Research Abstract
I lead the Bioinformatics and Computational Biology (BCB) group at the Center for Development of Therapeutics, Broad Institute. The overarching objective of my group is to develop mechanistic and predictive models that are data and machine learning (ML) driven, yet actionable and interpretable, to generate novel hypotheses for complex drug actions, discover new biomedical knowledge, and support decision-making in drug discovery and clinical practice. One large focus of my group is developing methods for drug target analysis by rationalizing functional consequences of genetic variants and variants generated by base-editing technology on protein structure and function, including the identification and analysis of 3D protein functional hotspots. Additionally, my group develops ML-driven innovative tools for small-molecule hit identification using data from DNA-encoded library (DEL) screening, HTS, Imaging, etc.
