Photo of Isaac S. Kohane,  MD, PhD

Isaac S. Kohane, MD, PhD

Harvard Medical School

Harvard Medical School
Phone: (617) 432-3226
Fax: (617) 432-0693


isaac_kohane@hms.harvard.edu

Isaac S. Kohane, MD, PhD

Harvard Medical School

EDUCATIONAL TITLES

  • Marion V. Nelson Professor & Chair, Biomedical Informatics, Harvard Medical School

DF/HCC PROGRAM AFFILIATION

Publications from Harvard Catalyst Profiles

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  • Valtchinov VI, Murphy SN, Lacson R, Ikonomov N, Zhai BK, Andriole K, Rousseau J, Hanson D, Kohane IS, Khorasani R. Analytics to monitor local impact of the Protecting Access to Medicare Act's imaging clinical decision support requirements. J Am Med Inform Assoc 2022. PubMed
  • Ektefaie Y, Yuan W, Dillon DA, Lin NU, Golden JA, Kohane IS, Yu KH. Integrative multiomics-histopathology analysis for breast cancer classification. NPJ Breast Cancer 2021; 7:147. PubMed
  • Wang F, Yang S, Palmer N, Fox K, Kohane IS, Liao KP, Yu KH, Kou SC. Real-world data analyses unveiled the immune-related adverse effects of immune checkpoint inhibitors across cancer types. NPJ Precis Oncol 2021; 5:82. PubMed
  • Gordon WJ, Gottlieb D, Kreda D, Mandel JC, Mandl KD, Kohane IS. Patient-led data sharing for clinical bioinformatics research: USCDI and beyond. J Am Med Inform Assoc 2021. PubMed
  • Marostica E, Barber R, Denize T, Kohane IS, Signoretti S, Golden JA, Yu KH. Development of a Histopathology Informatics Pipeline for Classification and Prediction of Clinical Outcomes in Subtypes of Renal Cell Carcinoma. Clin Cancer Res 2021; 27:2868-2878. PubMed
  • Kohane IS, Aronow BJ, Avillach P, Beaulieu-Jones BK, Bellazzi R, Bradford RL, Brat GA, Cannataro M, Cimino JJ, García-Barrio N, Gehlenborg N, Ghassemi M, Gutiérrez-Sacristán A, Hanauer DA, Holmes JH, Hong C, Klann JG, Loh NHW, Luo Y, Mandl KD, Mohamad D, Moore JH, Murphy SN, Neuraz A, Ngiam KY, Omenn GS, Palmer N, Patel LP, Pedrera-Jiménez M, Sliz P, South AM, Tan ALM, Taylor DM, Taylor BW, Torti C, Vallejos AK, Wagholikar KB, Weber GM, Cai T. What Every Reader Should Know About Studies Using Electronic Health Record Data but May be Afraid to Ask. J Med Internet Res 2021. PubMed
  • Yuan W, Beaulieu-Jones BK, Yu KH, Lipnick SL, Palmer N, Loscalzo J, Cai T, Kohane IS. Temporal bias in case-control design: preventing reliable predictions of the future. Nat Commun 2021; 12:1107. PubMed
  • Norgeot B, Quer G, Beaulieu-Jones BK, Torkamani A, Dias R, Gianfrancesco M, Arnaout R, Kohane IS, Saria S, Topol E, Obermeyer Z, Yu B, Butte AJ. Minimum information about clinical artificial intelligence modeling: the MI-CLAIM checklist. Nat Med 2020; 26:1320-1324. PubMed
  • Yu KH, Hu V, Wang F, Matulonis UA, Mutter GL, Golden JA, Kohane IS. Deciphering serous ovarian carcinoma histopathology and platinum response by convolutional neural networks. BMC Med 2020; 18:236. PubMed
  • Yu KH, Lee TM, Yen MH, Kou SC, Rosen B, Chiang JH, Kohane IS. Reproducible Machine Learning Methods for Lung Cancer Detection Using Computed Tomography Images: Algorithm Development and Validation. J Med Internet Res 2020; 22:e16709. PubMed
  • Yu KH, Wang F, Berry GJ, Ré C, Altman RB, Snyder M, Kohane IS. Classifying non-small cell lung cancer types and transcriptomic subtypes using convolutional neural networks. J Am Med Inform Assoc 2020; 27:757-769. PubMed
