Photo of Choi-Fong Cho, PhD

Choi-Fong Cho, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital

Photo of Choi-Fong Cho, PhD

Brigham And Women's Hospital

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Choi-Fong Cho, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Neurosurgery, Harvard Medical School
  • Assistant Professor, Neurosurgery, Brigham And Women's Hospital

HCC PROGRAM AFFILIATION

Research Abstract

Our mission is to design and engineer new medicines to benefit brain cancer patients. Our team is developing cutting edge technologies to model human brain tumor tissues and their associated blood vessels, and using these platforms to discover and design innovative new therapies and imaging agents to improve the effectiveness of brain cancer treatment.

Publications from Harvard Catalyst Profiles

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  • Jimenez-Macias JL, Vaughn-Beaucaire P, Bharati A, Xu Z, Forrest M, Hong J, Sun M, Schmidt A, Clark J, Hawkins W, Mercado N, Real J, Huntington K, Zdioruk M, Nowicki MO, Cho CF, Wu B, Li W, Logan T, Manz KE, Pennell KD, Fedeles BI, Bertone P, Punsoni M, Brodsky AS, Lawler SE. Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug delivery and potentiates chemotherapy in GBM. Sci Adv 2025; 11:eadr1481. PubMed
  • Yao Y, Wang J, Liu Y, Qu Y, Wang K, Zhang Y, Chang Y, Yang Z, Wan J, Liu J, Nakashima H, Lawler SE, Chiocca EA, Cho CF, Bei F. Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood-brain barrier in rodents and primates. Nat Biomed Eng 2022; 6:1257-1271. PubMed
  • Cho CF, Farquhar CE, Fadzen CM, Scott B, Zhuang P, von Spreckelsen N, Loas A, Hartrampf N, Pentelute BL, Lawler SE. A Tumor-Homing Peptide Platform Enhances Drug Solubility, Improves Blood-Brain Barrier Permeability and Targets Glioblastoma. Cancers (Basel) 2022. PubMed
  • von Spreckelsen N, Fadzen CM, Hartrampf N, Ghotmi Y, Wolfe JM, Dubey S, Yang BY, Kijewski MF, Wang S, Farquhar C, Bergmann S, Zdioruk M, Wasserburg JR, Scott B, Murrell E, Bononi FC, Luyt LG, DiCarli M, Lamfers MLM, Ligon KL, Chiocca EA, Viapiano MS, Pentelute BL, Lawler SE, Cho CF. Targeting glioblastoma using a novel peptide specific to a deglycosylated isoform of brevican. Adv Ther (Weinh) 2021. PubMed
  • Fadzen CM, Wolfe JM, Zhou W, Cho CF, von Spreckelsen N, Hutchinson KT, Lee YC, Chiocca EA, Lawler SE, Yilmaz OH, Lippard SJ, Pentelute BL. A Platinum(IV) Prodrug-Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain. J Med Chem 2020. PubMed
  • Bergmann S, Lawler SE, Qu Y, Fadzen CM, Wolfe JM, Regan MS, Pentelute BL, Agar NYR, Cho CF. Blood-brain-barrier organoids for investigating the permeability of CNS therapeutics. Nat Protoc 2018; 13:2827-2843. PubMed
  • Cho CF, Yu L, Nsiama TK, Kadam AN, Raturi A, Shukla S, Amadei GA, Steinmetz NF, Luyt LG, Lewis JD. Viral nanoparticles decorated with novel EGFL7 ligands enable intravital imaging of tumor neovasculature. Nanoscale 2017; 9:12096-12109. PubMed
  • Cho CF, Wolfe JM, Fadzen CM, Calligaris D, Hornburg K, Chiocca EA, Agar NYR, Pentelute BL, Lawler SE. Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents. Nat Commun 2017; 8:15623. PubMed
  • Lawler SE, Speranza MC, Cho CF, Chiocca EA. Oncolytic Viruses in Cancer Treatment: A Review. JAMA Oncol 2017; 3:841-849. PubMed
  • Fadzen CM, Wolfe JM, Cho CF, Chiocca EA, Lawler SE, Pentelute BL. Perfluoroarene-Based Peptide Macrocycles to Enhance Penetration Across the Blood-Brain Barrier. J Am Chem Soc 2017; 139:15628-15631. PubMed
  • Cho CF, Lee K, Speranza MC, Bononi FC, Viapiano MS, Luyt LG, Weissleder R, Chiocca EA, Lee H, Lawler SE. Design of a microfluidic chip for magnetic-activated sorting of one-bead-one-compound libraries. ACS Comb Sci 2016. PubMed
  • Cho CF, Amadei GA, Breadner D, Luyt LG, Lewis JD. Discovery of novel integrin ligands from combinatorial libraries using a multiplex "beads on a bead" approach. Nano Lett 2012; 12:5957-65. PubMed
  • Steinmetz NF, Cho CF, Ablack A, Lewis JD, Manchester M. Cowpea mosaic virus nanoparticles target surface vimentin on cancer cells. Nanomed 2011; 6:351-64. PubMed
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