Photo of Xihong Lin,  PhD

Xihong Lin, PhD

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-2914
Fax: (617) 432-5619

Xihong Lin, PhD

Harvard T.H. Chan School Of Public Health


  • Henry Pickering Walcott Professor of Biostatistics, Biostatistics, Harvard T.H. Chan School Of Public Health



  • Member, Center Scientific Council

Research Abstract

My research interests lie in developing and applying statistical and computational methods to analysis of correlated data and high throughput omics data. I am interested in observational studies such as case-control and longitudinal and cohort studies. My current interests center around analysis of high-dimensional genomic and omics data especially in population-based studies, such as genome-wide association studies and sequencing data, epigenetics, biomaker discovery, and genes and environment, especially in cancer epidemiology and cancer prevention and intervention studies.

Publications from Harvard Catalyst Profiles

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  • Wang X, Ricciuti B, Alessi JV, Nguyen T, Awad MM, Lin X, Johnson BE, Christiani DC. Smoking History as a Potential Predictor of Immune Checkpoint Inhibitor Efficacy in Metastatic Non-Small Cell Lung Cancer. Journal of the National Cancer Institute 2021. PubMed
  • Wang X, Ricciuti B, Nguyen T, Li X, Rabin MS, Awad MM, Lin X, Johnson BE, Christiani DC. Association between Smoking History and Tumor Mutation Burden in Advanced Non-Small Cell Lung Cancer. Cancer Res 2021; 81:2566-2573. PubMed
  • Naseri A, Shi J, Lin X, Zhang S, Zhi D. RAFFI: Accurate and fast familial relationship inference in large scale biobank studies using RaPID. PLoS Genet. 2021; 17:e1009315. PubMed
  • Sun R, Xu M, Li X, Gaynor S, Zhou H, Li Z, Bossé Y, Lam S, Tsao MS, Tardon A, Chen C, Doherty J, Goodman G, Bojesen SE, Landi MT, Johansson M, Field JK, Bickeböller H, Wichmann HE, Risch A, Rennert G, Arnold S, Wu X, Melander O, Brunnström H, Le Marchand L, Liu G, Andrew A, Duell E, Kiemeney LA, Shen H, Haugen A, Johansson M, Grankvist K, Caporaso N, Woll P, Dawn Teare M, Scelo G, Hong YC, Yuan JM, Lazarus P, Schabath MB, Aldrich MC, Albanes D, Mak R, Barbie D, Brennan P, Hung RJ, Amos CI, Christiani DC, Lin X. Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer. Genet Epidemiol 2020. PubMed
  • Li X, Li Z, Zhou H, Gaynor SM, Liu Y, Chen H, Sun R, Dey R, Arnett DK, Aslibekyan S, Ballantyne CM, Bielak LF, Blangero J, Boerwinkle E, Bowden DW, Broome JG, Conomos MP, Correa A, Cupples LA, Curran JE, Freedman BI, Guo X, Hindy G, Irvin MR, Kardia SLR, Kathiresan S, Khan AT, Kooperberg CL, Laurie CC, Liu XS, Mahaney MC, Manichaikul AW, Martin LW, Mathias RA, McGarvey ST, Mitchell BD, Montasser ME, Moore JE, Morrison AC, O'Connell JR, Palmer ND, Pampana A, Peralta JM, Peyser PA, Psaty BM, Redline S, Rice KM, Rich SS, Smith JA, Tiwari HK, Tsai MY, Vasan RS, Wang FF, Weeks DE, Weng Z, Wilson JG, Yanek LR, , , Neale BM, Sunyaev SR, Abecasis GR, Rotter JI, Willer CJ, Peloso GM, Natarajan P, Lin X. Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. Nat Genet 2020; 52:969-983. PubMed
  • Wang Z, Du M, Yuan Q, Guo Y, Hutchinson JN, Su L, Zheng Y, Wang J, Mucci LA, Lin X, Hou L, Christiani DC. Epigenomic analysis of 5-hydroxymethylcytosine (5hmC) reveals novel DNA methylation markers for lung cancers. Neoplasia 2020; 22:154-161. PubMed
  • Sun R, Lin X. Genetic Variant Set-Based Tests Using the Generalized Berk-Jones Statistic with Application to a Genome-Wide Association Study of Breast Cancer. Journal of the American Statistical Association 2020; 115:1079-1091. PubMed
