Photo of Hensin Tsao, MD, PhD

Hensin Tsao, MD, PhD

Massachusetts General Hospital

Massachusetts General Hospital

Photo of Hensin Tsao, MD, PhD

Massachusetts General Hospital

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Hensin Tsao, MD, PhD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Professor, Dermatology, Harvard Medical School
  • Director, MGH Melanoma and Pigmented Lesion Center, Dermatology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

Our laboratory is interested in the genetic determinants of melanoma predisposition, progression and therapeutic response.

Publications from Harvard Catalyst Profiles

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  • Njauw CN, Ji Z, Pham DM, Simoneau A, Kumar R, Flaherty KT, Zou L, Tsao H. Oncogenic KIT Induces Replication stress and Confers Cell Cycle Checkpoint Vulnerability in Melanoma. J Invest Dermatol 2021. PubMed
  • Rashid S, Tsao H. Effect of the COVID-19 Pandemic on Delayed Skin Cancer Services. Dermatol Clin 2021; 39:627-637. PubMed
  • Rashid S, Tsao H. Recognition, Staging, and Management of Melanoma. Med Clin North Am 2021; 105:643-661. PubMed
  • Coroiu A, Moran C, Davine JA, Brophy K, Bergeron C, Tsao H, Körner A, Swetter SM, Geller AC. Patient-identified early clinical warning signs of nodular melanoma: a qualitative study. BMC Cancer 2021; 21:371. PubMed
  • Guhan SM, Shaughnessy M, Rajadurai A, Taylor M, Kumar R, Ji Z, Rashid S, Flaherty K, Tsao H. The Molecular Context of Vulnerability for CDK9 Suppression in Triple Wild-Type Melanoma. J Invest Dermatol 2021. PubMed
  • Atkins MB, Curiel-Lewandrowski C, Fisher DE, Swetter SM, Tsao H, Aguirre-Ghiso JA, Soengas MS, Weeraratna AT, Flaherty KT, Herlyn M, Sosman JA, Tawbi HA, Pavlick AC, Cassidy PB, Chandra S, Chapman PB, Daud A, Eroglu Z, Ferris LK, Fox BA, Gerhsenwald JE, Gibney GT, Grossman D, Hanks BA, Hanniford D, Hernando E, Jeter JM, Johnson DB, Khleif SN, Kirkwood JM, Leachman SA, Mays D, Nelson KC, Sondak VK, Sullivan RJ, Merlino G. The State of Melanoma: Emergent Challenges and Opportunities. Clin Cancer Res 2021. PubMed
  • Ji Z, Njauw CN, Guhan S, Kumar R, Reddy B, Rajadurai A, Flaherty K, Tsao H. Loss of ACK1 Upregulates EGFR and Mediates Resistance to BRAF Inhibition. J Invest Dermatol 2020. PubMed
  • Guhan S, Boland G, Tanabe K, Lin W, Reddy B, Hawryluk EB, Sober AJ, Tsao H. Surgical Delay and Mortality for Primary Cutaneous Melanoma. J Am Acad Dermatol 2020. PubMed
  • Pham DDM, Guhan S, Tsao H. KIT and Melanoma: Biological Insights and Clinical Implications. Yonsei Med J 2020; 61:562-571. PubMed
  • Beaulieu D, Tsao H, Michaud DS, Okhovat JP, Halpern AC, Lundberg M, Geller AC. A Geographically-Based Cross-Sectional Analysis of SPOT me® Skin Cancer Screening Data. J Am Acad Dermatol 2020. PubMed
  • Kang Y, Roh MR, Rajadurai S, Rajadurai A, Kumar R, Njauw CN, Zheng Z, Tsao H. Hypoxia and HIF-1α Regulate Collagen Production in Keloids. J Invest Dermatol 2020. PubMed
  • Guhan SM, Artomov M, McCormick S, Njauw C-, Stratigos AJ, Shannon K, Ellisen LW, Tsao H. Cancer risks associated with the germline MITF(E318K) variant. Sci Rep 2020; 10:17051. PubMed
  • Shaughnessy M, Lamuraglia G, Klebanov N, Ji Z, Rajadurai A, Kumar R, Flaherty K, Tsao H. Selective uveal melanoma inhibition with calcium channel blockade. Int J Oncol 2019. PubMed
