Photo of Michelle C. Specht, MD

Michelle C. Specht, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-0340


mspecht@partners.org

Photo of Michelle C. Specht, MD

Massachusetts General Hospital
Phone: (617) 726-0340


mspecht@partners.org

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Michelle C. Specht, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Surgery, Harvard Medical School
  • Associate Professor of Surgery, Surgical Oncology, Massachusetts General Hospital

HCC PROGRAM AFFILIATION

Research Abstract

Dr. Michelle Specht research interests are focused on the local treatment of breast cancer. Optimal treatment of early stage breast cancers includes wide excision of the tumor with negative margins. Achieving negative margins often requires multiple operations which are both financially and emotionally costly to the patient. Re-excision rates for early stage breast cancer after lumpectomy are reported to range from 30 - 50 %. Dr. Specht's research focuses on identifying pre-operative tools to better determine the extent of early stage breast cancers in order to decrease the number of operations needed to acheive negative margins.

Publications from Harvard Catalyst Profiles

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  • Lehman CD, Mercaldo S, Lamb LR, King TA, Ellisen LW, Specht M, Tamimi RM. Deep Learning vs Traditional Breast Cancer Risk Models to Support Risk-Based Mammography Screening. Journal of the National Cancer Institute 2022. PubMed
  • Webster AJ, Kelly BN, McGugin C, Coopey SB, Smith BL, Gadd MA, Specht MC. Comparison of Wireless Localization Alternatives with Wire Localization for Nonpalpable Breast Lesions. J Am Coll Surg 2022; 234:1091-1099. PubMed
  • Specht MC, Kelly BN, Tomczyk E, Ford OA, Webster AJ, Smith BL, Gadd MA, Colwell AS, Liao EC. One-Year Experience of Same-Day Mastectomy and Breast Reconstruction Protocol. Ann Surg Oncol 2022. PubMed
  • O'Donnell E, Shapiro Y, Comander A, Isakoff S, Moy B, Spring L, Wander S, Kuter I, Shin J, Specht M, Kournioti C, Hu B, Sullivan C, Winters L, Horick N, Peppercorn J. Pilot study to assess prolonged overnight fasting in breast cancer survivors (longfast). Breast Cancer Res Treat 2022. PubMed
  • Lehman CD, Mercaldo SF, Wang GX, Dontchos BN, Specht MC, Lamb LR. Screening Mammography Recovery After COVID-19 Pandemic Facility Closures: Associations of Facility Access and Racial and Ethnic Screening Disparities. AJR Am J Roentgenol 2022. PubMed
  • Kelly BN, Webster AJ, Lamb L, Spivey T, Korotkin JE, Henriquez A, Gadd MA, Hughes KS, Lehman CR, Smith BL, Specht MC. Magnetic Seeds: An Alternative to Wire Localization for Nonpalpable Breast Lesions. Clin Breast Cancer 2022. PubMed
  • Faulkner HR, Coopey SB, Liao EC, Specht M, Smith BL, Colwell AS. The safety of performing breast reconstruction during the COVID-19 pandemic. Breast Cancer 2021. PubMed
  • Kelly BN, Faulkner HR, Smith BL, Korotkin JE, Lanahan CR, Brown C, Gadd MA, Specht MC, Hughes KS, Oseni TS, Colwell AS, Coopey SB. Nipple-Sparing Mastectomy versus Skin-Sparing Mastectomy: Does Saving the Nipple Impact Short- and Long-Term Patient Satisfaction? Ann Surg Oncol 2021. PubMed
