck AC, Silverman SG, Shyn PB, Pachamanova DA, Fintelmann FJ. Risk of persistent air leaks following percutaneous cryoablation and microwave ablation of peripheral lung tumors. Eur Radiol 2023. PubMed
  • Murphy MC, Tahir I, Saenger JA, Abrishami Kashani M, Muniappan A, Levesque VM, Shyn PB, Silverman SG, Fintelmann FJ. Safety and Effectiveness of Percutaneous Image-Guided Thermal Ablation of Juxta-cardiac Lung Tumors. J Vasc Interv Radiol 2023. PubMed
  • Frank AJ, Dagogo-Jack I, Dobre IA, Tait S, Schumacher L, Fintelmann FJ, Fingerman LM, Keane FK, Montesi SB. Management of Lung Cancer in the Patient with Interstitial Lung Disease. Oncologist 2023; 28:12-22. PubMed
  • Fintelmann FJ, Martin NA, Tahir I, Quinn EM, Allen TC, Joseph L, Nikolic B, Lee C. Optimizing molecular testing of lung cancer needle biopsy specimens: potential solutions from an interdisciplinary qualitative study. Respir Res 2023; 24:17. PubMed
  • Mikhael PG, Wohlwend J, Yala A, Karstens L, Xiang J, Takigami AK, Bourgouin PP, Chan P, Mrah S, Amayri W, Juan YH, Yang CT, Wan YL, Lin G, Sequist LV, Fintelmann FJ, Barzilay R. Sybil: A Validated Deep Learning Model to Predict Future Lung Cancer Risk From a Single Low-Dose Chest Computed Tomography. J Clin Oncol 2023. PubMed
  • Adams SJ, Stone E, Baldwin DR, Vliegenthart R, Lee P, Fintelmann FJ. Lung cancer screening. Lancet 2022. PubMed
  • Tahir I, Cahalane AM, Saenger JA, Leppelmann KS, Kashani MA, Marquardt JP, Silverman SG, Shyn PB, Mercaldo ND, Fintelmann FJ. Factors Associated with Hospital Length of Stay and Adverse Events following Percutaneous Ablation of Lung Tumors. J Vasc Interv Radiol 2022. PubMed
  • Fisher DA, Murphy MC, Montesi SB, Hariri LP, Hallowell RW, Keane FK, Lanuti M, Mooradian MJ, Fintelmann FJ. Diagnosis and Treatment of Lung Cancer in the Setting of Interstitial Lung Disease. Radiol Clin North Am 2022; 60:993-1002. PubMed
  • Phuong A, Marquardt JP, O'Malley R, Holt SK, Laidlaw G, Eagle Z, Ngo S, Orcutt D, Schade GR, Lin DW, Schweizer MT, Yezefski T, Yu EY, Montgomery B, Grivas P, Fintelmann FJ, Psutka SP. Changes in skeletal muscle and adipose tissue during cytotoxic chemotherapy for testicular germ cell carcinoma and associations with adverse events. Urol Oncol 2022; 40:456.e19-456.e30. PubMed
  • Wrobel MM, Cahalane AM, Pachamanova D, Leppelmann KS, Silverman SG, Sharma A, Shyn PB, Mercaldo ND, Fintelmann FJ. Comparison of expected imaging findings following percutaneous microwave and cryoablation of pulmonary tumors: ablation zones and thoracic lymph nodes. Eur Radiol 2022. PubMed
  • Little BP, Gagne SM, Fintelmann FJ, McDermott S, Mendoza DP, Petranovic M, Price MC, Stowell JT, Narayan AK, Flores EJ. United States lung cancer screening program websites: radiology representation, multimedia and multilingual content. Clin Imaging 2022; 86:83-88. PubMed
  • Mayne NR, Bajaj SS, Powell J, Elser HC, Civiello BS, Fintelmann FJ, Li X, Yang CJ. Extended Delay to Treatment for Stage III-IV Non-Small-Cell Lung Cancer and Survival: Balancing Risks During the COVID-19 Pandemic. Clin Lung Cancer 2022. PubMed
  • Abrishami Kashani M, Campbell-Washburn AE, Murphy MC, Catalano OA, McDermott S, Fintelmann FJ. Magnetic Resonance Imaging for Guidance and Follow-up of Thoracic Needle Biopsies and Thermal Ablations. J Thorac Imaging 2022. PubMed
  • Tahir I, Marquardt JP, Mercaldo ND, Bourgouin PP, Wrobel MM, Mrah S, Sharp GC, Khandekar MJ, Willers H, Keane FK, Fintelmann FJ. Utility of Noncancerous Chest CT Features for Predicting Overall Survival and Noncancer Death in Patients With Stage I Lung Cancer Treated With Stereotactic Body Radiotherapy. AJR Am J Roentgenol 2022. PubMed
