Photo of Mutlay Sayan,  MD

Mutlay Sayan, MD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (617) 732-6310


msayan@bwh.harvard.edu

Mutlay Sayan, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Instructor, Radiation Oncology, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Publications from Harvard Catalyst Profiles

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  • Sayan M, Kilic S, Zhang Y, Liu B, Jan I, George M, Kumar S, Haffty B, Ohri N. Early Toxicity and Patient-Reported Cosmetic Outcomes in Patients Treated With Adjuvant Proton-Based Radiotherapy After Breast-Conserving Surgery. Clin Breast Cancer 2023; 23:176-180. PubMed
  • Sayan M, Hathout L, Kilic SS, Jan I, Gilles A, Hassell N, Kowzun M, George M, Potdevin L, Kumar S, Sinkin J, Agag R, Haffty BG, Ohri N. Reconstructive complications and early toxicity in breast cancer patients treated with proton-based postmastectomy radiation therapy. 2023; 13:1067500. PubMed
  • Kizilkaya MC, Kilic SS, Oncel D, Mamidanna S, Daliparty V, Yilmaz S, Bozkurt MA, Sibic O, Sayan M. Barriers to Coronavirus Disease 19 vaccination in patients with obesity. Am J Surg 2022. PubMed
  • Sayan M, Kilic SS, Vergalasova I, Jan I, Eladoumikdachi F, Haffty B, Kumar S, Ohri N. Risk Factors for the Development of Clinical and Subclinical Lymphedema Detected by Bioimpedance Spectroscopy. Clin Breast Cancer 2022; 22:553-559. PubMed
  • Kizilkaya MC, Kilic SS, Bozkurt MA, Sibic O, Ohri N, Faggen M, Warren L, Wong J, Punglia R, Bellon J, Haffty B, Sayan M. Breast cancer awareness among Afghan refugee women in Turkey. EClinicalMedicine 2022; 49:101459. PubMed
  • Yehia ZA, Yoon J, Sayan M, Kumar S, Hathout L, Kowzun M, Potdevin L, George M, Haffty BG, Ohri N. Does the Use of BioZorb Result in Smaller Breast Seroma Volume? Anticancer Res 2022; 42:2961-2965. PubMed
  • Sayan M, Eren MF, Kilic SS, Kotek A, Kaplan SO, Duran O, Cukurcayır F, Babalıoglu I, Or OD, Ozturk GA, Eroglu C, Teke F, Kurtul N, Kutuk T, Bicakci BC, Senyurek S, Aktan M, Mamidanna S, Ohri N, Haffty B, Atalar B. Utilization of radiation therapy and predictors of noncompliance among Syrian refugees in Turkey. BMC Cancer 2022; 22:532. PubMed
  • Sayan M, Vergalasova I, George M, Kowzun M, Potdevin L, Kumar S, Haffty B, Ohri N. Patterns of postmastectomy radiation therapy in clinically node-positive breast cancerpatients with pathologically negative lymph nodes after neoadjuvant chemotherapy. Turk J Med Sci 2022; 52:279-285. PubMed
  • Sayan M, Jan I, Vergalasova I, Kilic SS, Kumar S, Haffty B, Ohri N. Incidence of clinical lymphedema in breast cancer patients treated with adjuvant proton-based radiotherapy. Rep Pract Oncol Radiother 2022; 27:474-478. PubMed
  • Sayan M, Yehia ZA, Jan I, Gupta A, Vergalasova I, Reviello M, Kumar S, Haffty B, Ohri N. Adaptive Lumpectomy Boost Planning Can Reduce Normal Tissue Exposure in Patients Receiving Hypofractionated Whole Breast Irradiation. Anticancer Res 2022; 42:53-57. PubMed