  • Garstka M, Henriquez A, Kelly BN, Webster A, Khubchandani JA, Hughes K, Nguyen A, Oseni T, Specht M, Coopey SB, Gadd MA, Smith BL. ASO Visual Abstract: How Protective are Nipple-Sparing Prophylactic Mastectomies in BRCA1 and BRCA2 Mutation Carriers? Ann Surg Oncol 2021. PubMed
  • Milligan MG, Zieminski S, Johnson A, Depauw N, Rosado N, Specht MC, Liao EC, Jimenez RB. Target coverage and cardiopulmonary sparing with the updated ESTRO-ACROP contouring guidelines for postmastectomy radiation therapy after breast reconstruction: a treatment planning study using VMAT and proton PBS techniques. Acta Oncol 2021. PubMed
  • Garstka M, Henriquez A, Kelly BN, Webster A, Khubchandani JA, Hughes K, Nguyen A, Oseni T, Specht M, Coopey SB, Gadd MA, Smith BL. How Protective are Nipple-Sparing Prophylactic Mastectomies in BRCA1 and BRCA2 Mutation Carriers? Ann Surg Oncol 2021. PubMed
  • Colwell AS, Lamb LR, Tomczyk E, Faulkner H, Specht MC. An Algorithm for Management of Cosmetic and Reconstructive Patients with Textured Implants: An Institutional Experience. Plast Reconstr Surg 2021; 147:39S-43S. PubMed
  • Lanahan CR, Kelly BN, Gadd MA, Specht MC, Brown CL, Hughes KS, Tang R, Rai U, Brachtel EF, Rice-Stitt T, Smith BL. Performance of a novel protease-activated fluorescent imaging system for intraoperative detection of residual breast cancer during breast conserving surgery. Breast Cancer Res Treat 2021. PubMed
  • Kelly BN, Kantor O, Tang R, Coopey SB, Smith BL, Lanahan CR, Korotkin JE, Specht MC. Similar rates of residual disease in patients with DCIS within 2 mm of lumpectomy margin regardless of the presence of invasive carcinoma. Breast Cancer Res Treat 2020. PubMed
  • Smith BL, Nguyen A, Korotkin JE, Kelly BN, Specht MC, Spring LM, Moy B, Isakoff SJ, Gadd MA. A system for risk stratification and prioritization of breast cancer surgeries delayed by the COVID-19 pandemic: preparing for re-entry. Breast Cancer Res Treat 2020; 183:515-524. PubMed
  • Panda N, Solsky I, Hawrusik B, Liu G, Reeder H, Lipsitz S, Desai EV, Lowery KW, Miller K, Gadd MA, Lubitz CC, Smith BL, Specht M, Onnela JP, Haynes AB. Smartphone Global Positioning System (GPS) Data Enhances Recovery Assessment After Breast Cancer Surgery. Ann Surg Oncol 2020. PubMed
  • Laws A, Dillon K, Kelly BN, Kantor O, Hughes KS, Gadd MA, Smith BL, Lamb LR, Specht M. Node-Positive Patients Treated with Neoadjuvant Chemotherapy Can Be Spared Axillary Lymph Node Dissection with Wireless Non-Radioactive Localizers. Ann Surg Oncol 2020. PubMed
  • Smith BL, Lanahan CR, Specht MC, Kelly BN, Brown C, Strasfeld DB, Ferrer JM, Rai U, Tang R, Rice-Stitt T, Biernacka A, Brachtel EF, Gadd MA. Feasibility Study of a Novel Protease-Activated Fluorescent Imaging System for Real-Time, Intraoperative Detection of Residual Breast Cancer in Breast Conserving Surgery. Ann Surg Oncol 2020. PubMed
  • Karaayvaz-Yildirim M, Silberman RE, Langenbucher A, Saladi SV, Ross KN, Zarcaro E, Desmond A, Yildirim M, Vivekanandan V, Ravichandran H, Mylavagnanam R, Specht MC, Ramaswamy S, Lawrence M, Amon A, Ellisen LW. Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of mutation carriers. Sci Adv 2020; 6:eaay2611. PubMed
