Photo of Amar H Kelkar,  MD, MPH, FACP

Amar H Kelkar, MD, MPH, FACP

Dana-Farber Cancer Institute

Dana-Farber Cancer Institute
Phone: (617) 632-6140


amarh_kelkar@dfci.harvard.edu

Photo of Amar H Kelkar,  MD, MPH, FACP

Dana-Farber Cancer Institute
Phone: (617) 632-6140


amarh_kelkar@dfci.harvard.edu

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Amar H Kelkar, MD, MPH, FACP

Dana-Farber Cancer Institute

EDUCATIONAL TITLES

  • Instructor, Medicine, Harvard Medical School
  • Physician, Medical Oncology, Dana-Farber Cancer Institute
  • Associate Physician, Medical Oncology, Brigham And Women's Hospital

HCC PROGRAM AFFILIATION

Research Abstract

I am a Physician in Medical Oncology at DFCI, an Associate Physician at BWH, and an Instructor in Medicine at HMS. As I begin my career in faculty, I hope to continue to grow in the three areas of medicine that I value most: (1) patient care, (2) medical science, and (3) meaningful access to novel therapies.

During my Internal Medicine residency, I identified a large cluster of young patients presenting with widespread parenchymal hemorrhages. In conjunction with state and national health departments, we identified a pattern of synthetic cannabinoid usage and positive mass spectrometry testing for brodifacoum and other coumarin derivatives. I published my work on these coagulopathy cases as first author in the New England Journal of Medicine. I thus entered my fellowship at the University of Florida with a focus on benign hematology and worked with Dr. Anita Rajasekhar on projects in hemostasis and thrombosis, including publishing two reviews in the 2020 American Society of Hematology Education Book. Then through the course of my fellowship, particularly through my work with Drs. Chris Cogle, John Hiemenz, and John Wingard, I discovered a passion for both the science and clinical management of cancer, blood disorders, and stem cell transplantation.

I believe our role as physicians for our patients and communities goes beyond clinical care because access to care is the ultimate bottleneck in medicine. To this end, I pursued research and policy work in health economics, care delivery, cost-effectiveness, bioethics, and public health. I completed coursework in decision analysis, biostatistics, and epidemiology through the Harvard T.H. Chan School of Public Health and will complete an MPH degree in 2023. Using techniques learned from these courses, and with mentorship from Dr. Corey Cutler, I completed a cost-effectiveness model comparing second-line CAR-T and ASCT in patients with diffuse large B cell lymphoma and presented our findings at the 2022 ASCO Meeting. We are currently working on other decision models in transplant and developing projects in post-transplant survivorship.

With my primary mentor, Dr. Gregory Abel, I am conducting a series of clinical trials evaluating an AI-based avatar in patients undergoing allogeneic transplantation with the goals of improving patient education, reducing anxiety and loneliness, and shortening hospitalizations. We are also designing an ethics-focused survey for patients undergoing cellular therapies that I plan to apply to future decision models and policy work.

My committee work also figures into this paradigm. I am currently serving on the American Society of Hematology Committee on Practice and Subcommittee on Reimbursements, and previously served on the American Medical Association (AMA) Council on Legislation. I am also working with Dr. Sam Silver to represent hematologists at the AMA/Specialty Society RVS Update Committee and CPT Advisory Committee. I plan to continue in these roles and hope to grow as a national leader in policy and advocacy within hematology and oncology.

I am dedicating my professional career to the delivery of effective therapies for patients with cancer and blood disorders and believe my diverse skill sets position me to shape the landscape of cell therapy for the better.

