Photo of Alejandro Bertolet,  PhD

Alejandro Bertolet, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-3665


abertoletreina@mgh.harvard.edu

Alejandro Bertolet, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Radiation Oncology, Harvard Medical School
  • Assistant Professor, Radiation Oncology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

In the evolving landscape of cancer care, the role of radiation oncology remains pivotal. A constant pursuit has driven my journey in this field to optimize the therapeutic index of radiation, therefore maximizing its efficacy while minimizing collateral damage to healthy tissues. As the head of the Bertolet Lab at Massachusetts General Hospital and an Assistant Professor at Harvard Medical School, my research is at the intersection of computational modeling, dosimetry, and radiopharmaceutical therapy.

Publications from Harvard Catalyst Profiles

Powered by Harvard Catalyst
  • Huesa-Berral C, Withrow JD, Dawson RJ, Beekman C, Bolch WE, Paganetti H, Wehrenberg-Klee E, Bertolet A. MIDOS: a novel stochastic model towards a treatment planning system for microsphere dosimetry in liver tumors. Eur J Nucl Med Mol Imaging 2023. PubMed
  • Garcia-Prada CD, Carmes L, Atis S, Parach A, Bertolet A, Jarlier M, Poty S, Garcia DS, Shin WG, Du Manoir S, Schuemann J, Tillement O, Lux F, Constanzo J, Pouget JP. Gadolinium-Based Nanoparticles Sensitize Ovarian Peritoneal Carcinomatosis to Targeted Radionuclide Therapy. J Nucl Med 2023. PubMed
  • Bertolet A, Chamseddine I, Paganetti H, Schuemann J. The complexity of DNA damage by radiation follows a Gamma distribution: insights from the Microdosimetric Gamma Model. 2023; 13:1196502. PubMed
  • Bertolet A, Ramos-Méndez J, McNamara A, Yoo D, Ingram S, Henthorn N, Warmenhoven JW, Faddegon B, Merchant M, McMahon SJ, Paganetti H, Schuemann J. Impact of DNA Geometry and Scoring on Monte Carlo Track-Structure Simulations of Initial Radiation-Induced Damage. Radiat Res 2022; 198:207-220. PubMed
  • Bertolet A, Abolfath R, Carlson DJ, Lustig RA, Hill-Kayser C, Alonso-Basanta M, Carabe A. Correlation of LET With MRI Changes in Brain and Potential Implications for Normal Tissue Complication Probability for Patients With Meningioma Treated With Pencil Beam Scanning Proton Therapy. Int J Radiat Oncol Biol Phys 2022; 112:237-246. PubMed
  • Bertolet A, Wehrenberg-Klee E, Bobić M, Grassberger C, Perl J, Paganetti H, Schuemann J. Pre- and post-treatment image-based dosimetry inY-microsphere radioembolization using the TOPAS Monte Carlo toolkit. Phys Med Biol 2021. PubMed
  • Bertolet A, Ramos-Méndez J, Paganetti H, Schuemann J. The relation between microdosimetry and induction of direct damage to DNA by alpha particles. Phys Med Biol 2021. PubMed