Photo of Jonathan E. Leeman, MD

Jonathan E. Leeman, MD

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute

Photo of Jonathan E. Leeman, MD

Dana-Farber Cancer Institute

Visualize Collaborations
Learn how these members are similar
Similar Members

DF/HCC members that share similar concepts* with Jonathan E. Leeman, MD but have yet to coauthor a publication with this researcher.

* Concepts are MeSH terms, automatically derived from member publications

Similar Members

Jonathan E. Leeman, MD

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Assistant Professor, Radiation Oncology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Research Abstract

My clinical expertise lies in the areas of MRI guided radiotherapy, adaptive radiotherapy and prostate cancer and I serve as the physician lead of the BWH/DFCI MRI guided radiation program.

My research focuses on the application of MR imaging technology and adaptive radiotherapy for the advancement of prostate cancer treatment to improve outcomes by reducing toxicity of treatment and improving tumor control. My specific area of interest lies in the application of advanced radiotherapy techniques, including the incorporation of MRI in the radiotherapy planning process, use of MR-Linac and adaptive technology for novel approaches to stereotactic body radiotherapy (SBRT), biomarker development to predict response to androgen deprivation therapy and radiotherapy and the role of prostate radiotherapy in patients with metastatic prostate cancer.

I am currently the principal investigator of multiple clinical trials including a master protocol for studying MR guided adaptive radiotherapy for multiple cancer types, a phase I/II randomized trial evaluating a gadolinium-based theranostic nanoparticle for radiosensitization with MR guided adaptive SBRT and a multi-center prospective trial evaluating CT-based adaptive prostate SBRT with urethral sparing.