  • Brown CL, McEvoy MP, Smith BL, Lanahan CR, Kelly BN, Coopey SB, Hughes KS, Oseni TS, McGugin C, Wong SM, Gadd MA, Specht MC. Long-Term Outcomes of Multiple-Wire Localizations for More Extensive Breast Cancer: Multiple-Wire Excision Does Not Increase Recurrence, Unplanned Imaging, or Biopsies. Clin Breast Cancer 2019. PubMed
  • Tang R, Acevedo F, Lanahan C, Coopey SB, Yala A, Barzilay R, Li C, Colwell A, Guidi AJ, Cetrulo C, Garber J, Smith BL, Gadd MA, Specht MC, Hughes KS. Incidental breast carcinoma: incidence, management, and outcomes in 4804 bilateral reduction mammoplasties. Breast Cancer Res Treat 2019; 177:741-748. PubMed
  • McGugin CJ, Coopey SB, Smith BL, Kelly BN, Brown CL, Gadd MA, Hughes KS, Specht MC. Enhanced Recovery Minimizes Opioid Use and Hospital Stay for Patients Undergoing Mastectomy with Reconstruction. Ann Surg Oncol 2019; 26:3464-3471. PubMed
  • Jimenez RB, Hickey S, DePauw N, Yeap BY, Batin E, Gadd MA, Specht M, Isakoff SJ, Smith BL, Liao EC, Colwell AS, Ho A, Januzzi JL, Passeri J, Neilan TG, Taghian AG, Lu HM, MacDonald SM. Phase II Study of Proton Beam Radiation Therapy for Patients With Breast Cancer Requiring Regional Nodal Irradiation. J Clin Oncol 2019. PubMed
  • Tang R, Kelly BN, Smith BL, Lanahan CR, Brown CL, Gadd MA, Hughes KS, Oseni TO, McGugin C, Specht MC, Coopey SB. Nipple Discharge After Nipple-Sparing Mastectomy With and Without Associated Pregnancy. Clin Breast Cancer 2019. PubMed
  • Chen Y, Chou SS, Blaschke EM, Specht MC, Lehman CD. Value of Mammography for Women 30-39 Years Old Presenting With Breast Symptoms. AJR Am J Roentgenol 2018. PubMed
  • Lamb LR, Bahl M, Specht MC, D'Alessandro HA, Lehman CD. Evaluation of a Nonradioactive Magnetic Marker Wireless Localization Program. AJR Am J Roentgenol 2018; 211:940-945. PubMed
  • Spring L, Niemierko A, Haddad S, Yuen M, Comander A, Reynolds K, Shin J, Bahn A, Brachtel E, Specht M, Smith BL, Taghian A, Jimenez R, Peppercorn J, Isakoff SJ, Moy B, Bardia A. Effectiveness and tolerability of neoadjuvant pertuzumab-containing regimens for HER2-positive localized breast cancer. Breast Cancer Res Treat 2018. PubMed
  • Karaayvaz M, Cristea S, Gillespie SM, Patel AP, Mylvaganam R, Luo CC, Specht MC, Bernstein BE, Michor F, Ellisen LW. Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq. Nat Commun 2018; 9:3588. PubMed
  • Smith BL, Gadd MA, Lanahan CR, Rai U, Tang R, Rice-Stitt T, Merrill AL, Strasfeld DB, Ferrer JM, Brachtel EF, Specht MC. Real-time, intraoperative detection of residual breast cancer in lumpectomy cavity walls using a novel cathepsin-activated fluorescent imaging system. Breast Cancer Res Treat 2018. PubMed
  • Coopey SB, Specht MC. Do Lumpectomy Cavity Shaved Margins Really Not Impact Re-Excision Rates in Breast Cancer? A Reply. Ann Surg Oncol 2017; 24:586-587. PubMed
  • Spring L, Greenup R, Niemierko A, Schapira L, Haddad S, Jimenez R, Coopey S, Taghian A, Hughes KS, Isakoff SJ, Ellisen LW, Smith BL, Specht M, Moy B, Bardia A. Pathologic Complete Response After Neoadjuvant Chemotherapy and Long-Term Outcomes Among Young Women With Breast Cancer. J Natl Compr Canc Netw 2017; 15:1216-1223. PubMed