  • Murphy MC, Wrobel MM, Fisher DA, Cahalane AM, Fintelmann FJ. Update on Image-Guided Thermal Lung Ablation: Society Guidelines, Therapeutic Alternatives, and Postablation Imaging Findings. AJR Am J Roentgenol 2022. PubMed
  • McDermott S, Frenk NE, Fintelmann FJ, Price MC, Ott HC, Muniappan A, Shepard JO, Sharma A. Preoperative CT-guided Fiducial Marker Placement for Surgical Localization of Pulmonary Nodules. 2022; 4:e210194. PubMed
  • Falade AS, Reynolds KL, Zubiri L, Deshpande V, Fintelmann FJ, Dougan M, Mooradian MJ. Case Report: Fulminant Celiac Disease With Combination Immune Checkpoint Therapy. 2022; 13:871452. PubMed
  • Potter AL, Rosenstein AL, Kiang MV, Shah SA, Gaissert HA, Chang DC, Fintelmann FJ, Yang CJ. Association of computed tomography screening with lung cancer stage shift and survival in the United States: quasi-experimental study. BMJ 2022; 376:e069008. PubMed
  • Marquardt JP, Roeland EJ, Van Seventer EE, Best TD, Horick NK, Nipp RD, Fintelmann FJ. Percentile-based averaging and skeletal muscle gauge improve body composition analysis: validation at multiple vertebral levels. J Cachexia Sarcopenia Muscle 2021. PubMed
  • Goiffon RJ, Best TD, Wrobel MM, McDermott S, Sharma A, Chang CY, Yang K, Fintelmann FJ. Reducing Time and Patient Radiation of Computed Tomography-guided Thoracic Needle Biopsies With Single-rotation Axial Acquisitions: An Alternative to "CT Fluoroscopy". J Thorac Imaging 2021; 36:389-396. PubMed
  • Bourgouin PP, Wrobel MM, Mercaldo N, Murphy MC, Leppelmann KS, Levesque VM, Muniappan A, Silverman SG, Shepard JO, Shyn PB, Fintelmann FJ. Comparison of Percutaneous Image-Guided Microwave and Cryoablation for Sarcoma Lung Metastases: 10-Year Experience. AJR Am J Roentgenol 2021. PubMed
  • Troschel FM, Jin Q, Eichhorn F, Muley T, Best TD, Leppelmann KS, Yang CJ, Troschel AS, Winter H, Heußel CP, Gaissert HA, Fintelmann FJ. Sarcopenia on preoperative chest computed tomography predicts cancer-specific and all-cause mortality following pneumonectomy for lung cancer: A multicenter analysis. Cancer Med 2021; 10:6677-6686. PubMed
  • Narayan AK, Chowdhry DN, Fintelmann FJ, Little BP, Shepard JO, Flores EJ. Racial and Ethnic Disparities in Lung Cancer Screening Eligibility. Radiology 2021. PubMed
  • Nandy S, Helland TL, Roop BW, Raphaely RA, Ly A, Lew M, Berigei SR, Villiger M, Sorokina A, Szabari MV, Fintelmann FJ, Suter MJ, Hariri LP. Rapid non-destructive volumetric tumor yield assessment in fresh lung core needle biopsies using polarization sensitive optical coherence tomography. Biomed Opt Express 2021; 12:5597-5613. PubMed
  • Bourgouin PP, Rodriguez KJ, Fintelmann FJ. Image-Guided Percutaneous Lung Needle Biopsy: How we do it. Tech Vasc Interv Radiol 2021; 24:100770. PubMed
  • Pisuchpen N, Durbin SM, Mooradian MJ, Fintelmann FJ, Reynolds KL, Dougan M, Kambadakone A. Multi-detector computed tomography (MDCT)-based severity score as a prognostic tool in patients with suspected immune checkpoint inhibitor therapy associated colitis. Eur Radiol 2021. PubMed
  • Wrobel MM, Bourgouin PP, Abrishami Kashani M, Leppelmann KS, Vazquez RM, Pachamanova DA, Fintelmann FJ. Active Versus Passive Thaw Following Percutaneous Cryoablation of Pulmonary Tumors: Effect on Incidence, Grade, and Onset of Hemoptysis. AJR Am J Roentgenol 2021. PubMed
  • Best TD, Roeland EJ, Horick NK, Van Seventer EE, El-Jawahri A, Troschel AS, Johnson PC, Kanter KN, Fish MG, Marquardt JP, Bridge CP, Temel JS, Corcoran RB, Nipp RD, Fintelmann FJ. Muscle Loss Is Associated with Overall Survival in Patients with Metastatic Colorectal Cancer Independent of Tumor Mutational Status and Weight Loss. Oncologist 2021. PubMed