  • Shaughnessy M, Njauw CN, Artomov M, Tsao H. Classifying melanoma by TERT promoter mutational status. J Invest Dermatol 2019. PubMed
  • Zhang AJ, Rush PS, Tsao H, Duncan LM. BRCA1-Associated Protein (BAP1) inactivated melanocytic tumors. J Cutan Pathol 2019. PubMed
  • Beaulieu D, Tsao H, Michaud DS, Okhovat JP, Halpern AC, Geller AC. Number needed to screen (NNS) for presumptive screening diagnoses among first-time SPOTme screening participants (1992-2010). J Am Acad Dermatol 2019. PubMed
  • Phung B, Cieśla M, Sanna A, Guzzi N, Beneventi G, Cao Thi Ngoc P, Lauss M, Cabrita R, Cordero E, Bosch A, Rosengren F, Häkkinen J, Griewank K, Paschen A, Harbst K, Olsson H, Ingvar C, Carneiro A, Tsao H, Schadendorf D, Pietras K, Bellodi C, Jönsson G. The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma. Cell Rep 2019; 27:3573-3586.e7. PubMed
  • Artomov M, Joseph V, Tiao G, Thomas T, Schrader K, Klein RJ, Kiezun A, Gupta N, Margolin L, Stratigos AJ, Kim I, Shannon K, Ellisen LW, Haber D, Getz G, Tsao H, Lipkin SM, Altshuler D, Offit K, Daly MJ. Case-control analysis identifies shared properties of rare germline variation in cancer predisposing genes. Eur J Hum Genet 2019; 27:824-828. PubMed
  • Klebanov N, Artomov M, Goggins WB, Daly E, Daly MJ, Tsao H. Burden of unique and low prevalence somatic mutations correlates with cancer survival. Sci Rep 2019; 9:4848. PubMed
  • Kumar R, Njauw CN, Reddy BY, Ji Z, Rajadurai A, Klebanov N, Tsao H. Growth suppression by dual BRAF(V600E) and NRAS(Q61) oncogene expression is mediated by SPRY4 in melanoma. Oncogene 2019. PubMed
  • Klebanov N, Lin WM, Artomov M, Shaughnessy M, Njauw CN, Bloom R, Eterovic AK, Chen K, Kim TB, Tsao SS, Tsao H. Use of Targeted Next-Generation Sequencing to Identify Activating Hot Spot Mutations in Cherry Angiomas. JAMA Dermatol 2019. PubMed
  • , Swetter SM, Tsao H, Bichakjian CK, Curiel-Lewandrowski C, Elder DE, Gershenwald JE, Guild V, Grant-Kels JM, Halpern AC, Johnson TM, Sober AJ, Thompson JA, Wisco OJ, Wyatt S, Hu S, Lamina T. Guidelines of care for the management of primary cutaneous melanoma. J Am Acad Dermatol 2019; 80:208-250. PubMed
  • Beaulieu D, Tsao H, Michaud DS, Okhovat JP, Halpern AC, Geller AC. Factors associated with suspected nonmelanoma skin cancers, dysplastic nevus, and cutaneous melanoma among first-time SPOTme screening program participants (2009-2010). J Am Acad Dermatol 2018. PubMed
  • Walpole S, Pritchard AL, Cebulla CM, Pilarski R, Stautberg M, Davidorf FH, de la Fouchardière A, Cabaret O, Golmard L, Stoppa-Lyonnet D, Garfield E, Njauw CN, Cheung M, Turunen JA, Repo P, Järvinen RS, van Doorn R, Jager MJ, Luyten GPM, Marinkovic M, Chau C, Potrony M, Höiom V, Helgadottir H, Pastorino L, Bruno W, Andreotti V, Dalmasso B, Ciccarese G, Queirolo P, Mastracci L, Wadt K, Kiilgaard JF, Speicher MR, van Poppelen N, Kilic E, Al-Jamal RT, Dianzani I, Betti M, Bergmann C, Santagata S, Dahiya S, Taibjee S, Burke J, Poplawski N, O'Shea SJ, Newton-Bishop J, Adlard J, Adams DJ, Lane AM, Kim I, Klebe S, Racher H, Harbour JW, Nickerson ML, Murali R, Palmer JM, Howlie M, Symmons J, Hamilton H, Warrier S, Glasson W, Johansson P, Robles-Espinoza CD, Ossio R, de Klein A, Puig S, Ghiorzo P, Nielsen M, Kivelä TT, Tsao H, Testa JR, Gerami P, Stern MH, Paillerets BB, Abdel-Rahman MH, Hayward NK. Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide. Journal of the National Cancer Institute 2018; 110:1328-1341. PubMed
