Photo of Tianxi Cai, DSc

Tianxi Cai, DSc

Harvard T.H. Chan School Of Public Health

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-1056


tcai@hsph.harvard.edu

Photo of Tianxi Cai, DSc

Harvard T.H. Chan School Of Public Health
Phone: (617) 432-1056


tcai@hsph.harvard.edu

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Tianxi Cai, DSc

Harvard T.H. Chan School Of Public Health

EDUCATIONAL TITLES

  • Professor, Biostatistics, Harvard T.H. Chan School Of Public Health

HCC PROGRAM AFFILIATION

Research Abstract

Dr. Cai's current research interests are mainly in the area of survival data including clustered failure time data, doubly censored and interval censored data; evaluating the accuracy of biomarkers for predicting clinical outcomes and treatment responses; robust model evaluation and model selection.

Publications from Harvard Catalyst Profiles

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  • Hou J, Chan SF, Wang X, Cai T. Risk prediction with imperfect survival outcome information from electronic health records. Biometrics 2021. PubMed
  • Yuan Q, Cai T, Hong C, Du M, Johnson BE, Lanuti M, Cai T, Christiani DC. Performance of a Machine Learning Algorithm Using Electronic Health Record Data to Identify and Estimate Survival in a Longitudinal Cohort of Patients With Lung Cancer. JAMA Netw Open 2021; 4:e2114723. PubMed
  • Chepelev LL, Wang X, Gold B, Bonzel CL, Rybicki F, Uyeda JW, Sheikh A, Anderson D, Lindaman J, Mogel G, Mitsouras D, Mahoney MC, Cai T, Rybicki FJ. Improved Appropriateness of Advanced Diagnostic Imaging After Implementation of Clinical Decision Support Mechanism. J Digit Imaging 2021. PubMed
  • Geva A, Liu M, Panickan VA, Avillach P, Cai T, Mandl KD. A high-throughput phenotyping algorithm is portable from adult to pediatric populations. J Am Med Inform Assoc 2021. PubMed
  • Kohane IS, Aronow BJ, Avillach P, Beaulieu-Jones BK, Bellazzi R, Bradford RL, Brat GA, Cannataro M, Cimino JJ, García-Barrio N, Gehlenborg N, Ghassemi M, Gutiérrez-Sacristán A, Hanauer DA, Holmes JH, Hong C, Klann JG, Loh NHW, Luo Y, Mandl KD, Mohamad D, Moore JH, Murphy SN, Neuraz A, Ngiam KY, Omenn GS, Palmer N, Patel LP, Pedrera-Jiménez M, Sliz P, South AM, Tan ALM, Taylor DM, Taylor BW, Torti C, Vallejos AK, Wagholikar KB, Weber GM, Cai T. What Every Reader Should Know About Studies Using Electronic Health Record Data but May be Afraid to Ask. J Med Internet Res 2021. PubMed
  • Yuan W, Beaulieu-Jones BK, Yu KH, Lipnick SL, Palmer N, Loscalzo J, Cai T, Kohane IS. Temporal bias in case-control design: preventing reliable predictions of the future. Nat Commun 2021; 12:1107. PubMed
  • Hong C, Wang Y, Cai T. A divide-and-conquer method for sparse risk prediction and evaluation. Biostatistics 2020. PubMed
  • Chan S, Wang X, Jazić I, Peskoe S, Zheng Y, Cai T. Developing and evaluating risk prediction models with panel current status data. Biometrics 2020. PubMed
  • Ahuja Y, Zhou D, He Z, Sun J, Castro VM, Gainer V, Murphy SN, Hong C, Cai T. sureLDA: A multidisease automated phenotyping method for the electronic health record. J Am Med Inform Assoc 2020. PubMed
  • Cheng D, Ananthakrishnan AN, Cai T. Robust and efficient semi-supervised estimation of average treatment effects with application to electronic health records data. Biometrics 2020. PubMed
  • Beam AL, Kompa B, Schmaltz A, Fried I, Weber G, Palmer N, Shi X, Cai T, Kohane IS. Clinical Concept Embeddings Learned from Massive Sources of Multimodal Medical Data. Pac Symp Biocomput 2020; 25:295-306. PubMed
  • Cheng D, Chakrabortty A, Ananthakrishnan AN, Cai T. Estimating average treatment effects with a double-index propensity score. Biometrics 2019. PubMed
  • Zhang Y, Cai T, Yu S, Cho K, Hong C, Sun J, Huang J, Ho YL, Ananthakrishnan AN, Xia Z, Shaw SY, Gainer V, Castro V, Link N, Honerlaw J, Huang S, Gagnon D, Karlson EW, Plenge RM, Szolovits P, Savova G, Churchill S, O'Donnell C, Murphy SN, Gaziano JM, Kohane I, Cai T, Liao KP. High-throughput phenotyping with electronic medical record data using a common semi-supervised approach (PheCAP). Nat Protoc 2019; 14:3426-3444. PubMed