  • McCaw ZR, Lane JM, Saxena R, Redline S, Lin X. Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies. Biometrics 2019. PubMed
  • Fagny M, Platig J, Kuijjer ML, Lin X, Quackenbush J. Nongenic cancer-risk SNPs affect oncogenes, tumour-suppressor genes, and immune function. Br J Cancer 2019. PubMed
  • Xu M, Yao Y, Chen H, Zhang S, Cao SM, Zhang Z, Luo B, Liu Z, Li Z, Xiang T, He G, Feng QS, Chen LZ, Guo X, Jia WH, Chen MY, Zhang X, Xie SH, Peng R, Chang ET, Pedergnana V, Feng L, Bei JX, Xu RH, Zeng MS, Ye W, Adami HO, Lin X, Zhai W, Zeng YX, Liu J. Genome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma. Nat Genet 2019; 51:1131-1136. PubMed
  • Gaynor SM, Sun R, Lin X, Quackenbush J. Identification of differentially expressed gene sets using the Generalized Berk-Jones statistica. Bioinformatics 2019. PubMed
  • Li Z, Li X, Liu Y, Shen J, Chen H, Zhou H, Morrison AC, Boerwinkle E, Lin X. Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies. Am J Hum Genet 2019; 104:802-814. PubMed
  • Liu Y, Chen S, Li Z, Morrison AC, Boerwinkle E, Lin X. ACAT: A Fast and Powerful p Value Combination Method for Rare-Variant Analysis in Sequencing Studies. Am J Hum Genet 2019; 104:410-421. PubMed
  • Chen H, Huffman JE, Brody JA, Wang C, Lee S, Li Z, Gogarten SM, Sofer T, Bielak LF, Bis JC, Blangero J, Bowler RP, Cade BE, Cho MH, Correa A, Curran JE, de Vries PS, Glahn DC, Guo X, Johnson AD, Kardia S, Kooperberg C, Lewis JP, Liu X, Mathias RA, Mitchell BD, O'Connell JR, Peyser PA, Post WS, Reiner AP, Rich SS, Rotter JI, Silverman EK, Smith JA, Vasan RS, Wilson JG, Yanek LR, , , Redline S, Smith NL, Boerwinkle E, Borecki IB, Cupples LA, Laurie CC, Morrison AC, Rice KM, Lin X. Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies. Am J Hum Genet 2019; 104:260-274. PubMed
  • Liu Z, Lin X. A Geometric Perspective on the Power of Principal Component Association Tests in Multiple Phenotype Studies. Journal of the American Statistical Association 2019; 114:975-990. PubMed
  • Gaynor SM, Schwartz J, Lin X. Mediation analysis for common binary outcomes. Stat Med 2018. PubMed
  • Wang Z, Wei Y, Zhang R, Su L, Gogarten SM, Liu G, Brennan P, Field JK, McKay JD, Lissowska J, Swiatkowska B, Janout V, Bolca C, Kontic M, Scelo G, Zaridze D, Laurie CC, Doheny KF, Pugh EK, Marosy BA, Hetrick KN, Xiao X, Pikielny C, Hung RJ, Amos CI, Lin X, Christiani DC. Multi-Omics Analysis Reveals a HIF Network and Hub Gene EPAS1 Associated with Lung Adenocarcinoma. EBioMedicine 2018; 32:93-101. PubMed
  • Wei Y, Liang J, Zhang R, Guo Y, Shen S, Su L, Lin X, Moran S, Helland Å, Bjaanæs MM, Karlsson A, Planck M, Esteller M, Fleischer T, Staaf J, Zhao Y, Chen F, Christiani DC. Epigenetic modifications inlysine demethylases associate with survival of early-stage NSCLC. Clin Epigenetics 2018; 10:41. PubMed
  • Barfield R, Shen J, Just AC, Vokonas PS, Schwartz J, Baccarelli AA, VanderWeele TJ, Lin X. Testing for the indirect effect under the null for genome-wide mediation analyses. Genet Epidemiol 2017; 41:824-833. PubMed
  • Sun R, Carroll RJ, Christiani DC, Lin X. Testing for gene-environment interaction under exposure misspecification. Biometrics 2017. PubMed
  • Liu Z, Lin X. Multiple phenotype association tests using summary statistics in genome-wide association studies. Biometrics 2017. PubMed
  • Sofer T, Schifano ED, Christiani DC, Lin X. Weighted pseudolikelihood for SNP set analysis with multiple secondary outcomes in case-control genetic association studies. Biometrics 2017. PubMed