  • Smith BL, Tang R, Rai U, Plichta JK, Colwell AS, Gadd MA, Specht MC, Austen WG, Coopey SB. Oncologic Safety of Nipple-Sparing Mastectomy in Women with Breast Cancer. J Am Coll Surg 2017; 225:361-365. PubMed
  • Mazzola E, Coopey SB, Griffin M, Polubriaginof F, Buckley JM, Parmigiani G, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi A, Hughes KS. Reassessing risk models for atypical hyperplasia: age may not matter. Breast Cancer Res Treat 2017. PubMed
  • Sajjadi AY, Isakoff SJ, Deng B, Singh B, Wanyo CM, Fang Q, Specht MC, Schapira L, Moy B, Bardia A, Boas DA, Carp SA. Normalization of compression-induced hemodynamics in patients responding to neoadjuvant chemotherapy monitored by dynamic tomographic optical breast imaging (DTOBI). Biomed Opt Express 2017; 8:555-569. PubMed
  • Merrill AL, Buckley J, Tang R, Brachtel E, Rai U, Michaelson J, Ly A, Specht MC, Yagi Y, Smith BL. A Study of the Growth Patterns of Breast Carcinoma Using 3D Reconstruction: A Pilot Study. Breast J 2017; 23:83-89. PubMed
  • Plichta JK, Rai U, Tang R, Coopey SB, Buckley JM, Gadd MA, Specht MC, Hughes KS, Taghian AG, Smith BL. Factors Associated with Recurrence Rates and Long-Term Survival in Women Diagnosed with Breast Cancer Ages 40 and Younger. Ann Surg Oncol 2016; 23:3212-20. PubMed
  • Merrill AL, Tang R, Plichta JK, Rai U, Coopey SB, McEvoy MP, Hughes KS, Specht MC, Gadd MA, Smith BL. Should New "No Ink On Tumor" Lumpectomy Margin Guidelines be Applied to Ductal Carcinoma In Situ (DCIS)? A Retrospective Review Using Shaved Cavity Margins. Ann Surg Oncol 2016. PubMed
  • Tang R, Coopey SB, Merrill AL, Rai U, Specht MC, Gadd MA, Colwell AS, Austen WG, Brachtel EF, Smith BL. Positive Nipple Margins in Nipple-Sparing Mastectomies: Rates, Management, and Oncologic Safety. J Am Coll Surg 2016. PubMed
  • Miller CL, Coopey SB, Rafferty E, Gadd M, Smith BL, Specht MC. Comparison of intra-operative specimen mammography to standard specimen mammography for excision of non-palpable breast lesions: a randomized trial. Breast Cancer Res Treat 2016; 155:513-9. PubMed
  • Ferguson CM, Swaroop MN, Horick N, Skolny MN, Miller CL, Jammallo LS, Brunelle C, O'Toole JA, Salama L, Specht MC, Taghian AG. Impact of Ipsilateral Blood Draws, Injections, Blood Pressure Measurements, and Air Travel on the Risk of Lymphedema for Patients Treated for Breast Cancer. J Clin Oncol 2015. PubMed
  • Sadek BT, Homayounfar G, Abi Raad RF, Niemierko A, Shenouda MN, Keruakous AR, Specht MC, Taghian AG. Is a higher boost dose of radiation necessary after breast-conserving therapy for patients with breast cancer with final close or positive margins? Breast Cancer Res Treat 2015. PubMed
  • Merrill AL, Coopey SB, Tang R, McEvoy MP, Specht MC, Hughes KS, Gadd MA, Smith BL. Implications of New Lumpectomy Margin Guidelines for Breast-Conserving Surgery: Changes in Reexcision Rates and Predicted Rates of Residual Tumor. Ann Surg Oncol 2015. PubMed
