Photo of Alison M. Friedmann,

Alison M. Friedmann

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-2737
Fax: (617) 724-0702


afriedmann@partners.org

Alison M. Friedmann

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Assistant Professor, Pediatrics, Harvard Medical School
  • Assistant Pediatrician, Pediatrics, Massachusetts General Hospital

Research Abstract

I am an active clinical researcher and serve as the Principal Investigator for our institution with the Children's Oncology Group. In addition to participating in clinical trials that are open through the COG, I have conducted extensive research into the management of low risk febrile neutropenia, developing a clinical pathway at the MGH for the outpatient management of children with low risk features. I have also collaborated closely with my radiation oncology colleagues, studying the safety and efficacy of proton beam irradiation for the treatment of childhood tumors, particularly soft tissue sarcomas. Other clinical research efforts are in the fields of acute lymphoblastic leukemia, Hodgkin lymphoma, and the role of imaging in the staging and follow-up of pediatric cancers

Publications from Harvard Catalyst Profiles

Powered by Harvard Catalyst
  • Lin M, Chen JJ, Bagatell R, Shaaban SG, Lerman BJ, Shusterman S, Ioakeim-Ioannidou M, Yock TI, Catalano PJ, Elhalawani H, Dusenbery KE, Vo KT, Huang MS, Friedmann AM, Diller LR, Marcus KJ, MacDonald SM, Terezakis SA, Braunstein SE, Hill-Kayser CE, Haas-Kogan DA, DuBois SG, Liu KX. Characterization of Clinical Outcomes for Patients with Relapsed High-Risk Neuroblastoma After Autologous Stem Cell Transplant and External Beam Radiotherapy. Cancers (Basel) 2026. PubMed
  • Flerlage JE, Feraco AM, Zhou Y, Zheng Y, Liang J, Lucas JT, Friedmann AM, Weinstein HJ, Yock TI, Shulkin BL, Kaste SC, Marks LJ, Ehrhardt MJ, Dixon SB, Howard S, de Alarcon P, Luna-Fineman S, Geddis AE, Larsen EC, Marcus KJ, Billett A, Donaldson SS, Hudson MM, Metzger ML, Krasin MJ, Link MP. Dose-dense chemotherapy enables elimination of RT for majority of low-risk pediatric Hodgkin lymphoma: PHC study HOD08. Blood 2026. PubMed
  • Liu KX, Shaaban SG, Chen JJ, Bagatell R, Lerman BJ, Catalano PJ, DuBois SG, Shusterman S, Ioakeim-Ioannidou M, Yock TI, Shamberger RC, Mattei P, Vu L, Elhalawani H, Dusenbery KE, Vo KT, Huang MS, Friedmann AM, Diller LR, Marcus KJ, MacDonald SM, Terezakis SA, Braunstein SE, Hill-Kayser CE, Haas-Kogan DA. Patterns of recurrence after radiotherapy for high-risk neuroblastoma: Implications for radiation dose and field. Radiother Oncol 2024; 198:110384. PubMed
  • Feraco AM, Zhou Y, Zheng Y, Marks LJ, Friedmann AM, Weinstein HJ, Link MP, Flerlage JE. Disease site number was not prognostic in a low-risk Hodgkin lymphoma combined modality trial: revisiting PHC HOD90. Blood Adv 2023. PubMed
  • Venkataraman V, Massoth LR, Sullivan RJ, Friedmann AM. Secondary histiocytic sarcoma with BRAF mutation responsive to MAPK-targeted therapy presenting with recurrence with mTOR mutation responsive to mTOR-targeted therapy. Pediatr Blood Cancer 2021. PubMed
  • Mattano LA, Devidas M, Maloney KW, Wang C, Friedmann AM, Buckley P, Borowitz MJ, Carroll AJ, Gastier-Foster JM, Heerema NA, Kadan-Lottick NS, Matloub YH, Marshall DT, Stork LC, Loh ML, Raetz EA, Wood BL, Hunger SP, Carroll WL, Winick NJ. Favorable Trisomies and Predict Cure in Low-Risk B-Cell Acute Lymphoblastic Leukemia: Results From Children's Oncology Group Trial AALL0331. J Clin Oncol 2021; 39:1540-1552. PubMed
  • Massoth LR, Hung YP, Ferry JA, Hasserjian RP, Nardi V, Nielsen GP, Sadigh S, Venkataraman V, Selig M, Friedmann AM, Samore W, Killian JK, Milante R, Giessinger J, Foley-Peres K, Marcus C, Severson E, Duncan D, Sivakumar S, Ross JS, Desphande V, Ramkissoon SH, Vergilio JA, Louissaint A, Zukerberg LR, Williams EA. Histiocytic and Dendritic Cell Sarcomas of Hematopoietic Origin Share Targetable Genomic Alterations Distinct from Follicular Dendritic Cell Sarcoma. Oncologist 2021. PubMed