Publications from Harvard Catalyst Profiles

Powered by Harvard Catalyst
  • Cho HL, Murthy V, Mouw KW, D'Amico AV, Nguyen PL, Leeman JE, Dee EC. Second malignancy probabilities in patients with prostate cancer treated with whole pelvis radiation therapy versus prostate only radiation therapy. Prostate 2022; 82:1098-1106. PubMed
  • Yang DD, Brennan VS, Huynh E, Williams CL, Han Z, Ampofo N, Vastola ME, Sangal P, Singer L, Mak RH, Leeman JE, Cagney DN, Huynh MA. Stereotactic Magnetic Resonance-Guided Adaptive Radiation Therapy (SMART) for Abdominopelvic Oligometastases. Int J Radiat Oncol Biol Phys 2022. PubMed
  • Huynh E, Boyle S, Campbell J, Penney J, Mak RH, Schoenfeld JD, Leeman JE, Williams CL. Technical note: Toward implementation of MR-guided radiation therapy for laryngeal cancer with healthy volunteer imaging and a custom MR-CT larynx phantom. Med Phys 2022; 49:1814-1821. PubMed
  • Hsu SH, Han Z, Leeman JE, Hu YH, Mak RH, Sudhyadhom A. Synthetic CT generation for MRI-guided adaptive radiotherapy in prostate cancer. 2022; 12:969463. PubMed
  • Dee EC, Leeman JE. Second malignancy probabilities in prostate cancer patients treated with SBRT and other contemporary radiation techniques: Reply. Radiother Oncol 2021; 165:191-192. PubMed
  • Hussain SS, Lundine D, Leeman JE, Higginson DS. Genomic Signatures in HPV-Associated Tumors. Viruses 2021. PubMed
  • Leeman JE, Chen YH, Catalano P, Bredfeldt J, King M, Mouw KW, D'Amico AV, Orio P, Nguyen PL, Martin N. Radiation Dose to the Intraprostatic Urethra Correlates Strongly With Urinary Toxicity After Prostate Stereotactic Body Radiation Therapy: A Combined Analysis of 23 Prospective Clinical Trials. Int J Radiat Oncol Biol Phys 2021. PubMed
  • Shepherd AF, Yu AF, Iocolano M, Leeman JE, Wild AT, Imber BS, Chaft JE, Offin M, Huang J, Isbell JM, Wu AJ, Gelblum DY, Shaverdian N, Simone CB, Gomez D, Yorke E, Jackson A, Rimner A. Increasing Heart Dose Reduces Overall Survival in Patients Undergoing Postoperative Radiation Therapy for NSCLC. JTO Clin Res Rep 2021; 2:100209. PubMed
  • Hussain SS, Majumdar R, Moore GM, Narang H, Buechelmaier ES, Bazil MJ, Ravindran PT, Leeman JE, Li Y, Jalan M, Anderson KS, Farina A, Soni R, Mohibullah N, Hamzic E, Rong-Mullins X, Sifuentes C, Damerla RR, Viale A, Powell SN, Higginson DS. Measuring nonhomologous end-joining, homologous recombination and alternative end-joining simultaneously at an endogenous locus in any transfectable human cell. Nucleic Acids Res 2021; 49:e74. PubMed
  • Dee EC, Muralidhar V, King MT, Martin NE, D'Amico AV, Mouw KW, Orio PF, Nguyen PL, Leeman JE. Second malignancy probabilities in prostate cancer patients treated with SBRT and other contemporary radiation techniques. Radiother Oncol 2021; 161:241-250. PubMed
  • Katsoulakis E, Yu Y, Apte AP, Leeman JE, Katabi N, Morris L, Deasy JO, Chan TA, Lee NY, Riaz N, Hatzoglou V, Oh JH. Radiomic analysis identifies tumor subtypes associated with distinct molecular and microenvironmental factors in head and neck squamous cell carcinoma. Oral Oncol 2020; 110:104877. PubMed
  • Lamba N, Butler S, Mahal BA, Trinh QD, Rose B, King M, Orio P, Mouw KW, Martin N, Leeman JE, Feng FY, Nguyen PL, Muralidhar V. Three-tiered Subclassification System of High-risk Prostate Cancer in Men Managed With Radical Prostatectomy: Implications for Treatment Decision-making. Urology 2020. PubMed
  • Xu AJ, Luo L, Leeman JE, Romesser PB, Spielsinger D, Sabol C, Waldenberg T, Brinkman T, Riaz N, McBride S, Kang J, Lee N, Tsai CJ. Beyond reirradiation: Efficacy and safety of three or more courses of radiation for head and neck malignancies. Clin Transl Radiat Oncol 2020; 23:30-34. PubMed