  • Liao KP, Sun J, Cai TA, Link N, Hong C, Huang J, Huffman JE, Gronsbell J, Zhang Y, Ho YL, Castro V, Gainer V, Murphy SN, O'Donnell CJ, Gaziano JM, Cho K, Szolovits P, Kohane IS, Yu S, Cai T. High-throughput multimodal automated phenotyping (MAP) with application to PheWAS. J Am Med Inform Assoc 2019; 26:1255-1262. PubMed
  • Cai T, Cai TT, Liao K, Liu W. Large-Scale Simultaneous Testing of Cross-Covariance Matrices with Applications to PheWAS. Stat Sin 2019; 29:983-1005. PubMed
  • Hejblum BP, Weber GM, Liao KP, Palmer NP, Churchill S, Shadick NA, Szolovits P, Murphy SN, Kohane IS, Cai T. Probabilistic record linkage of de-identified research datasets with discrepancies using diagnosis codes. Sci Data 2019; 6:180298. PubMed
  • Sinnott JA, Cai T. Pathway aggregation for survival prediction via multiple kernel learning. Stat Med 2018; 37:2501-2515. PubMed
  • Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK. Origins of lymphatic and distant metastases in human colorectal cancer. Science 2017; 357:55-60. PubMed
  • Zheng Y, Cai T. Augmented estimation for t-year survival with censored regression models. Biometrics 2017. PubMed
  • Maziarz M, Heagerty P, Cai T, Zheng Y. On longitudinal prediction with time-to-event outcome: Comparison of modeling options. Biometrics 2016. PubMed
  • Sinnott JA, Cai T. Inference for survival prediction under the regularized Cox model. Biostatistics 2016. PubMed
  • Huang YT, Cai T, Kim E. Integrative genomic testing of cancer survival using semiparametric linear transformation models. Stat Med 2016. PubMed
  • Uno H, Wittes J, Fu H, Solomon SD, Claggett B, Tian L, Cai T, Pfeffer MA, Evans SR, Wei LJ. Alternatives to Hazard Ratios for Comparing the Efficacy or Safety of Therapies in Noninferiority Studies. Ann Intern Med 2015; 163:127-34. PubMed
  • Minnier J, Yuan M, Liu JS, Cai T. Risk Classification with an Adaptive Naive Bayes Kernel Machine Model. Journal of the American Statistical Association 2015; 110:393-404. PubMed
  • Shen Y, Liao KP, Cai T. Sparse kernel machine regression for ordinal outcomes. Biometrics 2015. PubMed
  • Matsouaka RA, Li J, Cai T. Evaluating marker-guided treatment selection strategies. Biometrics 2014. PubMed
  • Parast L, Tian L, Cai T. Landmark Estimation of Survival and Treatment Effect in a Randomized Clinical Trial. Journal of the American Statistical Association 2014; 109:384-394. PubMed
  • Sinnott JA, Cai T. Omnibus risk assessment via accelerated failure time kernel machine modeling. Biometrics 2013; 69:861-73. PubMed
  • Zhou QM, Zheng Y, Cai T. Assessment of biomarkers for risk prediction with nested case-control studies. Clin Trials 2013; 10:677-9. PubMed
  • Parast L, Cai T. Landmark risk prediction of residual life for breast cancer survival. Stat Med 2013. PubMed
  • Uno H, Tian L, Cai T, Kohane IS, Wei LJ. A unified inference procedure for a class of measures to assess improvement in risk prediction systems with survival data. Stat Med 2013. PubMed
  • Gail MH, Pfeiffer RM, Cai T. Six articles related to risk assessment and prediction based on work presented at the October 12–14, 2011 Conference on Risk Assessment and Evaluation of Predictions in Silver Spring, Maryland. Lifetime Data Analysis 2013; 19:139-41. PubMed
  • Altschuler GM, Hofmann O, Kalatskaya I, Payne R, Ho Sui SJ, Saxena U, Krivtsov AV, Armstrong SA, Cai T, Stein L, Hide WA. Pathprinting: An integrative approach to understand the functional basis of disease. Genome Med 2013; 5:68. PubMed
  • Liu D, Cai T, Zheng Y. Evaluating the predictive value of biomarkers with stratified case-cohort design. Biometrics 2012. PubMed
  • Cai T, Lin X, Carroll RJ. Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test. Biostatistics 2012; 13:776-90. PubMed
  • Parast L, Cheng SC, Cai T. Landmark Prediction of Long Term Survival Incorporating Short Term Event Time Information. Journal of the American Statistical Association 2012; 107:1492-1501. PubMed
  • Cai T, Tonini G, Lin X. Kernel machine approach to testing the significance of multiple genetic markers for risk prediction. Biometrics 2011. PubMed
