Photo of Tina Y. Poussaint, MD

Tina Y. Poussaint, MD

Boston Children's Hospital

Boston Children's Hospital
Phone: (617) 355-6450
Fax: (617) 730-0573


Tina.Poussaint@childrens.harvard.edu

Photo of Tina Y. Poussaint, MD

Boston Children's Hospital
Phone: (617) 355-6450
Fax: (617) 730-0573


Tina.Poussaint@childrens.harvard.edu

Visualize Collaborations

Tina Y. Poussaint, MD

Boston Children's Hospital

EDUCATIONAL TITLES

  • Professor, Radiology, Harvard Medical School
  • Director, PBTC Neuroimaging Center, Neuroradiology Education and Neurooncologic Imaging, Boston Children's Hospital

HCC PROGRAM AFFILIATION

Research Abstract

1. Neuroimaging of pediatric brain and spine tumors including CT, MR, MR diffusion, MR perfusion and MR spectroscopy with attention to diagnosis, treatment, treatment effects, and followup. 2. Co-investigator: Natural history of plexiform neurofibromas using neuroimaging; U.S.Army grant. 3. PI, Neuroimaging Center, Children's Hospital Boston, Pediatric Brain Tumor Consortium

Publications from Harvard Catalyst Profiles

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  • Zapaishchykova A, Zielke J, Tak D, Climent Pardo JC, Mojahed-Yazdi R, Soto-Rivera CL, Liu KX, Saraf A, Ye Z, Wang W, Chen YH, Vajapeyam S, Mak RH, Mueller S, Nabavizadeh A, Wilson RL, Dieli-Conwright CM, Ligon KL, Haas-Kogan DA, Aerts HJWL, Poussaint TY, Benitez V, Chi SN, Kann BH. Artificial intelligence analysis of temporalis muscle thickness for monitoring sarcopenia and clinical outcomes in individuals with paediatric brain tumours: a retrospective cohort study. Lancet Digit Health 2026. PubMed
  • Tak D, Garomsa BA, Zapaishchykova A, Chaunzwa TL, Climent Pardo JC, Ye Z, Zielke J, Ravipati Y, Pai S, Vajapeyam S, Mahootiha M, Parker M, Pike LRG, Smith C, Familiar AM, Liu KX, Prabhu S, Arnaout O, Bandopadhayay P, Nabavizadeh A, Mueller S, Aerts HJ, Huang RY, Poussaint TY, Kann BH. A generalizable foundation model for analysis of human brain MRI. Nat Neurosci 2026. PubMed
  • Mandzak M, Yang E, Zapaishchykova A, Chen YH, Heilbroner L, Zielke J, Tak D, Mojahed-Yazdi R, Mussa FR, Ye Z, Vajapeyam S, Benitez V, Salloum R, Chi SN, Sotoudeh H, Seidlitz J, Mueller S, Aerts HJWL, Poussaint TY, Kann BH. TissUnet: Improved extracranial tissue and cranium segmentation for children through adulthood. Imaging Neurosci (Camb) 2026. PubMed
  • Rameh V, Aker L, Vajapeyam S, Ziaei A, Yeo KK, Alves C, Baird LC, Fehnel KP, Wright K, Chi S, Lidov HG, Alexandrescu S, Poussaint TY. An Emerging Pediatric CNS Tumor: Imaging Evaluation of and Comutated Midline Tumors. AJNR Am J Neuroradiol 2025. PubMed
  • Tak D, Garomsa BA, Zapaishchykova A, Ye Z, Vajapeyam S, Mahootiha M, Pardo JCC, Smith C, Familiar AM, Chaunzwa TL, Liu KX, Prabhu SP, Bandopadhayay P, Nabavizadeh A, Mueller S, Aerts HJWL, Haas-Kogan D, Poussaint TY, Kann BH. Longitudinal Risk Prediction for Pediatric Glioma with Temporal Deep Learning. NEJM AI 2025. PubMed
  • Rameh V, Ziaei A, Vajapeyam S, Chen N, London WB, Wright K, Poussaint TY. Post-radiation MR imaging features in Molecular and Mutational Analyses in Pontine Pediatric Diffuse Midline Gliomas. AJNR Am J Neuroradiol 2025. PubMed