  • Klebanov N, Gunasekera N, Lin WM, Hawryluk EB, Miller DM, Reddy BY, Christman MP, Beaulieu D, Rajadurai S, Duncan LM, Sober AJ, Tsao H. The Clinical Spectrum of Cutaneous Melanoma Morphology. J Am Acad Dermatol 2018. PubMed
  • Okhovat JP, Beaulieu D, Tsao H, Halpern AC, Michaud DS, Shaykevich S, Geller AC. The first 30 years of the American Academy of Dermatology skin cancer screening program: 1985-2014. J Am Acad Dermatol 2018. PubMed
  • Karagianni F, Njauw CN, Kypreou KP, Stergiopoulou A, Plaka M, Polydorou D, Chasapi V, Pappas L, Stratigos I, Champsas G, Panagiotou P, Gogas H, Evangelou E, Tsao H, Stratigos A, Stefanaki I. CDKN2A/CDK4 Status in Greek Patients with Familial Melanoma and Association with Clinico-epidemiological Parameters. Acta Derm. Venereol. 2018. PubMed
  • Bartenstein DW, Kelleher CM, Friedmann AM, Duncan LM, Tsao H, Sober AJ, Hawryluk EB. Contrasting features of childhood and adolescent melanomas. Pediatr Dermatol 2018. PubMed
  • Eliades P, Abraham BJ, Ji Z, Miller DM, Christensen CL, Kwiatkowski N, Kumar R, Njauw CN, Taylor M, Miao B, Zhang T, Wong KK, Gray NS, Young RA, Tsao H. High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma. J Invest Dermatol 2018. PubMed
  • Artomov M, Stratigos AJ, Kim I, Kumar R, Lauss M, Reddy BY, Miao B, Daniela Robles-Espinoza C, Sankar A, Njauw CN, Shannon K, Gragoudas ES, Marie Lane A, Iyer V, Newton-Bishop JA, Timothy Bishop D, Holland EA, Mann GJ, Singh T, Daly MJ, Tsao H. Rare Variant, Gene-Based Association Study of Hereditary Melanoma Using Whole-Exome Sequencing. Journal of the National Cancer Institute 2017. PubMed
  • Klebanov N, Reddy BY, Husain S, Silvers DN, Grossman ME, Tsao H. Cutaneous Presentation of Mesothelioma With a Sarcomatoid Transformation. Am J Dermatopathol 2017. PubMed
  • Haugh AM, Njauw CN, Bubley JA, Verzì AE, Zhang B, Kudalkar E, VandenBoom T, Walton K, Swick BL, Kumar R, Rana HQ, Cochrane S, McCormick SR, Shea CR, Tsao H, Gerami P. Genotypic and Phenotypic Features of BAP1 Cancer Syndrome: A Report of 8 New Families and Review of Cases in the Literature. JAMA Dermatol 2017. PubMed
  • Reddy BY, Miller DM, Tsao H. Somatic driver mutations in melanoma. Cancer 2017; 123:2104-2117. PubMed
  • Roh MR, Eliades P, Gupta S, Grant-Kels JM, Tsao H. Cutaneous melanoma in women. Int J Womens Dermatol 2017; 3:S11-S15. PubMed
  • Tsao H, Fukunaga-Kalabis M, Herlyn M. Recent Advances in Melanoma and Melanocyte Biology. J Invest Dermatol 2017. PubMed
  • Roh MR, Park KH, Chung KY, Shin SJ, Rha SY, Tsao H. Telomerase reverse transcriptase (TERT) promoter mutations in Korean melanoma patients. Am J Cancer Res 2017; 7:134-138. PubMed
  • Wang H, Osseiran S, Igras V, Nichols AJ, Roider EM, Pruessner J, Tsao H, Fisher DE, Evans CL. In vivo coherent Raman imaging of the melanomagenesis-associated pigment pheomelanin. Sci Rep 2016; 6:37986. PubMed
  • Eliades P, Tsao H. New Insights into the Molecular Distinction of Dysplastic Nevi and Common Melanocytic Nevi-Highlighting the Keratinocyte-Melanocyte Relationship. J Invest Dermatol 2016; 136:1933-5. PubMed
  • Tsao H, Weinstock MA. Visual Inspection and the US Preventive Services Task Force Recommendation on Skin Cancer Screening. JAMA 2016; 316:398-400. PubMed
  • Ratushny V, Kraft S, Moschella SL, Duncan LM, Lawrence DP, Tsao H. A Symmetric Eczematous Eruption Harboring Thousands of Melanocytic Lesions. JAMA Dermatol 2016. PubMed