  • Sayan M, Vergalasova I, Jan I, Kumar S, Chan N, Haffty BG, Ohri N. Toxicities and Locoregional Control After External Beam Chest Wall and/or Regional Lymph Node Re-irradiation for Recurrent Breast Cancer. Anticancer Res 2022; 42:93-96. PubMed
  • Neibart SS, Mamidanna S, Chundury A, Sayan M, Alexander HR, August DA, Berim LD, Boland PM, Grandhi MS, Gulhati P, Hochster HS, Langan RC, Spencer KR, Kennedy TJ, Deek MP, Jabbour SK. Outcomes of patients with borderline resectable and resectable pancreatic adenocarcinoma treated with neoadjuvant three-week course chemoradiotherapy using capecitabine-based versus gemcitabine-based concurrent chemotherapy. J Gastrointest Oncol 2021; 12:2557-2566. PubMed
  • Sayan M, Vergalasova I, George M, Kowzun M, Potdevin L, Kumar S, Haffty B, Ohri N. Patterns of post-mastectomy radiation therapy in clinically node positive breast cancer patients with pathologically negative lymph nodes after neoadjuvant chemotherapy. Turk J Med Sci 2021. PubMed
  • Gupta A, Jhawar SR, Sayan M, Yehia ZA, Haffty BG, Yu JB, Wang SY. Cost-Effectiveness of Adjuvant Treatment for Ductal Carcinoma In Situ. J Clin Oncol 2021; 39:2386-2396. PubMed
  • Jabbour SK, Williams TM, Sayan M, Miller ED, Ajani JA, Chang AC, Coleman N, El-Rifai W, Haddock M, Ilson D, Jamorabo D, Kunos C, Lin S, Liu G, Prasanna PG, Rustgi AK, Wong R, Vikram B, Ahmed MM. Potential Molecular Targets in the Setting of Chemoradiation for Esophageal Malignancies. Journal of the National Cancer Institute 2021; 113:665-679. PubMed
  • Vergalasova I, Ennis RD, Sayan M, Liu B, Yue NJ, Hathout L. The clinical impact of removing rectal gas on high-dose-rate brachytherapy dose distributions for gynecologic cancers. J Appl Clin Med Phys 2021; 22:35-41. PubMed
  • Sayan M, Vergalasova I, Jhawar S, Kumar S, George M, Kowzun M, Potdevin L, Toppmeyer D, Haffty B, Ohri N. Utilization of Hypofractionated Whole-Breast Radiotherapy With Concurrent Anti-Human Epidermal Growth Factor Receptor 2 (HER2) Therapy. Clin Breast Cancer 2021; 21:31-36. PubMed
  • Sayan M, Şahin B, Mustafayev TZ, Kefelioğlu EŞS, Vergalasova I, Gupta A, Balmuk A, Güngör G, Ohri N, Weiner J, Karaarslan E, Özyar E, Atalar B. Risk of symptomatic radiation necrosis in patients treated with stereotactic radiosurgery for brain metastases. Neurocirugia (Astur : Engl Ed) 2021; 32:261-267. PubMed
  • Sozio SJ, Jhawar S, Wang Y, Sayan M, Parikh R, Kim S. Comparing the Incidence of Buccal Mucosa Cancer in South Asian, White, and Black Populations Residing in the United States: A Cross-Sectional Analysis. Asian Pac. J. Cancer Prev. 2021; 22:195-199. PubMed
  • Sayan M, Yehia ZA, Ohri N, Haffty BG. Hypofractionated Postmastectomy Radiation Therapy. Adv Radiat Oncol 2021; 6:100618. PubMed
  • Jhawar SR, Alpert N, Taioli E, Sayan M, Bazan J, Park KU, Stover D, Cherian M, White J, Haffty B, Ohri N. Adjuvant radiation therapy alone is associated with improved overall survival compared to hormonal therapy alone in older women with estrogen receptor positive early stage breast cancer. Cancer Med 2020; 9:8345-8354. PubMed