  • Climent Pardo JC, Zapaishchykova A, Boyd A, Tak D, Zielke J, Mahootiha M, Ye Z, Vajapeyam S, Jones J, Smith C, Familiar AM, Nabavizadeh A, Bandopadhayay P, Mueller S, Aerts HJWL, Haas-Kogan DA, Michor F, Ligon KL, Poussaint TY, Faghihroohi S, Kann BH. Deep learning volumetrics reveal distinct clinical trajectories for pediatric low-grade gliomas under surveillance: A multicenter study. 2025; 7:vdaf145. PubMed
  • Mahootiha M, Tak D, Ye Z, Zapaishchykova A, Likitlersuang J, Climent Pardo JC, Boyd A, Vajapeyam S, Chopra R, Prabhu SP, Liu KX, Elhalawani H, Nabavizadeh A, Familiar A, Mueller S, Aerts HJWL, Bandopadhayay P, Ligon KL, Haas-Kogan D, Poussaint TY, Qadir HA, Balasingham I, Kann BH. Multimodal Deep Learning Improves Recurrence Risk Prediction in Pediatric Low-Grade Gliomas. 2024. PubMed
  • Rameh V, Löbel U, D'Arco F, Bhatia A, Mankad K, Poussaint TY, Alves CA. Cortically-based Brain Tumors in Children: A Decision-tree Approach in the Radiology Reading Room. AJNR Am J Neuroradiol 2024. PubMed
  • Zapaishchykova A, Liu KX, Saraf A, Ye Z, Catalano PJ, Benitez V, Ravipati Y, Jain A, Huang J, Hayat H, Likitlersuang J, Vajapeyam S, Chopra RB, Familiar AM, Nabavidazeh A, Mak RH, Resnick AC, Mueller S, Cooney TM, Haas-Kogan DA, Poussaint TY, Aerts HJWL, Kann BH. Automated temporalis muscle quantification and growth charts for children through adulthood. Nat Commun 2023; 14:6863. PubMed
  • Bhatia A, Sabin ND, Fisher MJ, Poussaint TY. Review of imaging recommendations from Response Assessment in Pediatric Neuro-Oncology (RAPNO). Pediatr Radiol 2023. PubMed
  • Snyder EJ, Sarma A, Poussaint TY, Krishnasarma R, Pruthi S. Complications of Cancer Therapy in Children: A Comprehensive Review of Neuroimaging Findings. J Comput Assist Tomogr 2023. PubMed
  • Shankar LK, Schöder H, Sharon E, Wolchok J, Knopp MV, Wahl RL, Ellingson BM, Hall NC, Yaffe MJ, Towbin AJ, Farwell MD, Pryma D, Poussaint TY, Wright CL, Schwartz L, Harisinghani M, Mahmood U, Wu AM, Leung D, de Vries EGE, Tang Y, Beach G, Reeves SA. Harnessing imaging tools to guide immunotherapy trials: summary from the National Cancer Institute Cancer Imaging Steering Committee workshop. Lancet Oncol. 2023; 24:e133-e143. PubMed
  • Rogers SN, Udayasankar U, Pruthi S, Lai HA, Kadom N, Guerin J, Malinzak M, Shulkin BL, Poussaint TY, Patay Z, Bag AK. Imaging of pediatric spine and spinal cord tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee/ASPNR White Paper. Pediatr Blood Cancer 2022. PubMed
  • Jaju A, Li Y, Dahmoush H, Gottardo NG, Laughlin S, Mirsky D, Panigrahy A, Sabin ND, Shaw D, Storm PB, Poussaint TY, Patay Z, Bhatia A. Imaging of pediatric brain tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee/ASPNR White Paper. Pediatr Blood Cancer 2022. PubMed
  • Lindsay HB, Massimino M, Avula S, Stivaros S, Grundy R, Metrock K, Bhatia A, Fernández-Teijeiro A, Chiapparini L, Bennett J, Wright K, Hoffman LM, Smith A, Pajtler KW, Poussaint TY, Warren KE, Foreman NK, Mirsky DM. Response assessment in paediatric intracranial ependymoma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Lancet Oncol. 2022; 23:e393-e401. PubMed
  • Peng J, Kim DD, Patel JB, Zeng X, Huang J, Chang K, Xun X, Zhang C, Sollee J, Wu J, Dalal DJ, Feng X, Zhou H, Zhu C, Zou B, Jin K, Wen PY, Boxerman JL, Warren KE, Poussaint TY, States LJ, Kalpathy-Cramer J, Yang L, Huang RY, Bai HX. Deep Learning-Based Automatic Tumor Burden Assessment of Pediatric High-Grade Gliomas, Medulloblastomas, and Other Leptomeningeal Seeding Tumors. 2021. PubMed