  • Roh MR, Gupta S, Park KH, Chung KY, Lauss M, Flaherty KT, Jönsson G, Rha SY, Tsao H. Promoter Methylation of PTEN Is a Significant Prognostic Factor in Melanoma Survival. J Invest Dermatol 2016; 136:1002-11. PubMed
  • Merlino G, Herlyn M, Fisher DE, Bastian BC, Flaherty KT, Davies MA, Wargo JA, Curiel-Lewandrowski C, Weber MJ, Leachman SA, Soengas MS, McMahon M, Harbour JW, Swetter SM, Aplin AE, Atkins MB, Bosenberg MW, Dummer R, Gershenwald JE, Halpern AC, Herlyn D, Karakousis GC, Kirkwood JM, Krauthammer M, Lo RS, Long GV, McArthur G, Ribas A, Schuchter L, Sosman JA, Smalley KS, Steeg P, Thomas NE, Tsao H, Tueting T, Weeraratna A, Xu G, Lomax R, Martin A, Silverstein S, Turnham T, Ronai ZA. The state of melanoma: challenges and opportunities. Pigment Cell Melanoma Res 2016. PubMed
  • Eliades P, Miller DM, Miao B, Kumar R, Taylor M, Buch S, Srinivasa SP, Flaherty KT, Tsao H. A novel multi-CDK inhibitor P1446A-05 restricts melanoma growth and produces synergistic effects in combination with MAPK pathway inhibitors. Cancer Biol Ther 2016. PubMed
  • Wu JW, Turcotte R, Alt C, Runnels JM, Tsao H, Lin CP. Defining Clonal Color in Fluorescent Multi-Clonal Tracking. Sci Rep 2016; 6:24303. PubMed
  • Gupta S, Artomov M, Goggins W, Daly M, Tsao H. Gender Disparity and Mutation Burden in Metastatic Melanoma. Journal of the National Cancer Institute 2015. PubMed
  • Roh MR, Eliades P, Gupta S, Tsao H. Genetics of melanocytic nevi. Pigment Cell Melanoma Res 2015. PubMed
  • Gerami P, Yélamos O, Lee CY, Obregon R, Yazdan P, Sholl LM, Guitart GE, Njauw CN, Tsao H. Multiple Cutaneous Melanomas and Clinically Atypical Moles in a Patient With a Novel Germline BAP1 Mutation. JAMA Dermatol 2015. PubMed
  • Wadt KA, Aoude LG, Johansson P, Solinas A, Pritchard A, Crainic O, Andersen MT, Kiilgaard JF, Heegaard S, Sunde L, Federspiel B, Madore J, Thompson JF, McCarthy SW, Goodwin A, Tsao H, Jönsson G, Busam K, Gupta R, Trent JM, Gerdes AM, Brown KM, Scolyer RA, Hayward NK. A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma. Clin Genet 2015. PubMed
  • Ho AW, Tsao H. Targeted Therapies in Melanoma: Translational Research at Its Finest. J Invest Dermatol 2015; 135:1929-33. PubMed
  • Ji Z, Erin Chen Y, Kumar R, Taylor M, Jenny Njauw CN, Miao B, Frederick DT, Wargo JA, Flaherty KT, Jönsson G, Tsao H. MITF Modulates Therapeutic Resistance through EGFR Signaling. J Invest Dermatol 2015. PubMed
  • Cirenajwis H, Ekedahl H, Lauss M, Harbst K, Carneiro A, Enoksson J, Rosengren F, Werner-Hartman L, Törngren T, Kvist A, Fredlund E, Bendahl PO, Jirström K, Lundgren L, Howlin J, Borg Å, Gruvberger-Saal SK, Saal LH, Nielsen K, Ringnér M, Tsao H, Olsson H, Ingvar C, Staaf J, Jönsson G. Molecular stratification of metastatic melanoma using gene expression profiling: Prediction of survival outcome and benefit from molecular targeted therapy. 2015; 6:12297-309. PubMed
  • Luo S, Lobo AZ, Tanabe KK, Muzikansky A, Durazzo T, Sober A, Tsao H, Cosimi AB, Lawrence DP, Duncan LM. Clinical significance of microscopic melanoma metastases in the nonhottest sentinel lymph nodes. JAMA Surg 2015. PubMed
  • Kumar R, Taylor M, Miao B, Ji Z, Njauw JC, Jönsson G, Frederick DT, Tsao H. BAP1 has a survival role in cutaneous melanoma. J Invest Dermatol 2015; 135:1089-97. PubMed