  • Sayan M, Şahin B, Mustafayev TZ, Kefelioğlu EŞS, Vergalasova I, Gupta A, Balmuk A, Güngör G, Ohri N, Weiner J, Karaarslan E, Özyar E, Atalar B. Risk of symptomatic radiation necrosis in patients treated with stereotactic radiosurgery for brain metastases. Neurocirugia (Astur : Engl Ed) 2020. PubMed
  • Jan I, Chen K, Sayan M, Uprety P, Laumbach RJ, Ennis RD, Haffty BG. Prevalence of Surface Contamination With SARS-CoV-2 in a Radiation Oncology Clinic. JAMA Oncol 2020; 6:1632-1634. PubMed
  • Sayan M, Mamidanna S, Oncel D, Jan I, Vergalasova I, Weiner J, Ohri N, Acikalin B, Chundury A. Clinical management of uveal melanoma: a comprehensive review with a treatment algorithm. Radiat Oncol J 2020; 38:162-169. PubMed
  • Sayan M, Mustafayev TZ, Balmuk A, Mamidanna S, Kefelioglu ESS, Gungor G, Chundury A, Ohri N, Karaarslan E, Ozyar E, Atalar B. Management of symptomatic radiation necrosis after stereotactic radiosurgery and clinical factors for treatment response. Radiat Oncol J 2020; 38:176-180. PubMed
  • Nasir UM, Mozeika AM, Sayan M, Jan I, Kowal N, Haffty B, Ahlawat S, Kothari N. Severe Gastrointestinal Mucositis Following Concurrent Palbociclib and Palliative Radiation Therapy. Anticancer Res 2020; 40:5291-5294. PubMed
  • Eren MF, Çolpan Öksüz D, Sayan M, Karaçam S, Vergalasova I, Ay Eren A, Öner Dinçbaş F. Comparison of kV Orthogonal Radiographs and kV-Cone-Beam Computed Tomography Image-Guided Radiotherapy Methods With and Without Implanted Fiducials in Prostate Cancer. Cureus 2020; 12:e9916. PubMed
  • Eren MF, Ay Eren A, Sayan M, Yücel B, Elagöz Ş, Özgüven Y, Vergalasova I, Altun A, Kılıçkap S, Daliparty V, Beşe N. The Impact of Everolimus and Radiation Therapy on Pulmonary Fibrosis. Medicina (Kaunas) 2020. PubMed
  • Sayan M, Mamidanna S, Fuat Eren M, Daliparty V, Zoto Mustafayev T, Nelson C, Ohri N, Jabbour SK, Guven Mert A, Atalar B. New horizons from novel therapies in malignant pleural mesothelioma. Adv Respir Med 2020; 88:343-351. PubMed
  • Sayan M, Serbez I, Teymur B, Gur G, Zoto Mustafayev T, Gungor G, Atalar B, Ozyar E. Patient-Reported Tolerance of Magnetic Resonance-Guided Radiation Therapy. 2020; 10:1782. PubMed
  • Sayan M, Mustafayev TZ, Atalar B, Gungor G, Ozyar E. Magnetic Resonance-Guided Radiation Therapy to Boost Cervical Cancer When Brachytherapy Is Not Available: A Case Report. Adv Radiat Oncol 2020; 5:1066-1070. PubMed
  • Sayan M, Zoto Mustafayev T, Sahin B, Kefelioglu ESS, Wang SJ, Kurup V, Balmuk A, Gungor G, Ohri N, Weiner J, Ozyar E, Atalar B. Evaluation of response to stereotactic radiosurgery in patients with radioresistant brain metastases. Radiat Oncol J 2019; 37:265-270. PubMed
  • Sayan M, Vergalasova I, Hard D, Wrigth H, Archambault J, Gagne H, Nelson C, Heimann R. Daily localization of partial breast irradiation patients with three-dimensional ultrasound imaging. Radiat Oncol J 2019; 37:259-264. PubMed