  • Ter-Minassian M, Zhang S, Brooks NV, Brais LK, Chan JA, Christiani DC, Lin X, Gabriel S, Dinet J, Kulke MH. Association Between Tumor Progression Endpoints and Overall Survival in Patients with Advanced Neuroendocrine Tumors. Oncologist 2017. PubMed
  • Barnett I, Mukherjee R, Lin X. The Generalized Higher Criticism for Testing SNP-Set Effects in Genetic Association Studies. Journal of the American Statistical Association 2017; 112:64-76. PubMed
  • Carmona JJ, Accomando WP, Binder AM, Hutchinson JN, Pantano L, Izzi B, Just AC, Lin X, Schwartz J, Vokonas PS, Amr SS, Baccarelli AA, Michels KB. Empirical comparison of reduced representation bisulfite sequencing and Infinium BeadChip reproducibility and coverage of DNA methylation in humans. NPJ Genom Med 2017; 2:13. PubMed
  • Kachouie NN, Lin X, Schwartzman A. FDR control of detected regions by multiscale matched filtering. Commun Stat Simul Comput 2017; 46:127-144. PubMed
  • Yung G, Lin X. Validity of using ad hoc methods to analyze secondary traits in case-control association studies. Genet Epidemiol 2016. PubMed
  • Qian ZR, Li T, Ter-Minassian M, Yang J, Chan JA, Brais LK, Masugi Y, Thiaglingam A, Brooks N, Nishihara R, Bonnemarie M, Masuda A, Inamura K, Kim SA, Mima K, Sukawa Y, Dou R, Lin X, Christiani DC, Schmidlin F, Fuchs CS, Mahmood U, Ogino S, Kulke MH. Association Between Somatostatin Receptor Expression and Clinical Outcomes in Neuroendocrine Tumors. Pancreas 2016. PubMed
  • Du Y, Ter-Minassian M, Brais L, Brooks N, Waldron A, Chan JA, Lin X, Kraft P, Christiani DC, Kulke MH. Genetic associations with neuroendocrine tumor risk: results from a genome-wide association study. Endocr. Relat. Cancer 2016; 23:587-94. PubMed
  • Liu CY, Stücker I, Chen C, Goodman G, McHugh MK, D'Amelio AM, Etzel CJ, Li S, Lin X, Christiani DC. Genome-wide Gene-Asbestos Exposure Interaction Association Study Identifies a Common Susceptibility Variant on 22q13.31 Associated with Lung Cancer Risk. Cancer Epidemiol Biomarkers Prev 2015; 24:1564-73. PubMed
  • Seow WJ, Pan WC, Kile ML, Tong L, Baccarelli AA, Quamruzzaman Q, Rahman M, Mostofa G, Rakibuz-Zaman M, Kibriya M, Ahsan H, Lin X, Christiani DC. A distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh. Cancer 2015. PubMed
  • Mukherjee R, Pillai NS, Lin X. HYPOTHESIS TESTING FOR HIGH-DIMENSIONAL SPARSE BINARY REGRESSION. Ann Statist 2015; 43:352-381. PubMed
  • Chan LW, Lin X, Yung G, Lui T, Chiu YM, Wang F, Tsui NB, Cho WC, Yip SP, Siu PM, Wong SC, Yung BY. Novel structural co-expression analysis linking the NPM1-associated ribosomal biogenesis network to chronic myelogenous leukemia. Sci Rep 2015; 5:10973. PubMed
  • Wang Z, Choi S, Lee J, Huang YT, Chen F, Zhao Y, Lin X, Neuberg D, Kim J, Christiani DC. Mitochondrial Variations in Non-Small Cell Lung Cancer (NSCLC) Survival. Cancer Inform 2015; 14:1-9. PubMed
  • Seow WJ, Kile ML, Baccarelli AA, Pan WC, Byun HM, Mostofa G, Quamruzzaman Q, Rahman M, Lin X, Christiani DC. Epigenome-wide DNA methylation changes with development of arsenic-induced skin lesions in Bangladesh: a case-control follow-up study. Environ Mol Mutagen 2014. PubMed
  • Cao Y, Lindström S, Schumacher F, Stevens VL, Albanes D, Berndt S, Boeing H, Bueno-de-Mesquita HB, Canzian F, Chamosa S, Chanock SJ, Diver WR, Gapstur SM, Gaziano JM, Giovannucci EL, Haiman CA, Henderson B, Johansson M, Le Marchand L, Palli D, Rosner B, Siddiq A, Stampfer M, Stram DO, Tamimi R, Travis RC, Trichopoulos D, Willett WC, Yeager M, Kraft P, Hsing AW, Pollak M, Lin X, Ma J. Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival. Journal of the National Cancer Institute 2014; 106:dju085. PubMed
