Research Abstract
Involved in the development and application of novel molecular markers imaged by MRI. Recently concluded tranlational clinical trials for the use of magnetic nanoparticles for use in cancer detection and staging
Mukesh G. Harisinghani, MD
Massachusetts General Hospital
Massachusetts General Hospital
Phone: (617) 726-8396
Fax: (617) 726-4891
Mukesh G. Harisinghani, MD
Massachusetts General Hospital
EDUCATIONAL TITLES
DF/HCC PROGRAM AFFILIATION
Publications from Harvard Catalyst Profiles
- Ursprung S, Zhang ML, Asmundo L, Hesami M, Najmi Z, Cañamaque LG, Shenoy-Bhangle AS, Pierce TT, Mojtahed A, Blake MA, Cochran R, Nikolau K, Harisinghani MG, Catalano OA. An Illustrated Review of the Recent 2019 World Health Organization Classification of Neuroendocrine Neoplasms: A Radiologic and Pathologic Correlation. J Comput Assist Tomogr 2024. PubMed
- Dahl DM, Wu S, Lin SX, Hu M, Barney AA, Kim MM, Cornejo KM, Harisinghani MG, Feldman AS, Wu CL. Clinical significance of prostate cancer identified by transperineal standard template biopsy in men with nonsuspicious multiparametric magnetic resonance imaging. Urol Oncol 2024. PubMed
- Wu S, Feldman AS, Lin SX, Kim MM, Cornejo KM, Harisinghani MG, Wu CL, Dahl DM. Estimated prostate volume by semiautomatic segmentation of MRI is more accurately correlated with radical prostatectomy specimen weight than the volume calculated by ellipsoid formula. Urol. Int. 2023. PubMed
- Seguin CL, Davidi B, Linton B Peters M, Eckel A, Harisinghani MG, Goiffon RJ, Knudsen AB, Pandharipande PV. Ultrasound Surveillance of Small Incidentally Detected Gallbladder Polyps: Projected Benefits by Sex, Age, and Comorbidity Level. J Am Coll Radiol 2023. PubMed
- Wu S, Feldman AS, Kim MM, Lin SX, Cornejo KM, Harisinghani MG, Dahl DM, Wu CL. Gleason grade group concordance between systematic template combining magnetic resonance imaging fusion targeted biopsy and radical prostatectomy specimens: A comparison of transperineal and transrectal approaches. Urology 2023. PubMed
- Furtado FS, Mercaldo ND, Vahle T, Benkert T, Bradley WR, Ratanaprasatporn L, Seethamraju RT, Harisinghani MG, Lee S, Suarez-Weiss K, Umutlu L, Catana C, Pomykala KL, Domachevsky L, Bernstine H, Groshar D, Rosen BR, Catalano OA. Simultaneous multislice diffusion-weighted imaging versus standard diffusion-weighted imaging in whole-body PET/MRI. Eur Radiol 2022. PubMed
- Dahl DM, Kim MM, Wu S, Lin SX, Crotty RK, Cornejo KM, Harisinghani MG, Feldman AS, Wu CL. Detection of clinically significant prostate cancer by transperineal multiparametric magnetic resonance imaging-ultrasound fusion targeted prostate biopsy in smaller prostates. Urol Oncol 2022; 40:451.e9-451.e14. PubMed
- Atre ID, Watane GV, Harisinghani MG. Malignant peritoneal mesothelioma: correlation between CT imaging features and histologic subtypes. Abdom Radiol (NY) 2021. PubMed
- Suarez-Weiss KE, Jhaveri KS, Harisinghani MG. MRI Evaluation of Rectal Cancer Following Preoperative Chemoradiotherapy. Semin Roentgenol 2021; 56:177-185. PubMed
- Atre ID, Eurboonyanun K, Noda Y, Parakh A, O'Shea A, Lahoud RM, Sell NM, Kunitake H, Harisinghani MG. Utility of texture analysis on T2-weighted MR for differentiating tumor deposits from mesorectal nodes in rectal cancer patients, in a retrospective cohort. Abdom Radiol (NY) 2020. PubMed
- O'Shea A, Kilcoyne A, Hedgire SS, Harisinghani MG. Pelvic lymph nodes and pathways of disease spread in male pelvic malignancies. Abdom Radiol (NY) 2019. PubMed
- Kordbacheh H, Baliyan V, Parakh A, Wojtkiewicz GR, Hedgire S, Harisinghani MG. Pictorial review on abdominal applications of ferumoxytol in MR imaging. Abdom Radiol (NY) 2019; 44:3273-3284. PubMed