  • Gupta A, Khan AJ, Yegya-Raman N, Sayan M, Ahlawat S, Ohri N, Goyal S, Moore DF, Eladoumikdachi F, Toppmeyer D, Haffty BG. 5-Year Results of a Prospective Phase 2 Trial Evaluating 3-Week Hypofractionated Whole Breast Radiation Therapy Inclusive of a Sequential Boost. Int J Radiat Oncol Biol Phys 2019; 105:267-274. PubMed
  • Zhang A, Deek MP, Kim S, Sayan M, Grann A, Wagman RT, Malhotra U, Hathout L, Biswal N, Zhang Y, Langenfeld J, Kennedy T, August DA, Jabbour SK. Vertebral body irradiation during chemoradiation therapy for esophageal cancer contributes to acute bone marrow toxicity. J Gastrointest Oncol 2019; 10:513-522. PubMed
  • Sayan M, Eren MF, Gupta A, Ohri N, Kotek A, Babalioglu I, Oskeroglu Kaplan S, Duran O, Derinalp Or O, Cukurcayir F, Kurtul N, Ceylaner Bicakci B, Kutuk T, Senyurek S, Turk A, Jabbour SK, Atalar B. Current treatment strategies in malignant pleural mesothelioma with a treatment algorithm. Adv Respir Med 2019; 87:289-297. PubMed
  • Yegya-Raman N, Aisner J, Kim S, Sayan M, Li D, Langenfeld J, Patel M, Malhotra J, Jabbour SK. Synchronous Oligometastatic Non-small Cell Lung Cancer Managed With Curative-Intent Chemoradiation Therapy: Long-term Outcomes From a Single Institution. Adv Radiat Oncol 2019; 4:541-550. PubMed
  • Sayan M, Yegya-Raman N, Greco SH, Gui B, Zhang A, Chundury A, Grandhi MS, Hochster HS, Kennedy TJ, Langan RC, Malhotra U, Rustgi VK, Shah MM, Spencer KR, Carpizo DR, Nosher JL, Jabbour SK. Rethinking the Role of Radiation Therapy in the Treatment of Unresectable Hepatocellular Carcinoma: A Data Driven Treatment Algorithm for Optimizing Outcomes. 2019; 9:345. PubMed
  • Sayan M, Ohri N, Lee A, Abou Yehia Z, Gupta A, Byun J, Jabbour SK, Wagman R, Haffty BG, Weiner J, Kim S. The Impact of Formal Mentorship Programs on Mentorship Experience Among Radiation Oncology Residents From the Northeast. 2019; 9:1369. PubMed
  • Sayan M, Abou Yehia Z, Gupta A, Toppmeyer D, Ohri N, Haffty BG. Acute Cardiotoxicity With Concurrent Trastuzumab and Hypofractionated Radiation Therapy in Breast Cancer Patients. 2019; 9:970. PubMed
  • Li D, Yegya-Raman N, Kim S, Ganesan S, Sayan M, August D, Spencer K, Hathout L, Maloney-Patel N, Malhotra U, Yue NJ, Jabbour SK. Multiple primary malignancies in patients with anal squamous cell carcinoma. J Gastrointest Oncol 2018; 9:853-857. PubMed
  • Yegya-Raman N, Wang K, Kim S, Reyhan M, Deek MP, Sayan M, Li D, Patel M, Malhotra J, Aisner J, Marks LB, Jabbour SK. Dosimetric Predictors of Symptomatic Cardiac Events After Conventional-Dose Chemoradiation Therapy for Inoperable NSCLC. J Thorac Oncol 2018; 13:1508-1518. PubMed
  • Sayan M, Hard D, Wilson K, Nelson C, Gagne H, Rubin D, Heimann R. Long-term cosmesis following a novel schedule of accelerated partial breast radiation in selected early stage breast cancer: result of a prospective clinical trial. Radiat Oncol J 2017; 35:325-331. PubMed