  • Miller CL, Colwell AS, Horick N, Skolny MN, Jammallo LS, O'Toole JA, Shenouda MN, Sadek BT, Swaroop MN, Ferguson CM, Smith BL, Specht MC, Taghian AG. Immediate Implant Reconstruction Is Associated With a Reduced Risk of Lymphedema Compared to Mastectomy Alone: A Prospective Cohort Study. Ann Surg 2015. PubMed
  • McEvoy MP, Coopey SB, Mazzola E, Buckley J, Belli A, Polubriaginof F, Merrill AL, Tang R, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi AJ, Roche CA, Hughes KS. Breast Cancer Risk and Follow-up Recommendations for Young Women Diagnosed with Atypical Hyperplasia and Lobular Carcinoma In Situ (LCIS). Ann Surg Oncol 2015; 22:3346-9. PubMed
  • Tang R, Coopey SB, Colwell AS, Specht MC, Gadd MA, Kansal K, McEvoy MP, Merrill AL, Rai U, Taghian A, Austen WG, Smith BL. Nipple-Sparing Mastectomy in Irradiated Breasts: Selecting Patients to Minimize Complications. Ann Surg Oncol 2015; 22:3331-7. PubMed
  • Bevers TB, Ward JH, Arun BK, Colditz GA, Cowan KH, Daly MB, Garber JE, Gemignani ML, Gradishar WJ, Jordan JA, Korde LA, Kounalakis N, Krontiras H, Kumar S, Kurian A, Laronga C, Layman RM, Loftus LS, Mahoney MC, Merajver SD, Meszoely IM, Mortimer J, Newman L, Pritchard E, Pruthi S, Seewaldt V, Specht MC, Visvanathan K, Wallace A, Bergman MA, Kumar R. Breast Cancer Risk Reduction, Version 2.2015. J Natl Compr Canc Netw 2015; 13:880-915. PubMed
  • Tang R, Coopey SB, Specht MC, Lei L, Gadd MA, Hughes KS, Brachtel EF, Smith BL. Lumpectomy specimen margins are not reliable in predicting residual disease in breast conserving surgery. Am J Surg 2015. PubMed
  • Swaroop MN, Ferguson CM, Horick NK, Skolny MN, Miller CL, Jammallo LS, Brunelle CL, O'Toole JA, Isakoff SJ, Specht MC, Taghian AG. Impact of adjuvant taxane-based chemotherapy on development of breast cancer-related lymphedema: results from a large prospective cohort. Breast Cancer Res Treat 2015; 151:393-403. PubMed
  • O'Toole JA, Ferguson CM, Swaroop MN, Horick N, Skolny MN, Brunelle CL, Miller CL, Jammallo LS, Specht MC, Taghian AG. The impact of breast cancer-related lymphedema on the ability to perform upper extremity activities of daily living. Breast Cancer Res Treat 2015; 150:381-8. PubMed
  • Chandra RA, Miller CL, Skolny MN, Warren LE, Horick N, Jammallo LS, Sadek BT, Shenouda MN, O'Toole J, Specht MC, Taghian AG. Radiation therapy risk factors for development of lymphedema in patients treated with regional lymph node irradiation for breast cancer. Int J Radiat Oncol Biol Phys 2015; 91:760-4. PubMed
  • Gfrerer L, Mattos D, Mastroianni M, Weng QY, Ricci JA, Heath MP, Lin A, Specht MC, Haynes AB, Austen WG, Liao EC. Assessment of patient factors, surgeons, and surgeon teams in immediate implant-based breast reconstruction outcomes. Plast Reconstr Surg 2015; 135:245e-52e. PubMed
  • Moy B, Specht MC, Lanuti M, Rafferty EA, Lerwill MF. Case records of the Massachusetts General Hospital. Case 1-2015. A 66-year-old woman with metastatic breast cancer after endocrine therapy. N Engl J Med 2015; 372:162-70. PubMed
  • Gfrerer L, Mattos D, Mastroianni M, Weng QY, Ricci JA, Heath P, Lin A, Specht MC, Haynes AB, Austen WG, Liao EC. Impact of surgeon and surgical team on outcomes in immediate implant based breast reconstruction. Plast Reconstr Surg 2014; 134:94-5. PubMed