  • Erker C, Tamrazi B, Poussaint TY, Mueller S, Mata-Mbemba D, Franceschi E, Brandes AA, Rao A, Haworth KB, Wen PY, Goldman S, Vezina G, MacDonald TJ, Dunkel IJ, Morgan PS, Jaspan T, Prados MD, Warren KE. Response assessment in paediatric high-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Lancet Oncol. 2020; 21:e317-e329. PubMed
  • Goldman S, Pollack IF, Jakacki RI, Billups CA, Poussaint TY, Adesina AM, Panigrahy A, Parsons DW, Broniscer A, Robinson GW, Robison NJ, Partap S, Kilburn LB, Onar-Thomas A, Dunkel IJ, Fouladi M. Phase II study of peginterferon alpha-2b for patients with unresectable or recurrent craniopharyngiomas: a Pediatric Brain Tumor Consortium report. 2020. PubMed
  • Devine CA, Liu KX, Ioakeim-Ioannidou M, Susko M, Poussaint TY, Huisman TAGM, Aboian M, Brown D, Zaslowe-Dude C, Rao AD, Orlina LT, Rawal B, Mueller S, Marcus KJ, Terezakis SA, Braunstein SE, Haas-Kogan DA. Brainstem injury in pediatric patients receiving posterior fossa photon radiation. Int J Radiat Oncol Biol Phys 2019. PubMed
  • Warren KE, Vezina G, Poussaint TY, Warmuth-Metz M, Chamberlain MC, Packer RJ, Brandes AA, Reiss M, Goldman S, Fisher MJ, Pollack IF, Prados MD, Wen PY, Chang SM, Dufour C, Zurakowski D, Kortmann RD, Kieran MW. Response Assessment in Medulloblastoma and Leptomeningeal Seeding Tumors: Recommendations from the Response Assessment in Pediatric Neuro-Oncology Committee. 2017. PubMed
  • Zukotynski K, Vajapeyam S, Fahey FH, Kocak M, Brown D, Ricci K, Onar-Thomas A, Fouladi M, Poussaint TY. Correlation of (18)F-FDG PET and MR Apparent Diffusion Coefficient (ADC) Histogram Metrics with Survival in Diffuse Intrinsic Pontine Glioma: A Report from the Pediatric Brain Tumor Consortium. J Nucl Med 2017. PubMed
  • Salloum R, Hummel TR, Kumar SS, Dorris K, Li S, Lin T, Daryani VM, Stewart CF, Miles L, Poussaint TY, Stevenson C, Goldman S, Dhall G, Packer R, Fisher P, Pollack IF, Fouladi M, Boyett J, Drissi R. A molecular biology and phase II study of imetelstat (GRN163L) in children with recurrent or refractory central nervous system malignancies: a pediatric brain tumor consortium study. J. Neurooncol. 2016. PubMed
  • Poussaint TY, Vajapeyam S, Ricci KI, Panigrahy A, Kocak M, Kun LE, Boyett JM, Pollack IF, Fouladi M. Apparent diffusion coefficient histogram metrics correlate with survival in diffuse intrinsic pontine glioma: a report from the Pediatric Brain Tumor Consortium. 2016; 18:725-34. PubMed
  • Poussaint TY, Panigrahy A, Huisman TA. Pediatric brain tumors. Pediatr Radiol 2015; 45 Suppl 3:S443-53. PubMed
  • Mulkern RV, Ricci KI, Vajapeyam S, Chenevert TL, Malyarenko DI, Kocak M, Poussaint TY. Pediatric brain tumor consortium multisite assessment of apparent diffusion coefficient z-axis variation assessed with an ice-water phantom. Acad Radiol 2015; 22:363-9. PubMed
  • Zukotynski K, Fahey F, Kocak M, Kun L, Boyett J, Fouladi M, Vajapeyam S, Treves T, Poussaint TY. 18F-FDG PET and MR imaging associations across a spectrum of pediatric brain tumors: a report from the pediatric brain tumor consortium. J Nucl Med 2014; 55:1473-80. PubMed
  • Dombi E, Ardern-Holmes SL, Babovic-Vuksanovic D, Barker FG, Connor S, Evans DG, Fisher MJ, Goutagny S, Harris GJ, Jaramillo D, Karajannis MA, Korf BR, Mautner V, Plotkin SR, Poussaint TY, Robertson K, Shih CS, Widemann BC, . Recommendations for imaging tumor response in neurofibromatosis clinical trials. Neurology 2013; 81:S33-40. PubMed