  • Fan D, Ma J, Bell AC, Groen AH, Olsen KS, Lok BH, Leeman JE, Anderson E, Riaz N, McBride S, Ganly I, Shaha AR, Sherman EJ, Tsai CJ, Kang JJ, Lee NY. Outcomes of multimodal therapy in a large series of patients with anaplastic thyroid cancer. Cancer 2020; 126:444-452. PubMed
  • Leeman JE, Nguyen PL. Less Is More During COVID 19. Int J Radiat Oncol Biol Phys 2020; 108:339. PubMed
  • Leeman JE, Chen MH, Huland H, Graefen M, D'Amico AV, Tilki D. Advancing Age and the Odds of Upgrading and Upstaging at Radical Prostatectomy in Men with Gleason Score 6 Prostate Cancer. Clin Genitourin Cancer 2019; 17:e1116-e1121. PubMed
  • Beckham TH, Leeman JE, Xie P, Li X, Goldman DA, Zhang Z, Sherman E, McBride S, Riaz N, Lee N, Tsai CJ. Long-term survival in patients with metastatic head and neck squamous cell carcinoma treated with metastasis-directed therapy. Br J Cancer 2019; 121:897-903. PubMed
  • Leeman JE, Li Y, Bell A, Hussain SS, Majumdar R, Rong-Mullins X, Blecua P, Damerla R, Narang H, Ravindran PT, Lee NY, Riaz N, Powell SN, Higginson DS. Human papillomavirus 16 promotes microhomology-mediated end-joining. Proc Natl Acad Sci U S A 2019; 116:21573-21579. PubMed
  • Leeman JE, Lee NY, Zhou Y, Neal B, Sine K, Tabar V, Cohen MA. Endoscopic Resection Followed by Proton Therapy With Pencil Beam Scanning for Skull Base Tumors. Laryngoscope 2019; 129:1313-1317. PubMed
  • Leeman JE, Schoenfeld JD. Radiation Therapy and Immune Modulation. Hematol Oncol Clin North Am 2019; 33:233-248. PubMed
  • Katsoulakis E, Leeman JE, Lok BH, Shi W, Zhang Z, Tsai JC, McBride SM, Sherman EJ, Cohen M, Wong R, Ganly I, Lee NY, Riaz N. Long-term outcomes in oral cavity squamous cell carcinoma with adjuvant and salvage radiotherapy after surgery. Laryngoscope 2018; 128:2539-2545. PubMed
  • Brandt WS, Yan W, Leeman JE, Tan KS, Park BJ, Adusumilli PS, Bott MJ, Molena D, Isbell J, Chaft J, Rimner A, Jones DR. Postoperative Radiotherapy for Surgically Resected ypN2 Non-Small Cell Lung Cancer. Ann Thorac Surg 2018; 106:848-855. PubMed
  • Leeman JE, McBride SM, Spielsinger D, Sherman EJ, Wong R, Riaz N, Lee NY, Tsai CJ. Head and neck cancers associated with exposure to the September 11, 2001 World Trade Center terrorist attacks. Int. J. Cancer 2018; 142:2485-2490. PubMed
  • Kim JK, Leeman JE, Riaz N, McBride S, Tsai CJ, Lee NY. Proton Therapy for Head and Neck Cancer. Curr Treat Options Oncol 2018; 19:28. PubMed
  • Leeman JE, Li JG, Pei X, Venigalla P, Zumsteg ZS, Katsoulakis E, Lupovitch E, McBride SM, Tsai CJ, Boyle JO, Roman BR, Morris LGT, Dunn LA, Sherman EJ, Lee NY, Riaz N. Patterns of Treatment Failure and Postrecurrence Outcomes Among Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma After Chemoradiotherapy Using Modern Radiation Techniques. JAMA Oncol 2017; 3:1487-1494. PubMed
  • Grkovski M, Lee NY, Schöder H, Carlin SD, Beattie BJ, Riaz N, Leeman JE, O'Donoghue JA, Humm JL. Monitoring early response to chemoradiotherapy with F-FMISO dynamic PET in head and neck cancer. Eur J Nucl Med Mol Imaging 2017; 44:1682-1691. PubMed
  • Grkovski M, Schöder H, Lee NY, Carlin SD, Beattie BJ, Riaz N, Leeman JE, O'Donoghue JA, Humm JL. Multiparametric Imaging of Tumor Hypoxia and Perfusion with F-Fluoromisonidazole Dynamic PET in Head and Neck Cancer. J Nucl Med 2017; 58:1072-1080. PubMed
  • Leeman JE, Romesser PB, Zhou Y, McBride S, Riaz N, Sherman E, Cohen MA, Cahlon O, Lee N. Proton therapy for head and neck cancer: expanding the therapeutic window. Lancet Oncol. 2017; 18:e254-e265. PubMed
  • Li JG, Venigalla P, Leeman JE, LaPlant Q, Setton J, Sherman E, Tsai J, McBride S, Riaz N, Lee N. Patterns of nodal failure after intensity modulated radiotherapy for nasopharyngeal carcinoma. Laryngoscope 2017; 127:377-382. PubMed