  • Metzger ML, Link MP, Billett AL, Flerlage J, Lucas JT, Mandrell BN, Ehrhardt MJ, Bhakta N, Yock TI, Friedmann AM, de Alarcon P, Luna-Fineman S, Larsen E, Kaste SC, Shulkin B, Lu Z, Li C, Hiniker SM, Donaldson SS, Hudson MM, Krasin MJ. Excellent Outcome for Pediatric Patients With High-Risk Hodgkin Lymphoma Treated With Brentuximab Vedotin and Risk-Adapted Residual Node Radiation. J Clin Oncol 2021. PubMed
  • Llanos-Chea A, Shapiro JM, Winter RW, Jerger L, Menz T, Gibson M, Friedmann AM, Treaba D, Papamichael K, Cheifetz AS, Friedman S, Hamilton MJ, Winter HS. Lymphoma in Pediatric-Onset Inflammatory Bowel Disease Treated with Infliximab Monotherapy: A Case Series. Dig Dis Sci 2021. PubMed
  • Venkataraman V, Massoth LR, Sullivan RJ, Friedmann AM. Secondary histiocytic sarcoma with BRAF mutation after T-cell acute lymphoblastic leukemia in a very young child with dramatic response to dabrafenib and trametinib. Pediatr Blood Cancer 2020; 67:e28200. PubMed
  • Maloney KW, Devidas M, Wang C, Mattano LA, Friedmann AM, Buckley P, Borowitz MJ, Carroll AJ, Gastier-Foster JM, Heerema NA, Kadan-Lottick N, Loh ML, Matloub YH, Marshall DT, Stork LC, Raetz EA, Wood B, Hunger SP, Carroll WL, Winick NJ. Outcome in Children With Standard-Risk B-Cell Acute Lymphoblastic Leukemia: Results of Children's Oncology Group Trial AALL0331. J Clin Oncol 2019. PubMed
  • Raef HS, Friedmann AM, Hawryluk EB. Medical Options for the Adjuvant Treatment and Management of Pediatric Melanoma. Paediatr Drugs 2019. PubMed
  • Kamran SC, Goldberg SI, Kuhlthau KA, Lawell MP, Weyman EA, Gallotto SL, Hess CB, Huang MS, Friedmann AM, Abrams AN, MacDonald SM, Pulsifer MB, Tarbell NJ, Ebb DH, Yock TI. Quality of life in patients with proton-treated pediatric medulloblastoma: Results of a prospective assessment with 5-year follow-up. Cancer 2018. PubMed
  • Bartenstein DW, Kelleher CM, Friedmann AM, Duncan LM, Tsao H, Sober AJ, Hawryluk EB. Contrasting features of childhood and adolescent melanomas. Pediatr Dermatol 2018. PubMed
  • Wang JC, Jiménez Pérez JC, Friedmann AM, Louissaint A, Freitag SK. Myeloid sarcoma involving the greater wing of the sphenoid bone and additional skeletal sites presenting with unilateral proptosis and fevers. Orbit 2018. PubMed
  • Bartenstein DW, Coe TM, Gordon SC, Friedmann AM, Senna MM, Kelleher CM, Antonescu CR, Nazarian RM, Hawryluk EB. Lipofibromatosis-like neural tumor: Case report of a unique infantile presentation. JAAD Case Rep 2018; 4:185-188. PubMed
  • Schwartz KR, Hanson JM, Friedmann AM. Pediatric Acute Promyelocytic Leukemia Presenting to the Emergency Department as Refusal to Ambulate. Case Rep Emerg Med 2018; 2018:5241425. PubMed
  • Yang Y, Kazlas M, Sharma M, Friedmann A. AML presenting with a preleukemic episode and acquired heterochromia in a child with macrosomia. Pediatr Blood Cancer 2017. PubMed
  • Lu BY, Kojima L, Huang MS, Friedmann AM, Ferry JA, Weinstein HJ. Facial manifestations of Epstein-Barr virus-related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations. Pediatr Blood Cancer 2016. PubMed
  • Misra M, Sagar P, Friedmann AM, Ryan DP, Sgroi DC. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 12-2016. An 8-Year-Old Boy with an Enlarging Mass in the Right Breast. N Engl J Med 2016; 374:1565-74. PubMed
  • Pugmire BS, Guimaraes AR, Lim R, Friedmann AM, Huang M, Ebb D, Weinstein H, Catalano OA, Mahmood U, Catana C, Gee MS. Simultaneous whole body (18)F-fluorodeoxyglucose positron emission tomography magnetic resonance imaging for evaluation of pediatric cancer: Preliminary experience and comparison with (18)F-fluorodeoxyglucose positron emission tomography computed tomograp World J Radiol 2016; 8:322-30. PubMed
  • Walter JE, Armanios M, Shah U, Friedmann AM, Spitzer T, Sharatz SM, Hagen C. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 41-2015. A 14-Year-Old Boy with Immune and Liver Abnormalities. N Engl J Med 2015; 373:2664-76. PubMed
  • Lucas JT, Ladra MM, MacDonald SM, Busse PM, Friedmann AM, Ebb DH, Marcus KJ, Tarbell NJ, Yock TI. Proton therapy for pediatric and adolescent esthesioneuroblastoma. Pediatr Blood Cancer 2015. PubMed