  • Warren KE, Poussaint TY, Vezina G, Hargrave D, Packer RJ, Goldman S, Wen PY, Pollack IF, Zurakowski D, Kun LE, Prados MD, Rutkowski S, Kieran MW. Challenges with defining response to antitumor agents in pediatric neuro-oncology: a report from the response assessment in pediatric neuro-oncology (RAPNO) working group. Pediatr Blood Cancer 2013. PubMed
  • Zukotynski KA, Fahey FH, Vajapeyam S, Ng SS, Kocak M, Gururangan S, Kun LE, Poussaint TY. Exploratory evaluation of MR permeability with 18F-FDG PET mapping in pediatric brain tumors: a report from the Pediatric Brain Tumor Consortium. J Nucl Med 2013; 54:1237-43. PubMed
  • Gururangan S, Fangusaro J, Young Poussaint T, Onar-Thomas A, Gilbertson RJ, Vajapeyam S, Gajjar A, Goldman S, Friedman HS, Packer RJ, Boyett JM, Kun LE, McLendon R. Lack of efficacy of bevacizumab + irinotecan in cases of pediatric recurrent ependymoma--a Pediatric Brain Tumor Consortium study. 2012; 14:1404-12. PubMed
  • Prabhu SP, Ng S, Vajapeyam S, Kieran MW, Pollack IF, Geyer R, Haas-Kogan D, Boyett JM, Kun L, Poussaint TY. DTI assessment of the brainstem white matter tracts in pediatric BSG before and after therapy: a report from the Pediatric Brain Tumor Consortium. 2011; 27:11-8. PubMed
  • Fahey FH, Kinahan PE, Doot RK, Kocak M, Thurston H, Poussaint TY. Variability in PET quantitation within a multicenter consortium. Med Phys 2010; 37:3660-6. PubMed
  • Kieran MW,Supko JG,Wallace D,Fruscio R,Poussaint TY,Phillips P,Pollack I,Packer R,Boyett JM,Blaney S,Banerjee A,Geyer R,Friedman H,Goldman S,Kun LE,Macdonald T. Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors. Pediatr Blood Cancer 2009; 52:169-76. PubMed
  • Mulkern RV,Forbes P,Dewey K,Osganian S,Clark M,Wong S,Ramamurthy U,Kun L,Poussaint TY. Establishment and results of a magnetic resonance quality assurance program for the pediatric brain tumor consortium. Acad Radiol 2008; 15:1099-110. PubMed
  • Williams G, Fahey FH, Treves ST, Kocak M, Pollack IF, Boyett JM, Kun LE, Poussaint TY. Exploratory evaluation of two-dimensional and three-dimensional methods of FDG PET quantification in pediatric anaplastic astrocytoma: a report from the Pediatric Brain Tumor Consortium (PBTC). Eur J Nucl Med Mol Imaging 2008; 35:1651-8. PubMed
  • Haas-Kogan DA, Banerjee A, Kocak M, Prados MD, Geyer JR, Fouladi M, McKnight T, Poussaint TY, Broniscer A, Blaney SM, Boyett JM, Kun LE. Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma. Neuro-oncol 2008; 10:341-7. PubMed
  • MacDonald TJ, Stewart CF, Kocak M, Goldman S, Ellenbogen RG, Phillips P, Lafond D, Poussaint TY, Kieran MW, Boyett JM, Kun LE. Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012. J Clin Oncol 2008; 26:919-24. PubMed
  • Gururangan S, Turner CD, Stewart CF, O'Shaughnessy M, Kocak M, Poussaint TY, Phillips PC, Goldman S, Packer R, Pollack IF, Blaney SM, Karsten V, Gerson SL, Boyett JM, Friedman HS, Kun LE. Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors: a pediatric brain tumor consortium study. Clin Cancer Res 2008; 14:1124-30. PubMed