  • Beam AL, Kompa B, Schmaltz A, Fried I, Weber G, Palmer N, Shi X, Cai T, Kohane IS. Clinical Concept Embeddings Learned from Massive Sources of Multimodal Medical Data. Pac Symp Biocomput 2020; 25:295-306. PubMed
  • Liao KP, Sun J, Cai TA, Link N, Hong C, Huang J, Huffman JE, Gronsbell J, Zhang Y, Ho YL, Castro V, Gainer V, Murphy SN, O'Donnell CJ, Gaziano JM, Cho K, Szolovits P, Kohane IS, Yu S, Cai T. High-throughput multimodal automated phenotyping (MAP) with application to PheWAS. J Am Med Inform Assoc 2019; 26:1255-1262. PubMed
  • Beaulieu-Jones BK, Finlayson S, Yuan W, Altman RB, Kohane IS, Prasad V, Yu KH. Examining the Use of Real-World Evidence in the Regulatory Process. Clin Pharmacol Ther 2019. PubMed
  • Yang S, Yu KH, Palmer N, Fox K, Kou SC, Kohane IS. Autoimmune Effects of Lung Cancer Immunotherapy Revealed by Data-Driven Analysis on a Nationwide Cohort. Clin Pharmacol Ther 2019. PubMed
  • Somekh J, Shen-Orr SS, Kohane IS. Batch correction evaluation framework using a-priori gene-gene associations: applied to the GTEx dataset. BMC Bioinformatics 2019; 20:268. PubMed
  • Kehl KL, Yang S, Awad MM, Palmer N, Kohane IS, Schrag D. Pre-existing autoimmune disease and the risk of immune-related adverse events among patients receiving checkpoint inhibitors for cancer. Cancer Immunol Immunother 2019. PubMed
  • Hejblum BP, Weber GM, Liao KP, Palmer NP, Churchill S, Shadick NA, Szolovits P, Murphy SN, Kohane IS, Cai T. Probabilistic record linkage of de-identified research datasets with discrepancies using diagnosis codes. Sci Data 2019; 6:180298. PubMed
  • Beaulieu-Jones BK, Kohane IS, Beam AL. Learning Contextual Hierarchical Structure of Medical Concepts with Poincairé Embeddings to Clarify Phenotypes. Pac Symp Biocomput 2019; 24:8-17. PubMed
  • Yu KH, Miron O, Palmer N, Lemos DR, Fox K, Kou SC, Sahin M, Kohane IS. Data-driven analyses revealed the comorbidity landscape of tuberous sclerosis complex. Neurology 2018; 91:974-976. PubMed
  • Yu KH, Lee TM, Chen YJ, Ré C, Kou SC, Chiang JH, Snyder M, Kohane IS. A Cloud-Based Metabolite and Chemical Prioritization System for the Biology/Disease-Driven Human Proteome Project. J Proteome Res 2018. PubMed
  • Sinnott JA, Cai F, Yu S, Hejblum BP, Hong C, Kohane IS, Liao KP. PheProb: probabilistic phenotyping using diagnosis codes to improve power for genetic association studies. J Am Med Inform Assoc 2018. PubMed
  • Agniel D, Kohane IS, Weber GM. Biases in electronic health record data due to processes within the healthcare system: retrospective observational study. BMJ 2018; 361:k1479. PubMed
  • Yu KH, Lee TM, Wang CS, Chen YJ, Ré C, Kou SC, Chiang JH, Kohane IS, Snyder M. Systematic Protein Prioritization for Targeted Proteomics Studies through Literature Mining. J Proteome Res 2018; 17:1383-1396. PubMed
  • Beam AL, Kohane IS. Big Data and Machine Learning in Health Care. JAMA 2018; 319:1317-1318. PubMed
  • Sagers JE, Brown AS, Vasilijic S, M Lewis R, Sahin MI, Landegger LD, Perlis RH, Kohane IS, Welling DB, Patel CJ, Stankovic KM. Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma. Sci Rep 2018; 8:5437. PubMed
  • Diao J, Kohane IS, Manrai AK. Biomedical Informatics and Machine Learning for Clinical Genomics. Hum Mol Genet 2018. PubMed