  • , Tsao H, Olazagasti JM, Cordoro KM, Brewer JD, Taylor SC, Bordeaux JS, Chren MM, Sober AJ, Tegeler C, Bhushan R, Begolka WS. Early detection of melanoma: reviewing the ABCDEs. J Am Acad Dermatol 2015; 72:717-23. PubMed
  • Paraiso KH, Das Thakur M, Fang B, Koomen JM, Fedorenko IV, John JK, Tsao H, Flaherty KT, Sondak VK, Messina JL, Pasquale EB, Villagra A, Rao UN, Kirkwood JM, Meier F, Sloot S, Gibney GT, Stuart D, Tawbi H, Smalley KS. Ligand-independent EPHA2 signaling drives the adoption of a targeted therapy-mediated metastatic melanoma phenotype. 2015; 5:264-73. PubMed
  • Miao B, Ji Z, Tan L, Taylor M, Zhang J, Choi HG, Frederick DT, Kumar R, Wargo JA, Flaherty KT, Gray NS, Tsao H. EPHA2 is a mediator of vemurafenib resistance and a novel therapeutic target in melanoma. 2015; 5:274-87. PubMed
  • Roh MR, Eliades P, Gupta S, Tsao H. Cutaneous Melanoma in Women. Int J Womens Dermatol 2015; 1:21-25. PubMed
  • Lin WM, Luo S, Muzikansky A, Lobo AZ, Tanabe KK, Sober AJ, Cosimi AB, Tsao H, Duncan LM. Outcome of patients with de novo versus nevus-associated melanoma. J Am Acad Dermatol 2015; 72:54-8. PubMed
  • Strazzula L, Vedak P, Hoang MP, Sober A, Tsao H, Kroshinsky D. The utility of re-excising mildly and moderately dysplastic nevi: a retrospective analysis. J Am Acad Dermatol 2014. PubMed
  • Luo S, Tsao H. Epidermal, sebaceous, and melanocytic nevoid proliferations are spectrums of mosaic RASopathies. J Invest Dermatol 2014; 134:2493-6. PubMed
  • Hawryluk EB, Tsao H. Melanoma: clinical features and genomic insights. Cold Spring Harb Perspect Med 2014; 4:a015388. PubMed
  • Yonekawa Y, Kim IK, Gragoudas ES, Njauw CN, Tsao H, Jakobiec FA, Stacy RC. Aggressive skull base metastasis from uveal melanoma: a clinicopathologic study. Eur J Ophthalmol 2014. PubMed
  • Miller DM, Flaherty KT, Tsao H. Commentary: Molecular testing in melanoma. J Am Acad Dermatol 2014; 70:863-70. PubMed
  • Redmond RW, Rajadurai A, Udayakumar D, Sviderskaya EV, Tsao H. Melanocytes are selectively vulnerable to UVA-mediated bystander oxidative signaling. J Invest Dermatol 2014; 134:1083-90. PubMed
  • Marzuka-Alcalá A, Gabree MJ, Tsao H. Melanoma susceptibility genes and risk assessment. Methods Mol Biol 2014; 1102:381-93. PubMed
  • Ji Z, Kumar R, Taylor M, Rajadurai A, Marzuka-Alcalá A, Chen YE, Njauw CN, Flaherty K, Jönsson G, Tsao H. Vemurafenib synergizes with nutlin-3 to deplete survivin and suppresses melanoma viability and tumor growth. Clin Cancer Res 2013; 19:4383-91. PubMed
  • Salas Fragomeni RA, Chung HW, Landesman Y, Senapedis W, Saint-Martin JR, Tsao H, Flaherty KT, Shacham S, Kauffman M, Cusack JC. CRM1 and BRAF inhibition synergize and induce tumor regression in BRAF-mutant melanoma. Mol Cancer Ther 2013. PubMed
  • Puntervoll HE, Yang XR, Vetti HH, Bachmann IM, Avril MF, Benfodda M, Catricalà C, Dalle S, Duval-Modeste AB, Ghiorzo P, Grammatico P, Harland M, Hayward NK, Hu HH, Jouary T, Martin-Denavit T, Ozola A, Palmer JM, Pastorino L, Pjanova D, Soufir N, Steine SJ, Stratigos AJ, Thomas L, Tinat J, Tsao H, Veinalde R, Tucker MA, Bressac-de Paillerets B, Newton-Bishop JA, Goldstein AM, Akslen LA, Molven A. Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants. J Med Genet 2013; 50:264-70. PubMed
  • Chen ST, Geller AC, Tsao H. Update on the Epidemiology of Melanoma. Curr Dermatol Rep 2013; 2:24-34. PubMed