  • Cassidy RJ, Switchenko JM, Jegadeesh N, Sayan M, Ferris MJ, Eaton BR, Higgins KA, Wadsworth JT, Magliocca KR, Saba NF, Beitler JJ. Association of Lymphovascular Space Invasion With Locoregional Failure and Survival in Patients With Node-Negative Oral Tongue Cancers. JAMA Otolaryngol Head Neck Surg 2017; 143:382-388. PubMed
  • Sayan M, Wilson K, Nelson C, Gagne H, Rubin D, Heimann R. A novel schedule of accelerated partial breast radiation using intensity-modulated radiation therapy in elderly patients: survival and toxicity analysis of a prospective clinical trial. Radiat Oncol J 2017; 35:32-38. PubMed
  • Sayan M, Mossman BT. The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases. 2016; 13:51. PubMed
  • Hadley Strout E, Fox L, Castro A, Haroun P, Leavitt B, Ross C, Sayan M, Delaney T, Platzer A, Hutchins J, Carney JK. Access to transportation for Chittenden County Vermont older adults. 2016; 28:769-74. PubMed
  • Sayan M, Vempati P, Miles B, Teng M, Genden E, Demicco EG, Misiukiewicz K, Posner M, Gupta V, Bakst RL. Adjuvant Therapy for Salivary Gland Carcinomas. Anticancer Res 2016; 36:4165-70. PubMed
  • Sayan M, Cassidy RJ, Switchenko JM, Kayode OA, Saba NF, Steuer CE, Shin DM, Wadsworth JT, El-Deiry M, Patel M, Beitler JJ, Higgins KA. Development of Late Toxicities in Patients with Oral Tongue Cancer Treated with Surgical Resection and Adjuvant Radiation Therapy. 2016; 6:272. PubMed
  • Sayan M, Shukla A, MacPherson MB, Macura SL, Hillegass JM, Perkins TN, Thompson JK, Beuschel SL, Miller JM, Mossman BT. Extracellular signal-regulated kinase 5 and cyclic AMP response element binding protein are novel pathways inhibited by vandetanib (ZD6474) and doxorubicin in mesotheliomas. Am J Respir Cell Mol Biol 2014; 51:595-603. PubMed
  • Miller JM, Thompson JK, MacPherson MB, Beuschel SL, Westbom CM, Sayan M, Shukla A. Curcumin: a double hit on malignant mesothelioma. Cancer Prev Res (Phila Pa) 2014; 7:330-40. PubMed
  • Macura SL, Steinbacher JL, Macpherson MB, Lathrop MJ, Sayan M, Hillegass JM, Beuschel SL, Perkins TN, Spiess PC, van der Vliet A, Butnor KJ, Shukla A, Wadsworth M, Landry CC, Mossman BT. Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts. BMC Cancer 2013; 13:400. PubMed
  • Hillegass JM, Miller JM, MacPherson MB, Westbom CM, Sayan M, Thompson JK, Macura SL, Perkins TN, Beuschel SL, Alexeeva V, Pass HI, Steele C, Mossman BT, Shukla A. Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells. 2013; 10:39. PubMed
  • Shukla A, Miller JM, Cason C, Sayan M, MacPherson MB, Beuschel SL, Hillegass J, Vacek PM, Pass HI, Mossman BT. Extracellular signal-regulated kinase 5: a potential therapeutic target for malignant mesotheliomas. Clin Cancer Res 2013; 19:2071-83. PubMed
  • Macura SL, Hillegass JM, Steinbacher JL, MacPherson MB, Shukla A, Beuschel SL, Perkins TN, Butnor KJ, Lathrop MJ, Sayan M, Hekmatyar K, Taatjes DJ, Kauppinen RA, Landry CC, Mossman BT. A multifunctional mesothelin antibody-tagged microparticle targets human mesotheliomas. J. Histochem. Cytochem. 2012; 60:658-74. PubMed
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