  • Gutiérrez-Sacristán A, Guedj R, Korodi G, Stedman J, Furlong LI, Patel CJ, Kohane IS, Avillach P. Rcupcake: an R package for querying and analyzing biomedical data through the BD2K PIC-SURE RESTful API. Bioinformatics 2017. PubMed
  • Deverka PA, Majumder MA, Villanueva AG, Anderson M, Bakker AC, Bardill J, Boerwinkle E, Bubela T, Evans BJ, Garrison NA, Gibbs RA, Gentleman R, Glazer D, Goldstein MM, Greely H, Harris C, Knoppers BM, Koenig BA, Kohane IS, La Rosa S, Mattison J, O'Donnell CJ, Rai AK, Rehm HL, Rodriguez LL, Shelton R, Simoncelli T, Terry SF, Watson MS, Wilbanks J, Cook-Deegan R, McGuire AL. Creating a data resource: what will it take to build a medical information commons? Genome Med 2017; 9:84. PubMed
  • Feiglin A, Allen BK, Kohane IS, Kong SW. Comprehensive Analysis of Tissue-wide Gene Expression and Phenotype Data Reveals Tissues Affected in Rare Genetic Disorders. Cell Syst 2017; 5:140-148.e2. PubMed
  • Patel CJ, Manrai AK, Corona E, Kohane IS. Systematic correlation of environmental exposure and physiological and self-reported behaviour factors with leukocyte telomere length. Int J Epidemiol 2016. PubMed
  • Manrai AK, Patel CJ, Gehlenborg N, Tatonetti NP, Ioannidis JP, Kohane IS. METHODS TO ENHANCE THE REPRODUCIBILITY OF PRECISION MEDICINE. Pac Symp Biocomput 2016; 21:180-182. PubMed
  • Beauchemin KJ, Wells JM, Kho AT, Philip VM, Kamir D, Kohane IS, Graber JH, Bult CJ. Temporal dynamics of the developing lung transcriptome in three common inbred strains of laboratory mice reveals multiple stages of postnatal alveolar development. PeerJ 2016; 4:e2318. PubMed
  • Manrai AK, Patel CJ, Gehlenborg N, Tatonetti NP, Ioannidis JP, Kohane IS. METHODS TO ENHANCE THE REPRODUCIBILITY OF PRECISION MEDICINE. Pac Symp Biocomput 2016; 21:180-2. PubMed
  • Wang F, Remke M, Bhat K, Wong ET, Zhou S, Ramaswamy V, Dubuc A, Fonkem E, Salem S, Zhang H, Hsieh TC, O'Rourke ST, Wu L, Li DW, Hawkins C, Kohane IS, Wu JM, Wu M, Taylor MD, Wu E. A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma. 2015; 6:2709-24. PubMed
  • Hwang KB, Lee IH, Park JH, Hambuch T, Choe Y, Kim M, Lee K, Song T, Neu MB, Gupta N, Kohane IS, Green RC, Kong SW. Reducing false-positive incidental findings with ensemble genotyping and logistic regression based variant filtering methods. Hum Mutat 2014. PubMed
  • Mandl KD, Kohane IS, McFadden D, Weber GM, Natter M, Mandel J, Schneeweiss S, Weiler S, Klann JG, Bickel J, Adams WG, Ge Y, Zhou X, Perkins J, Marsolo K, Bernstam E, Showalter J, Quarshie A, Ofili E, Hripcsak G, Murphy SN. Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): architecture. J Am Med Inform Assoc 2014; 21:615-20. PubMed
  • Weber GM, Mandl KD, Kohane IS. Finding the missing link for big biomedical data. JAMA 2014. PubMed
  • Manrai AK, Bhatia G, Strymish J, Kohane IS, Jain SH. Medicine's uncomfortable relationship with math: calculating positive predictive value. JAMA Intern Med 2014. PubMed
  • Lee IH, Lee K, Hsing M, Choe Y, Park JH, Kim SH, Bohn JM, Neu MB, Hwang KB, Green RC, Kohane IS, Kong SW. Prioritizing disease-linked variants, genes, and pathways with an interactive whole-genome analysis pipeline. Hum Mutat 2014; 35:537-47. PubMed
  • Kong SW, Sahin M, Collins CD, Wertz MH, Campbell MG, Leech JD, Krueger D, Bear MF, Kunkel LM, Kohane IS. Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis. Mol Autism 2014; 5:16. PubMed