  • Hung T, Piris A, Lobo A, Mihm MC, Sober AJ, Tsao H, Tanabe KK, Duncan LM. Sentinel lymph node metastasis is not predictive of poor outcome in patients with problematic spitzoid melanocytic tumors. Hum Pathol 2013. PubMed
  • Lobo AZ, Tanabe KK, Luo S, Muzikansky A, Sober AJ, Tsao H, Cosimi AB, Duncan LM. The distribution of microscopic melanoma metastases in sentinel lymph nodes: implications for pathology protocols. Am J Surg Pathol 2012; 36:1841-8. PubMed
  • Hawryluk EB, Sober AJ, Piris A, Nazarian RM, Hoang MP, Tsao H, Mihm MC, Duncan LM. Histologically challenging melanocytic tumors referred to a tertiary care pigmented lesion clinic. J Am Acad Dermatol 2012; 67:727-35. PubMed
  • Harbst K, Staaf J, Lauss M, Karlsson A, Måsbäck A, Johansson I, Bendahl PO, Vallon-Christersson J, Törngren T, Ekedahl H, Geisler J, Höglund M, Höglund M, Ringnér M, Ringnér M, Lundgren L, Jirström K, Olsson H, Ingvar C, Borg Å, Tsao H, Jönsson G. Molecular profiling reveals low- and high-grade forms of primary melanoma. Clin Cancer Res 2012; 18:4026-36. PubMed
  • Tsao H, Chin L, Garraway LA, Fisher DE. Melanoma: from mutations to medicine. Genes Dev 2012; 26:1131-55. PubMed
  • Lipworth AD, Park JM, Trefrey BL, Rubin KM, Geller AC, Sober AJ, Tsao H. Urgent access to a specialty care melanoma clinic is associated with a higher rate of melanoma detection. J Am Acad Dermatol 2011. PubMed
  • Luo S, Chaplin AC, Langley RG, Njauw CN, Duncan LM, Miller RA, Tsao H. Agminated segmental nevi demonstrating intranevic concordance of BRAF status. J Invest Dermatol 2011; 131:788-90. PubMed
  • Lang JM, Shennan M, Njauw JC, Luo S, Bishop JN, Harland M, Hayward NK, Tucker MA, Goldstein AM, Landi MT, Puig S, Gruis NA, Bergman W, Bianchi-Scarra G, Ghiorzo P, Hogg D, Tsao H. A flexible multiplex bead-based assay for detecting germline CDKN2A and CDK4 variants in melanoma-prone kindreds. J Invest Dermatol 2011; 131:480-6. PubMed
  • Ko JM, Velez NF, Tsao H. Pathways to melanoma. 2010; 29:210-7. PubMed
  • Tsao H, Tanabe KK, Lawrence DP, Piris A. Case records of the Massachusetts General Hospital. Case 30-2010. A 15-year-old boy with a recurrent skin lesion. N Engl J Med 2010; 363:1352-60. PubMed
  • Udayakumar D, Mahato B, Gabree M, Tsao H. Genetic determinants of cutaneous melanoma predisposition. 2010; 29:190-5. PubMed
  • Boni A, Cogdill AP, Dang P, Udayakumar D, Njauw CN, Sloss CM, Ferrone CR, Flaherty KT, Lawrence DP, Fisher DE, Tsao H, Wargo JA. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res 2010; 70:5213-9. PubMed
  • Feramisco JD, Tsao H, Siegel DH. Genetics for the Practicing Dermatologist. 2010; 29:127-136. PubMed
  • Ji Z, Flaherty KT, Tsao H. Molecular therapeutic approaches to melanoma. Mol Aspects Med 2010; 31:194-204. PubMed
  • Sober AJ, Tsao H. Martin C. Mihm, Jr and the history of the Pigmented Lesion Clinic at the Massachusetts General Hospital. J Cutan Pathol 2010; 37 Suppl 1:8-11. PubMed
  • Wang W, Niendorf KB, Patel D, Blackford A, Marroni F, Sober AJ, Parmigiani G, Tsao H. Estimating CDKN2A carrier probability and personalizing cancer risk assessments in hereditary melanoma using MelaPRO. Cancer Res 2010; 70:552-9. PubMed
  • Yang G, Thieu K, Tsai KY, Piris A, Udayakumar D, Njauw CN, Ramoni MF, Tsao H. Dynamic gene expression analysis links melanocyte growth arrest with nevogenesis. Cancer Res 2009; 69:9029-37. PubMed