  • Wong JY, De Vivo I, Lin X, Grashow R, Cavallari J, Christiani DC. The association between global DNA methylation and telomere length in a longitudinal study of boilermakers. Genet Epidemiol 2014; 38:254-64. PubMed
  • Wang C, Zhan X, Bragg-Gresham J, Kang HM, Stambolian D, Chew EY, Branham KE, Heckenlively J, , Fulton R, Wilson RK, Mardis ER, Lin X, Swaroop A, Zöllner S, Abecasis GR. Ancestry estimation and control of population stratification for sequence-based association studies. Nat Genet 2014; 46:409-15. PubMed
  • Wong JY, De Vivo I, Lin X, Fang SC, Christiani DC. The relationship between inflammatory biomarkers and telomere length in an occupational prospective cohort study. PLoS ONE 2014; 9:e87348. PubMed
  • Wong JY, De Vivo I, Lin X, Christiani DC. Cumulative PM(2.5) exposure and telomere length in workers exposed to welding fumes. J. Toxicol. Environ. Health Part A 2014; 77:441-55. PubMed
  • Wang X, Lee S, Zhu X, Redline S, Lin X. GEE-based SNP set association test for continuous and discrete traits in family-based association studies. Genet Epidemiol 2013; 37:778-86. PubMed
  • Qian ZR, Ter-Minassian M, Chan JA, Imamura Y, Hooshmand SM, Kuchiba A, Morikawa T, Brais LK, Daskalova A, Heafield R, Lin X, Christiani DC, Fuchs CS, Ogino S, Kulke MH. Prognostic significance of MTOR pathway component expression in neuroendocrine tumors. J Clin Oncol 2013; 31:3418-25. PubMed
  • Ionita-Laza I, Lee S, Makarov V, Buxbaum JD, Lin X. Sequence kernel association tests for the combined effect of rare and common variants. Am J Hum Genet 2013; 92:841-53. PubMed
  • Ter-Minassian M, Chan JA, Hooshmand SM, Brais LK, Daskalova A, Heafield R, Buchanan L, Qian ZR, Fuchs CS, Lin X, Christiani DC, Kulke MH. Clinical presentation, recurrence, and survival in patients with neuroendocrine tumors: results from a prospective institutional database. Endocr. Relat. Cancer 2013; 20:187-96. PubMed
  • Dicker L, Lin X. Parallelism, uniqueness, and large-sample asymptotics for the Dantzig selector. 2013; 41:23-35. PubMed
  • Barnett IJ, Lee S, Lin X. Detecting rare variant effects using extreme phenotype sampling in sequencing association studies. Genet Epidemiol 2013; 37:142-51. PubMed
  • Huang YT, Lin X. Gene set analysis using variance component tests. BMC Bioinformatics 2013; 14:210. PubMed
  • Liao SY, Lin X, Christiani DC. Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study. Environ Health 2013; 12:101. PubMed
  • Cai T, Lin X, Carroll RJ. Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test. Biostatistics 2012; 13:776-90. PubMed
  • Lee S, Wu MC, Lin X. Optimal tests for rare variant effects in sequencing association studies. Biostatistics 2012; 13:762-75. PubMed
  • Lee S, Emond MJ, Bamshad MJ, Barnes KC, Rieder MJ, Nickerson DA, , Christiani DC, Wurfel MM, Lin X. Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies. Am J Hum Genet 2012; 91:224-37. PubMed
  • Wang L, Rotnitzky A, Lin X, Millikan RE, Thall PF. Evaluation of Viable Dynamic Treatment Regimes in a Sequentially Randomized Trial of Advanced Prostate Cancer. Journal of the American Statistical Association 2012; 107:493-508. PubMed
  • Zhao Y, Chen F, Zhai R, Lin X, Diao N, Christiani DC. Association test based on SNP set: logistic kernel machine based test vs. principal component analysis. PLoS ONE 2012; 7:e44978. PubMed
  • Cai T, Tonini G, Lin X. Kernel machine approach to testing the significance of multiple genetic markers for risk prediction. Biometrics 2011. PubMed
