Photo of Annie W. Chan, MD

Annie W. Chan, MD

Massachusetts General Hospital

Massachusetts General Hospital
Phone: (617) 726-5184
Fax: (617) 726-3603


awchan@partners.org

Photo of Annie W. Chan, MD

Massachusetts General Hospital
Phone: (617) 726-5184
Fax: (617) 726-3603


awchan@partners.org

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Annie W. Chan, MD

Massachusetts General Hospital

EDUCATIONAL TITLES

  • Associate Professor, Radiation Oncology, Harvard Medical School
  • MD, Director, Head and Neck Service, Radiation Oncology, Massachusetts General Hospital, Radiation Oncology, Massachusetts General Hospital

DF/HCC PROGRAM AFFILIATION

Research Abstract

My clinical research has exploited the superior dose distribution of proton beam to improve clinical outcome and decrease the treatment-related morbidity in patients with head and neck and skull base malignancies. My translational research is to develop novel imaging technologies to improve cancer diagnosis and outcome.

Publications from Harvard Catalyst Profiles

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  • Naegele S, Efthymiou V, Hirayama S, Zhao BY, Das D, Chan AW, Richmon JD, Iafrate AJ, Faden DL. Double trouble: Synchronous and metachronous primaries confound ctHPVDNA monitoring. Head Neck 2023; 45:E25-E30. PubMed
  • Bobić M, Lalonde A, Nesteruk KP, Lee H, Nenoff L, Gorissen BL, Bertolet A, Busse PM, Chan AW, Winey BA, Sharp GC, Verburg JM, Lomax AJ, Paganetti H. Large anatomical changes in head-and-neck cancers - A dosimetric comparison of online and offline adaptive proton therapy. Clin Transl Radiat Oncol 2023; 40:100625. PubMed
  • Hassan MZO, Tawakol A, Wang Y, Alvi RM, Awadalla M, Jones-O'Connor M, B Bakar R, Banerji D, Rokicki A, Zhang L, Mulligan CP, Osborne MT, Zarif A, Hammad B, Chan AW, Wirth LJ, Warner ET, Pitman RK, Armstrong KA, Addison D, Neilan TG. Amygdalar activity measured using FDG-PET/CT at head and neck cancer staging independently predicts survival. PLoS ONE 2023; 18:e0279235. PubMed
  • Alvi RM, Quinaglia T, Spahillari A, Suero-Abreu GA, Hassan MZO, Gongora C, Gilman HK, Nikolaidou S, Sama S, Wirth LJ, Chan AW, Addison D, Neilan TG. The Prediction of Cardiac Events Using Contemporary Risk Prediction Models after Radiation Therapy for Head and Neck Cancer. Cancers (Basel) 2022. PubMed
  • Mokhtari TE, Warinner C, Edwards H, Chan AW, Annino D, Schoenfeld JD, Sethi RKV, Rettig EM. Unusual presentation of HPV-positive squamous cell carcinoma of the nasolacrimal duct as carcinoma of unknown primary. Am J Otolaryngol 2022; 43:103457. PubMed
  • O'Boyle CJ, Siravegna G, Varmeh S, Queenan N, Michel A, Pang KCS, Stein J, Thierauf JC, Sadow PM, Faquin WC, Wang W, Deschler DG, Emerick KS, Varvares MA, Park JC, Clark JR, Chan AW, Busse PM, Corcoran RB, Wirth LJ, Lin DT, Iafrate AJ, Richmon JD, Faden DL. Cell-free human papillomavirus DNA kinetics after surgery for human papillomavirus-associated oropharyngeal cancer. Cancer 2022. PubMed
  • Luo H, Yang C, Kuang D, Shi S, Chan AW. Visualizing dynamic changes in PD-L1 expression in non-small cell lung carcinoma with radiolabeled recombinant human PD-1. Eur J Nucl Med Mol Imaging 2022. PubMed
