Photo of Alejandro Bertolet,  PhD

Alejandro Bertolet, PhD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 724-3665


abertoletreina@mgh.harvard.edu

Alejandro Bertolet, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Radiation Oncology, Harvard Medical School
  • Assistant Professor, Radiation Oncology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

In the evolving landscape of cancer care, the role of radiation oncology remains pivotal. A constant pursuit has driven my journey in this field to optimize the therapeutic index of radiation, therefore maximizing its efficacy while minimizing collateral damage to healthy tissues. As the head of the Bertolet Lab at Massachusetts General Hospital and an Assistant Professor at Harvard Medical School, my research is at the intersection of computational modeling, dosimetry, and radiopharmaceutical therapy.

Publications from Harvard Catalyst Profiles

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  • Onecha VV, Suarez-García D, Bosque JJ, Lee H, Simpkins F, Gitto SB, Pryma DA, Bertolet A. Space- and time-defined Monte Carlo dosimetry explains ovarian cancer cell viability in targeted α-particle therapy with [At]At-PTT. Int J Radiat Oncol Biol Phys 2025. PubMed
  • Dawson RJ, Huesa-Berral C, Carter LM, Beekman C, Choi C, Shin B, Bobić M, Cogno N, Withrow JD, Jokisch DW, Bertolet A, Paganetti H, Bolch WE. Dosimetrically coupled multiscale tetrahedral mesh models of human liver vasculature: implications for radiopharmaceutical dosimetry of both organ blood and parenchyma. Phys Med Biol 2025. PubMed
  • Chamseddine I, Cowan C, Donnelly L, Abergel RJ, Schuemann J, Bertolet A, Maitz CA. Prognostic Role of Patient, Tumour and Radiomic Factors Influencing Outcomes in Dogs With Thyroid Cancer Treated With Iodine-131. Vet Comp Oncol 2025. PubMed
  • Wehrenberg-Klee E, An T, Heidari P, Huesa-Berral C, Dreher MR, Eldridge A, Fowers K, Schuemann J, Bertolet A. SPECT/CT Dosimetry of Bronchial Artery Tc Macroaggregated Albumin Injection in Pulmonary Malignancies: Feasibility Evaluation of Bronchial Artery Y Radioembolization. Radiology 2025; 314:e240331. PubMed
  • Quintana JM, Jiang F, Kang M, Valladolid Onecha V, Könik A, Qin L, Rodriguez VE, Hu H, Borges N, Khurana I, Banla LI, Le Fur M, Caravan P, Schuemann J, Bertolet A, Weissleder R, Miller MA, Ng TSC. Localized In Vivo Prodrug Activation Using Radionuclides. J Nucl Med 2025; 66:91-97. PubMed
  • Shin WG, D-Kondo JN, Ramos-Méndez J, LaVerne JA, Rothwell B, Bertolet A, McNamara A, Faddegon B, Paganetti H, Schuemann J. Investigation of hydrogen peroxide yields and oxygen consumption in high dose rate irradiation: a TOPAS-nBio Monte Carlo study. Phys Med Biol 2024. PubMed
  • Rothwell B, Bertolet A, Schuemann J. Proton FLASH-arc therapy (PFAT): A feasibility study for meeting FLASH dose-rate requirements in the clinic. Radiother Oncol 2024; 202:110623. PubMed
  • Kunz LV, Bosque JJ, Nikmaneshi M, Chamseddine I, Munn LL, Schuemann J, Paganetti H, Bertolet A. AMBER: A Modular Model for Tumor Growth, Vasculature and Radiation Response. Bull. Math. Biol. 2024; 86:139. PubMed
  • Huesa-Berral C, Terry JF, Kunz L, Bertolet A. Sequencing microsphere selective internal radiotherapy after external beam radiotherapy for hepatocellular carcinoma: proof of concept of a synergistic combination. Br J Radiol 2024. PubMed
  • Chamseddine I, Shah K, Lee H, Ehret F, Schuemann J, Bertolet A, Shih HA, Paganetti H. Decoding Patient Heterogeneity Influencing Radiation-Induced Brain Necrosis. Clin Cancer Res 2024. PubMed
  • Bobić M, Huesa-Berral C, Terry JF, Kunz LV, Schuemann J, Fisher DR, Maitz C, Bertolet A. Monte Carlo dosimetric analyses on the use ofY-IsoPet intratumoral therapy in canine subjects. Phys Med Biol 2024. PubMed
  • Meyer I, Peters N, Tamborino G, Lee H, Bertolet A, Faddegon BA, Mille MM, Lee C, Schuemann J, Paganetti H. A framework for in-field and out-of-field patient specific secondary cancer risk estimates from treatment plans using the TOPAS Monte Carlo system. Phys Med Biol 2024. PubMed
  • Huesa-Berral C, Withrow JD, Dawson RJ, Beekman C, Bolch WE, Paganetti H, Wehrenberg-Klee E, Bertolet A. MIDOS: a novel stochastic model towards a treatment planning system for microsphere dosimetry in liver tumors. Eur J Nucl Med Mol Imaging 2023. PubMed
  • Garcia-Prada CD, Carmes L, Atis S, Parach A, Bertolet A, Jarlier M, Poty S, Garcia DS, Shin WG, Du Manoir S, Schuemann J, Tillement O, Lux F, Constanzo J, Pouget JP. Gadolinium-Based Nanoparticles Sensitize Ovarian Peritoneal Carcinomatosis to Targeted Radionuclide Therapy. J Nucl Med 2023. PubMed
  • Bertolet A, Chamseddine I, Paganetti H, Schuemann J. The complexity of DNA damage by radiation follows a Gamma distribution: insights from the Microdosimetric Gamma Model. 2023; 13:1196502. PubMed
  • Bertolet A, Ramos-Méndez J, McNamara A, Yoo D, Ingram S, Henthorn N, Warmenhoven JW, Faddegon B, Merchant M, McMahon SJ, Paganetti H, Schuemann J. Impact of DNA Geometry and Scoring on Monte Carlo Track-Structure Simulations of Initial Radiation-Induced Damage. Radiat Res 2022; 198:207-220. PubMed
  • Bertolet A, Abolfath R, Carlson DJ, Lustig RA, Hill-Kayser C, Alonso-Basanta M, Carabe A. Correlation of LET With MRI Changes in Brain and Potential Implications for Normal Tissue Complication Probability for Patients With Meningioma Treated With Pencil Beam Scanning Proton Therapy. Int J Radiat Oncol Biol Phys 2022; 112:237-246. PubMed
  • Bertolet A, Wehrenberg-Klee E, Bobić M, Grassberger C, Perl J, Paganetti H, Schuemann J. Pre- and post-treatment image-based dosimetry inY-microsphere radioembolization using the TOPAS Monte Carlo toolkit. Phys Med Biol 2021. PubMed
  • Bertolet A, Ramos-Méndez J, Paganetti H, Schuemann J. The relation between microdosimetry and induction of direct damage to DNA by alpha particles. Phys Med Biol 2021. PubMed
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