Photo of Geoffrey S. Young, MD

Geoffrey S. Young, MD

Brigham And Women's Hospital

Brigham And Women's Hospital

Photo of Geoffrey S. Young, MD

Brigham And Women's Hospital

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Geoffrey S. Young, MD

Brigham And Women's Hospital

EDUCATIONAL TITLES

  • Associate Professor, Radiology, Harvard Medical School
  • Associate Neuroradiologist, Radiology, Brigham And Women's Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Dr. Young is an active researcher in advanced brain imaging with MRI and optical techniques focused on clinical translation of advanced functional and physiologic MRI techniques for assessing brain tumor bloodflow, invasion, cellularity, oxygenation (DSC PWI, DWI, DTI, BOLD, ASL and volumetrics) and clinical translation of image guided stereotactic minimally invasive optical imaging techniques for diagnosis and therapy of brain tumor.

Publications from Harvard Catalyst Profiles

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  • Chen X, Lim-Fat MJ, Qin L, Li A, Bryant A, Bay CP, Gao L, Miskin N, Liu Z, Iorgulescu JB, Xu X, Reardon DA, Young GS. A Comparative Retrospective Study of Immunotherapy RANO Standard RANO Criteria in Glioblastoma Patients Receiving Immune Checkpoint Inhibitor Therapy. 2021; 11:679331. PubMed
  • Zhang M, Young GS, Chen H, Qin L, McFaline-Figueroa JR, Reardon DA, Cao X, Wu X, Xu X. Deep-Learning Detection of Cancer Metastases to the Brain on MRI. J Magn Reson Imaging 2020. PubMed
  • Miskin N, Unadkat P, Carlton ME, Golby AJ, Young GS, Huang RY. Frequency and Evolution of New Postoperative Enhancement on 3 Tesla Intraoperative and Early Postoperative Magnetic Resonance Imaging. Neurosurgery 2019. PubMed
  • Li T, Chen H, Zhang M, Liu S, Xia S, Cao X, Young GS, Xu X. A New Design in Iterative Image Deblurring for Improved Robustness and Performance. Pattern Recognit 2019; 90:134-146. PubMed
  • Wen PY, Touat M, Alexander BM, Mellinghoff IK, Ramkissoon S, McCluskey CS, Pelton K, Haidar S, Basu SS, Gaffey SC, Brown LE, Martinez-Ledesma JE, Wu S, Kim J, Wei W, Park MA, Huse JT, Kuhn JG, Rinne ML, Colman H, Agar NYR, Omuro AM, DeAngelis LM, Gilbert MR, de Groot JF, Cloughesy TF, Chi AS, Roberts TM, Zhao JJ, Lee EQ, Nayak L, Heath JR, Horky LL, Batchelor TT, Beroukhim R, Chang SM, Ligon AH, Dunn IF, Koul D, Young GS, Prados MD, Reardon DA, Yung WKA, Ligon KL. Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial. J Clin Oncol 2019; 37:741-750. PubMed
  • Unadkat P, Fumagalli L, Rigolo L, Vangel MG, Young GS, Huang R, Mukundan S, Golby A, Tie Y. Functional MRI Task Comparison for Language Mapping in Neurosurgical Patients. J Neuroimaging 2019. PubMed
  • Qin L, Li X, Li A, Cheng S, Qu J, Reinshagen K, Hu J, Himes N, Lu G, Xu X, Young GS. Clinical Validation of Automatable Gaussian Normalized CBV in Brain Tumor Analysis: Superior Reproducibility and Slightly Better Association with Survival than Current Standard Manual Normal Appearing White Matter Normalization. Transl Oncol 2018; 11:1398-1405. PubMed
  • Qin L, Li A, Qu J, Reinshagen K, Li X, Cheng SC, Bryant A, Young GS. Normalization of ADC does not improve correlation with overall survival in patients with high-grade glioma (HGG). J. Neurooncol. 2018; 137:313-319. PubMed
  • Qin L, Li X, Stroiney A, Qu J, Helgager J, Reardon DA, Young GS. Advanced MRI assessment to predict benefit of anti-programmed cell death 1 protein immunotherapy response in patients with recurrent glioblastoma. Neuroradiology 2017. PubMed
  • Qu J, Qin L, Cheng S, Leung K, Li X, Li H, Dai J, Jiang T, Akgoz A, Seethamraju R, Wang Q, Rahman R, Li S, Ai L, Jiang T, Young GS. Residual low ADC and high FA at the resection margin correlate with poor chemoradiation response and overall survival in high-grade glioma patients. Eur J Radiol 2016; 85:657-64. PubMed
  • Abd-El-Barr MM, Santos SM, Aglio LS, Young GS, Mukundan S, Golby AJ, Gormley WB, Dunn IF. "Extraoperative" MRI (eoMRI) for Brain Tumor Surgery: Initial Results at a Single Institution. World Neurosurg 2015. PubMed
  • Akgoz A, Rahman R, You H, Qu J, Hamdan A, Seethamraju RT, Wen PY, Young GS. Spin-echo echo-planar perfusion prior to chemoradiation is a strong independent predictor of progression-free and overall survival in newly diagnosed glioblastoma. J. Neurooncol. 2014. PubMed