  • Brownstein CA, Beggs AH, Homer N, Merriman B, Yu TW, Flannery KC, DeChene ET, Towne MC, Savage SK, Price EN, Holm IA, Luquette LJ, Lyon E, Majzoub J, Neupert P, McCallie D, Szolovits P, Willard HF, Mendelsohn NJ, Temme R, Finkel RS, Yum SW, Medne L, Sunyaev SR, Adzhubey I, Cassa CA, de Bakker PI, Duzkale H, Dworzyński P, Fairbrother W, Francioli L, Funke BH, Giovanni MA, Handsaker RE, Lage K, Lebo MS, Lek M, Leshchiner I, MacArthur DG, McLaughlin HM, Murray MF, Pers TH, Polak PP, Raychaudhuri S, Rehm HL, Soemedi R, Stitziel NO, Vestecka S, Supper J, Gugenmus C, Klocke B, Hahn A, Schubach M, Menzel M, Biskup S, Freisinger P, Deng M, Braun M, Perner S, Smith RJ, Andorf JL, Huang J, Ryckman K, Sheffield VC, Stone EM, Bair T, Black-Ziegelbein EA, Braun TA, Darbro B, DeLuca AP, Kolbe DL, Scheetz TE, Shearer AE, Sompallae R, Wang K, Bassuk AG, Edens E, Mathews K, Moore SA, Shchelochkov OA, Trapane P, Bossler A, Campbell CA, Heusel JW, Kwitek A, Maga T, Panzer K, Wassink T, Van Daele D, Azaiez H, Booth K, Meyer N, Segal MM, Williams MS, Tromp G, White P, Corsmeier D, Fitzgerald-Butt S, Herman G, Lamb-Thrush D, McBride KL, Newsom D, Pierson CR, Rakowsky AT, Maver A, Lovrečić L, Palandačić A, Peterlin B, Torkamani A, Wedell A, Huss M, Alexeyenko A, Lindvall JM, Magnusson M, Nilsson D, Stranneheim H, Taylan F, Gilissen C, Hoischen A, van Bon B, Yntema H, Nelen M, Zhang W, Sager J, Zhang L, Blair K, Kural D, Cariaso M, Lennon GG, Javed A, Agrawal S, Ng PC, Sandhu KS, Krishna S, Veeramachaneni V, Isakov O, Halperin E, Friedman E, Shomron N, Glusman G, Roach JC, Caballero J, Cox HC, Mauldin D, Ament SA, Rowen L, Richards DR, San Lucas FA, Gonzalez-Garay ML, Caskey CT, Bai Y, Huang Y, Fang F, Zhang Y, Wang Z, Barrera J, Garcia-Lobo JM, González-Lamuño D, Llorca J, Rodriguez MC, Varela I, Reese MG, De La Vega FM, Kiruluta E, Cargill M, Hart RK, Sorenson JM, Lyon GJ, Stevenson DA, Bray BE, Moore BM, Eilbeck K, Yandell M, Zhao H, Hou L, Chen X, Yan X, Chen M, Li C, Yang C, Gunel M, Li P, Kong Y, Alexander AC, Albertyn ZI, Boycott KM, Bulman DE, Gordon PM, Innes AM, Knoppers BM, Majewski J, Marshall CR, Parboosingh JS, Sawyer SL, Samuels ME, Schwartzentruber J, Kohane IS, Margulies DM. An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol 2014; 15:R53. PubMed
  • Uno H, Tian L, Cai T, Kohane IS, Wei LJ. A unified inference procedure for a class of measures to assess improvement in risk prediction systems with survival data. Stat Med 2013. PubMed
  • Chute CG, Kohane IS. Genomic medicine, health information technology, and patient care. JAMA 2013; 309:1467-8. PubMed
  • Altman RB, Clayton EW, Kohane IS, Malin BA, Roden DM. Data re-identification: societal safeguards. Science 2013; 339:1032-3. PubMed
  • Weber GM, Kohane IS. Extracting physician group intelligence from electronic health records to support evidence based medicine. PLoS ONE 2013; 8:e64933. PubMed
  • Palmer NP, Schmid PR, Berger B, Kohane IS. A gene expression profile of stem cell pluripotentiality and differentiation is conserved across diverse solid and hematopoietic cancers. Genome Biol 2012; 13:R71. PubMed
  • Ferrazzi F, Engel FB, Wu E, Moseman AP, Kohane IS, Bellazzi R, Ramoni MF. Inferring cell cycle feedback regulation from gene expression data. J Biomed Inform 2011. PubMed
