Photo of Uma M. Sachdeva,  MD, PhD

Uma M. Sachdeva, MD, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-5200


uma.sachdeva@mgh.harvard.edu

Uma M. Sachdeva, MD, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Surgery, Harvard Medical School
  • Assistant in Surgery, Thoracic Surgery, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Sachdeva is a thoracic surgeon at Massachusetts General Hospital and Assistant Professor of Surgery at Harvard Medical School. She received her MD and PhD in cell and molecular biology through the Medical Scientist Training Program from the University of Pennsylvania, after completing an undergraduate degree in Biochemical Sciences from Harvard College. She is a graduate of the General Surgery and Cardiothoracic Surgery training programs at Massachusetts General Hospital and specializes in thoracic surgical oncology, focusing on esophageal and lung cancers using minimally invasive, endoscopic, and robotic approaches. Her lab studies molecular pathways underlying the development of esophageal cancers and precursor lesions, including Barrett’s esophagus, using patient-derived 2D and 3D culture systems. She has received research support through the 2nd David C. Sabiston Research Scholarship from the American Association for Thoracic Surgery, the 2021 Research Scholarship from the Thoracic Surgery Foundation, and the Inaugural Patricia K. Donahoe Early Career Catalyst Award from the Massachusetts General Hospital Department of Surgery. Her lab aims to develop more personalized medicine approaches for treatment of esophageal cancers and serves as a training environment for students and postdoctoral researchers. She is also actively involved in the training of clinical residents and fellows in thoracic surgery.

Publications from Harvard Catalyst Profiles

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  • Sachdeva UM, Axtell AL, Kroese TE, Chang DC, Mathisen DJ, Morse CR. Contributing factors to lymph node recovery with esophagectomy by thoracic surgeons: an analysis of the Society of Thoracic Surgeons General Thoracic Surgery Database. Dis. Esophagus 2022. PubMed
  • Karakasheva TA, Gabre JT, Sachdeva UM, Cruz-Acuña R, Lin EW, DeMarshall M, Falk GW, Ginsberg GG, Yang Z, Kim MM, Diffenderfer ES, Pitarresi JR, Li J, Muir AB, Hamilton KE, Nakagawa H, Bass AJ, Rustgi AK. Patient-derived organoids as a platform for modeling a patient's response to chemoradiotherapy in esophageal cancer. Sci Rep 2021; 11:21304. PubMed
  • Shimonosono M, Tanaka K, Flashner S, Takada S, Matsuura N, Tomita Y, Sachdeva UM, Noguchi E, Sangwan V, Ferri L, Momen-Heravi F, Yoon AJ, Klein-Szanto AJ, Diehl JA, Nakagawa H. Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy. Biomolecules 2021. PubMed
  • Sachdeva UM, Shimonosono M, Flashner S, Cruz-Acuña R, Gabre JT, Nakagawa H. Understanding the cellular origin and progression of esophageal cancer using esophageal organoids. Cancer Lett 2021; 509:39-52. PubMed
  • Suzuki K, Masuike Y, Mizuno R, Sachdeva UM, Chatterji P, Andres SF, Sun W, Klein-Szanto AJ, Besharati S, Remotti HE, Verzi MP, Rustgi AK. LIN28B induces a differentiation program through CDX2 in colon cancer. JCI Insight 2021. PubMed
  • Sachdeva UM, Axtell AL, Kroese TE, Chang DC, Morse CR. Impact of Obesity on Treatment Approach for Resectable Esophageal Cancer. Ann Thorac Surg 2021; 112:1059-1066. PubMed
  • Sachdeva UM, Colson YL. Commentary: Through the looking glass: Deciding who we want to be. J Thorac Cardiovasc Surg 2020. PubMed
  • Chandramouleeswaran PM, Guha M, Shimonosono M, Whelan KA, Maekawa H, Sachdeva UM, Ruthel G, Mukherjee S, Engel N, Gonzalez MV, Garifallou J, Ohashi S, Klein-Szanto AJ, Mesaros CA, Blair IA, Pellegrino da Silva R, Hakonarson H, Noguchi E, Baur JA, Nakagawa H. Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes. PLoS ONE 2020; 15:e0239625. PubMed
  • Sachdeva UM, Molena D. One-stop shop for diagnosis and treatment of lung nodules: Can thoracic surgeons do it all? J Thorac Cardiovasc Surg 2019; 157:1246-1247. PubMed
  • Sachdeva UM, Lanuti M. Cervical exenteration. Ann Cardiothorac Surg 2018; 7:217-226. PubMed
  • Moonsamy P, Sachdeva UM, Morse CR. Management of laryngotracheal trauma. Ann Cardiothorac Surg 2018; 7:210-216. PubMed
  • Sachdeva UM, O'Brien JM. Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma. J Clin Invest 2012; 122:425-34. PubMed
  • Wise DR, Ward PS, Shay JE, Cross JR, Gruber JJ, Sachdeva UM, Platt JM, DeMatteo RG, Simon MC, Thompson CB. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A 2011; 108:19611-6. PubMed
  • Lamia KA, Sachdeva UM, DiTacchio L, Williams EC, Alvarez JG, Egan DF, Vasquez DS, Juguilon H, Panda S, Shaw RJ, Thompson CB, Evans RM. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 2009; 326:437-40. PubMed
  • Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 2009; 324:1076-80. PubMed
  • Sachdeva UM, Thompson CB. Diurnal rhythms of autophagy: implications for cell biology and human disease. Autophagy 2008; 4:581-9. PubMed
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