Photo of Filipe De Carvalho,  MD, PhD

Filipe De Carvalho, MD, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital

Filipe De Carvalho, MD, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Surgery, Harvard Medical School
  • Associate Surgeon, Surgery, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My main effort at Brigham and Women's Hospital is in translational research, with a specific focus on funcional genomics and single-cell technologies. My research interests integrate genomic and transcriptomic data with pre-clinical models to define molecular mechanisms of cancer progression and resistance to therapy, with a particular focus on bladder and prostate cancer.

Publications from Harvard Catalyst Profiles

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  • Carvalho FLF, Wang Y, Dall CP, Nayan M, Chou WH, McGregor B, Stopfkuchen-Evans MF, Stamatakis L, Preston MA, Kibel AS, Chang SL, Mossanen M. Preoperative anemia is associated with increased radical cystectomy complications. Urol Oncol 2022. PubMed
  • Mossanen M, Carvalho FLF, Muralidhar V, Preston MA, Reardon B, Conway JR, Curran C, Freeman D, Sha S, Sonpavde G, Hirsch M, Kibel AS, Van Allen EM, Mouw KW. Genomic Features of Muscle-invasive Bladder Cancer Arising After Prostate Radiotherapy. Eur Urol 2022; 81:466-473. PubMed
  • Nayan M, Carvalho FLF, Feldman AS. Active surveillance for intermediate-risk prostate cancer. World J Urol 2022; 40:79-86. PubMed
  • Bakouny Z, Sadagopan A, Ravi P, Metaferia NY, Li J, AbuHammad S, Tang S, Denize T, Garner ER, Gao X, Braun DA, Hirsch L, Steinharter JA, Bouchard G, Walton E, West D, Labaki C, Dudani S, Gan CL, Sethunath V, Carvalho FLF, Imamovic A, Ricker C, Vokes NI, Nyman J, Berchuck JE, Park J, Hirsch MS, Haq R, Mary Lee GS, McGregor BA, Chang SL, Feldman AS, Wu CJ, McDermott DF, Heng DYC, Signoretti S, Van Allen EM, Choueiri TK, Viswanathan SR. Integrative clinical and molecular characterization of translocation renal cell carcinoma. Cell Rep 2022; 38:110190. PubMed
  • Yu A, Wang Y, Mossanen M, Preston M, Carvalho FL, Chung BI, Chang SL. Robotic-assisted radical cystectomy is associated with lower perioperative mortality in octogenarians. Urol Oncol 2021. PubMed
  • Matulewicz RS, Bjurlin MA, Carvalho FL, Mossanen M, El-Shahawy O. Best practices for assessing and reporting tobacco use in urology oncology practice and research. Urol Oncol 2021; 39:446-451. PubMed
  • Chou WH, McGregor B, Schmidt A, Carvalho FLF, Hirsch MS, Chang SL, Kibel A, Mossanen M. Cyclophosphamide-associated bladder cancers and considerations for survivorship care: A systematic review. Urol Oncol 2021. PubMed
  • Egan J, Marhamati S, Carvalho FLF, Davis M, O'Neill J, Lee H, Lynch JH, Hankins RA, Hu JC, Kowalczyk KJ. Retzius-sparing Robot-assisted Radical Prostatectomy Leads to Durable Improvement in Urinary Function and Quality of Life Versus Standard Robot-assisted Radical Prostatectomy Without Compromise on Oncologic Efficacy: Single-surgeon Series and Step-by-step Eur Urol 2021; 79:839-857. PubMed
  • Dall CP, Shaw N, Egan J, Carvalho FL, Galloway LAS, Krasnow R, Stamatakis L. Practice patterns for extended venous thromboembolism chemoprophylaxis among urologic oncologists after radical cystectomy. Urol Oncol 2020; 38:849.e19-849.e23. PubMed
  • Carvalho FL, Zeymo A, Egan J, Kelly CH, Zheng C, Lynch JH, Hwang J, Stamatakis L, Krasnow RE, Kowalczyk KJ. Determinants of neoadjuvant chemotherapy use in muscle-invasive bladder cancer. Investig Clin Urol 2020; 61:390-396. PubMed
  • Carvalho FLF, Zheng C, Witmer K, O'neill J, Lynch JH, Kowalczyk KJ. Complications associated with perioperative use of tyrosine kinase inhibitor in cytoreductive nephrectomy. Sci Rep 2019; 9:15272. PubMed
  • Sussman R, Carvalho FLF, Harbin A, Zheng C, Lynch JH, Stamatakis L, Hwang J, Williams SB, Hu JC, Kowalczyk KJ. Survival and secondary interventions following treatment for locally-advanced prostate cancer. Can J Urol 2018; 25:9516-9524. PubMed
  • Rayn KN, Hale GR, Bloom JB, Gold SA, Carvalho FLF, Mehralivand S, Czarniecki M, Wood BJ, Merino MJ, Choyke P, Türkbey B, Pinto PA, Agarwal PK. Incidental bladder cancers found on multiparametric MRI of the prostate gland: a single center experience. 2018; 24:316-320. PubMed
  • Xie W, Kagiampakis I, Pan L, Zhang YW, Murphy L, Tao Y, Kong X, Kang B, Xia L, Carvalho FLF, Sen S, Chiu Yen RW, Zahnow CA, Ahuja N, Baylin SB, Easwaran H. DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk. Cancer Cell 2018; 33:309-321.e5. PubMed
  • Dunphy KM, Garino MC, Shaw NM, Carvalho FLF, Stamatakis L. When the Gold Standard Proves to Be Fool's Gold-Blue-light Cystoscopy in a Case of High-risk Non-muscle-invasive Bladder Cancer. Urology 2017; 110:27-30. PubMed
  • Viúdez A, Carvalho FL, Maleki Z, Zahurak M, Laheru D, Stark A, Azad NS, Wolfgang CL, Baylin S, Herman JG, De Jesus-Acosta A. A new immunohistochemistry prognostic score (IPS) for recurrence and survival in resected pancreatic neuroendocrine tumors (PanNET). 2016; 7:24950-61. PubMed
  • Carvalho FL, Marchionni L, Gupta A, Kummangal BA, Schaeffer EM, Ross AE, Berman DM. HES6 promotes prostate cancer aggressiveness independently of Notch signalling. J Cell Mol Med 2015; 19:1624-36. PubMed
  • Lotan TL, Carvalho FL, Peskoe SB, Hicks JL, Good J, Fedor H, Humphreys E, Han M, Platz EA, Squire JA, De Marzo AM, Berman DM. PTEN loss is associated with upgrading of prostate cancer from biopsy to radical prostatectomy. Mod Pathol 2015; 28:128-137. PubMed
  • Carvalho FL, Simons BW, Eberhart CG, Berman DM. Notch signaling in prostate cancer: a moving target. Prostate 2014; 74:933-45. PubMed
  • Carvalho FL, Simons BW, Antonarakis ES, Rasheed Z, Douglas N, Villegas D, Matsui W, Berman DM. Tumorigenic potential of circulating prostate tumor cells. 2013; 4:413-21. PubMed
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