  • Siravegna G, O'Boyle CJ, Varmeh S, Queenan N, Michel A, Stein J, Thierauf J, Sadow PM, Faquin WC, Perry SK, Bard AZ, Wang W, Deschler DG, Emerick KS, Varvares MA, Park JC, Clark JR, Chan AW, Andreu Arasa VC, Sakai O, Lennerz J, Corcoran RB, Wirth LJ, Lin DT, Iafrate AJ, Richmon JD, Faden DL. Cell-Free HPV DNA Provides an Accurate and Rapid Diagnosis of HPV-Associated Head and Neck Cancer. Clin Cancer Res 2022; 28:719-727. PubMed
  • Zhang YY, Huo WL, Goldberg SI, Slater JM, Adams JA, Deng XW, Sun Y, Ma J, Fullerton BC, Paganetti H, Loeffler JS, Lu HM, Chan AW. Brain-specific RBE of Protons Based on Long-term Outcome of Patients with Nasopharyngeal Carcinoma. Int J Radiat Oncol Biol Phys 2021. PubMed
  • Sanford NN, Lau J, Lam MB, Juliano AF, Adams JA, Goldberg SI, Lu HM, Lu YC, Liebsch NJ, Curtin HD, Chan AW. Individualization of Clinical Target Volume Delineation Based on Stepwise Spread of Nasopharyngeal Carcinoma: Outcome of More Than a Decade of Clinical Experience. Int J Radiat Oncol Biol Phys 2019; 103:654-668. PubMed
  • Shusharina N, Fullerton B, Adams JA, Sharp GC, Chan AW. Impact of aeration change and beam arrangement on the robustness of proton plans. J Appl Clin Med Phys 2019; 20:14-21. PubMed
  • Koenigs MB, Lefranc-Torres A, Bonilla-Velez J, Patel KB, Hayes DN, Glomski K, Busse PM, Chan AW, Clark JR, Deschler DG, Emerick KS, Hammon RJ, Wirth LJ, Lin DT, Mroz EA, Faquin WC, Rocco JW. Association of Estrogen Receptor Alpha Expression With Survival in Oropharyngeal Cancer Following Chemoradiation Therapy. Journal of the National Cancer Institute 2019. PubMed
  • Yerramilli D, Kovatch KJ, Chan AW, Swiecicki P, Margalit DN, Shuman AG. Palliative Head and Neck Cancer Treatment for Asymptomatic Disease. 2018. PubMed
  • Addison D, Lawler PR, Emami H, Janjua SA, Staziaki PV, Hallett TR, Hennessy O, Lee H, Szilveszter B, Lu M, Mousavi N, Nayor MG, Delling FN, Romero JM, Wirth LJ, Chan AW, Hoffmann U, Neilan TG. Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck Cancer. J Stroke 2018; 20:71-79. PubMed
  • Addison D, Seidelmann SB, Janjua SA, Emami H, Staziaki PV, Hallett TR, Szilveszter B, Lu MT, Cambria RP, Hoffmann U, Chan AW, Wirth LJ, Neilan TG. Human Papillomavirus Status and the Risk of Cerebrovascular Events Following Radiation Therapy for Head and Neck Cancer. J Am Heart Assoc 2017. PubMed
  • Gentile MS, Yip D, Liebsch NJ, Adams JA, Busse PM, Chan AW. Definitive proton beam therapy for adenoid cystic carcinoma of the nasopharynx involving the base of skull. Oral Oncol 2017; 65:38-44. PubMed
  • Russo AL, Adams JA, Weyman EA, Busse PM, Goldberg SI, Varvares M, Deschler DD, Lin DT, Delaney TF, Chan AW. Long-Term Outcomes After Proton Beam Therapy for Sinonasal Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys 2016; 95:368-76. PubMed
  • Gray ST, Herr MW, Sethi RK, Diercks G, Lee L, Curry W, Chan A, Clark J, Holbrook EH, Rocco J, Sadow PM, Lin DT. Treatment outcomes and prognostic factors, including human papillomavirus, for sinonasal undifferentiated carcinoma: a retrospective review. Head Neck 2015. PubMed
  • McBride SM, Rothenberg SM, Faquin WC, Chan AW, Clark JR, Ellisen LW, Wirth LJ. Mutation frequency in 15 common cancer genes in high-risk head and neck squamous cell carcinoma. Head Neck 2014. PubMed
