Research Abstract
1) FGFR1 Oncogenic Mechanisms in Breast Cancer
2) Characterization the fusion oncogene ZNF198/FGFR1 in stem-cell lymphoma/leukemia syndrome
3) tumor induced hypoglycemia
Sheng Xiao, MD
Brigham And Women's Hospital
Brigham And Women's Hospital
Phone: (617) 732-6528
Fax: (617) 264-6301
Sheng Xiao, MD
Brigham And Women's Hospital
EDUCATIONAL TITLES
HCC PROGRAM AFFILIATION
Publications from Harvard Catalyst Profiles
- Chen N, Feng J, Wan D, Li D, Xiao S. Enhanced Detection of EGFRvIII in Tumors: A Comparative Study of Split Read and Read Depth-Based DNA Sequencing Approaches. J Mol Diagn 2025. PubMed
- Wei H, Liu D, Li Y, Shi H, Xiao S, Han A. A pediatric low-grade sinonasal mesenchymal tumor harboring a novel CHD9::BEND2 fusion. Virchows Arch 2025. PubMed
- Zheng J, Wang Y, Li Z, Xiao P, Lu J, Liu H, Hu Y, Wu S, Li B, Gao L, Ji Q, He H, Wang Y, Li J, Chen N, Meng L, Tian Y, Li Y, Xiao S, Hu S. Frequent TCR rearrangements in pediatric B-cell lymphoblastic acute leukemia: genomic and phenotypic features. Ann. Hematol. 2025. PubMed
- Zhang H, Liu L, Zhang X, Chen P, Lang X, Feng J, Wang Y, Xie Y, Wang S, Xiao S, Li B. Circulating tumor DNA from blood and cerebrospinal fluid in DLBCL: simultaneous evaluation of mutations, IG rearrangement, and IG clonality. Br J Cancer 2025. PubMed
- Zhang D, Zhao M, Jiang P, Zhou Y, Yan X, Zhou C, Mu Y, Xiao S, Ji G, Wu N, Sun D, Cui X, Ning S, Meng H, Xiao S, Jin Y. RPL22L1 fosters malignant features of cervical cancer via the modulation of DUSP6-ERK axis. J Transl Med 2025; 23:244. PubMed
- Li Y, Zhan T, Chen T, Zhong Q, Xiao S, Wang A, Jiao Y. RPL41 inhibits the proliferation and migration of retinoblastoma through the ARL5B-associated lysosomal trafficking. 2025; 16:1704080. PubMed
- Zhang C, Lang X, Liu L, Chen N, Chen H, Chen X, Chen Y, Jin L, Liu C, Wang H, Fu A, Xiao S. A AML with a simultaneous false positive rearrangement: FISH interpretation pitfalls. Hematology 2024; 29:2420306. PubMed
- Mi X, Duan Y, Sun J, Tai Q, Yao H, Meng L, Yang X, Shi X, Shi B, Chen J, Sun L, Zhou D, Xiao S, Yao Y, He S. The ketogenic diet modulates tumor-associated neutrophil polarization via the AMOT-YAP/TAZ axis to inhibit colorectal cancer progression. Pharmacol. Res. 2024; 210:107494. PubMed
- Zhou S, Abdihamid O, Tan F, Zhou H, Liu H, Li Z, Xiao S, Li B. KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST. Cell Commun. Signal 2024; 22:153. PubMed
- Zhang L, Yang X, Ge X, Li B, Zhang H, Li J, Liu L, Chen X, Hu W, Sun Y, Xiao S. CMSS1::FLT1 rearrangement leads to ligand-independent activation of FLT1 signaling in acute myeloid leukemia. Am J Hematol 2023; 98:E380-E382. PubMed
- Zhou S, Zhang C, Zhang Z, Hu Y, Zhao L, Hu W, Chen S, Li B, Xiao S. A novel HMGA2::KITLG fusion in a dedifferentiated liposarcoma with amplification of MDM2 and HMGA2. Genes Chromosomes Cancer 2023. PubMed
- Wu X, Chen S, Chen P, Zhang H, Zhang L, Wang P, Li B, Rong R, Wang Y, Lang X, Wang K, Zhang X, Xiao S. rearrangement in diffuse large B cell lymphoma and its therapeutic implication. EJHaem 2023; 4:442-445. PubMed
- Xiao P, Chen N, Shao T, Bian X, Miao J, Zheng J, Lang X, Wang Y, Chen X, Jin L, Hu S, Xiao S. Intragenic β-synuclein rearrangements in malignancy. 2023; 13:1167143. PubMed