  • Tong MY, Cassa CA, Kohane IS. Automated validation of genetic variants from large databases: ensuring that variant references refer to the same genomic locations. Bioinformatics 2011; 27:891-3. PubMed
  • Kohane IS, Margulies DM. Counterpoint: Do not opine before it's time. Nat Biotechnol 2011; 29:218-9. PubMed
  • Schachter AD, Kohane IS. Drug target-gene signatures that predict teratogenicity are enriched for developmentally related genes. Reprod Toxicol 2010. PubMed
  • Kohane IS, Taylor PL. Multidimensional results reporting to participants in genomic studies: getting it right. Sci Transl Med 2010; 2:37cm19. PubMed
  • Lee JM, Zhang J, Su AI, Walker JR, Wiltshire T, Kang K, Dragileva E, Gillis T, Lopez ET, Boily MJ, Cyr M, Kohane I, Gusella JF, Macdonald ME, Wheeler VC. A novel approach to investigate tissue-specific trinucleotide repeat instability. BMC Syst Biol 2010; 4:29. PubMed
  • Brownstein JS, Murphy SN, Goldfine AB, Grant RW, Sordo M, Gainer V, Colecchi JA, Dubey A, Nathan DM, Glaser JP, Kohane IS. Rapid identification of myocardial infarction risk associated with diabetes medications using electronic medical records. Diabetes Care 2010; 33:526-31. PubMed
  • Kho AT, Bhattacharya S, Tantisira KG, Carey VJ, Gaedigk R, Leeder JS, Kohane IS, Weiss ST, Mariani TJ. Transcriptomic analysis of human lung development. Am J Respir Crit Care Med 2010; 181:54-63. PubMed
  • Davis AR, Kohane IS. Expression differences by continent of origin point to the immortalization process. Hum Mol Genet 2009; 18:3864-75. PubMed
  • Tian Z,An N,Zhou B,Xiao P,Kohane IS,Wu E. Cytotoxic diarylheptanoid induces cell cycle arrest and apoptosis via increasing ATF3 and stabilizing p53 in SH-SY5Y cells. Cancer Chemother Pharmacol 2009; 63:1131-9. PubMed
  • Eran A,Graham KR,Vatalaro K,McCarthy J,Collins C,Peters H,Brewster SJ,Hanson E,Hundley R,Rappaport L,Holm IA,Kohane IS,Kunkel LM. Comment on "Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients". J Clin Invest 2009; 119:679-80; author reply 680-1. PubMed
  • Kohane IS. The twin questions of personalized medicine: who are you and whom do you most resemble? Genome Med 2009; 1:4. PubMed
  • Tian Z,Palmer N,Schmid P,Yao H,Galdzicki M,Berger B,Wu E,Kohane IS. A practical platform for blood biomarker study by using global gene expression profiling of peripheral whole blood. PLoS ONE 2009; 4:e5157. PubMed
  • Kohane I, Uzuner O. No Structure Before Its Time. J Am Med Inform Assoc 2008. PubMed
  • Mandl KD, Kohane IS. Tectonic shifts in the health information economy. N Engl J Med 2008; 358:1732-7. PubMed
  • Tian Z, Shen J, Moseman AP, Yang Q, Yang J, Xiao P, Wu E, Kohane IS. Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells. Int J Cancer 2008; 122:31-8. PubMed
  • Uzuner O, Goldstein I, Luo Y, Kohane I. Identifying patient smoking status from medical discharge records. J Am Med Inform Assoc 2008; 15:14-24. PubMed
  • Cassa CA,Schmidt B,Kohane IS,Mandl KD. My sister's keeper?: genomic research and the identifiability of siblings. BMC Med Genomics 2008; 1:32. PubMed
  • Naxerova K,Bult CJ,Peaston A,Fancher K,Knowles BB,Kasif S,Kohane IS. Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers. Genome Biol 2008; 9:R108. PubMed
  • Wu E,Palmer N,Tian Z,Moseman AP,Galdzicki M,Wang X,Berger B,Zhang H,Kohane IS. Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells. PLoS ONE 2008; 3:e3794. PubMed