  • Jammallo LS, Miller CL, Horick NK, Skolny MN, O'Toole J, Specht MC, Taghian AG. Factors associated with fear of lymphedema after treatment for breast cancer. Oncol Nurs Forum 2014; 41:473-83. PubMed
  • Miller CL, West JA, Bettini AC, Koerner FC, Gudewicz TM, Freer PE, Coopey SB, Gadd MA, Hughes KS, Smith BL, Rafferty E, Specht MC. Surgical excision of radial scars diagnosed by core biopsy may help predict future risk of breast cancer. Breast Cancer Res Treat 2014. PubMed
  • Warren LE, Miller CL, Horick N, Skolny MN, Jammallo LS, Sadek BT, Shenouda MN, O'Toole JA, MacDonald SM, Specht MC, Taghian AG. The impact of radiation therapy on the risk of lymphedema after treatment for breast cancer: a prospective cohort study. Int J Radiat Oncol Biol Phys 2014; 88:565-71. PubMed
  • Miller CL, Specht MC, Skolny MN, Horick N, Jammallo LS, O'Toole J, Shenouda MN, Sadek BT, Smith BL, Taghian AG. Risk of lymphedema after mastectomy: potential benefit of applying ACOSOG Z0011 protocol to mastectomy patients. Breast Cancer Res Treat 2014; 144:71-7. PubMed
  • Jammallo LS, Miller CL, Singer M, Horick NK, Skolny MN, Specht MC, O'Toole J, Taghian AG. Impact of body mass index and weight fluctuation on lymphedema risk in patients treated for breast cancer. Breast Cancer Res Treat 2013; 142:59-67. PubMed
  • O'Toole J, Jammallo LS, Skolny MN, Miller CL, Elliott K, Specht MC, Taghian AG. Lymphedema following treatment for breast cancer: a new approach to an old problem. Crit Rev Oncol Hematol 2013; 88:437-46. PubMed
  • Coopey SB, Tang R, Lei L, Freer PE, Kansal K, Colwell AS, Gadd MA, Specht MC, Austen WG, Smith BL. Increasing eligibility for nipple-sparing mastectomy. Ann Surg Oncol 2013; 20:3218-22. PubMed
  • Specht MC, Miller CL, Skolny MN, Jammallo LS, O'Toole J, Horick N, Isakoff SJ, Smith BL, Taghian AG. Residual lymph node disease after neoadjuvant chemotherapy predicts an increased risk of lymphedema in node-positive breast cancer patients. Ann Surg Oncol 2013; 20:2835-41. PubMed
  • Specht MC, Miller CL, Russell TA, Horick N, Skolny MN, O'Toole JA, Jammallo LS, Niemierko A, Sadek BT, Shenouda MN, Finkelstein DM, Smith BL, Taghian AG. Defining a threshold for intervention in breast cancer-related lymphedema: what level of arm volume increase predicts progression? Breast Cancer Res Treat 2013; 140:485-94. PubMed
  • O'Toole J, Miller CL, Specht MC, Skolny MN, Jammallo LS, Horick N, Elliott K, Niemierko A, Taghian AG. Cording following treatment for breast cancer. Breast Cancer Res Treat 2013; 140:105-11. PubMed
  • MacDonald SM, Patel SA, Hickey S, Specht M, Isakoff SJ, Gadd M, Smith BL, Yeap BY, Adams J, Delaney TF, Kooy H, Lu HM, Taghian AG. Proton therapy for breast cancer after mastectomy: early outcomes of a prospective clinical trial. Int J Radiat Oncol Biol Phys 2013. PubMed
  • Coopey SB, Specht MC, Warren L, Smith BL, Winograd JM, Fleischmann K. Use of preoperative paravertebral block decreases length of stay in patients undergoing mastectomy plus immediate reconstruction. Ann Surg Oncol 2013. PubMed