  • Ladra MM, Mandeville HC, Niemierko A, Padera TP, Friedmann AM, MacDonald SM, Ebb D, Chen YL, Tarbell NJ, Yock TI. Local failure in parameningeal rhabdomyosarcoma correlates with poor response to induction chemotherapy. Int J Radiat Oncol Biol Phys 2015; 92:358-67. PubMed
  • Ladra MM, Szymonifka JD, Mahajan A, Friedmann AM, Yong Yeap B, Goebel CP, MacDonald SM, Grosshans DR, Rodriguez-Galindo C, Marcus KJ, Tarbell NJ, Yock TI. Preliminary results of a phase II trial of proton radiotherapy for pediatric rhabdomyosarcoma. J Clin Oncol 2014. PubMed
  • Ladra MM, Edgington SK, Mahajan A, Grosshans D, Szymonifka J, Khan F, Moteabbed M, Friedmann AM, MacDonald SM, Tarbell NJ, Yock TI. A dosimetric comparison of proton and intensity modulated radiation therapy in pediatric rhabdomyosarcoma patients enrolled on a prospective phase II proton study. Radiother Oncol 2014; 113:77-83. PubMed
  • Friedmann AM, Wolfson JA, Hudson MM, Weinstein HJ, Link MP, Billett A, Larsen EC, Yock T, Donaldson SS, Marcus K, Krasin MJ, Howard SC, Metzger ML. Relapse after treatment of pediatric Hodgkin lymphoma: outcome and role of surveillance after end of therapy. Pediatr Blood Cancer 2013; 60:1458-63. PubMed
  • Siegel MJ, Acharyya S, Hoffer FA, Wyly JB, Friedmann AM, Snyder BS, Babyn PS, Khanna G, Siegel BA. Whole-body MR imaging for staging of malignant tumors in pediatric patients: results of the American College of Radiology Imaging Network 6660 Trial. Radiology 2013; 266:599-609. PubMed
  • Childs SK, Kozak KR, Friedmann AM, Yeap BY, Adams J, MacDonald SM, Liebsch NJ, Tarbell NJ, Yock TI. Proton radiotherapy for parameningeal rhabdomyosarcoma: clinical outcomes and late effects. Int J Radiat Oncol Biol Phys 2012. PubMed
  • El Saleeby CM, Grottkau BE, Friedmann AM, Westra SJ, Sohani AR. Case records of the Massachusetts General Hospital. Case 4-2011. A 4-year-old boy with back pain and hypercalcemia. N Engl J Med 2011; 364:552-62. PubMed
  • Aftandilian CC, Friedmann AM. Burkitt lymphoma with pancreatic involvement. J Pediatr Hematol Oncol 2010; 32:e338-40. PubMed
  • Cotter SE, Herrup DA, Friedmann A, Macdonald SM, Pieretti RV, Robinson G, Adams J, Tarbell NJ, Yock TI. Proton Radiotherapy for Pediatric Bladder/Prostate Rhabdomyosarcoma: Clinical Outcomes and Dosimetry Compared to Intensity-Modulated Radiation Therapy. Int J Radiat Oncol Biol Phys 2010. PubMed
  • Friedmann A, Dehnhardt J, Kleber BM, Bernimoulin JP. Cytobiocompatibility of collagen and ePTFE membranes on osteoblast-like cells in vitro. J Biomed Mater Res A 2008; 86:935-41. PubMed
  • Lipkin E, Tal-Stein R, Friedmann A, Soller M. Effect of quantitative trait loci for milk protein percentage on milk protein yield and milk yield in Israeli Holstein dairy cattle. J Dairy Sci 2008; 91:1614-27. PubMed
  • Friedmann AM. Evaluation and management of lymphadenopathy in children. Pediatr Rev 2008; 29:53-60. PubMed
  • Bagnato A, Schiavini F, Rossoni A, Maltecca C, Dolezal M, Medugorac I, Solkner J, Russo V, Fontanesi L, Friedmann A, Soller M, Lipkin E. Quantitative trait loci affecting milk yield and protein percentage in a three-country Brown Swiss population. J Dairy Sci 2008; 91:767-83. PubMed
  • Friedmann AM, Weinstein HJ. The evolving standard of care for hodgkin lymphoma. J Pediatr Hematol Oncol 2008; 30:121-3. PubMed
  • Kaner D, Bernimoulin JP, Hopfenmuller W, Kleber BM, Friedmann A. Controlled-delivery chlorhexidine chip versus amoxicillin/metronidazole as adjunctive antimicrobial therapy for generalized aggressive periodontitis: a randomized controlled clinical trial. J Clin Periodontol 2007; 34:880-91. PubMed
  • Kaner D, Christan C, Dietrich T, Bernimoulin JP, Kleber BM, Friedmann A. Timing affects the clinical outcome of adjunctive systemic antibiotic therapy for generalized aggressive periodontitis. J Periodontol 2007; 78:1201-8. PubMed
  • Friedmann AC, Ameen M, Swale VJ. Familial pityriasis rotunda in black-skinned patients; a first report. Br J Dermatol 2007; 156:1365-7. PubMed
Hide