  • Sadreyev RI, Feramisco JD, Tsao H, Grishin NV. Phenotypic categorization of genetic skin diseases reveals new relations between phenotypes, genes and pathways. Bioinformatics 2009; 25:2891-6. PubMed
  • Feramisco JD, Sadreyev RI, Murray ML, Grishin NV, Tsao H. Phenotypic and genotypic analyses of genetic skin disease through the Online Mendelian Inheritance in Man (OMIM) database. J Invest Dermatol 2009; 129:2628-36. PubMed
  • Leachman SA, Carucci J, Kohlmann W, Banks KC, Asgari MM, Bergman W, Bianchi-Scarrà G, Brentnall T, Bressac-de Paillerets B, Bruno W, Curiel-Lewandrowski C, de Snoo FA, Debniak T, Demierre MF, Elder D, Goldstein AM, Grant-Kels J, Halpern AC, Ingvar C, Kefford RF, Lang J, MacKie RM, Mann GJ, Mueller K, Newton-Bishop J, Olsson H, Petersen GM, Puig S, Rigel D, Swetter SM, Tucker MA, Yakobson E, Zitelli JA, Tsao H. Selection criteria for genetic assessment of patients with familial melanoma. J Am Acad Dermatol 2009; 61:677.e1-14. PubMed
  • Park JM, Tsao H, Tsao S. Acquired bilateral nevus of Ota-like macules (Hori nevus): etiologic and therapeutic considerations. J Am Acad Dermatol 2009; 61:88-93. PubMed
  • Udayakumar D,Tsao H. Melanoma genetics: an update on risk-associated genes. Hematol Oncol Clin North Am 2009; 23:415-29, vii. PubMed
  • Udayakumar D, Tsao H. Moderate- to low-risk variant alleles of cutaneous malignancies and nevi: lessons from genome-wide association studies. Genome Med 2009; 1:95. PubMed
  • Nelson AA,Tsao H. Melanoma and genetics. Clin Dermatol 2009; 27:46-52. PubMed
  • Sun BK,Tsao H. X-chromosome inactivation and skin disease. J Invest Dermatol 2008; 128:2753-9. PubMed
  • Hocker TL,Singh MK,Tsao H. Melanoma genetics and therapeutic approaches in the 21st century: moving from the benchside to the bedside. J Invest Dermatol 2008; 128:2575-95. PubMed
  • Sun BK,Tsao H. Small RNAs in development and disease. J Am Acad Dermatol 2008; 59:725-37; quiz 738-40. PubMed
  • Harland M, Goldstein AM, Kukalizch K, Taylor C, Hogg D, Puig S, Badenas C, Gruis N, Ter Huurne J, Bergman W, Hayward NK, Stark M, Tsao H, Tucker MA, Landi MT, Scarra GB, Ghiorzo P, Kanetsky PA, Elder D, Mann GJ, Holland EA, Bishop DT, Newton Bishop J. A comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL). Eur J Cancer 2008; 44:1269-74. PubMed
  • Friedman RJ, Gutkowicz-Krusin D, Farber MJ, Warycha M, Schneider-Kels L, Papastathis N, Mihm MC Jr, Googe P, King R, Prieto VG, Kopf AW, Polsky D, Rabinovitz H, Oliviero M, Cognetta A, Rigel DS, Marghoob A, Rivers J, Johr R, Grant-Kels JM, Tsao H. The diagnostic performance of expert dermoscopists vs a computer-vision system on small-diameter melanomas. Arch Dermatol 2008; 144:476-82. PubMed
  • Zhang G, Njauw CN, Park JM, Naruse C, Asano M, Tsao H. EphA2 is an essential mediator of UV radiation-induced apoptosis. Cancer Res 2008; 68:1691-6. PubMed
  • Park JM, Tsao H, Tsao S. Combined use of intense pulsed light and Q-switched ruby laser for complex dyspigmentation among Asian patients. Lasers Surg Med 2008; 40:128-33. PubMed
  • Feramisco JD, Casey RL, Tsao H. Recent updates on genetics: teaching old dogmas new tricks. Pediatr Dermatol 2008; 25:99-108. PubMed
  • Somoano B, Tsao H. Genodermatoses with cutaneous tumors and internal malignancies. Dermatol Clin 2008; 26:69-87, viii. PubMed
