Photo of Sungwhan Oh,  PhD

Sungwhan Oh, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital


sungwhan_oh@hms.harvard.edu

Sungwhan Oh, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Anesthesia, Harvard Medical School
  • Lead investigator, Anetsthesiology, perioperative and pain medicine, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

It is well appreciated that symbiotic microbiota can critically contribute to GI development and immune maturation, as well as immune diseases and cancer development. My research interest focuses on structural and functional elucidation of small molecule metabolites, originated from gut symbiotic microbiota. We use various IBD models to assess immunomodulatory actions and we are interested in whether our molecules of interest can modulate prevention/progression GI malignancies such as CRC.

Publications from Harvard Catalyst Profiles

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  • Oh SF, Praveena T, Song H, Yoo JS, Jung DJ, Erturk-Hasdemir D, Hwang YS, Lee CC, Le Nours J, Kim H, Lee J, Blumberg RS, Rossjohn J, Park SB, Kasper DL. Host immunomodulatory lipids created by symbionts from dietary amino acids. Nature 2021. PubMed
  • Erturk-Hasdemir D, Oh SF, Okan NA, Stefanetti G, Gazzaniga FS, Seeberger PH, Plevy SE, Kasper DL. Symbionts exploit complex signaling to educate the immune system. Proc Natl Acad Sci U S A 2019. PubMed
  • Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med 2016; 22:421-6. PubMed
  • An D, Oh SF, Olszak T, Neves JF, Avci FY, Erturk-Hasdemir D, Lu X, Zeissig S, Blumberg RS, Kasper DL. Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Cell 2014; 156:123-33. PubMed
  • Oh SF, Pillai PS, Recchiuti A, Yang R, Serhan CN. Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation. J Clin Invest 2011; 121:569-81. PubMed