  • Troschel AS, Troschel FM, Fuchs G, Marquardt JP, Ackman JB, Yang K, Fintelmann FJ. Significance of Acquisition Parameters for Adipose Tissue Segmentation on CT Images. AJR Am J Roentgenol 2021. PubMed
  • Leppelmann KS, Fintelmann FJ. ASO Author Reflections: Percutaneous Image-Guided Ablation and Multi-modality Management of Lung Metastases. Ann Surg Oncol 2021. PubMed
  • Leppelmann KS, Levesque VM, Bunck AC, Cahalane AM, Lanuti M, Silverman SG, Shyn PB, Fintelmann FJ. Outcomes Following Percutaneous Microwave and Cryoablation of Lung Metastases from Adenoid Cystic Carcinoma of the Head and Neck: A Bi-Institutional Retrospective Cohort Study. Ann Surg Oncol 2021. PubMed
  • van Seventer E, Marquardt JP, Troschel AS, Best TD, Horick N, Azoba C, Newcomb R, Roeland EJ, Rosenthal M, Bridge CP, Greer JA, El-Jawahri A, Temel J, Fintelmann FJ, Nipp RD. Associations of Skeletal Muscle With Symptom Burden and Clinical Outcomes in Hospitalized Patients With Advanced Cancer. J Natl Compr Canc Netw 2021. PubMed
  • Leppelmann KS, Mooradian MJ, Ganguli S, Uppot RN, Yamada K, Irani Z, Wehrenberg-Klee EP, Zubiri L, Reynolds KL, Arellano RS, Hirsch JA, Sullivan RJ, Fintelmann FJ. Thermal Ablation, Embolization, and Selective Internal Radiation Therapy Combined with Checkpoint Inhibitor Cancer Immunotherapy: Safety Analysis. J Vasc Interv Radiol 2021; 32:187-195. PubMed
  • Magudia K, Bridge CP, Bay CP, Babic A, Fintelmann FJ, Troschel FM, Miskin N, Wrobel WC, Brais LK, Andriole KP, Wolpin BM, Rosenthal MH. Population-Scale CT-based Body Composition Analysis of a Large Outpatient Population Using Deep Learning to Derive Age-, Sex-, and Race-specific Reference Curves. Radiology 2020. PubMed
  • Wang GX, Neil JM, Fintelmann FJ, Little BP, Narayan AK, Flores EJ. Guideline-Discordant Lung Cancer Screening: Emerging Demand and Provided Indications. J Am Coll Radiol 2020. PubMed
  • Stowell JT, Narayan AK, Wang GX, Fintelmann FJ, Flores EJ, Sharma A, Petranovic M, Shepard JO, Little BP. Factors affecting patient adherence to lung cancer screening: A multisite analysis. J Med Screen 2020. PubMed
  • Best TD, Mercaldo SF, Bryan DS, Marquardt JP, Wrobel MM, Bridge CP, Troschel FM, Javidan C, Chung JH, Muniappan A, Bhalla S, Meyers BF, Ferguson MK, Gaissert HA, Fintelmann FJ. Multilevel Body Composition Analysis on Chest Computed Tomography Predicts Hospital Length of Stay and Complications After Lobectomy for Lung Cancer: A Multicenter Study. Ann Surg 2020. PubMed
  • Fintelmann FJ, Troschel AS, Chiles C. Radiomics Toolkit: Available Chest Computed Tomography Data Sets. J Thorac Imaging 2020; 35:W40-W42. PubMed
  • Zubiri L, Allen IM, Taylor MS, Guidon AC, Chen ST, Schoenfeld SR, Neilan TG, Sise ME, Mooradian MJ, Rubin KM, Leaf RK, Parikh AR, Faje A, Gainor JF, Cohen JV, Fintelmann FJ, Kohler MJ, Dougan M, Reynolds KL. Immune-Related Adverse Events in the Setting of PD-1/L1 Inhibitor Combination Therapy. Oncologist 2020; 25:e398-e404. PubMed
  • Fintelmann FJ, Braun P, Mirzan SH, Huang AJ, Best TD, Keyes CM, Choy E, Leppelmann KS, Muniappan A, Soto DE, Som A, Uppot RN. Percutaneous Cryoablation: Safety and Efficacy for Pain Palliation of Metastases to Pleura and Chest Wall. J Vasc Interv Radiol 2020; 31:294-300. PubMed
  • van Seventer EE, Fintelmann FJ, Roeland EJ, Nipp RD. Leveraging the Potential Synergy Between Patient-Reported Outcomes and Body Composition Analysis in Patients with Cancer. Oncologist 2020. PubMed
  • Gagne SM, Fintelmann FJ, Flores EJ, McDermott S, Mendoza DP, Petranovic M, Price MC, Stowell JT, Little BP. Evaluation of the Informational Content and Readability of US Lung Cancer Screening Program Websites. JAMA Netw Open 2020; 3:e1920431. PubMed