  • McDermott U, Sharma SV, Dowell L, Greninger P, Montagut C, Lamb J, Archibald H, Raudales R, Tam A, Lee D, Rothenberg SM, Supko JG, Sordella R, Ulkus LE, Iafrate AJ, Maheswaran S, Njauw CN, Tsao H, Drew L, Hanke JH, Ma XJ, Erlander MG, Gray NS, Haber DA, Settleman J. Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc Natl Acad Sci U S A 2007; 104:19936-41. PubMed
  • Tsao H, Florez JC. Introduction to genetic association studies. J Invest Dermatol 2007; 127:2283-7. PubMed
  • Yang G, Curley D, Bosenberg MW, Tsao H. Loss of xeroderma pigmentosum C (Xpc) enhances melanoma photocarcinogenesis in Ink4a-Arf-deficient mice. Cancer Res 2007; 67:5649-57. PubMed
  • Hocker T, Tsao H. Ultraviolet radiation and melanoma: a systematic review and analysis of reported sequence variants. Hum Mutat 2007; 28:578-88. PubMed
  • Tsai KY, Tsao H. Primer on the human genome. J Am Acad Dermatol 2007; 56:719-35. PubMed
  • Lang J, Hayward N, Goldgar D, Tsao H, Hogg D, Palmer J, Stark M, Tobias ES, MacKie R. The M53I mutation in CDKN2A is a founder mutation that predominates in melanoma patients with Scottish ancestry. Genes Chromosomes Cancer 2007; 46:277-87. PubMed
  • Goldstein AM, Chan M, Harland M, Hayward NK, Demenais F, Bishop DT, Azizi E, Bergman W, Bianchi-Scarra G, Bruno W, Calista D, Albright LA, Chaudru V, Chompret A, Cuellar F, Elder DE, Ghiorzo P, Gillanders EM, Gruis NA, Hansson J, Hogg D, Holland EA, Kanetsky PA, Kefford RF, Landi MT, Lang J, Leachman SA, MacKie RM, Magnusson V, Mann GJ, Bishop JN, Palmer JM, Puig S, Puig-Butille JA, Stark M, Tsao H, Tucker MA, Whitaker L, Yakobson E. Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents. J Med Genet 2007; 44:99-106. PubMed
  • Yang G, Zhang G, Pittelkow MR, Ramoni M, Tsao H. Expression Profiling of UVB Response in Melanocytes Identifies a Set of p53-Target Genes. J Invest Dermatol 2006; 126:2490-506. PubMed
  • Goldstein AM, Chan M, Harland M, Gillanders EM, Hayward NK, Avril MF, Azizi E, Bianchi-Scarra G, Bishop DT, Bressac-de Paillerets B, Bruno W, Calista D, Cannon Albright LA, Demenais F, Elder DE, Ghiorzo P, Gruis NA, Hansson J, Hogg D, Holland EA, Kanetsky PA, Kefford RF, Landi MT, Lang J, Leachman SA, Mackie RM, Magnusson V, Mann GJ, Niendorf K, Newton Bishop J, Palmer JM, Puig S, Puig-Butille JA, de Snoo FA, Stark M, Tsao H, Tucker MA, Whitaker L, Yakobson E. High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMEL. Cancer Res 2006; 66:9818-28. PubMed
  • Haluska FG, Tsao H, Wu H, Haluska FS, Lazar A, Goel V. Genetic alterations in signaling pathways in melanoma. Clin Cancer Res 2006; 12:2301s-2307s. PubMed
  • Niendorf KB, Tsao H. Cutaneous melanoma: family screening and genetic testing. Dermatol Ther 2006; 19:1-8. PubMed
  • Rheinwald JG, Hahn WC, Ramsey MR, Wu JY, Guo Z, Tsao H, De Luca M, Catricalà C, O'Toole KM. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol 2002; 22:5157-72. PubMed
  • Bis S, Tsao H. Melanoma genetics: the other side. Clin Dermatol ; 31:148-55. PubMed
  • Nguyen ED, Xue YK, Danesh M, Ameri A, Weng CQ, Klebanov N, Foreman RK, Nazarian RM, Demehri S, Tsao H, Kroshinsky D. A Case of Nivolumab-Induced Cutaneous Toxicity with Multiple Morphologies. Dermatopathology (Basel) ; 6:255-259. PubMed
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DF/HCC members that share similar concepts* with Hensin Tsao, MD, PhD but have yet to coauthor a publication with this researcher.

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