Photo of Simon K. Warfield,  PhD

Simon K. Warfield, PhD

Boston Children's Hospital

Boston Children's Hospital
Phone: (617) 355-4566
Fax: (617) 730-4644

Simon K. Warfield, PhD

Boston Children's Hospital


  • Professor, Radiology, Harvard Medical School
  • Director, Computational Radiology Laboratory, Boston Children's Hospital
  • Director of Research, Department of Radiology, Boston Children's Hospital


Research Abstract

My research focus is on the development of novel algorithms that improve our capability to extract information from images and to apply that information for the treatment of cancer. The applications of this technology include:

1. improved targeting and monitoring for brain tumor surgeries and prostate cancer treatment

2. preoperative surgical planning

3. assessment of tumor volume and infiltration by 3D segmentation of multimodality imaging data

4. nonrigid registration for multimodality image fusion

Publications from Harvard Catalyst Profiles

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  • Karimi D, Peters JM, Ouaalam A, Prabhu SP, Sahin M, Krueger DA, Kolevzon A, Eng C, Warfield SK, Gholipour A. LEARNING TO DETECT BRAIN LESIONS FROM NOISY ANNOTATIONS. Proc IEEE Int Symp Biomed Imaging 2020; 2020:1910-1914. PubMed
  • Miller K, Joldes GR, Bourantas G, Warfield SK, Hyde DE, Kikinis R, Wittek A. Biomechanical modeling and computer simulation of the brain during neurosurgery. Int J Numer Method Biomed Eng 2019. PubMed
  • Peters JM, Prohl A, Kapur K, Nath A, Scherrer B, Clancy S, Prabhu SP, Sahin M, Franz DN, Warfield SK, Krueger DA. Longitudinal Effects of Everolimus on White Matter Diffusion in Tuberous Sclerosis Complex. Pediatr Neurol 2019; 90:24-30. PubMed
  • Alexander B, Murray AL, Loh WY, Matthews LG, Adamson C, Beare R, Chen J, Kelly CE, Rees S, Warfield SK, Anderson PJ, Doyle LW, Spittle AJ, Cheong JL, Seal ML, Thompson DK. A new neonatal cortical and subcortical brain atlas: the Melbourne Children's Regional Infant Brain (M-CRIB) atlas. Neuroimage 2017; 147:841-851. PubMed
  • Im K, Ahtam B, Haehn D, Peters JM, Warfield SK, Sahin M, Ellen Grant P. Altered Structural Brain Networks in Tuberous Sclerosis Complex. Cereb Cortex 2015. PubMed
  • Taquet M, Scherrer B, Commowick O, Peters JM, Sahin M, Macq B, Warfield SK. A mathematical framework for the registration and analysis of multi-fascicle models for population studies of the brain microstructure. IEEE Trans Med Imaging 2014; 33:504-17. PubMed
  • Taimouri V, Akhondi-Asl A, Tomas-Fernandez X, Peters JM, Prabhu SP, Poduri A, Takeoka M, Loddenkemper T, Bergin AM, Harini C, Madsen JR, Warfield SK. Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy. 2014; 9:91-105. PubMed
  • Hunold A, Haueisen J, Ahtam B, Doshi C, Harini C, Camposano S, Warfield SK, Grant PE, Okada Y, Papadelis C. Localization of the epileptogenic foci in tuberous sclerosis complex: a pediatric case report. Front Hum Neurosci 2014; 8:175. PubMed
  • Akhondi-Asl A, Warfield SK. Simultaneous truth and performance level estimation through fusion of probabilistic segmentations. IEEE Trans Med Imaging 2013; 32:1840-52. PubMed
  • Weisenfeld NI, Peters JM, Tsai PT, Prabhu SP, Dies KA, Sahin M, Warfield SK. A magnetic resonance imaging study of cerebellar volume in tuberous sclerosis complex. Pediatr Neurol 2013; 48:105-10. PubMed
  • Hyde DE, Duffy FH, Warfield SK. Anisotropic partial volume CSF modeling for EEG source localization. Neuroimage 2012; 62:2161-70. PubMed
  • Lee JW, Wen PY, Hurwitz S, Black P, Kesari S, Drappatz J, Golby AJ, Wells WM, Warfield SK, Kikinis R, Bromfield EB. Morphological characteristics of brain tumors causing seizures. Arch Neurol 2010; 67:336-42. PubMed
  • Commowick O, Warfield SK. Estimation of inferential uncertainty in assessing expert segmentation performance from STAPLE. IEEE Trans Med Imaging 2010; 29:771-80. PubMed
  • Krishnan ML, Commowick O, Jeste SS, Weisenfeld N, Hans A, Gregas MC, Sahin M, Warfield SK. Diffusion features of white matter in tuberous sclerosis with tractography. Pediatr Neurol 2010; 42:101-6. PubMed
  • Gholipour A, Estroff JA, Sahin M, Prabhu SP, Warfield SK. Maximum a posteriori estimation of isotropic high-resolution volumetric MRI from orthogonal thick-slice scans. Med Image Comput Comput Assist Interv 2010; 13:109-16. PubMed
  • Commowick O, Warfield SK. Incorporating priors on expert performance parameters for segmentation validation and label fusion: a maximum a posteriori STAPLE. Med Image Comput Comput Assist Interv 2010; 13:25-32. PubMed
  • Benders MJ, Groenendaal F, van Bel F, Ha Vinh R, Dubois J, Lazeyras F, Warfield SK, Hüppi PS, de Vries LS. Brain development of the preterm neonate after neonatal hydrocortisone treatment for chronic lung disease. Pediatr Res 2009; 66:555-9. PubMed
  • Vigneron LM, Duflot MP, Robe PA, Warfield SK, Verly JG. 2D XFEM-based modeling of retraction and successive resections for preoperative image update. Comput Aided Surg 2009. PubMed
  • Commowick O,Warfield SK. A continuous STAPLE for scalar, vector, and tensor images: an application to DTI analysis. IEEE Trans Med Imaging 2009; 28:838-46. PubMed
  • Warfield SK,Zou KH,Wells WM. Validation of image segmentation by estimating rater bias and variance. Philos Transact A Math Phys Eng Sci 2008; 366:2361-75. PubMed
  • Archip N, Clatz O, Whalen S, Dimaio SP, Black PM, Jolesz FA, Golby A, Warfield SK. Compensation of geometric distortion effects on intraoperative magnetic resonance imaging for enhanced visualization in image-guided neurosurgery. Neurosurgery 2008; 62:209-15; discussion 215-6. PubMed
  • Archip N, Jolesz FA, Warfield SK. A validation framework for brain tumor segmentation. Acad Radiol 2007; 14:1242-51. PubMed
  • Archip N, Clatz O, Whalen S, Kacher D, Fedorov A, Kot A, Chrisochoides N, Jolesz F, Golby A, Black PM, Warfield SK. Non-rigid alignment of pre-operative MRI, fMRI, and DT-MRI with intra-operative MRI for enhanced visualization and navigation in image-guided neurosurgery. Neuroimage 2007; 35:609-24. PubMed
  • Dimaio SP, Archip N, Hata N, Talos IF, Warfield SK, Majumdar A, Mcdannold N, Hynynen K, Morrison PR, Wells WM, Kacher DF, Ellis RE, Golby AJ, Black PM, Jolesz FA, Kikinis R. Image-guided neurosurgery at Brigham and Women's Hospital. IEEE Eng Med Biol Mag 2006; 25:67-73. PubMed