  • Ji M, Orringer DA, Freudiger CW, Ramkissoon S, Liu X, Lau D, Golby AJ, Norton I, Hayashi M, Agar NY, Young GS, Spino C, Santagata S, Camelo-Piragua S, Ligon KL, Sagher O, Xie XS. Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy. Sci Transl Med 2013; 5:201ra119. PubMed
  • Freudiger CW, Pfannl R, Orringer DA, Saar BG, Ji M, Zeng Q, Ottoboni L, Wei Y, Ying W, Waeber C, Sims JR, De Jager PL, Sagher O, Philbert MA, Xu X, Kesari S, Xie XS, Young GS. Multicolored stain-free histopathology with coherent Raman imaging. Lab Invest 2012; 92:1492-502. PubMed
  • Zhu Y, Young GS, Xue Z, Huang RY, You H, Setayesh K, Hatabu H, Cao F, Wong ST. Semi-automatic segmentation software for quantitative clinical brain glioblastoma evaluation. Acad Radiol 2012; 19:977-85. PubMed
  • Pope WB, Qiao XJ, Kim HJ, Lai A, Nghiemphu P, Xue X, Ellingson BM, Schiff D, Aregawi D, Cha S, Puduvalli VK, Wu J, Yung WK, Young GS, Vredenburgh J, Barboriak D, Abrey LE, Mikkelsen T, Jain R, Paleologos NA, Rn PL, Prados M, Goldin J, Wen PY, Cloughesy T. Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: a multi-center study. J. Neurooncol. 2012. PubMed
  • Wong K, Young GS, Makale M, Hu X, Yildirim N, Cui K, Wong ST, Kesari S. Characterization of a human tumorsphere glioma orthotopic model using magnetic resonance imaging. J. Neurooncol. 2011. PubMed
  • Hu X, Wong KK, Young GS, Guo L, Wong ST. Support vector machine multiparametric MRI identification of pseudoprogression from tumor recurrence in patients with resected glioblastoma. J Magn Reson Imaging 2011; 33:296-305. PubMed
  • Young GS, Macklin EA, Setayesh K, Lawson JD, Wen PY, Norden AD, Drappatz J, Kesari S. Longitudinal MRI evidence for decreased survival among periventricular glioblastoma. J. Neurooncol. 2010. PubMed
  • Drappatz J, Norden AD, Wong ET, Doherty LM, Lafrankie DC, Ciampa A, Kesari S, Sceppa C, Gerard M, Phan P, Schiff D, Batchelor TT, Ligon KL, Young G, Muzikansky A, Weiss SE, Wen PY. Phase I Study of Vandetanib with Radiotherapy and Temozolomide for Newly Diagnosed Glioblastoma. Int J Radiat Oncol Biol Phys 2010; 78:85-90. PubMed
  • Young GS, Feng F, Shen H, Chen NK. Susceptibility-enhanced 3-Tesla T1-weighted spoiled gradient echo of the midbrain nuclei for guidance of deep brain stimulation implantation. Neurosurgery 2009; 65:809-15. PubMed
  • Nie J,Xue Z,Liu T,Young GS,Setayesh K,Guo L,Wong ST. Automated brain tumor segmentation using spatial accuracy-weighted hidden Markov Random Field. Comput Med Imaging Graph 2009; 33:431-41. PubMed
  • Wong KK,Tam CP,Ng M,Wong ST,Young GS. Improved residue function and reduced flow dependence in MR perfusion using least-absolute-deviation regularization. Magn Reson Med 2009; 61:418-28. PubMed
  • Kwong KK, Kloetzer L, Wong KK, Ren JQ, Kuo B, Jiang Y, Chen YI, Chan ST, Young GS, Wong ST. Bioluminescence imaging of heme oxygenase-1 upregulation in the Gua Sha procedure. 2009. PubMed
  • Norden AD, Young GS, Setayesh K, Muzikansky A, Klufas R, Ross GL, Ciampa AS, Ebbeling LG, Levy B, Drappatz J, Kesari S, Wen PY. Bevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrence. Neurology 2008; 70:779-87. PubMed
  • Love RR, Van Dinh N, Quy TT, Linh ND, Tung ND, Shen TZ, Hade EM, Young GS, Jarjoura D. Survival after adjuvant oophorectomy and tamoxifen in operable breast cancer in premenopausal women. J Clin Oncol 2008; 26:253-7. PubMed
  • Young GS. Advanced MRI of adult brain tumors. Neurol Clin 2007; 25:947-73, viii. PubMed
  • Monje ML, Ramakrishna NR, Young G, Drappatz J, Doherty LM, Wen PY, Kesari S. Durable response of a radiation-induced, high-grade cerebellar glioma to temozolomide. J Neurooncol 2007; 84:179-83. PubMed
  • Liu T, Young G, Huang L, Chen NK, Wong ST. 76-Space analysis of grey matter diffusivity: Methods and applications. Neuroimage 2006; 31:51-65. PubMed
  • Chen XZ, Dai JP, Ai L*, Ru XJ, Wang JM, Li SW, Young GS*.. Clival invasion on CT is seen in 8% of pituitary macroadenoma, is more common in women and null-cell adenomas and is associated with higher rates of surgical complication and recurrence. 2000.
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Visualize Collaborations
Learn how these members are similar
Similar Members

DF/HCC members that share similar concepts* with Geoffrey S. Young, MD but have yet to coauthor a publication with this researcher.

* Concepts are MeSH terms, automatically derived from member publications

Similar Members