  • Levine M, Adida B, Mandl K, Kohane I, Halamka J. What are the benefits and risks of fitting patients with radiofrequency identification devices. PLoS Med 2007; 4:e322. PubMed
  • Eisenberg I, Eran A, Nishino I, Moggio M, Lamperti C, Amato AA, Lidov HG, Kang PB, North KN, Mitrani-Rosenbaum S, Flanigan KM, Neely LA, Whitney D, Beggs AH, Kohane IS, Kunkel LM. Distinctive patterns of microRNA expression in primary muscular disorders. Proc Natl Acad Sci U S A 2007; 104:17016-21. PubMed
  • Lee JM, Ivanova EV, Seong IS, Cashorali T, Kohane I, Gusella JF, MacDonald ME. Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism. PLoS Genet 2007; 3:e135. PubMed
  • Drake TA, Braun J, Marchevsky A, Kohane IS, Fletcher C, Chueh H, Beckwith B, Berkowicz D, Kuo F, Zeng QT, Balis U, Holzbach A, McMurry A, Gee CE, McDonald CJ, Schadow G, Davis M, Hattab EM, Blevins L, Hook J, Becich M, Crowley RS, Taube SE, Berman J,. A system for sharing routine surgical pathology specimens across institutions: the Shared Pathology Informatics Network. Hum Pathol 2007; 38:1212-25. PubMed
  • Turchin A, Kolatkar NS, Pendergrass ML, Kohane IS. Computational analysis of non-adherence and non-attendance using the text of narrative physician notes in the electronic medical record. Med Inform Internet Med 2007; 32:93-102. PubMed
  • Kohane IS, Mandl KD, Taylor PL, Holm IA, Nigrin DJ, Kunkel LM. Medicine. Reestablishing the researcher-patient compact. Science 2007; 316:836-7. PubMed
  • Inaoka H, Fukuoka Y, Kohane IS. Evidence of spatially bound gene regulation in Mus musculus: decreased gene expression proximal to microRNA genomic location. Proc Natl Acad Sci U S A 2007; 104:5020-5. PubMed
  • Loscalzo J, Kohane I, Barabasi AL. Human disease classification in the postgenomic era: a complex systems approach to human pathobiology. Mol Syst Biol 2007; 3:124. PubMed
  • Allocco DJ, Song Q, Gibbons GH, Ramoni MF, Kohane IS. Geography and genography: prediction of continental origin using randomly selected single nucleotide polymorphisms. BMC Genomics 2007; 8:68. PubMed
  • Patel AA, Gupta D, Seligson D, Hattab EM, Balis UJ, Ulbright TM, Kohane IS, Berman JJ, Gilbertson JR, Dry S, Schirripa O, Yu H, Becich MJ, Parwani AV,. Availability and quality of paraffin blocks identified in pathology archives: a multi-institutional study by the Shared Pathology Informatics Network (SPIN). BMC Cancer 2007; 7:37. PubMed
  • Liu F, Park PJ, Lai W, Maher E, Chakravarti A, Durso L, Jiang X, Yu Y, Brosius A, Thomas M, Chin L, Brennan C, DePinho RA, Kohane I, Carroll RS, Black PM, Johnson MD. A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. Cancer Res 2006; 66:10815-23. PubMed
  • Frank NY, Kho AT, Schatton T, Murphy GF, Molloy MJ, Zhan Q, Ramoni MF, Frank MH, Kohane IS, Gussoni E. Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. J Cell Biol 2006; 175:99-110. PubMed
  • Carter SL, Eklund AC, Kohane IS, Harris LN, Szallasi Z. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet 2006; 38:1043-8. PubMed
  • Gazda HT, Kho AT, Sanoudou D, Zaucha JM, Kohane IS, Sieff CA, Beggs AH. Defective Ribosomal Protein Gene Expression Alters Transcription, Translation, Apoptosis And Oncogenic Pathways In Diamond-Blackfan Anemia. Stem Cells 2006; 24:2034-44. PubMed