- Chulroek T, Wangcharoenrung D, Cattapan K, Kordbacheh H, Mitchell AJ, Harisinghani MG, De EJB. Can magnetic resonance imaging differentiate among transurethral bulking agent, urethral diverticulum, and periurethral cyst? Abdom Radiol (NY) 2019; 44:2852-2863. PubMed
- Kordbacheh H, Seethamraju RT, Weiland E, Kiefer B, Nickel MD, Chulroek T, Cecconi M, Baliyan V, Harisinghani MG. Image quality and diagnostic accuracy of complex-averaged high b value images in diffusion-weighted MRI of prostate cancer. Abdom Radiol (NY) 2019. PubMed
- Chulroek T, Kordbacheh H, Wangcharoenrung D, Cattapan K, Heidari P, Harisinghani MG. Comparative accuracy of qualitative and quantitative 18F-FDG PET/CT analysis in detection of lymph node metastasis from anal cancer. Abdom Radiol (NY) 2019; 44:828-835. PubMed
- Hedgire S, Kilcoyne A, Tonyushkin A, Mao Y, Uyeda JW, Gervais DA, Harisinghani MG. Effect of androgen deprivation and radiation therapy on MRI fiber tractography in prostate cancer: can we assess treatment response on imaging? Br J Radiol 2018. PubMed
- Oliveira IS, Kilcoyne A, Everett JM, Mino-Kenudson M, Harisinghani MG, Ganesan K. Cholangiocarcinoma: classification, diagnosis, staging, imaging features, and management. Abdom Radiol (NY) 2017. PubMed
- Kilcoyne A, Price MC, McDermott S, Harisinghani MG. Imaging on nodal staging of prostate cancer. Future Oncol 2017; 13:551-565. PubMed
- Hedgire SS, Kudrimoti S, Oliveira IS, Nadkarni N, McDermott S, Hahn PF, Mino-Kenudson M, Harisinghani MG. Extranodal lymphomas of abdomen and pelvis: imaging findings and differential diagnosis. Abdom Radiol (NY) 2016. PubMed
- Kilcoyne A, Harisinghani MG, Mahmood U. Prostate Cancer Imaging and Therapy: Potential Role of Nanoparticles. J Nucl Med 2016; 57:105S-110S. PubMed
- Hassanzadeh E, Glazer DI, Dunne RM, Fennessy FM, Harisinghani MG, Tempany CM. Prostate imaging reporting and data system version 2 (PI-RADS v2): a pictorial review. Abdom Radiol (NY) 2016. PubMed
- Diaz-Gil D, Fintelmann FJ, Molaei S, Elmi A, Hedgire SS, Harisinghani MG. Prediction of 5-year survival in advanced-stage ovarian cancer patients based on computed tomography peritoneal carcinomatosis index. Abdom Radiol (NY) 2016. PubMed
- Agarwal S, Grajo JR, Fuentes-Orrego JM, Abtahi SM, Harisinghani MG, Saini S, Hahn PF. Distinguishing hemangiomas from metastases on liver MRI performed with gadoxetate disodium: Value of the extended washout sign. Eur J Radiol 2016; 85:635-40. PubMed
- Iyer VR, Hedgire SS, Hoskote SS, Borczuk D, Harisinghani MG. Retrospective cohort study of portacaval lymphadenopathy identified on multidetector CT and implications for follow-up. Abdom Imaging 2015. PubMed
- Hedgire SS, Eberhardt SC, Borczuk R, McDermott S, Harisinghani MG. Interpretation and reporting multiparametric prostate MRI: a primer for residents and novices. Abdom Imaging 2014. PubMed
- Hedgire SS, Mino-Kenudson M, Elmi A, Thayer S, Fernandez-del Castillo C, Harisinghani MG. Enhanced primary tumor delineation in pancreatic adenocarcinoma using ultrasmall super paramagnetic iron oxide nanoparticle-ferumoxytol: an initial experience with histopathologic correlation. 2014; 9:1891-6. PubMed
- McDermott S, Thayer SP, Fernandez-Del Castillo C, Mino-Kenudson M, Weissleder R, Harisinghani MG. Accurate prediction of nodal status in preoperative patients with pancreatic ductal adenocarcinoma using next-gen nanoparticle. Transl Oncol 2013; 6:670-5. PubMed