  • McBride SM, Parambi RJ, Jang JW, Goldsmith T, Busse PM, Chan AW. Intensity-modulated versus conventional radiation therapy for oropharyngeal carcinoma: long-term dysphagia and tumor control outcomes. Head Neck 2014. PubMed
  • McBride SM, Busse PM, Clark JR, Wirth LJ, Ancukiewicz M, Chan AW. Long-term survival after distant metastasis in patients with oropharyngeal cancer. Oral Oncol 2014; 50:208-12. PubMed
  • Jang JW, Parambi RJ, McBride SM, Goldsmith TA, Holman AS, Chan AW. Clinical factors predicting for prolonged enteral supplementation in patients with oropharyngeal cancer treated with chemoradiation. Oral Oncol 2013; 49:438-42. PubMed
  • Jang JW, Chan AW. Prevention and management of complications after radiotherapy for skull base tumors: a multidisciplinary approach. Adv. Otorhinolaryngol. 2013; 74:163-73. PubMed
  • Aizer AA, Chan AW. A tale of two tumors: pediatric and adult medulloblastoma. Oncology (Huntingt) 2012; 26:1095-7. PubMed
  • Wong HK, Lahdenranta J, Kamoun WS, Chan AW, McClatchey AI, Plotkin SR, Jain RK, di Tomaso E. Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors. Cancer Res 2010; 70:3483-93. PubMed
  • Truong MT, Kamat UR, Liebsch NJ, Curry WT, Lin DT, Barker FG, Loeffler JS, Chan AW. Proton radiation therapy for primary sphenoid sinus malignancies: treatment outcome and prognostic factors. Head Neck 2009; 31:1297-308. PubMed
  • Nichols AC,Chan AW,Curry WT,Barker FG,Deschler DG,Lin DT. Esthesioneuroblastoma: the massachusetts eye and ear infirmary and massachusetts general hospital experience with craniofacial resection, proton beam radiation, and chemotherapy. Skull Base 2008; 18:327-37. PubMed
  • Chan AW,Liebsch NJ. Proton radiation therapy for head and neck cancer. J Surg Oncol 2008; 97:697-700. PubMed
  • Cole BK, Curto M, Chan AW, McClatchey AI. Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing. Mol Cell Biol 2008; 28:1274-84. PubMed
  • Resto VA, Chan AW, Deschler DG, Lin DT. Extent of surgery in the management of locally advanced sinonasal malignancies. Head Neck 2008; 30:222-9. PubMed
  • Johannessen CM, Johnson BW, Williams SM, Chan AW, Reczek EE, Lynch RC, Rioth MJ, McClatchey A, Ryeom S, Cichowski K. TORC1 is essential for NF1-associated malignancies. Curr Biol 2008; 18:56-62. PubMed
  • Weber DC, Chan AW, Lessell S, McIntyre JF, Goldberg SI, Bussiere MR, Fitzek MM, Thornton AF, Delaney TF. Visual outcome of accelerated fractionated radiation for advanced sinonasal malignancies employing photons/protons. Radiother Oncol 2006; 81:243-9. PubMed
  • Pommier P, Liebsch NJ, Deschler DG, Lin DT, McIntyre JF, Barker FG, Adams JA, Lopes VV, Varvares M, Loeffler JS, Chan AW. Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg 2006; 132:1242-9. PubMed
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Visualize Collaborations
Learn how these members are similar
Similar Members

DF/HCC members that share similar concepts* with Annie W. Chan, MD but have yet to coauthor a publication with this researcher.

* Concepts are MeSH terms, automatically derived from member publications

Similar Members