Photo of Martin Hemberg,  PhD

Martin Hemberg, PhD

Brigham And Women's Hospital

Brigham And Women's Hospital
Phone: (857) 354-1637


mhemberg@bwh.harvard.edu

Photo of Martin Hemberg,  PhD

Brigham And Women's Hospital
Phone: (857) 354-1637


mhemberg@bwh.harvard.edu

Visualize Collaborations

Martin Hemberg, PhD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Immunology, Harvard Medical School
  • Associate Professor, Neurology, Brigham And Women's Hospital

HCC PROGRAM AFFILIATION

Research Abstract

As a computational genomics group, our goal is to develop machine learning methods that will provide new insights both for basic biology as well as for understanding how aberrant gene regulation plays a role in cancer, neurodegeneration, and other diseases. We seek to develop scalable, robust, rigorous computational tools for tackling important biological problems. We are particularly interested in areas involving single-cell analysis, including multi-omics assay, spatial methods, and datasets from population studies.

Publications from Harvard Catalyst Profiles

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  • Shiau C, Cao J, Gong D, Gregory MT, Caldwell NJ, Yin X, Cho JW, Wang PL, Su J, Wang S, Reeves JW, Kim TK, Kim Y, Guo JA, Lester NA, Bae JW, Zhao R, Schurman N, Barth JL, Ganci ML, Weissleder R, Jacks T, Qadan M, Hong TS, Wo JY, Roberts H, Beechem JM, Castillo CF, Mino-Kenudson M, Ting DT, Hemberg M, Hwang WL. Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment. Nat Genet 2024. PubMed
  • Song Y, Parada G, Lee JTH, Hemberg M. Mining alternative splicing patterns in scRNA-seq data using scASfind. Genome Biol 2024; 25:197. PubMed
  • Cha J, Kim DH, Kim G, Cho JW, Sung E, Baek S, Hong MH, Kim CG, Sim NS, Hong HJ, Lee JE, Hemberg M, Park S, Yoon SO, Ha SJ, Koh YW, Kim HR, Lee I. Single-cell analysis reveals cellular and molecular factors counteracting HPV-positive oropharyngeal cancer immunotherapy outcomes. J Immunother Cancer 2024. PubMed
  • Cho JW, Cao J, Hemberg M. Joint analysis of mutational and transcriptional landscapes in human cancer reveals key perturbations during cancer evolution. Genome Biol 2024; 25:65. PubMed
  • Wang Y, Cho JW, Kastrunes G, Buck A, Razimbaud C, Culhane AC, Sun J, Braun DA, Choueiri TK, Wu CJ, Jones K, Nguyen QD, Zhu Z, Wei K, Zhu Q, Signoretti S, Freeman GJ, Hemberg M, Marasco WA. Immune-restoring CAR-T cells display antitumor activity and reverse immunosuppressive TME in a humanized ccRCC mouse model. iScience 2024; 27:108879. PubMed
  • Suh J, Kim H, Min J, Yeon HJ, Hemberg M, Scimeca L, Wu MR, Kang HG, Kim YJ, Kim JH. Decoupling NAD metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis. Cell Rep Med 2024; 5:101342. PubMed
  • Cha J, Yu J, Cho JW, Hemberg M, Lee I. scHumanNet: a single-cell network analysis platform for the study of cell-type specificity of disease genes. Nucleic Acids Res 2023; 51:e8. PubMed