  • Johnson DB, Taylor KB, Cohen JV, Ayoubi N, Haugh AM, Wang DY, Schlick BD, Voorhees AL, Gage KL, Fintelmann FJ, Sullivan RJ, Eroglu Z, Abramson RG. Anti-PD-1-Induced Pneumonitis Is Associated with Persistent Imaging Abnormalities in Melanoma Patients. Cancer Immunol Res 2019. PubMed
  • Troschel AS, Troschel FM, Best TD, Gaissert HA, Torriani M, Muniappan A, Van Seventer EE, Nipp RD, Roeland EJ, Temel JS, Fintelmann FJ. Computed Tomography-based Body Composition Analysis and Its Role in Lung Cancer Care. J Thorac Imaging 2019. PubMed
  • Troschel FM, Kuklinski MW, Knoll SJ, Best TD, Muniappan A, Gaissert HA, Fintelmann FJ. Preoperative thoracic muscle area on computed tomography predicts long-term survival following pneumonectomy for lung cancer. Interact Cardiovasc Thorac Surg 2018. PubMed
  • Fuchs G, Chretien YR, Mario J, Do S, Eikermann M, Liu B, Yang K, Fintelmann FJ. Quantifying the effect of slice thickness, intravenous contrast and tube current on muscle segmentation: Implications for body composition analysis. Eur Radiol 2018; 28:2455-2463. PubMed
  • DeFilipp Z, Troschel FM, Qualls DA, Li S, Kuklinski MW, Kempner ME, Hochberg E, Chen YB, El-Jawahri A, Fintelmann FJ. Evolution of Body Composition Following Autologous and Allogeneic Hematopoietic Cell Transplantation: Incidence of Sarcopenia and Association with Clinical Outcomes. Biol Blood Marrow Transplant 2018. PubMed
  • Fintelmann FJ, Troschel FM, Mario J, Chretien YR, Knoll SJ, Muniappan A, Gaissert HA. Thoracic Skeletal Muscle is Associated with Adverse Outcomes After Lobectomy for Lung Cancer. Ann Thorac Surg 2018. PubMed
  • Fuchs G, Thevathasan T, Chretien YR, Mario J, Piriyapatsom A, Schmidt U, Eikermann M, Fintelmann FJ. Lumbar skeletal muscle index derived from routine computed tomography exams predict adverse post-extubation outcomes in critically ill patients. 2018; 44:117-123. PubMed
  • Nipp RD, Fuchs G, El-Jawahri A, Mario J, Troschel FM, Greer JA, Gallagher ER, Jackson VA, Kambadakone A, Hong TS, Temel JS, Fintelmann FJ. Sarcopenia Is Associated with Quality of Life and Depression in Patients with Advanced Cancer. Oncologist 2017. PubMed
  • Lee H, Troschel FM, Tajmir S, Fuchs G, Mario J, Fintelmann FJ, Do S. Pixel-Level Deep Segmentation: Artificial Intelligence Quantifies Muscle on Computed Tomography for Body Morphometric Analysis. J Digit Imaging 2017; 30:487-498. PubMed
  • Wang GX, Guo LQ, Gainor JF, Fintelmann FJ. Immune Checkpoint Inhibitors in Lung Cancer: Imaging Considerations. AJR Am J Roentgenol 2017. PubMed
  • Fintelmann FJ, Brinkmann JK, Jeck WR, Troschel FM, Digumarthy SR, Mino-Kenudson M, Shepard JO. Lung Cancers Associated With Cystic Airspaces: Natural History, Pathologic Correlation, and Mutational Analysis. J Thorac Imaging 2017. PubMed
  • Wang GX, Kurra V, Gainor JF, Sullivan RJ, Flaherty KT, Lee SI, Fintelmann FJ. Immune Checkpoint Inhibitor Cancer Therapy: Spectrum of Imaging Findings. Radiographics ; 37:2132-2144. PubMed
  • Fintelmann FJ, Bernheim A, Digumarthy SR, Lennes IT, Kalra MK, Gilman MD, Sharma A, Flores EJ, Muse VV, Shepard JA. The 10 Pillars of Lung Cancer Screening: Rationale and Logistics of a Lung Cancer Screening Program. Radiographics ; 35:1893-908. PubMed
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DF/HCC members that share similar concepts* with Florian J. Fintelmann, MD but have yet to coauthor a publication with this researcher.

* Concepts are MeSH terms, automatically derived from member publications

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