  • Broniscer A, Gururangan S, MacDonald TJ, Goldman S, Packer RJ, Stewart CF, Wallace D, Danks MK, Friedman HS, Poussaint TY, Kun LE, Boyett JM, Gajjar A. Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report. Clin Cancer Res 2007; 13:6712-8. PubMed
  • Liu AK, Marcus KJ, Fischl B, Grant PE, Young Poussaint T, Rivkin MJ, Davis P, Tarbell NJ, Yock TI. Changes in cerebral cortex of children treated for medulloblastoma. Int J Radiat Oncol Biol Phys 2007; 68:992-8. PubMed
  • Poussaint TY, Phillips PC, Vajapeyam S, Fahey FH, Robertson RL, Osganian S, Ramamurthy U, Mulkern RV, Treves ST, Boyett JM, Kun LE. The Neuroimaging Center of the Pediatric Brain Tumor Consortium-collaborative neuroimaging in pediatric brain tumor research: a work in progress. AJNR Am J Neuroradiol 2007; 28:603-7. PubMed
  • Pollack IF, Jakacki RI, Blaney SM, Hancock ML, Kieran MW, Phillips P, Kun LE, Friedman H, Packer R, Banerjee A, Geyer JR, Goldman S, Poussaint TY, Krasin MJ, Wang Y, Hayes M, Murgo A, Weiner S, Boyett JM. Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: a Pediatric Brain Tumor Consortium report. Neuro-oncol 2007; 9:145-60. PubMed
  • Marcus KJ, Astrakas LG, Zurakowski D, Zarifi MK, Mintzopoulos D, Poussaint TY, Anthony DC, De Girolami U, Black PM, Tarbell NJ, Tzika AA. Predicting survival of children with CNS tumors using proton magnetic resonance spectroscopic imaging biomarkers. Int J Oncol 2007; 30:651-7. PubMed
  • Turner CD, Chi S, Marcus KJ, MacDonald T, Packer RJ, Poussaint TY, Vajapeyam S, Ullrich N, Goumnerova LC, Scott RM, Briody C, Chordas C, Zimmerman MA, Kieran MW. Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme. J Neurooncol 2007; 82:95-101. PubMed
  • Fouladi M, Blaney SM, Poussaint TY, Freeman BB, McLendon R, Fuller C, Adesina AM, Hancock ML, Danks MK, Stewart C, Boyett JM, Gajjar A. Phase II study of oxaliplatin in children with recurrent or refractory medulloblastoma, supratentorial primitive neuroectodermal tumors, and atypical teratoid rhabdoid tumors: a pediatric brain tumor consortium study. Cancer 2006; 107:2291-7. PubMed
  • Gururangan S, Petros WP, Poussaint TY, Hancock ML, Phillips PC, Friedman HS, Bomgaars L, Blaney SM, Kun LE, Boyett JM. Phase I trial of intrathecal spartaject busulfan in children with neoplastic meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004). Clin Cancer Res 2006; 12:1540-6. PubMed
  • Anselm IM, Alkuraya FS, Salomons GS, Jakobs C, Fulton AB, Mazumdar M, Rivkin M, Frye R, Poussaint TY, Marsden D. X-linked creatine transporter defect: a report on two unrelated boys with a severe clinical phenotype. J Inherit Metab Dis 2006; 29:214-9. PubMed
  • Poussaint TY, Rodriguez D. Advanced neuroimaging of pediatric brain tumors: MR diffusion, MR perfusion, and MR spectroscopy. Neuroimaging Clin N Am 2006; 16:169-92, ix. PubMed
  • Heath JA, Turner CD, Poussaint TY, Scott RM, Goumnerova L, Kieran MW. Chemotherapy for progressive low-grade gliomas in children older than ten years: the Dana-Farber experience. Pediatr Hematol Oncol 2003; 20:497-504. PubMed
  • Snyder EJ, Sarma A, Poussaint TY, Krishnasarma R, Pruthi S. Complications of Cancer Therapy in Children: A Comprehensive Review of Neuroimaging Findings. J Comput Assist Tomogr ; 47:820-832. PubMed
  • Saad A, Folkerth R, Poussaint T, Smith E, Ligon K. Meningioangiomatosis associated with meningioma: a case report. Acta Cytol ; 53:93-7. PubMed
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