Research Abstract
We seek to understand host immune responses against viruses (such as HIV, SIV, SARS-CoV-2, and tumor viruses including EBV), cancers (eg lymphomas) and immune dysregulation (eg HIV, lymphomas, Chronic Rhinosinusitis). To maximize our success, we partner with clinical collaborators in our quest toward a systems-level understanding of the immune-disease interface through 1) archival clinical samples, 2) small and large animal models and 3) organoid systems. By combining technology development ("Spatial-omics") with the questions above, we will decipher higher-order host-disease interactions to understand disease mechanisms with the long-term goal of improving therapeutics.