- Liu X, Dai X, Dai C, Zhu Q, Chen A, Chen Y, Chen N, Chen P, Rong R, Shi C, Xiao S, Dong J. Rare adult pilocytic astrocytoma of the septum pellucidum with novel RIN2::BRAF fusion. Virchows Arch 2022. PubMed
- Cao M, Nawalaniec K, Ajay AK, Luo Y, Moench R, Jin Y, Xiao S, Hsiao LL, Waaga-Gasser AM. PDE4D targeting enhances anti-tumor effects of sorafenib in clear cell renal cell carcinoma and attenuates MAPK/ERK signaling in a CRAF-dependent manner. Transl Oncol 2022; 19:101377. PubMed
- Chen Y, Zhou S, Zhou X, Dai X, Wang L, Chen P, Zhao S, Shi C, Xiao S, Dong J. Gliosarcoma with osteosarcomatous component: A case report and short review illustration. Pathol Res Pract 2022; 232:153837. PubMed
- Xiao P, Chen P, Lang X, An Q, Yang C, Chen S, Wang K, Chen N, Hao Y, Ding J, Li Z, Hu S, Xiao S. Ovarian germ cell tumor/mastocytosis with KIT mutation: A unique clinicopathological entity. Genes Chromosomes Cancer 2022; 61:50-54. PubMed
- Jiang F, Lang X, Chen N, Jin L, Liu L, Wei X, Pan J, Yu F, Blake A, Xiao S. A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid leukemia. Genes Chromosomes Cancer 2022; 61:503-508. PubMed
- Dixon KO, Tabaka M, Schramm MA, Xiao S, Tang R, Dionne D, Anderson AC, Rozenblatt-Rosen O, Regev A, Kuchroo VK. TIM-3 restrains anti-tumour immunity by regulating inflammasome activation. Nature 2021. PubMed
- Pitel BA, Sharma N, Zepeda-Mendoza C, Smadbeck JB, Pearce KE, Cook JM, Vasmatzis G, Sachs Z, Kanagal-Shamanna R, Viswanatha D, Xiao S, Jenkins RB, Xu X, Hoppman NL, Ketterling RP, Peterson JF, Greipp PT, Baughn LB. Myeloid malignancies with 5q and 7q deletions are associated with extreme genomic complexity, biallelic TP53 variants, and very poor prognosis. Blood Cancer J 2021; 11:18. PubMed
- Wu J, Hu Y, Abdihamid O, Huang G, Xiao S, Li B. Crizotinib in Sarcomatous Malignancies Harboring ALK Fusion With a Definitive Partner(s): Response and Efficacy. 2021; 11:684865. PubMed
- Li Z, Chu X, Gao L, Ling J, Xiao P, Lu J, Wang Y, He H, Li J, Hu Y, Li J, Pan J, Xiao S, Hu S. High Expression of Interleukin-3 Receptor Alpha Chain (CD123) Predicts Favorable Outcome in Pediatric B-Cell Acute Lymphoblastic Leukemia Lacking Prognosis-Defining Genomic Aberrations. 2021; 11:614420. PubMed
- Zhou X, Yang C, Zou Z, Lang X, Chen P, Chen S, Wang K, Chen Y, Hao Y, Chen N, Ding J, Li Y, Shen Y, Xiao S. ZBTB44-FLT3 fusion in a patient with a myeloproliferative neoplasm. British Journal of Haematology 2020. PubMed
- Geng W, Ren J, Shi H, Qin F, Xu X, Xiao S, Jiao Y, Wang A. RPL41 sensitizes retinoblastoma cells to chemotherapeutic drugs via ATF4 degradation. J Cell Physiol 2020. PubMed
- Xiao S, Bod L, Pochet N, Kota SB, Hu D, Madi A, Kilpatrick J, Shi J, Ho A, Zhang H, Sobel R, Weiner HL, Strom TB, Quintana FJ, Joller N, Kuchroo VK. Checkpoint Receptor TIGIT Expressed on Tim-1 B Cells Regulates Tissue Inflammation. Cell Rep 2020; 32:107892. PubMed
- Xiao AW, Jia Y, Baughn LB, Pearce KE, Pitel BA, Aster JC, Dal Cin P, Xiao S. IGH rearrangement in myeloid neoplasms. Haematologica 2020. PubMed
- Yang RY, Yang CX, Lang XP, Duan LJ, Wang RJ, Zhou W, Wu GS, Li Y, Qian T, Xiao S, Fu L. Identification of a novel RUNX1-TACC1 fusion transcript in acute myeloid leukaemia. British Journal of Haematology 2020. PubMed