  • Leeman JE, Gutiontov S, Romesser P, McBride S, Riaz N, Lee N, Tsai CJ. Sparing of high retropharyngeal nodal basins in patients with unilateral oropharyngeal carcinoma treated with intensity modulated radiation therapy. 2017; 7:254-259. PubMed
  • Leeman JE, Rimner A, Montecalvo J, Hsu M, Zhang Z, von Reibnitz D, Panchoo K, Yorke E, Adusumilli PS, Travis W, Wu AJ. Histologic Subtype in Core Lung Biopsies of Early-Stage Lung Adenocarcinoma is a Prognostic Factor for Treatment Response and Failure Patterns After Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys 2017; 97:138-145. PubMed
  • Leeman JE, Bilsky M, Laufer I, Folkert MR, Taunk NK, Osborne JR, Arevalo-Perez J, Zatcky J, Alektiar KM, Yamada Y, Spratt DE. Stereotactic body radiotherapy for metastatic spinal sarcoma: a detailed patterns-of-failure study. J Neurosurg Spine 2016; 25:52-8. PubMed
  • Cleary C, Leeman JE, Higginson DS, Katabi N, Sherman E, Morris L, McBride S, Lee N, Riaz N. Biological Features of Human Papillomavirus-related Head and Neck Cancers Contributing to Improved Response. Clin Oncol (R Coll Radiol) 2016; 28:467-74. PubMed
  • Spratt DE, Arevalo-Perez J, Leeman JE, Gerber NK, Folkert M, Taunk NK, Alektiar KM, Karimi S, Lyo JK, Tap WD, Bilsky MH, Laufer I, Yamada Y, Osborne JR. Early magnetic resonance imaging biomarkers to predict local control after high dose stereotactic body radiotherapy for patients with sarcoma spine metastases. Spine J 2016; 16:291-8. PubMed
  • Wegner RE, Leeman JE, Kabolizadeh P, Rwigema JC, Mintz AH, Burton SA, Heron DE. Fractionated stereotactic radiosurgery for large brain metastases. Am J Clin Oncol 2015; 38:135-9. PubMed
  • Holt DE, Gill BS, Clump DA, Leeman JE, Burton SA, Amankulor NM, Engh JA, Heron DE. Tumor bed radiosurgery following resection and prior stereotactic radiosurgery for locally persistent brain metastasis. 2015; 5:84. PubMed
  • Chen X, Leeman JE, Wang J, Pacella JJ, Villanueva FS. New insights into mechanisms of sonothrombolysis using ultra-high-speed imaging. Ultrasound Med Biol 2014; 40:258-62. PubMed
  • Leeman JE, Clump DA, Flickinger JC, Mintz AH, Burton SA, Heron DE. Extent of perilesional edema differentiates radionecrosis from tumor recurrence following stereotactic radiosurgery for brain metastases. 2013; 15:1732-8. PubMed
  • Clump DA, Leeman JE, Wegner RE, Burton SA, Mintz AH, Heron DE. Stereotactic radiosurgery for the treatment and palliation of base of skull metastases. J Radiosurg SBRT 2013; 2:217-223. PubMed
  • Leeman JE, Kim JS, Yu FT, Chen X, Kim K, Wang J, Chen X, Villanueva FS, Pacella JJ. Effect of acoustic conditions on microbubble-mediated microvascular sonothrombolysis. Ultrasound Med Biol 2012; 38:1589-98. PubMed
  • Leeman JE, Clump DA, Wegner RE, Heron DE, Burton SA, Mintz AH. Prescription dose and fractionation predict improved survival after stereotactic radiotherapy for brainstem metastases. Radiat Oncol 2012; 7:107. PubMed
  • Kim JS, Leeman JE, Kagemann L, Yu FT, Chen X, Pacella JJ, Schuman JS, Villanueva FS, Kim K. Volumetric quantification of in vitro sonothrombolysis with microbubbles using high-resolution optical coherence tomography. J Biomed Opt 2012; 17:070502. PubMed
  • Leeman JE, Cagney DN, Mak RH, Huynh MA, Tanguturi SK, Singer L, Catalano P, Martin NE, D'Amico AV, Mouw KW, Nguyen PL, King MT, Han Z, Williams C, Huynh E. Magnetic Resonance-Guided Prostate Stereotactic Body Radiation Therapy With Daily Online Plan Adaptation: Results of a Prospective Phase 1 Trial and Supplemental Cohort. Adv Radiat Oncol ; 7:100934. PubMed
Hide
Visualize Collaborations
Learn how these members are similar
Similar Members

DF/HCC members that share similar concepts* with Jonathan E. Leeman, MD but have yet to coauthor a publication with this researcher.

* Concepts are MeSH terms, automatically derived from member publications

Similar Members