  • Camp MS, Greenup RA, Taghian A, Coopey SB, Specht M, Gadd M, Hughes K, Smith BL. Application of ACOSOG Z0011 criteria reduces perioperative costs. Ann Surg Oncol 2013. PubMed
  • Carp SA, Sajjadi AY, Wanyo CM, Fang Q, Specht MC, Schapira L, Moy B, Bardia A, Boas DA, Isakoff SJ. Hemodynamic signature of breast cancer under fractional mammographic compression using a dynamic diffuse optical tomography system. Biomed Opt Express 2013; 4:2911-24. PubMed
  • Coopey SB, Mazzola E, Buckley JM, Sharko J, Belli AK, Kim EM, Polubriaginof F, Parmigiani G, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi AJ, Roche CA, Hughes KS. The role of chemoprevention in modifying the risk of breast cancer in women with atypical breast lesions. Breast Cancer Res Treat 2012. PubMed
  • Ancukiewicz M, Miller CL, Skolny MN, O'Toole J, Warren LE, Jammallo LS, Specht MC, Taghian AG. Erratum to: Comparison of relative versus absolute arm size change as criteria for quantifying breast cancer-related lymphedema: the flaws in current studies and need for universal methodology. Breast Cancer Res Treat 2012; 136:623. PubMed
  • Pashtan IM, Recht A, Ancukiewicz M, Brachtel E, Abi-Raad RF, D'Alessandro HA, Levy A, Wo JY, Hirsch AE, Kachnic LA, Goldberg S, Specht M, Gadd M, Smith BL, Powell SN, Taghian AG. External beam accelerated partial-breast irradiation using 32 gy in 8 twice-daily fractions: 5-year results of a prospective study. Int J Radiat Oncol Biol Phys 2012; 84:e271-7. PubMed
  • Miller CL, Specht MC, Skolny MN, Jammallo LS, Horick N, O'Toole J, Coopey SB, Hughes K, Gadd M, Smith BL, Taghian AG. Sentinel lymph node biopsy at the time of mastectomy does not increase the risk of lymphedema: implications for prophylactic surgery. Breast Cancer Res Treat 2012; 135:781-9. PubMed
  • Greenup RA, Camp MS, Taghian AG, Buckley J, Coopey SB, Gadd M, Hughes K, Specht M, Smith BL. Cost comparison of radiation treatment options after lumpectomy for breast cancer. Ann Surg Oncol 2012; 19:3275-81. PubMed
  • Ancukiewicz M, Miller CL, Skolny MN, O'Toole J, Warren LE, Jammallo LS, Specht MC, Taghian AG. Comparison of relative versus absolute arm size change as criteria for quantifying breast cancer-related lymphedema: the flaws in current studies and need for universal methodology. Breast Cancer Res Treat 2012; 135:145-52. PubMed
  • Buckley JM, Coopey SB, Sharko J, Polubriaginof F, Drohan B, Belli AK, Kim EM, Garber JE, Smith BL, Gadd MA, Specht MC, Roche CA, Gudewicz TM, Hughes KS. The feasibility of using natural language processing to extract clinical information from breast pathology reports. J Pathol Inform 2012; 3:23. PubMed
  • Ancukiewicz M, Russell TA, Otoole J, Specht M, Singer M, Kelada A, Murphy CD, Pogachar J, Gioioso V, Patel M, Skolny M, Smith BL, Taghian AG. Standardized Method for Quantification of Developing Lymphedema in Patients Treated for Breast Cancer. Int J Radiat Oncol Biol Phys 2010. PubMed
  • Samphao S, Wheeler AJ, Rafferty E, Michaelson JS, Specht MC, Gadd MA, Hughes KS, Smith BL. Diagnosis of breast cancer in women age 40 and younger: delays in diagnosis result from underuse of genetic testing and breast imaging. Am J Surg 2009; 198:538-43. PubMed