  • Dicker L, Lin X, Ivanov AR. Increased power for the analysis of label-free LC-MS/MS proteomic data by combining spectral counts and peptide peak attributes. Mol Cell Proteomics 2010; 9:2704-18. PubMed
  • Paulus JK, Zhou W, Kraft P, Johnson BE, Lin X, Christiani DC. Haplotypes of estrogen receptor-beta and risk of non-small cell lung cancer in women. Lung Cancer 2010. PubMed
  • Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC. A Large Scale Genetic Association Study of Esophageal Adenocarcinoma Risk. Carcinogenesis 2010; 31:1259-63. PubMed
  • Wu MC, Kraft P, Epstein MP, Taylor DM, Chanock SJ, Hunter DJ, Lin X. Powerful SNP-set analysis for case-control genome-wide association studies. Am J Hum Genet 2010; 86:929-42. PubMed
  • Zhai R, Chen F, Liu G, Su L, Kulke MH, Asomaning K, Lin X, Heist RS, Nishioka NS, Sheu CC, Wain JC, Christiani DC. Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma. J Clin Oncol 2010; 28:2445-51. PubMed
  • Li Y,Lin X,Muller P. Bayesian Inference in Semiparametric Mixed Models for Longitudinal Data. Biometrics 2010; 66:70-8. PubMed
  • Paulus JK, Asomaning K, Kraft P, Johnson BE, Lin X, Christiani DC. Parity and risk of lung cancer in women. Am J Epidemiol 2010; 171:557-63. PubMed
  • Naylor MG, Lin X, Weiss ST, Raby BA, Lange C. Using canonical correlation analysis to discover genetic regulatory variants. PLoS ONE 2010; 5:e10395. PubMed
  • Wu MC, Lin X. Prior biological knowledge-based approaches for the analysis of genome-wide expression profiles using gene sets and pathways. 2009; 18:577-93. PubMed
  • Epstein MP, Hunter JE, Allen EG, Sherman SL, Lin X, Boehnke M. A Variance-Component Framework for Pedigree Analysis of Continuous and Categorical Outcomes. 2009; 1:181-198. PubMed
  • Pan W,Zeng D,Lin X. Estimation in Semiparametric Transition Measurement Error Models for Longitudinal Data. Biometrics 2009; 65:728-36. PubMed
  • Huang YT,Heist RS,Chirieac LR,Lin X,Skaug V,Zienolddiny S,Haugen A,Wu MC,Wang Z,Su L,Asomaning K,Christiani DC. Genome-wide analysis of survival in early-stage non-small-cell lung cancer. J Clin Oncol 2009; 27:2660-7. PubMed
  • Little RJ,Long Q,Lin X. A Comparison of Methods for Estimating the Causal Effect of a Treatment in Randomized Clinical Trials Subject to Noncompliance. Biometrics 2009; 65:640-9. PubMed
  • Wu MC,Zhang L,Wang Z,Christiani DC,Lin X. Sparse linear discriminant analysis for simultaneous testing for the significance of a gene set/pathway and gene selection. Bioinformatics 2009; 25:1145-51. PubMed
  • Zhai R,Liu G,Asomaning K,Su L,Kulke MH,Heist RS,Nishioka NS,Lynch TJ,Wain JC,Lin X,Christiani DC. Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk. Carcinogenesis 2008; 29:2330-4. PubMed
  • Ye W, Lin X, Taylor JM. Semiparametric Modeling of Longitudinal Measurements and Time-to-Event Data-A Two-Stage Regression Calibration Approach. Biometrics 2008; 64:1238-46. PubMed
  • Li Y,Prentice RL,Lin X. Semiparametric Maximum Likelihood Estimation in Normal Transformation Models for Bivariate Survival Data. Biometrika 2008; 95:947-960. PubMed
  • Ter-Minassian M,Zhai R,Asomaning K,Su L,Zhou W,Liu G,Heist RS,Lynch TJ,Wain JC,Lin X,De Vivo I,Christiani DC. Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer. Carcinogenesis 2008; 29:2147-52. PubMed
  • Nan B, Lin X. Analysis of case-control age-at-onset data using a modified case-cohort method. Biom J 2008; 50:311-20. PubMed