- Mitchell DG, Javitt MC, Glanc P, Bennett GL, Brown DL, Dubinsky T, Harisinghani MG, Harris RD, Horowitz NS, Pandharipande PV, Pannu HK, Podrasky AE, Royal HD, Shipp TD, Siegel CL, Simpson L, Wong-You-Cheong JJ, Zelop CM, . ACR appropriateness criteria staging and follow-up of ovarian cancer. J Am Coll Radiol 2013; 10:822-7. PubMed
- Olumi AF, Kaufman DS, Zietman A, Harisinghani MG, Wu CL. Case records of the Massachusetts General Hospital. Case 25-2013. A 71-year-old man with hematuria and a mass in the bladder. N Engl J Med 2013; 369:660-7. PubMed
- Preston MA, Harisinghani MG, Mucci L, Witiuk K, Breau RH. Diagnostic tests in urology: magnetic resonance imaging (MRI) for the staging of prostate cancer. BJU Int 2013; 111:514-7. PubMed
- Paly JJ, Efstathiou JA, Hedgire SS, Chung PW, O'Malley M, Shah A, Bekelman JE, Harisinghani M, Shipley WU, Zietman AL, Beard C. Mapping patterns of nodal metastases in seminoma: rethinking radiotherapy fields. Radiother Oncol 2013; 106:64-8. PubMed
- Hartman RI, Chang CY, Wo JY, Eisenberg JD, Hong TS, Harisinghani MG, Gazelle GS, Pandharipande PV. Optimizing adjuvant treatment decisions for stage t2 rectal cancer based on mesorectal node size: a decision analysis. Acad Radiol 2013. PubMed
- Jhaveri KS, Harisinghani MG. Guest editors. Radiol Clin North Am 2012; 50:xi. PubMed
- Hedgire SS, Pargaonkar VK, Elmi A, Harisinghani AM, Harisinghani MG. Pelvic nodal imaging. Radiol Clin North Am 2012; 50:1111-25. PubMed
- Hedgire SS, Oei TN, McDermott S, Cao K, Patel M Z, Harisinghani MG. Multiparametric magnetic resonance imaging of prostate cancer. Indian J Radiol Imaging 2012; 22:160-9. PubMed
- Kaufman DS, Zietman AL, Dahl DM, Harisinghani MG, Wu CL. Case records of the Massachusetts General Hospital. Case 5-2011. A 65-year-old man with hematuria after treatment for prostate cancer. N Engl J Med 2011; 364:667-75. PubMed
- Pandharipande PV, Gervais DA, Hartman RI, Harisinghani MG, Feldman AS, Mueller PR, Gazelle GS. Renal mass biopsy to guide treatment decisions for small incidental renal tumors: a cost-effectiveness analysis. Radiology 2010; 256:836-46. PubMed
- Islam T, Harisinghani MG. Prostate cancer imaging: what the next decade holds. Expert Rev Med Devices 2010; 7:577-9. PubMed
- Macdonald SM, Harisinghani MG, Katkar A, Napolitano B, Wolfgang J, Taghian AG. Nanoparticle-Enhanced MRI to Evaluate Radiation Delivery to the Regional Lymphatics for Patients With Breast Cancer. Int J Radiat Oncol Biol Phys 2010; 77:1098-104. PubMed
- Uppot RN, Harisinghani MG, Gervais DA. Imaging-guided percutaneous renal biopsy: rationale and approach. AJR Am J Roentgenol 2010; 194:1443-9. PubMed
- Eisner BH, Kurtz MP, Harisinghani MG. Evolving role of magnetic resonance imaging in renal cancer imaging. J Endourol 2010; 24:707-11. PubMed
- Iyer VR, Hahn PF, Blaszkowsky LS, Thayer SP, Halpern EF, Harisinghani MG. Added value of selected images embedded into radiology reports to referring clinicians. J Am Coll Radiol 2010; 7:205-10. PubMed
- Baier ND, Hahn PF, Gervais DA, Samir A, Halpern EF, Mueller PR, Harisinghani MG. Fine-needle aspiration biopsy of thyroid nodules: experience in a cohort of 944 patients. AJR Am J Roentgenol 2009; 193:1175-9. PubMed
- Kaufman DS, McDougal WS, Harisinghani MG, Wu CL. Case records of the Massachusetts General Hospital. Case 30-2009. A 77-year-old man with recurrent transitional-cell carcinoma of the ureter. N Engl J Med 2009; 361:1292-9. PubMed
- Pandharipande PV, Mora JT, Uppot RN, Goehler A, Braschi M, Halpern EF, Gazelle GS, Harisinghani MG. Lymphotropic nanoparticle-enhanced MRI for independent prediction of lymph node malignancy: a logistic regression model. AJR Am J Roentgenol 2009; 193:W230-7. PubMed