Publications from Harvard Catalyst Profiles

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  • Kakkilaya A, Trando A, Cliff ERS, Mian H, Al Hadidi S, Aziz M, Goodman AM, Jeong AR, Smith WL, Kelkar AH, Russler-Germain DA, Mehra N, Chakraborty R, Gertz MA, Mohyuddin GR. Evaluating early intervention in smoldering myeloma clinical trials: a systematic review. Oncologist 2024. PubMed
  • Kelkar AH, Kerssens C, Groblewski N, Clancy D, Close SD, Sullivan LM, Sherman-Manhard D, Cutler C, Wang V, Abel GA. Human-in-the-loop avatar chatbot shows promise in supporting hematopoietic stem cell transplantation patients. Bone Marrow Transplant 2024. PubMed
  • Shapiro RM, Kim HT, Dulery R, Liney D, Garrity HM, Panaro KM, Au C, Gervais C, Little JS, Ho VT, Cutler CS, Koreth J, Gooptu M, Antin JH, Kelkar AH, Romee R, Wu CJ, Ritz J, Soiffer RJ, Nikiforow S. Active infection at the time of CD34+ selected stem cell boost is associated with treatment failure and poor survival. Blood Adv 2024. PubMed
  • Khera N, Ailawadhi S, Brazauskas R, Patel J, Jacobs B, Ustun C, Ballen K, Abid MB, Díaz MA, Al-Homsi AS, Hashem H, Hong S, Munker R, Schears R, Lazarus HM, Ciurea SO, Badawy SM, Savani BN, Wirk B, LeMaistre CF, Bhatt NS, Beitinjaneh A, Aljurf M, Sharma A, Cerny J, Knight JM, Kelkar AH, Yared JA, Kindwall-Keller T, Winestone LE, Steinberg A, Arnold SD, Seo S, Preussler JM, Hossain NM, Fingrut WB, Agrawal V, Hashmi S, Lehmann LE, Wood WA, Rangarajan HG, Saber W, Hahn T. Trends in Volumes and Survival After Hematopoietic Cell Transplantation in Racial/Ethnic Minorities. Blood Adv 2024. PubMed
  • Abusamak AA, Abusamak M, Al-Abbadi M, Rayyan A, Oran O, Mohyuddin GR, Kelkar AH, Goodman AM, Chakraborty R, Cliff ERS, Al Hadidi S. Use of subjective minimizing language at hematology and oncology conferences: A systematic review. J Cancer Policy 2023; 39:100461. PubMed
  • Kelkar AH, Cliff ERS, Jacobson CA, Abel GA, Dijk SW, Krijkamp EM, Redd R, Zurko JC, Hamadani M, Hunink MGM, Cutler C. Second-Line Chimeric Antigen Receptor T-Cell Therapy in Diffuse Large B-Cell Lymphoma : A Cost-Effectiveness Analysis. Ann Intern Med 2023; 176:1625-1637. PubMed
  • Kelkar AH, Hantel A, Koranteng E, Cutler CS, Hammer MJ, Abel GA. Digital Health to Patient-Facing Artificial Intelligence: Ethical Implications and Threats to Dignity for Patients With Cancer. JCO Oncol Pract 2023. PubMed
  • Auletta JJ, Khera N, DeMartino P, Kelkar AH, Yusuf RA, Davies SM, Knutson J, Beaver E, Maloney A, Majhail NS. Assessing Medicaid Coverage for Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T Cell Therapy: A Project from the American Society for Transplantation and Cellular Therapy and the National Marrow Donor Program ACCESS Initiative. Transplant Cell Ther 2023; 29:713-720. PubMed
  • Blue BJ, Brazauskas R, Chen K, Patel J, Zeidan AM, Steinberg A, Ballen K, Kwok J, Rotz SJ, Perez MAD, Kelkar AH, Ganguly S, Wingard JR, Lad D, Sharma A, Badawy SM, Lazarus HM, Hashem H, Szwajcer D, Knight JM, Bhatt NS, Page K, Beattie S, Arai Y, Liu H, Arnold SD, Freytes CO, Abid MB, Beitinjaneh A, Farhadfar N, Wirk B, Winestone LE, Agrawal V, Preussler JM, Seo S, Hashmi S, Lehmann L, Wood WA, Rangarajan HG, Saber W, Majhail NS. Racial and Socioeconomic Disparities in Long-Term Outcomes in ≥1 Year Allogeneic Hematopoietic Cell Transplantation Survivors: A CIBMTR Analysis. Transplant Cell Ther 2023; 29:709.e1-709.e11. PubMed
  • Alrawabdeh J, Alzu'bi M, Alzyoud M, Odeh N, Hamadneh Y, Mian H, Mohyuddin GR, Kelkar AH, Goodman AM, Chakraborty R, Russler-Germain DA, Mehra N, Baggio D, Cliff ERS, Al Hadidi S. Characteristics of post hoc subgroup analyses of oncology clinical trials: a systematic review. JNCI Cancer Spectr 2023. PubMed
  • Steinbach M, Neupane K, Aziz M, Lee-Smith W, Julian K, Godara A, McClune B, Kelkar AH, Sborov D, Mohyuddin GR. Multiple Myeloma in Young Patients: A Scoping Review. Clin Lymphoma Myeloma Leuk 2023. PubMed
  • Cliff ERS, Kelkar AH, Russler-Germain DA, Tessema FA, Raymakers AJN, Feldman WB, Kesselheim AS. High Cost of Chimeric Antigen Receptor T-Cells: Challenges and Solutions. Am Soc Clin Oncol Educ Book 2023; 43:e397912. PubMed
  • Banerjee R, Kelkar AH, Durani U, Anagnostou T, Nishitani M, Mallhi K, Majhail NS, Logan AC. Demographics, Motivations, and Experiences of Participants in Transplantation or Cellular Therapy Fellowships. Transplant Cell Ther 2023; 29:394.e1-394.e7. PubMed
  • Sawalha L, Kelkar AH, Mohyuddin GR, Goodman AM, Gagelmann N, Al Hadidi S. Analysis of repeated roles in editorial boards at oncology focused journals. J Cancer Policy 2023; 35:100380. PubMed
  • Kelkar AH, Antin JH, Shapiro RM. Long-term health outcomes of allogeneic hematopoietic stem cell transplantation. 2023; 13:1175794. PubMed
  • Cliff ERS, Kelkar AH. Cost-effectiveness of Aducanumab and Donanemab for Early Alzheimer Disease-Estimating the True Value. JAMA Neurol 2022. PubMed
  • Farhadfar N, Ahn KW, Bo-Subait S, Logan B, Stefanski HE, Hsu JW, Panch S, Confer D, Liu H, Badawy SM, Beitinjaneh A, Diaz MA, Hildebrandt GC, Kelkar AH, Lazarus HM, Murthy HS, Preussler JM, Schears RM, Sharma A, van der Poel M, Bruce JG, Pulsipher MA, Shaw BE, Wingard JR, Switzer GE. The Impact of Pre-Apheresis Health Related Quality of Life on Peripheral Blood Progenitor Cell Yield and Donor's Health and Outcome: Secondary Analysis of Patient-Reported Outcome Data from the RDSafe and BMT CTN 0201 Clinical Trials. Transplant Cell Ther 2022; 28:603.e1-603.e7. PubMed
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