  • Javid SH, Kirstein LJ, Rafferty E, Lipsitz S, Moore R, Rusby JE, Murphy CD, Hughes KS, Specht MC, Taghian AG, Smith BL. Outcome of multiple-wire localization for larger breast cancers: do multiple wires translate into additional imaging, biopsies, and recurrences? Am J Surg 2009; 198:368-72. PubMed
  • Murphy CD,Lee JM,Drohan B,Euhus DM,Kopans DB,Gadd MA,Rafferty EA,Specht MC,Smith BL,Hughes KS. The American Cancer Society guidelines for breast screening with magnetic resonance imaging: an argument for genetic testing. Cancer 2008; 113:3116-20. PubMed
  • Pandharipande PV,Harisinghani MG,Ozanne EM,Specht MC,Hur C,Lee JM,Gazelle GS. Staging MR lymphangiography of the axilla for early breast cancer: cost-effectiveness analysis. AJR Am J Roentgenol 2008; 191:1308-19. PubMed
  • Murphy CD,Jones JL,Javid SH,Michaelson JS,Nolan ME,Lipsitz SR,Specht MC,Lesnikoski BA,Hughes KS,Gadd MA,Smith BL. Do sentinel node micrometastases predict recurrence risk in ductal carcinoma in situ and ductal carcinoma in situ with microinvasion? Am J Surg 2008; 196:566-8. PubMed
  • Kirstein LJ,Rafferty E,Specht MC,Moore RH,Taghian AG,Hughes KS,Gadd MA,Smith BL. Outcomes of multiple wire localization for larger breast cancers: when can mastectomy be avoided? J Am Coll Surg 2008; 207:342-6. PubMed
  • Katz A, Smith BL, Golshan M, Niemierko A, Kobayashi W, Raad RA, Kelada A, Rizk L, Wong JS, Bellon JR, Gadd M, Specht M, Taghian AG. Nomogram for the prediction of having four or more involved nodes for sentinel lymph node-positive breast cancer. J Clin Oncol 2008; 26:2093-8. PubMed
  • Miller JC, Rafferty EA, Specht MC, Thrall JH, Lee SI. When is breast magnetic resonance imaging recommended for cancer detection? J Am Coll Radiol 2008; 5:224-6. PubMed
  • Dominguez FJ, Golshan M, Black DM, Hughes KS, Gadd MA, Christian R, Lesnikoski BA, Specht M, Michaelson J, Smith BL. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ. Ann Surg Oncol 2008; 15:268-73. PubMed
  • Black D, Specht M, Lee JM, Dominguez F, Gadd M, Hughes K, Rafferty E, Smith B. Detecting occult malignancy in prophylactic mastectomy: preoperative MRI versus sentinel lymph node biopsy. Ann Surg Oncol 2007; 14:2477-84. PubMed
  • Dominguez FJ, Lawrence C, Halpern EF, Drohan B, Grinstein G, Black DM, Smith BL, Gadd MA, Specht M, Kopans DB, Moore RH, Hughes SS, Roche CA, Hughes KS. Accuracy of Self-Reported Personal History of Cancer in an Outpatient Breast Center. J Genet Couns 2007; 16:341-5. PubMed
  • Zabicki K, Colbert JA, Dominguez FJ, Gadd MA, Hughes KS, Jones JL, Specht MC, Michaelson JS, Smith BL. Breast Cancer Diagnosis in Women PubMed
  • Tang R, Coopey SB, Buckley JM, Aftreth OP, Fernandez LJ, Brachtel EF, Michaelson JS, Gadd MA, Specht MC, Koerner FC, Smith BL. A pilot study evaluating shaved cavity margins with micro-computed tomography: a novel method for predicting lumpectomy margin status intraoperatively. Breast J ; 19:485-9. PubMed
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* Concepts are MeSH terms, automatically derived from member publications

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