  • Hung KE, Kho AT, Sarracino D, Richard LG, Krastins B, Forrester S, Haab BB, Kohane IS, Kucherlapati R. Mass spectrometry-based study of the plasma proteome in a mouse intestinal tumor model. J Proteome Res 2006; 5:1866-78. PubMed
  • Kohane IS, Masys DR, Altman RB. The incidentalome: a threat to genomic medicine. JAMA 2006; 296:212-5. PubMed
  • Liu H, Kho AT, Kohane IS, Sun Y. Predicting Survival within the Lung Cancer Histopathological Hierarchy Using a Multi-Scale Genomic Model of Development. PLoS Med 2006; 3:e232. PubMed
  • Sebastiani P, Mandl KD, Szolovits P, Kohane IS, Ramoni MF. A Bayesian dynamic model for influenza surveillance. Stat Med 2006; 25:1823-5. PubMed
  • Marinescu VD, Kohane IS, Kim TK, Harmin DA, Greenberg ME, Riva A. START: an automated tool for serial analysis of chromatin occupancy data. Bioinformatics 2006; 22:999-1001. PubMed
  • Kho AT, Kang PB, Kohane IS, Kunkel LM. Transcriptome-scale similarities between mouse and human skeletal muscles with normal and myopathic phenotypes. BMC Musculoskelet Disord 2006; 7:23. PubMed
  • Simons W, Halamka J, Kohane IS, Nigrin D, Finstein N, Mandl KD. Integration of the Personally Controlled Electronic Medical Record into Regional Inter-regional Data Exchanges: A National Demonstration. AMIA Annu Symp Proc 2006. PubMed
  • Adida B, Kohane IS. GenePING: secure, scalable management of personal genomic data. BMC Genomics 2006; 7:93. PubMed
  • Inaoka H, Fukuoka Y, Kohane IS. Lower expression of genes near microRNA in C. elegans germline. BMC Bioinformatics 2006; 7:112. PubMed
  • Butte AJ, Kohane IS. Creation and implications of a phenome-genome network. Nat Biotechnol 2006; 24:55-62. PubMed
  • Murphy SN, Mendis ME, Berkowicz DA, Kohane IS, Chueh HC. Integration of Clinical and Genetic Data in the i2b2 Architecture. AMIA Annu Symp Proc 2006. PubMed
  • Hackett KL, Kohane IS, Chueh HC, Murphy SN. Mapping tool for maintaining vocabulary relationships. AMIA Annu Symp Proc 2006. PubMed
  • Brownstein JS, Cassa CA, Kohane IS, Mandl KD. An unsupervised classification method for inferring original case locations from low-resolution disease maps. Int J Health Geogr 2006; 5:56. PubMed
  • Brownstein JS, Cassa CA, Kohane IS, Mandl KD. Reverse geocoding: concerns about patient confidentiality in the display of geospatial health data. AMIA Annu Symp Proc 2005. PubMed
  • Turchin A, Pendergrass ML, Kohane IS. DITTO - a tool for identification of patient cohorts from the text of physician notes in the electronic medical record. AMIA Annu Symp Proc 2005. PubMed
  • Manrai AK, Ioannidis JP, Kohane IS. Clinical Genomics: From Pathogenicity Claims to Quantitative Risk Estimates. JAMA ; 315:1233-4. PubMed
  • Roach KL, King KR, Uygun BE, Kohane IS, Yarmush ML, Toner M. High throughput single cell bioinformatics. Biotechnol. Prog. ; 25:1772-9. PubMed
  • Weber GM, Murphy SN, McMurry AJ, Macfadden D, Nigrin DJ, Churchill S, Kohane IS. The Shared Health Research Information Network (SHRINE): a prototype federated query tool for clinical data repositories. J Am Med Inform Assoc ; 16:624-30. PubMed
  • McMurry AJ, Gilbert CA, Reis BY, Chueh HC, Kohane IS, Mandl KD. A Self Scaling, Distributed Architecture for Public Health, Research, and Clinical Care. J Am Med Inform Assoc ; 14:527-33. PubMed
  • The Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature ; 455:1061-8.
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