  • Sanda MG, Dunn RL, Michalski J, Sandler HM, Northouse L, Hembroff L, Lin X, Greenfield TK, Litwin MS, Saigal CS, Mahadevan A, Klein E, Kibel A, Pisters LL, Kuban D, Kaplan I, Wood D, Ciezki J, Shah N, Wei JT. Quality of life and satisfaction with outcome among prostate-cancer survivors. N Engl J Med 2008; 358:1250-61. PubMed
  • Heist RS, Zhai R, Liu G, Zhou W, Lin X, Su L, Asomaning K, Lynch TJ, Wain JC, Christiani DC. VEGF polymorphisms and survival in early-stage non-small-cell lung cancer. J Clin Oncol 2008; 26:856-62. PubMed
  • Kwee LC,Liu D,Lin X,Ghosh D,Epstein MP. A powerful and flexible multilocus association test for quantitative traits. Am J Hum Genet 2008; 82:386-97. PubMed
  • Zhai R, Liu G, Zhou W, Su L, Heist RS, Lynch TJ, Wain JC, Asomaning K, Lin X, Christiani DC. Vascular endothelial growth factor genotypes, haplotypes, gender, and the risk of non-small cell lung cancer. Clin Cancer Res 2008; 14:612-7. PubMed
  • Liu D,Ghosh D,Lin X. Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via logistic mixed models. BMC Bioinformatics 2008; 9:292. PubMed
  • Harezlak J,Wu MC,Wang M,Schwartzman A,Christiani DC,Lin X. Biomarker discovery for arsenic exposure using functional data. Analysis and feature learning of mass spectrometry proteomic data. J Proteome Res 2008; 7:217-24. PubMed
  • Lin X. Estimation using penalized quasilikelihood and quasi-pseudo-likelihood in Poisson mixed models. Lifetime Data Analysis 2007; 13:533-44. PubMed
  • Liu D, Lin X, Ghosh D. Semiparametric regression of multidimensional genetic pathway data: least-squares kernel machines and linear mixed models. Biometrics 2007; 63:1079-88. PubMed
  • Schipper M, Taylor JM, Lin X. Bayesian generalized monotonic functional mixed models for the effects of radiation dose histograms on normal tissue complications. Stat Med 2007; 26:4643-56. PubMed
  • Harezlak J,Wang M,Christiani D,Lin X. Quantitative quality-assessment techniques to compare fractionation and depletion methods in SELDI-TOF mass spectrometry experiments. Bioinformatics 2007; 23:2441-8. PubMed
  • Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Janne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007; 448:807-10. PubMed
  • Grewal J, Sowers MR, Randolph JF, Harlow SD, Lin X. Low bone mineral density in the early menopausal transition: role for ovulatory function. J Clin Endocrinol Metab 2006; 91:3780-5. PubMed
  • Diez Roux AV, Auchincloss AH, Astor B, Barr RG, Cushman M, Dvonch T, Jacobs DR, Kaufman J, Lin X, Samson P. Recent exposure to particulate matter and C-reactive protein concentration in the multi-ethnic study of atherosclerosis. Am J Epidemiol 2006; 164:437-48. PubMed
  • Cabana MD, Slish KK, Evans D, Mellins RB, Brown RW, Lin X, Kaciroti N, Clark NM. Impact of physician asthma care education on patient outcomes. Pediatrics 2006; 117:2149-57. PubMed
  • Li Y, Lin X. Semiparametric normal transformation models for spatially correlated survival data Journal of the American Statistical Association 2006; 101:591-603.
  • Wu M, Lin X. Prior biological knowledge based approaches for the analysis of genome-wide expression profiles using gene sets and pathways .
  • Ye W, Lin X. A penalized likelihood approach to joint modeling of longitudinal measurements and time to event data .
  • Yu Z, Lin X. Nonparametric regression using local kernel estimating equations for correlated failure time data Biometrika ; 95:123-137.
  • Long Q, Little RJ, Lin X. Causal Inference in Hybrid Intervention Trials Involving Treatment Choice JASA ; 103:474-484.
  • Wang L, Rotnitzky A, Lin X. Nonparametric Regression With Missing Outcomes Using Weighted Kernel Estimating Equations JASA ; 105:1135-1146.