- Dai HP, Yin J, Li Z, Yang CX, Cao T, Chen P, Zong YH, Zhu MQ, Zhu XM, Xiao S, Wu DP, Tang XW. Rapid Molecular Response to Dasatinib in a Pediatric Relapsed Acute Lymphoblastic Leukemia With Fusion. 2020; 10:359. PubMed
- Lang XP, Pan J, Yang CX, Chen P, Shi CC, Hong Y, Wang J, Xiao S. A renal cell carcinoma with EWSR1-TFE3 fusion gene. Genes Chromosomes Cancer 2019. PubMed
- Hafeez F, Xiao S, Dal Cin P, Krane JF, Chen P, Hayek J, Lian CL. Polymorphous sweat gland carcinoma found to have MYB gene rearrangement. Histopathology 2019. PubMed
- Wang X, Huang X, Pang H, Xiao S, Gu H, Zhang H, Wang B, Zhang L, Yan X. Myeloid/Lymphoid Neoplasm With FGFR1 Rearrangement Accompanying and Gene Mutations. 2019; 9:1304. PubMed
- Cao M, Carrasco RD, Dubuc AM, Dal Cin P, Fletcher JA, Xiao S. ZMYM2-FGFR1 fusion as secondary change in acute myeloid leukemia. Leuk Lymphoma 2018. PubMed
- Wu C, Chen Z, Xiao S, Thalhamer T, Madi A, Han T, Kuchroo V. SGK1 Governs the Reciprocal Development of Th17 and Regulatory T Cells. Cell Rep 2018; 22:653-665. PubMed
- Wu N, Ren D, Li S, Ma W, Hu S, Jin Y, Xiao S. RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation. BMC Cancer 2018; 18:67. PubMed
- Wang L, Fan J, Francis JM, Georghiou G, Hergert S, Li S, Gambe R, Zhou CW, Yang C, Xiao S, Cin PD, Bowden M, Kotliar D, Shukla SA, Brown JR, Neuberg D, Alessi DR, Zhang CZ, Kharchenko PV, Livak KJ, Wu CJ. Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia. Genome Res 2017. PubMed
- Pang B, Wu N, Guan R, Pang L, Li X, Li S, Tang L, Guo Y, Chen J, Sun D, Sun H, Dai J, Bai J, Ji G, Liu P, Liu A, Wang Q, Xiao S, Fu S, Jin Y. Overexpression of RCC2 Enhances Cell Motility and Promotes Tumor Metastasis in Lung Adenocarcinoma by Inducing Epithelial-Mesenchymal Transition. Clin Cancer Res 2017. PubMed
- Wu C, Chen Z, Dardalhon V, Xiao S, Thalhamer T, Liao M, Madi A, Franca RF, Han T, Oukka M, Kuchroo V. The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program. Nat Immunol 2017. PubMed
- Meyer Zu Horste G, Wu C, Wang C, Cong L, Pawlak M, Lee Y, Elyaman W, Xiao S, Regev A, Kuchroo VK. RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression. Cell Rep 2016. PubMed
- Giersch AB, Bieber FR, Dubuc AM, Fletcher JA, Ligon AH, Mason-Suares H, Morton CC, Weremowicz S, Xiao S, Dal Cin P. Reporting of Diagnostic Cytogenetic Results. Curr Protoc Hum Genet 2016; 89:A.1D.1-A.1D.23. PubMed
- Wang C, Yosef N, Gaublomme J, Wu C, Lee Y, Clish CB, Kaminski J, Xiao S, Meyer Zu Horste G, Pawlak M, Kishi Y, Joller N, Karwacz K, Zhu C, Ordovas-Montanes M, Madi A, Wortman I, Miyazaki T, Sobel RA, Park H, Regev A, Kuchroo VK. CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity. Cell 2015; 163:1413-27. PubMed
- Wong WJ, Lauria A, Hornick JL, Xiao S, Fletcher JA, Marino-Enriquez A. Alternate PAX3-FOXO1 oncogenic fusion in biphenotypic sinonasal sarcoma. Genes Chromosomes Cancer 2015. PubMed
- Xiao S, Brooks CR, Sobel RA, Kuchroo VK. Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation. J Immunol 2015; 194:1602-8. PubMed
- Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK. An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nat Commun 2015; 6:6072. PubMed
- Wu C, Thalhamer T, Franca RF, Xiao S, Wang C, Hotta C, Zhu C, Hirashima M, Anderson AC, Kuchroo VK. Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity 2014; 41:270-82. PubMed
- Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest 2014; 124:2513-22. PubMed
- Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity 2014; 40:477-89. PubMed
- Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity 2014; 40:569-81. PubMed
- Angiari S, Donnarumma T, Rossi B, Dusi S, Pietronigro E, Zenaro E, Della Bianca V, Toffali L, Piacentino G, Budui S, Rennert P, Xiao S, Laudanna C, Casasnovas JM, Kuchroo VK, Constantin G. TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity 2014; 40:542-53. PubMed
- Zhu B, Buttrick T, Bassil R, Zhu C, Olah M, Wu C, Xiao S, Orent W, Elyaman W, Khoury SJ. IL-4 and retinoic acid synergistically induce regulatory dendritic cells expressing Aldh1a2. J Immunol 2013; 191:3139-51. PubMed
- Humphreys BD, Xu F, Sabbisetti V, Grgic I, Movahedi Naini S, Wang N, Chen G, Xiao S, Patel D, Henderson JM, Ichimura T, Mou S, Soeung S, McMahon AP, Kuchroo VK, Bonventre JV. Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest 2013; 123:4023-35. PubMed
- Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, Murugaiyan G, Xiao S, Lee Y, Rangachari M, Yosef N, Kuchroo VK. Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Proc Natl Acad Sci U S A 2013; 110:7802-7. PubMed
- Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regev A, Kuchroo VK. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 2013. PubMed
- Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev A. Dynamic regulatory network controlling TH17 cell differentiation. Nature 2013. PubMed
- Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic TH17 cells. Nat Immunol 2012; 13:991-9. PubMed
- Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, Kuchroo VK. Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion. Nat Med 2012; 18:1394-400. PubMed
- Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK. Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol 2012; 13:770-7. PubMed
- Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med 2012. PubMed
- Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proc Natl Acad Sci U S A 2012; 109:12105-10. PubMed
- Xiao S, Zhu B, Jin H, Zhu C, Umetsu DT, DeKruyff RH, Kuchroo VK. Tim-1 stimulation of dendritic cells regulates the balance between effector and regulatory T cells. Eur J Immunol 2011. PubMed
- Wu X, Gao H, Ke W, Hager M, Xiao S, Freeman MR, Zhu Z. VentX trans-activates p53 and p16ink4a to regulate cellular senescence. J Biol Chem 2011. PubMed
- Ligon AH, Morton CC, Bieber FR, Fletcher JA, Giersch AB, Kantarci S, Leach N, Lee C, Sandstrom M, Weremowicz S, Xiao S, Dal Cin P. Reporting of diagnostic cytogenetic results. Curr Protoc Hum Genet 2010; Appendix 1:1D.1-23. PubMed
- Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, Kumar D, Burns EJ, Sherr DH, Weiner HL, Kuchroo VK. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol 2010; 11:854-61. PubMed
- Rodriguez-Manzanet R, Sanjuan MA, Wu HY, Quintana FJ, Xiao S, Anderson AC, Weiner HL, Green DR, Kuchroo VK. T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A 2010; 107:8706-11. PubMed
- Li Y, Chang Q, Rubin BP, Fletcher CD, Morgan TW, Mentzer SJ, Sugarbaker DJ, Fletcher JA, Xiao S. Insulin receptor activation in solitary fibrous tumours. J Pathol 2007; 211:550-4. PubMed