- Gee MS,Harisinghani MG,Tabatabaei S. Molecular imaging in urologic surgery. Urol Clin North Am 2009; 36:125-32. PubMed
- Harisinghani MG. Nanoparticle enhanced imaging. Cancer Biomark 2009; 5:59. PubMed
- Islam T,Harisinghani MG. Overview of nanoparticle use in cancer imaging. Cancer Biomark 2009; 5:61-7. PubMed
- Pandharipande PV,Harisinghani MG,Ozanne EM,Specht MC,Hur C,Lee JM,Gazelle GS. Staging MR lymphangiography of the axilla for early breast cancer: cost-effectiveness analysis. AJR Am J Roentgenol 2008; 191:1308-19. PubMed
- Roedl JB,Harisinghani MG,Colen RR,Fischman AJ,Blake MA,Mathisen DJ,Mueller PR. Assessment of treatment response and recurrence in esophageal carcinoma based on tumor length and standardized uptake value on positron emission tomography-computed tomography. Ann Thorac Surg 2008; 86:1131-8. PubMed
- Li CS,Harisinghani MG,Lin WC,Braschi M,Hahn PF,Mueller PR. Enhancement characteristics of ultrasmall superparamagnetic iron oxide particle within the prostate gland in patients with primary prostate cancer. J Comput Assist Tomogr 2008; 32:523-8. PubMed
- Michaelson MD,Iliopoulos O,McDermott DF,McGovern FJ,Harisinghani MG,Oliva E. Case records of the Massachusetts General Hospital. Case 17-2008. A 63-year-old man with metastatic renal-cell carcinoma. N Engl J Med 2008; 358:2389-96. PubMed
- Guimaraes AR, Tabatabei S, Dahl D, McDougal WS, Weissleder R, Harisinghani MG. Pilot study evaluating use of lymphotrophic nanoparticle-enhanced magnetic resonance imaging for assessing lymph nodes in renal cell cancer. Urology 2008; 71:708-12. PubMed
- Feldman AS, McDougal WS, Harisinghani MG. The potential of nanoparticle-enhanced imaging. Urol Oncol 2008; 26:65-73. PubMed
- Harisinghani M, Ross RW, Guimaraes AR, Weissleder R. Utility of a new bolus-injectable nanoparticle for clinical cancer staging. Neoplasia 2007; 9:1160-5. PubMed
- Singh AK, Gonzalez-Torrez P, Kaewlai R, Tabatabaei S, Harisinghani MG. Imaging of penile neoplasm. Semin Ultrasound CT MR 2007; 28:287-96. PubMed
- Ross R, Harisinghani M. Prostate cancer imaging--what the urologic oncologist needs to know. Radiol Clin North Am 2006; 44:711-22, viii. PubMed
- Ross R, Harisinghani M. New clinical imaging modalities in prostate cancer. Hematol Oncol Clin North Am 2006; 20:811-30. PubMed
- Saokar A, Gee MS, Islam T, Mueller PR, Harisinghani MG. Appearance of primary lymphoid malignancies on lymphotropic nanoparticle-enhanced magnetic resonance imaging using ferumoxtran-10. Clin Imaging ; 34:448-52. PubMed
- Saokar A, Islam T, Jantsch M, Saksena MA, Hahn PF, Harisinghani MG. Detection of lymph nodes in pelvic malignancies with Computed Tomography and Magnetic Resonance Imaging. Clin Imaging ; 34:361-6. PubMed
- Ross RW, Zietman AL, Xie W, Coen JJ, Dahl DM, Shipley WU, Kaufman DS, Islam T, Guimaraes AR, Weissleder R, Harisinghani M. Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy. Clin Imaging ; 33:301-5. PubMed
- Ventura E, Islam T, Gee MS, Mahmood U, Braschi M, Harisinghani MG. Detection of nodal metastatic disease in patients with non-small cell lung cancer: comparison of positron emission tomography (PET), contrast-enhanced computed tomography (CT), and combined PET-CT. Clin Imaging ; 34:20-8. PubMed
- Roedl JB,Blake MA,Holalkere NS,Mueller PR,Colen RR,Harisinghani MG. Lymph node staging in esophageal adenocarcinoma with PET-CT based on a visual analysis and based on metabolic parameters. Abdom Imaging ; 34:610-7. PubMed
- Hedgire SS, Elmi A, Nadkarni ND, Cao K, McDermott S, Harisinghani MG. Preoperative evaluation of perinephric fat invasion in patients with renal cell carcinoma: correlation with pathological findings. Clin Imaging ; 37:91-6. PubMed