  • Parast L, Cheng SC, Cai T. Incorporating short-term outcome information to predict long-term survival with discrete markers. Biom J 2011; 53:294-307. PubMed
  • Uno H, Cai T, Pencina MJ, D'Agostino RB, Wei LJ. On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data. Stat Med 2011. PubMed
  • Cai T, Tian L, Wong PH, Wei LJ. Analysis of randomized comparative clinical trial data for personalized treatment selections. Biostatistics 2010. PubMed
  • Cai T, Parast L, Ryan L. Meta-analysis for rare events. Stat Med 2010; 29:2078-89. PubMed
  • Hunsaker AR, Oliva IB, Cai T, Trotman-Dickenson B, Gill RR, Hatabu H, Rybicki FJ. Contrast opacification using a reduced volume of iodinated contrast material and low peak kilovoltage in pulmonary CT angiography: Objective and subjective evaluation. AJR Am J Roentgenol 2010; 195:W118-24. PubMed
  • Cai T, Gerds TA, Zheng Y, Chen J. Robust Prediction of t-Year Survival with Data from Multiple Studies. Biometrics 2010. PubMed
  • Zheng Y,Cai T,Stanford JL,Feng Z. Semiparametric Models of Time-Dependent Predictive Values of Prognostic Biomarkers. Biometrics 2010; 66:50-60. PubMed
  • Tian L, Cai T, Wei LJ. Identifying subjects who benefit from additional information for better prediction of the outcome variables. Biometrics 2009; 65:894-902. PubMed
  • Cai T, Huang J, Tian L. Regularized estimation for the accelerated failure time model. Biometrics 2009; 65:394-404. PubMed
  • Tian L,Cai T,Pfeffer MA,Piankov N,Cremieux PY,Wei LJ. Exact and efficient inference procedure for meta-analysis and its application to the analysis of independent 2 x 2 tables with all available data but without artificial continuity correction. Biostatistics 2009; 10:275-81. PubMed
  • Wu CJ, Cai T, Rikova K, Merberg D, Kasif S, Steffen M. A predictive phosphorylation signature of lung cancer. PLoS ONE 2009; 4:e7994. PubMed
  • Gerds TA,Cai T,Schumacher M. The performance of risk prediction models. Biom J 2008; 50:457-79. PubMed
  • Cai T,Cheng S. Robust combination of multiple diagnostic tests for classifying censored event times. Biostatistics 2008; 9:216-33. PubMed
  • Zheng Y, Cai T, Pepe MS, Levy WC. Time-dependent Predictive Values of Prognostic Biomarkers with Failure Time Outcome. Journal of the American Statistical Association 2008; 103:362-368. PubMed
  • Ersoy H, Goldhaber SZ, Cai T, Luu T, Rosebrook J, Mulkern R, Rybicki F. Time-resolved MR angiography: a primary screening examination of patients with suspected pulmonary embolism and contraindications to administration of iodinated contrast material. AJR Am J Roentgenol 2007; 188:1246-54. PubMed
  • Cai T, Zheng Y. Model checking for ROC regression analysis. Biometrics 2007; 63:152-63. PubMed
  • Chuang SK, Cai T. Predicting clustered dental implant survival using frailty methods. J Dent Res 2006; 85:1147-51. PubMed
  • Zheng Y, Cai T, Feng Z. Application of the time-dependent ROC curves for prognostic accuracy with multiple biomarkers. Biometrics 2006; 62:279-87. PubMed
  • Cai T, Gilbert PB, Self SG. Joint inferences on vaccine efficacy against infection and disease with application to the first HIV vaccine efficacy trial. J Biopharm Stat 2006; 16:517-38. PubMed
  • Cai T, Tian L, Solomon S, Wei LJ. Predicting Future Responses Based on Possibly Misspecified Working Models ; 95:75-92.
  • Tian L, Cai T, Goetghebeur E, Wei LJ. Model Evaluation Based on the Distribution of Estimated Absolute Prediction Error ; 94:297-311.
  • Uno H, Cai T, Tian L, Wei LJ. Evaluating Prediction Rules for t-Year Survivors With Censored Regression Models J Am Stat Assoc ; 102:527-37.
  • Ware J, Cai T. Comments on Evaluation the added predictive ability of a new markier: From area under the ROC curve to reclassification and beyond ; 27:185-187.
  • Cai T, Tian L, Uno H, Solomon SD, Wei LJ. Calibrating parametric subject-specific risk estimation Biometrika ; 97:389-404.
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HCC members that share similar concepts* with Tianxi Cai, DSc but have yet to coauthor a publication with this researcher.

* Concepts are MeSH terms, automatically derived from member publications

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